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| 1 | Nature:死亡的肿瘤细胞释放出胞内钾离子来阻断免疫系统显示文摘在一项新的研究中。来自美国国家癌症研究所和英国巴布拉汉研究所的研究人员发现当肿瘤组织死亡时从它当中泄露出来的一种无机离子起着阻止抗肿瘤免疫细胞发挥功能的作用。这一发现为开发调动免疫系统抵抗癌症的疗法提供一种新的方法。相关研究结果在线发表在Nature期刊上。 | Robert Eil, Suman K. Vodnala, David Clever, Christopher A. Klebanoff, Madhusudhanan Sukumar, Jenny H. Pan, Douglas C. Palmer, Alena Gros, Tori N. Yamamoto, Shashank J. Patel, Geoffrey C. Guittard, Zhiya Yu, David S. Schrump, W. Marston Linehan, Nicholas P. Restifo Christopher A. Klebanoff Valentina Carbonaro, Klaus Okkenhaug, Rahul Roychoudhuri | 2016 | 现代生物医学进展2016，16，31： | 12 |
| 2 | Copper Delivery by the Copper Chaperone for Chloroplast and Cytosolic Copper/Zinc- Superoxide Dismutases: Regulation and Unexpected Phenotypes in an Arabidopsis Mutant显示文摘铜(Cu ) 是作为与 plastocyanin 和 Cu/Zn superoxide dismutase (Cu/ZnSOD ) 联系的一个余因子在叶绿体发现的重要矿物质营养素。Superoxide dismutases 是在减少氧化应力与建议角色在很氧的有机体发现的 metallo 酶。在 Arabidopsis 的几最近的研究显示出那 microRNAs 和一个 SQUAMOSA 倡导者绑定 protein-like7 (SPL7 ) 抄写因素函数到下面调整许多 Cu 蛋白质的表达式包括在质体和 cytosol 的 Cu/ZnSOD,在低 Cu 上的生长期间。植物为把 Cu 送到 Cu/ZnSODs 的草皮(CCS ) 包含 Cu 女伴,并且,在 Arabidopsis, cytosolic 和 plastidic CCS 版本被一基因编码。在这研究,我们证明 Arabidopsis CCS 抄本层次被 Cu 调整,由 microRNA 调停了 398 那以前没被预言指向 CCS。microRNA 目标地点在 Oryza sativa 的 CCS 被保存。数据建议那调整 Cu 的 microRNAs 可以有更多的 mRNA 目标比以前被预言。CCS 空异种不在叶绿体和 cytosol 举办可测量的草皮活动,显示为 CCS 的一个绝对要求。当 CCS 空异种在高 Cu 媒介上是成年的时,它缺乏两 Fe superoxide dismutase (FeSOD ) 和 Cu/ZnSOD 活动。然而,这没导致视觉显型,没有光合的缺乏被检测,甚至在高轻的应力以后。这些结果显示 Cu/ZnSOD 不在处于实验室条件的生长期间是光合的抗氧化剂系统的一个枢轴的部件。 | Christopher M. Cohu Salah E. Abdel-Ghany Kathryn A. Gogolin Reynolds Alexander M. Onofrio Jared R. Bodecker Jeffrey A. Kimbrel Krishna K. Niyogi Marinus Pilon | 2009 | Molecular Plant2009，2，6： | 9 |
| 3 | Combined analysis of land cover change and NDVI trends in the Northern Eurasian grain belt显示文摘我们在场在联合 MODIS 的时间系列分析的北欧亚的谷物带的地区性的环境监视的一条途径使差别植被索引(NDVI ) 正常化在时期 2001-2008 和陆地盖子变化(LCC ) 上的数据 2001 和 2008 MODIS 全球陆地盖子的分析产品(MCD12Q1 ) 。NDVI 趋势越过谷物带与是压倒性地否定的统计上重要(p0.05 ) 仅仅盖住 1% 土地的积极趋势出现。LCC 被在三个班之间的转变统治;农田,草地,和混合农田 / 天赋植被马赛克。联合我们 NDVI 趋势和 LCC 的分析,我们在与一致与的谷物带的南部的范围发现了农业放弃(到草地的农田) 的一个模式统计上重要(p0.05 ) 否定 NDVI 趋势并且多半由地区性的干旱开车。在谷物带的北范围,我们向农业增强发现了一个相反的趋势;在这种情况中,从农田马赛克由 LCC 代表了到纯农田,并且也与联系了统计上重要(p0.05 ) 否定 NDVI 趋势。相对小的簇统计上重要(p0.05 ) 与放弃和局部性的农业增强显示出的两块局部性的陆地相应的积极 NDVI 趋势那项陆地使用决策不是越过这个区域的制服。在北欧亚的谷物带的陆地表面变化在社会主义陆地任期和农业市场的苏联后面的重组的东方欧洲,俄国,和以前的领土是陆地盖子陆地使用变化(LCLUC ) 的一个更大的模式的部分。这里,我们证明 LCC 和 NDVI 趋势的联合分析在北欧亚的谷物带提供 LCLUC 的复杂性的一幅更完全的图画,包含更宽广的气候的强迫,和更狭窄的人为的影响,与力量独自从任何一个分析被获得比[出版摘要] | Christopher K. WRIGHT Kirsten M. de BEURS Geoffrey M. HENEBRY | 2012 | Frontiers of Earth Science2012，6，2： | 8 |
| 4 | Recent progress in pancreatic cancer显示文摘 | Christopher L. Wolfgang Joseph M. Herman Daniel A. Laheru Alison P. Klein Michael A. Erdek Elliot K. Fishman Ralph H. Hruban | 2013 | CA A Cancer Journal for Clinicians2013，，5： | 7 |
| 5 | Determinant-Based Classification of Acute Pancreatitis Severity: An International Multidisciplinary Consultation显示文摘 | E. Patchen Dellinger Christopher E. Forsmark Peter Layer Philippe Lévy Enrique Maraví-Poma Maxim S. Petrov Tooru Shimosegawa Ajith K. Siriwardena Generoso Uomo David C. Whitcomb John A. Windsor | 2012 | Annals of Surgery2012，，6： | 7 |
| 6 | 联合评估和单独评估:富有潜力的助推手段显示文摘人们有两种基本的评估模式:一是联合评估,即所有选项一起呈现和被评估;二是单独评估,各个选项单独地呈现和被评估。所有决策都是在其中一种评估模式或者两种模式的中间地带中做出的。联合和单独评估可以导致偏好反转和次优选择,理解其机制能帮助人们提高决策结果,包括慈善、定价、消费、甚至幸福感等方面。作为对各类决策影响广泛的重要变量,评估模式产生了不少反直觉的效应,目前研究尚不全面,是一块值得探索的沃土。 | 路西 HSEE Christopher K. | 2018 | 心理学报2018，50，8： | 7 |
| 7 | Pancreaticoduodenectomy with vascular resection: margin status and survival duration显示文摘 | Jennifer F. Tseng M.D. Chandrajit P. Raut M.D. Jeffrey E. Lee M.D. Peter W. T. Pisters M.D. Jean-Nicolas Vauthey M.D. Eddie K. Abdalla M.D. Henry F. Gomez M.D. Charlotte C. Sun Dr.P.H. Christopher H. Crane M.D. Robert A. Wolff M.D. Douglas B. Evans M.D | 2004 | Journal of Gastrointestinal Surgery2004，，8： | 6 |
| 8 | pH modeling for maximum dissolved organic matter removal by enhanced coagulation显示文摘Correlations between raw water characteristics and pH after enhanced coagulation to maximize dissolved organic matter(DOM) removal using four typical coagulants(FeCl3,Al2(SO4)3,polyaluminum chloride(PACl) and high performance polyaluminum chloride(HPAC)) without pH control were investigated.These correlations were analyzed on the basis of the raw water quality and the chemical and physical fractionations of DOM of thirteen Chinese source waters over three seasons.It was found that the final pH after enhanced coagulation for each of the four coagulants was in?uenced by the content of removable DOM(i.e.hydrophobic and higher apparent molecular weight(AMW) DOM),the alkalinity and the initial pH of raw water.A set of feed-forward semi-empirical models relating the final pH after enhanced coagulation for each of the four coagulants with the raw water characteristics were developed and optimized based on correlation analysis.The established models were preliminarily validated for prediction purposes,and it was found that the deviation between the predicted data and actual data was low.This result demonstrated the potential for the application of these models in practical operation of drinking water treatment plants. | Jiankun Xie Dongsheng Wang John van Leeuwen Yanmei Zhao Linan Xing Christopher W. K. Chow | 2012 | Journal of Environmental Sciences2012，24，2： | 5 |
| 9 | Red Cell Distribution Width as a Novel Prognostic Marker in Heart Failure显示文摘 | G. Michael Felker Larry A. Allen Stuart J. Pocock Linda K. Shaw John J.V. McMurray Marc A. Pfeffer Karl Swedberg Duolao Wang Salim Yusuf Eric L. Michelson Christopher B. Granger | 2007 | Journal of the American College of Cardiology2007，，1： | 5 |
| 10 | Unusual switchable peroxidase-mimicking nanozyme for the determination of proteolytic biomarker显示文摘Detection of enzyme biomarkers originating from either bio-fluids or contaminating microorganisms is of utmost importance in clinical diagnostics and food safety. Herein, we present a simple, low-cost and easy-to-use sensing approach based on the switchable peroxidase-mimicking activity of plasmonic gold nanoparticles (AuNPs) that can catalyse for the oxidation of 3,3’,5’5-tetramethylbenzidine (TMB) for the determination of protease enzyme. The AuNP surface is modified with casein, showing dual functionalities. The first function of the coating molecule is to suppress the intrinsic peroxidase-mimicking activity of AuNPs by up to 77.1%, due to surface shielding effects. Secondly, casein also functions as recognition sites for the enzyme biomarker. In the presence of protease, the enzyme binds to and catalyses the degradation of the coating layer on the AuNP surface, resulting in the recovery of peroxidase-mimicking activity. This is shown visually in the development of a blue colored product (oxidised TMB) or spectroscopically as an increase in absorbance at 370 and 650 nm. This mechanism allows for the detection of protease at 44 ng·mL^-1 in 90 min. The nanosensor circumvents issues associated with current methods of detection in terms of ease of use, compatibility with point-of-care testing, low-cost production and short analysis time. The sensing approach has also been applied for the detection of protease spiked in ultra-heat treated (UHT) milk and synthetic human urine samples at a limit of detection of 490 and 176 ng·mL^-1, respectively, showing great potential in clinical diagnostics, food safety and quality control. | Claire McVey Natasha Logan Nguyen T. K. Thanh Christopher Elliott Cuong Cao | 2019 | Nano Research2019，12，3： | 5 |
| 11 | Progress and Challenges for Live-cell Imaging of Genomic Loci Using CRISPR-based Platforms显示文摘Chromatin conformation,localization,and dynamics are crucial regulators of cellular behaviors. Although fluorescence in situ hybridization-based techniques have been widely utilized for investigating chromatin architectures in healthy and diseased states,the requirement for cell fix-ation precludes the comprehensive dynamic analysis necessary to fully understand chromatin activ-ities. This has spurred the development and application of a variety of imaging methodologies for visualizing single chromosomal loci in the native cellular context. In this review,we describe currently-available approaches for imaging single genomic loci in cells,with special focus on clus-tered regularly interspaced short palindromic repeats (CRISPR)-based imaging approaches. In addition,we discuss some of the challenges that limit the application of CRISPR-based genomic imaging approaches,and potential solutions to address these challenges. We anticipate that,with continued refinement of CRISPR-based imaging techniques,significant understanding can be gained to help decipher chromatin activities and their relevance to cellular physiology and pathogenesis. | Xiaotian Wu Shiqi Mao Yachen Ying Christopher J.Krueger Antony K. Chen | 2019 | Genomics, Proteomics & Bioinformatics2019，17，2： | 5 |
| 12 | Natural-orifice transgastric endoscopic peritoneoscopy in humans: Initial clinical trial显示文摘 | Jeffrey W. Hazey Vimal K. Narula David B. Renton Kevin M. Reavis Christopher M. Paul Kristen E. Hinshaw Peter Muscarella E. Christopher Ellison W. Scott Melvin | 2008 | Surgical Endoscopy2008，，1： | 4 |
| 13 | Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-Analysis显示文摘 | Ulrike Peters Shuo Jiao Fredrick R. Schumacher Carolyn M. Hutter Aaron K. Aragaki John A. Baron Sonja I. Berndt Stéphane Bézieau Hermann Brenner Katja Butterbach Bette J. Caan Peter T. Campbell Christopher S. Carlson Graham Casey Andrew T. Chan Jenny Chan | 2012 | Gastroenterology2012，，： | 4 |
| 14 | Presence of extensive intraductal component in patients undergoing breast conservative surgery predicts presence of residual disease in subsequent completion mastectomy显示文摘背景本地复发在经历胸保守人士外科的病人之中仍然是一个严重问题。这研究瞄准了在这回顾的研究基于的胸保守人士 surgery.Methods 以后为剩余疾病识别风险因素收到了胸保守人士外科和随后的结束乳房切除术的有侵略乳癌的病人。所有病人在起始的操作有清楚的切除术边缘。我们在结束乳房切除术和下列风险因素期间分析了在剩余疾病的存在之间的协会:广泛的 intraductal 部件(EIC ) 的 T 阶段,年轻年龄,和存在,靠近的边缘, lymphovascular 浸透(LVP ) ,雌激素受体的确实,孕酮受体,和 c-erbB-2.Results 剩余疾病在 21 被遇到(45.7%) 46 个病人;EIC 在 28 个病人(60.9%) 是在场的,谁 17 有的剩余疾病。EIC 的存在在结束乳房切除术(P=0.011 ) 期间与剩余疾病的更高的风险在胸保存外科期间被联系。另外的变量不是为剩余疾病的存在的统计上重要的风险因素。在结束乳房切除术为有有 EIC 的存在是的 not.Conclusions 的剩余疾病和那些的病人是类似的以后,没有本地复发在我们的队,和没有疾病的幸存和全面幸存被记录为在在胸保守人士外科以后的病人的剩余疾病的一个重要风险因素。我们的调查结果可以在起始的胸保守人士外科期间与 EIC 在病人建议结束乳房切除术的显示的价值减少随后的本地失败的风险。 | Christopher C. E Yiu Wings T. Y. Loo C. K. Lam Louis W. C. Chow | 2009 | Chinese Medical Journal2009，，8： | 4 |
| 15 | A multi‐institutional phase 2 study of neoadjuvant gemcitabine and oxaliplatin with radiation therapy in patients with pancreatic cancer显示文摘 | Edward J. Kim Edgar Ben‐Josef Joseph M. Herman Tanios Bekaii‐Saab Laura A. Dawson Kent A. Griffith Isaac R. Francis Joel K. Greenson Diane M. Simeone Theodore S. Lawrence Daniel Laheru Christopher L. Wolfgang Terence Williams Mark Bloomston Malcolm J. Moo | 2013 | Cancer2013，，15： | 3 |
| 16 | TH17 Cells in Asthma and COPD显示文摘 | John F. Alcorn Christopher R. Crowe Jay K. Kolls | 2010 | Annual Review of Physiology2010，，： | 3 |
| 17 | Hydrolyzed Al(Ⅲ) clusters:Speciation stability of nano-Al_(13)显示文摘Pure nano-Al13 and aggregates at various concentrations were prepared to examine the particle size effect of coagulation with inorganic polymer flocculant.The property and stability of various species formed were characterized using Infrared,27Al-NMR,photo correlation spectroscopy(PCS),and Ferron assay.Results showed that concentration and temperature exhibited different roles on the stability of Al13.The quantity of Alb species analyzed by ferron assay in the initial aging period corresponded well with that of Al13,which has been confirmed in a dimension range of 1-2 nm by PCS.Al13 solutions at high concentrations(0.5-2.11 mol/L) were observed to undergo further aggregation with aging.The aggregates with a wide particle size distribution would contribute to the disappeared/decreased Al13 basis on the 27Al-NMR spectrum,whereas a part of Al13 would still remain as Alb.At low concentrations,Al13 solution was quite stable at normal temperature,but lost its stability quickly when heating to 90°C. | Shuifeng Wang Chihpin Huang Christopher W K. Chow | 2011 | Journal of Environmental Sciences2011，23，5： | 3 |
| 18 | Diagnostic yield and safety of jumbo biopsy forceps in patients with subepithelial lesions of the upper and lower GI tract显示文摘 | Jonathan M. Buscaglia Satish Nagula Vijay Jayaraman David H. Robbins Deepak Vadada Seth A. Gross Christopher J. DiMaio Shireen Pais Kal Patel Divyesh V. Sejpal Michelle K. Kim | 2012 | Gastrointestinal Endoscopy2012，，6： | 3 |
| 19 | Paleotemperatures from fluid inclusions in halite: method verification and a 100,000 year paleotemperature record, Death Valley, CA显示文摘 | Tim K. Lowenstein Jianren Li Christopher B. Brown | 1998 | Chemical Geology1998，，3： | 3 |
| 20 | Tuning the translational freedom of DNA for high speed AFM显示文摘直接观察可以证明是调查在二分子的建筑群之间的相互作用的比较喜欢的方法。与高度的发展加速原子力量显微镜学(AFM ) ,直接与相关空间、时间的分辨率观察 DNA 蛋白质相互作用正在变得可能。这些相互作用具有到生物学, bionanotechnology,和功能的生物学上启发的材料的中央重要性。作为在所有显微镜学研究,样品准备在 AFM 观察和样品的最小的不安起一个中央作用被需要。这里,我们表明能力调节在 DNA 分子和表面之间的相互作用创造足够强壮的一个协会当也提供足够的翻译自由允许相关 protein-DNA 相互作用发生时,启用高分辨率的 AFM 成像。而且,我们为测量 DNA 活动性描述一个量的方法,当也决定贡献 DNA 运动的单个力量时。我们发现为一个弱表面协会,对运动的重要贡献从和 DNA 的 AFM 尖端的相互作用产生。在联合,这些方法启用调节表面由高度允许大量核蛋白相互作用的直接学习的分子加速的 DNA 的翻译自由原子力量显微镜学。 | Andrew J. Lee Michal Szymonik Jamie K. Hobbs Christoph Walti | 2015 | Nano Research2015，8，6： | 3 |
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