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| 1 | 成人自发性脑出血处理指南——2007年更新版:美国心脏协会/美国卒中协会卒中委员会、高血压研究委员会、医疗质量和转归研究跨学科工作组指南:美国神经病学学会确认本指南作为神经科医生教学工具的价值显示文摘目的:本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法:通过Medline正式检索截止2006年8月的相关文献,并将撰写委员会已知相关问题的其他论文作为补充,用证据表合并资料。采用美国心脏协会卒中委员会的证据水平分级标准对每项推荐意见进行分级。由5位同行评议专家和卒中委员会领导委员会成员对指南草案进行发表前审阅。预期本指南在3年内完全更新。结果:本文陈述了脑出血的诊断、动脉血压和颅内压增高的处理、脑出血内科并发症的治疗以及复发性脑出血的预防等方面的循证指南。对重组Ⅶ因子延缓早期出血的近期试验进行了讨论。对自发性脑出血治疗的各种外科手术方法提出了推荐意见。最后,对脑出血患者的撤销治疗和临终问题进行了分析。 | Joseph Broderick Sander Connolly Edward Feldmann Daniel Hanley Carlos Kase Derk Krieger Marc Mayberg Lewis Morgenstern Christopher S. Ogilvy Paul Vespa Mario Zuccarello 王玉洁(译) 刘娟(译) 白璇(译) 李新辉 孙虹(译) 姚志成(译) 张慧(译) 牛英翔(译) | 2007 | 国际脑血管病杂志2007，15，7： | 234 |
| 2 | Hypertriglyceridemia-induced pancreatitis: A case-based review显示文摘Hypertriglyceridemia is an established cause of pancreatitis. In a case-based approach, we present a review of hypertriglyceridemia and how it can cause pancreatitis. We outline how to investigate and manage such patients. A 35 year old man presented to the emergency department with abdominal pain and biochemical evidence of acute pancreatitis. There was no history of alcohol consumption and biliary imaging was normal. The only relevant past medical history was that of mild hyperlipidemia, treated with diet alone. Physical exam revealed epigastric tenderness, right lateral rectus palsy, lipemia retinalis, bitemporal hemianopsia and a delay in the relaxation phase of his ankle reflexes. Subsequent laboratory investigation revealed marked hypertriglyceridemia and panhypopituarism. An enhanced CT scan of the head revealed a large suprasellar mass impinging on the optic chiasm and hypothalamus. The patient was treated supportively; thyroid replacement and lipid lowering agents were started. He underwent a successful resection of a craniopharyngioma. Post- operatively, the patient did well on hormone replacement therapy. He has had no further attacks of pancreatitis. This case highlights many of the factors involved in the regulation of triglyceride metabolism. We review the common causes of hypertriglyceridemia and the proposed mechanisms resulting in pancreatitis. The incidence and management of hypertriglyceridemia- induced pancreatitis are also discussed. | S Ian Gan Alun L Edwards Christopher J Symonds Paul L Beck | 2006 | World Journal of Gastroenterology2006，12，44： | 35 |
| 3 | 成人自发性脑出血处理指南——2007年更新版 美国心脏协会/美国卒中协会卒中委员会、高血压研究委员会、医疗质量和转归研究跨学科工作组指南 美国神经病学学会确认本指南作为神经科医生教学工具的价值显示文摘目的:本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法:通过Medline正式检索截止2006年8月的相关文献,并将撰写委员会已知相关问题的其他论文作为补充,用证据表合并资料。采用美国心脏协会卒中委员会的证据水平分级标准对每项推荐意见进行分级。由5位同行评议专家和卒中委员会领导委员会成员对指南草案进行发表前审阅。预期本指南在3年内完全更新。结果:本文陈述了脑出血的诊断、动脉血压和颅内压增高的处理、脑出血内科并发症的治疗以及复发性脑出血的预防等方面的循证指南。对重组Ⅶ因子延缓早期出血的近期试验进行了讨论。对自发性脑出血治疗的各种外科手术方法提出了推荐意见。最后,对脑出血患者的撤销治疗和临终问题进行了分析。 | Joseph Broderick Sander Connolly Edward Feldmann Daniel Hanley Carlos Kase Derk Krieger Marc Mayberg Lewis Morgenstern Christopher S.Ogilvy Paul Vespa Mario Zuccarello 王玉洁 刘娟 白璇 李新辉 孙虹 姚志成 张慧 牛英翔 | 2008 | 中华脑血管病杂志(电子版)2008，2，1： | 29 |
| 4 | 综合性卒中中心医疗质量的度量标准:对脑卒中联盟综合性卒中中心推荐意见的详细随访美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘背景卒中是一种主要的残疾和死亡原因。脑卒巾联盟提议,建立初级卒中中心(primary stroke center,PSC)和综合性卒中中心(comprehensive stroke center,csc)以分别为需要基本或高级下预的卒中患者提供适当的医疗服务。从2003年开始,美国医疗卫生机构认证联合委员会和各州已指定了一些PSC,目前正在考虑CSC的指定工作。为了推进该过程,我们提出了一套CSC应追踪监测医疗质量并促进质量改进的标准和相关数据。方法和结果我们分析了现有指南、综述和其他文献,以识别区分CSC与PSC的主要特征;起草了一套标准和相关数据元素,以评价这些卒中医疗方面的关键部分;然后通过反复修改达成共识。我们提出的这套标准和相关数据元素,涵盖了CSC内缺血性脯血管病、非外伤性蛛网膜下腔出血和腩出血患者专、№医疗的主要方面。结论我们提出这套标准,旨在为CSC的标准化数据采集提供一个框架,以促进当地医疗质量改进,并允许对来自不同CSC的数据进行合并分析。这将有助于将来CSC国家执行标准的制定。 | 何晟(译) 蔡可夫(译) 张元媛(译) 胡旻婧(译) 倪耀辉(译) 芮瑛(译) 柯开富(译) Dana Leifer Dawn M. Bravata J.J. (Buddy) Connors Ⅲ Judith A. Hinchey Edward C. Jauch S. Claibome Johnston Richard Latchaw William kikosky Christopher Ogilvy Adrian I. Qureshi Debbie Summers Gene Y. Sung Linda S. Williams Richard Zorowitz | 2011 | 国际脑血管病杂志2011，19，3： | 21 |
| 5 | 采用ART技术封闭恒牙防龋的6年临床效果观察显示文摘目的:评价非创伤性充填(ART)技术对恒牙窝沟封闭后,封闭剂保留及新生龋损发生情况。方法:1996年在四川省德阳市4所中学选取12~13岁儿童140名作191个牙ART封闭。采用WHO的ART标准器械,德国ESPE公司生产的高强度玻璃离子材料,对选择的牙面窝沟进行封闭;操作者为经中等口腔专业训练的医生。封闭后每年对ART封闭及牙龋损情况进行评价。结果:封闭后1、2、4、6年的完整保留率分别为75.4%、62.5%、50.0%、34.6%;成功率分别为89.6%、78.8%、68.5%、57.9%。试验后1年没有新生龋牙的发生,试验后2、3年,龋患发生率分别为1.6%、2.8%。试验后4年龋病有明显增加,试验4、5、6年后,龋病发生率分别为8.5%、16.1%、15.0%。结论:ART封闭试验3年的保存率较高、新生龋发生率低;试验6年封闭剂保留率虽然有所降低,但其结果还是令人满意的,预防龋病的效果是显著的。但封闭物脱落3年后,若没有重新修复,新龋患率大幅度上升,作为恒牙龋病防治的措施是适合和可接受的;是一种适合于在学校、社区开展的有效、实用的龋病预防方法。 | 万呼春 胡德渝 李雪 范旭 Edward C.M.Lo Christopher J.Holmgren | 2007 | 实用口腔医学杂志2007，23，5： | 9 |
| 6 | ART技术封闭恒牙的3年临床效果观察显示文摘目的 :评价非创伤性充填 (ART)技术对恒牙窝沟封闭后 ,封闭剂保留及新生龋病发生情况。方法 :1996年在四川省德阳市 4所中学选取 12~ 13岁儿童 14 0名作 191个ART封闭。采用WHO的ART标准器械 ,德国ESPE公司生产的高强度玻璃离子材料 ,对选择的牙面窝沟进行封闭 ;操作者为经中等口腔专业训练的医生。试验 3年后对ART封闭及牙龋病情况进行评价。结果 :封闭后 1、2、3年的封闭成功率分别为 89.6% ,78.8% ,71.9%。试验后 1年没有新生龋齿的发生 ,试验后 2、3年 ,龋患率较低 ,分别为 1.6% ,2 .8%。结论 :ART封闭试验 3年的保存率较高 ,新生龋发生率低 ;作为恒牙龋病防治的措施是适合和可接受的 ;是一种适合于在学校、社区开展的有效、实用的龋病预防方法。 | 万呼春 胡德渝 刘红春 李雪 范旭 童冠雄 Edward C.M.Lo Christopher J.olmgren | 2004 | 实用口腔医学杂志2004，20，5： | 8 |
| 7 | Gastric intestinal metaplasia is associated with gastric dysplasia but is inversely correlated with esophageal dysplasia显示文摘AIM To determine which clinical factors might be associated with gastric intestinal metaplasia(IM) in a North American population.METHODS Pathology and endoscopy databases at an academicmedical center were reviewed to identify patients with and without gastric IM on biopsies for a retrospective cohort study. Patient demographics, insurance status, and other clinical factors were reviewed.RESULTS Four hundred and sixty-eight patients with gastric IM(mean age: 61.0 years ± 14.4 years, 55.5% female) and 171 without gastric IM(mean age: 48.8 years ± 20.8 years, 55.0% female) were compared. The endoscopic appearance of atrophic gastritis correlated with finding gastric IM on histopathology(OR = 2.05, P = 0.051). Gastric IM was associated with histologic findings of chronic gastritis(OR = 2.56, P < 0.001), gastric ulcer(OR = 6.97, P = 0.015), gastric dysplasia(OR = 6.11, P = 0.038), and gastric cancer(OR = 6.53, P = 0.027). Histologic findings of Barrett's esophagus(OR = 0.28, P = 0.003) and esophageal dysplasia(OR = 0.11, P = 0.014) were inversely associated with gastric IM. Tobacco use(OR = 1.73, P = 0.005) was associated with gastric IM.CONCLUSION Patients who smoke or have the endoscopic finding of atrophic gastritis are more likely to have gastric IM and should have screening gastric biopsies during esophagogastroduodenoscopy(EGD). Patients with gastric IM are at increased risk for having gastric dysplasia and cancer, and surveillance EGD with gastric biopsies in these patients might be reasonable. | Justin M Gomez James T Patrie Wissam Bleibel Jeanetta W Frye Bryan G Sauer Vanessa M Shami Edward B Stelow Christopher A Moskaluk Andrew Y Wang | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 3 |
| 8 | A multi‐institutional phase 2 study of neoadjuvant gemcitabine and oxaliplatin with radiation therapy in patients with pancreatic cancer显示文摘 | Edward J. Kim Edgar Ben‐Josef Joseph M. Herman Tanios Bekaii‐Saab Laura A. Dawson Kent A. Griffith Isaac R. Francis Joel K. Greenson Diane M. Simeone Theodore S. Lawrence Daniel Laheru Christopher L. Wolfgang Terence Williams Mark Bloomston Malcolm J. Moo | 2013 | Cancer2013，，15： | 3 |
| 9 | Vitamin C in the critically ill-indications and controversies显示文摘Ascorbic acid(vitamin C) elicits pleiotropic effects in thebody. Among its functions, it serves as a potent antioxidant, a co-factor in collagen and catecholamine synthesis, and a modulator of immune cell biology. Furthermore, an increasing body of evidence suggests that highdose vitamin C administration improves hemodynamics, end-organ function, and may improve survival in critically ill patients. This article reviews studies that evaluate vitamin C in pre-clinical models and clinical trials with respect to its therapeutic potential. | Christoph S Nabzdyk Edward A Bittner | 2018 | World Journal of Critical Care Medicine2018，7，5： | 3 |
| 10 | Diagnosis and Initial Management of Blunt Pancreatic Trauma: Guidelines From a Multiinstitutional Review显示文摘 | Edward L. Bradley Peter R. Young Michael C. Chang James E. Allen Christopher C. Baker Wayne Meredith Larry Reed Michael Thomason | 1998 | Annals of Surgery1998，，6： | 2 |
| 11 | Peripheral neuropathy incidence in inflammatory bowel disease: A population-based study显示文摘 | Juan J. Figueroa Edward V. Loftus William S. Harmsen P. James B. Dyck Christopher J. Klein | 2013 | Neurology2013，，18： | 2 |
| 12 | 采用浸渍硅藻土作为多相催化剂从废植物油中生产生物柴油(英文)显示文摘In this study, biodiesel was produced from waste vegetable oil using a heterogeneous base catalyst synthesized by impregnating potassium hydroxide(KOH) onto diatomite. Response surface methodology based on a central composite design was used to optimize four transesterification variables: temperature(30–120 °C), reaction time(2–6 h), methanol to oil mass ratio(10%–50%) and catalyst to oil mass ratio(2.1%–7.9%). A quadratic polynomial equation was obtained to correlate biodiesel yield to the transesterification variables. The diatomite–KOH catalyst was characterized using X-ray diffraction(XRD), Fourier transform infra-red spectroscopy(FTIR) and a scanning electron microscope(SEM) equipped with an energy dispersive X-ray detector(EDS). A maximum biodiesel yield of 90%(by mass) was obtained. The reaction conditions were as follows: methanol to oil mass ratio 30%, catalyst to oil mass ratio 5%, reaction time 4 h, and reaction temperature 75 °C. The XRD, FTIR and SEM(EDS) results confirm that the addition of KOH modifies the structure of diatomite. During impregnation and calcination of the diatomite catalyst the K2 O phase forms in the diatomite structural matrix and the active basicity of this compound facilitates the transesterification process. It is possible to recycle the diatomite–KOH catalyst up to three times. The crucial biodiesel properties from waste vegetable oil are within the American Standard Test Method specifications. | Edward Modiba Christopher Enweremadu Hilary Rutto | 2015 | Chinese Journal of Chemical Engineering2015，23，1： | 2 |
| 13 | The mitochondria‐targeted anti‐oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients显示文摘 | Edward J.Gane FrankWeilert David W.Orr Geraldine F.Keogh MichaelGibson Michelle M.Lockhart Christopher M.Frampton Kenneth M.Taylor Robin A. J.Smith Michael P.Murphy | 2010 | Liver International2010，，7： | 2 |
| 14 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 15 | The mitochondria‐targeted anti‐oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients显示文摘 | Edward J.Gane FrankWeilert David W.Orr Geraldine F.Keogh MichaelGibson Michelle M.Lockhart Christopher M.Frampton Kenneth M.Taylor Robin A. J.Smith Michael P.Murphy | 2010 | Liver International2010，，7： | 1 |
| 16 | The sticholysin family of pore-forming toxins induces the mixing of lipids in membrane domains显示文摘 | Uris Ros Michelle A. Edwards Raquel F. Epand Maria E. Lanio Shirley Schreier Christopher M. Yip Carlos Alvarez Richard M. Epand | 2013 | BBA - Biomembranes2013，，11： | 1 |
| 17 | Preoperative chemoradiotherapy with capecitabine versus protracted infusion 5-fluorouracil for rectal cancer: A matched-pair analysis显示文摘 | Prajnan Das Edward H. Lin Sumita Bhatia John M. Skibber Miguel A. Rodriguez-Bigas Barry W. Feig George J. Chang Paulo M. Hoff Cathy Eng Robert A. Wolff Marc E. Delclos Sunil Krishnan Nora A. Janjan Christopher H. Crane | 2006 | International Journal of Radiation Oncology Biology Physics2006，，5： | 1 |
| 18 | Identification of pathway-selective estrogen receptor ligands that inhibit NF-KB transcriptional activity显示文摘 | Christopher C C Susan C Edward M | 2005 | PNAS2005，102，7： | 1 |
| 19 | Sliding Mode Observers for Fault Detection and Isolation 显示文摘 | Christopher Edwards Sarah K Spurgeon Ran J Patton | 2000 | Automatiea2000，36，4： | 1 |
| 20 | Small-bowel imaging in Crohn’s disease: a prospective, blinded, 4-way comparison trial显示文摘 | Craig A. Solem Edward V. Loftus Joel G. Fletcher Todd H. Baron Christopher J. Gostout Bret T. Petersen William J. Tremaine Laurence J. Egan William A. Faubion Kenneth W. Schroeder Darrell S. Pardi Karen A. Hanson Debra A. Jewell John M. Barlow Jeff L. Fid | 2008 | Gastrointestinal Endoscopy2008，，2： | 1 |
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