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| 1 | Medical management of gastric cancer:A 2014 update显示文摘Gastric cancer represents a serious health problem on a global scale. It is the second leading cause of cancer-related death worldwide. Novel therapeutic targets are desperately needed because the meager improvement in the cure rate of about 10% realized by adjunctive treatments to surgery is unacceptable as > 50% patients with localized gastric cancer succumb to their disease. Either postoperative chemoradiotherapy(United States),pre-and post-operative chemotherapy(Europe),and adjuvant chemotherapy after a D2 resection(Asia) can all be regarded as standards of care in the localized gastric cancer management. In metastatic disease the addition of trastuzumab to chemotherapy is standard of care in Her2 positive disease. In the HER2 negative population,the treatments remain limited.In the first line setting,the standard of care is a combination of fluoropyrimidine and platinum containing chemotherapy,with or without epirubicin or docetaxel.The results of targeted therapy trials have by and large been disappointing,but none of these trials looked at an appropriately enriched population.Finally there is a meager overall survival benefit in treating patients with metastatic disease in the second line setting,with either irinotecan,docetaxel or ramucirumab however none of these drugs have been compared head to head in a well-powered randomized controlled trial. | Elena Elimova Hironori Shiozaki Roopma Wadhwa Kazuki Sudo Qiongrong Chen Jeannelyn S Estrella Mariela A Blum Brian Badgwell Prajnan Das Shumei Song Jaffer A Ajani | 2014 | World Journal of Gastroenterology2014，20，38： | 10 |
| 2 | Evolution of gastric surgery techniques and outcomes显示文摘Surgical management of gastric cancer improves survival.However,for some time,surgeons have had diverse opinions about the extent of gastrectomy.Researchers have conducted many clinical studies,making slow but steady progress in determining the optimal surgical approach.The extent of lymph node dissection has been one of the major issues in surgery for gastric cancer.Many trials demonstrated that D2 dissection resulted in greater morbidity and mortality than D1 dissection.However,long-term outcomes demonstrated that D2 dissection resulted in longer survival than D1 dissection.In 2004,the Japan Clinical Oncology Group reported a pivotal trial which was performed to determine whether para-aortic lymph node dissection combined with D2 dissection was superior to D2 dissection alone and found no benefit of the additional surgery.Gastrectomy with pancreatectomy,splenectomy,and bursectomy was initially recommended as part of the D2 dissection.Now,pancreas-preserving total gastrectomy with D2 dissection is standard,and ongoing trials are addressing the role of splenectomy.Furthermore,the feasibility and safety of laparoscopic gastrectomy are well established.Survival and quality of life are increasingly recognized as the most important endpoints.In this review,we present perspectives on surgical techniques and important trials of these techniques in gastric cancer patients. | Hironori Shiozaki Yusuke Shimodaira Elena Elimova Roopma Wadhwa Kazuki Sudo Kazuto Harada Jeannelyn S.Estrella Prajnan Das Brian Badgwell Jaffer A.Ajani | 2016 | Chinese Journal of Cancer2016，35，8： | 9 |
| 3 | Clinical Significance of Acellular Mucin in Rectal Adenocarcinoma Patients With a Pathologic Complete Response to Preoperative Chemoradiation显示文摘 | Kerrington D. Smith Dongfeng Tan Prajnan Das George J. Chang Kiran Kattepogu Barry W. Feig John M. Skibber Miguel A. Rodriguez-Bigas | 2010 | Annals of Surgery2010，，2： | 2 |
| 4 | Preoperative chemoradiotherapy with capecitabine versus protracted infusion 5-fluorouracil for rectal cancer: A matched-pair analysis显示文摘 | Prajnan Das Edward H. Lin Sumita Bhatia John M. Skibber Miguel A. Rodriguez-Bigas Barry W. Feig George J. Chang Paulo M. Hoff Cathy Eng Robert A. Wolff Marc E. Delclos Sunil Krishnan Nora A. Janjan Christopher H. Crane | 2006 | International Journal of Radiation Oncology Biology Physics2006，，5： | 1 |
| 5 | Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data显示文摘 | Monique Maas Patty J Nelemans Vincenzo Valentini Prajnan Das Claus R?del Li-Jen Kuo Felipe A Calvo Julio García-Aguilar Rob Glynne-Jones Karin Haustermans Mohammed Mohiuddin Salvatore Pucciarelli William Small Javier Suárez George Theodoropoulos Sebastian | 2010 | Lancet Oncology2010，，9： | 1 |
| 6 | Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data显示文摘 | Monique Maas Patty J Nelemans Vincenzo Valentini Prajnan Das Claus R?del Li-Jen Kuo Felipe A Calvo Julio García-Aguilar Rob Glynne-Jones Karin Haustermans Mohammed Mohiuddin Salvatore Pucciarelli William Small Javier Suárez George Theodoropoulos Sebastian | 2010 | Lancet Oncology2010，，9： | 1 |
| 7 | Spectroscopy of rubbers and rubbery materials显示文摘 | Victor M Litvinov Prajnan P De | 2002 | RAPRA Technology Limited2002，，10： | 1 |
| 8 | Phase II Trial of Neoadjuvant Bevacizumab, Capecitabine, and Radiotherapy for Locally Advanced Rectal Cancer显示文摘 | Christopher H. Crane Cathy Eng Barry W. Feig Prajnan Das John M. Skibber George J. Chang Robert A. Wolff Sunil Krishnan Stanley Hamilton Nora A. Janjan Dipen M. Maru Lee M. Ellis Miguel A. Rodriguez-Bigas | 2010 | International Journal of Radiation Oncology Biology Physics2010，，3： | 1 |
| 9 | Long-Term Survival and Recurrence Outcomes Following Surgery for Distal Rectal Cancer显示文摘 | Eric J. Silberfein Kiran M. Kattepogu Chung-Yuan Hu John M. Skibber Miguel A. Rodriguez-Bigas Barry Feig Prajnan Das Sunil Krishnan Christopher Crane Scott Kopetz Cathy Eng George J. Chang | 2010 | Annals of Surgical Oncology2010，，11： | 1 |
| 10 | Extrahepatic Bile Duct Adenocarcinoma: Patients at High-Risk for Local Recurrence Treated with Surgery and Adjuvant Chemoradiation Have an Equivalent Overall Survival to Patients with Standard-Risk Treated with Surgery Alone显示文摘 | Yerko Borghero MD Christopher H. Crane MD Janio Szklaruk MD Mauricio Oyarzo MD Steven Curley BS MD Peter W. Pisters MD Douglas Evans BS MD Eddie K. Abdalla MD Melanie B. Thomas BA MS MD Prajnan Das MD Ignacio I. Wistuba MD Sunil Krishnan MD Jean-Nicol | 2008 | Annals of Surgical Oncology2008，，11： | 1 |
| 11 | Preopera- tive chemoradiotherapy with capecitabine versus protracted i'nfusion 5-fluorouracil for rectal cancer: A matched-pair a- nalysis 显示文摘 | Prajnan Das Edward H Lin Sumita Bhatia | 2006 | Int J Radiat Oncol Biol Phys2006，66，5： | 1 |
| 12 | Staging, prognostic factors, and therapy of localized rectal cancer显示文摘 | Prajnan Das Christopher H. Crane | 2009 | Current Oncology Reports2009，，3： | 1 |
| 13 | Local Excision After Preoperative Chemoradiation Results in an Equivalent Outcome to Total Mesorectal Excision in Selected Patients with T3 Rectal Cancer显示文摘 | Glenda G. Callender MD Prajnan Das MD Miguel A. Rodriguez-Bigas MD John M. Skibber MD Christopher H. Crane MD Sunil Krishnan MD Marc E. Delclos MD Barry W. Feig MD | 2010 | Annals of Surgical Oncology2010，，2： | 1 |
| 14 | Long‐term results of weekly/daily cisplatin‐based chemoradiation for locally advanced squamous cell carcinoma of the anal canal显示文摘 | Cathy Eng George J. Chang Y. Nancy You Prajnan Das Yan Xing Marc Delclos Robert A. Wolff Miguel A. Rodriguez‐Bigas John Skibber Aki Ohinata Spencer Gould Jonathan Phillips Christopher H. Crane | 2013 | Cancer2013，，21： | 1 |
| 15 | Patterns of Locoregional Recurrence After Surgery and Radiotherapy or Chemoradiation for Rectal Cancer显示文摘 | Tse-Kuan Yu Priya R. Bhosale Christopher H. Crane Revathy B. Iyer John M. Skibber Miguel A. Rodriguez-Bigas Barry W. Feig George J. Chang Cathy Eng Robert A. Wolff Nora A. Janjan Marc E. Delclos Sunil Krishnan Prajnan Das | 2008 | International Journal of Radiation Oncology Biology Physics2008，，4： | 1 |
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