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| 1 | Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer显示文摘 | Patrick C. Hermann Stephan L. Huber Tanja Herrler Alexandra Aicher Joachim W. Ellwart Markus Guba Christiane J. Bruns Christopher Heeschen | 2007 | Cell Stem Cell2007，，3： | 5 |
| 2 | Prognostic value of CA 19-9, CEA, CRP, LDH and bilirubin levels in locally advanced and metastatic pancreatic cancer: results from a multicenter, pooled analysis of patients receiving palliative chemotherapy显示文摘 | Michael Haas Volker Heinemann Frank Kullmann Rüdiger P. Laubender Christina Klose Christiane J. Bruns Stefan Holdenrieder Dominik P. Modest Christoph Schulz Stefan Boeck | 2013 | Journal of Cancer Research and Clinical Oncology2013，，4： | 4 |
| 3 | Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer显示文摘Enolase 2(ENO2)is a key glycolytic enzyme in the metabolic process of glycolysis,but its potential function in pancreatic ductal adenocarcinoma(PDAC)is unclear.In this study,we observed a significant overexpression of ENO2 in PDAC tissues,and its expression was correlated with metastasis and poor prognosis in PDAC patients.K394 was identified as a major acetylation site in ENO2 that regulates its enzymatic activity,cell metabolism and PDAC progression.Knockdown of ENO2 suppressed tumor growth and liver metastasis in PDAC.Re-expression of wild-type(WT)ENO2,but not the K394 acetylation mimetic mutant,could reverse the decreased tumor malignancy.We further characterized histone deacetylase 3(HDAC3)and P300/CBP-associated factor(PCAF)as the potential deacetylase and acetyltransferase for ENO2,respectively.HDAC3-mediated deacetylation was shown to lead to ENO2 activation and enhancement of glycolysis.Importantly,insulin-like growth factor-1(IGF-1)was found to decrease K394 acetylation and stimulate ENO2 activity in a dose-and time-dependent manner.The PI3K/AKT/mTOR pathway facilitated the phosphorylation of HDAC3 on S424,which promoted K394 deacetylation and activation of ENO2.Linsitinib,an oral small-molecule inhibitor of IGF-1R,could inhibit IGF-1-induced ENO2 deacetylation by HDAC3 and the PI3K/AKT/mTOR pathway.Furthermore,linsitinib showed a different effect on the growth and metastasis of PDAC depending on the overexpression of WT versus K394-mutant ENO2.Our results reveal a novel mechanism by which acetylation negatively regulates ENO2 activity in the metastasis of PDAC by modulating glycolysis.Blockade of IGF-1-induced ENO2 deacetylation represents a promising strategy to prevent the development of PDAC. | Yan Zheng Chao Wu Jimeng Yang Yue Zhao Huliang Jia Min Xue Da Xu Feng Yang Deliang Fu Chaoqun Wang Beiyuan Hu Ze Zhang Tianen Li Shican Yan Xuan Wang Peter J.Nelson Christiane Bruns Lunxiu Qin Qiongzhu Dong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 4 | Cloud based infrastructure, the new business possibilities and barriers显示文摘 | Christian Kloch Ebbe B Petersen and Ole Brun Madsen | 2011 | Wireless Personal Communitions2011，58，1： | 1 |
| 5 | Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer显示文摘 | Patrick C. Hermann Stephan L. Huber Tanja Herrler Alexandra Aicher Joachim W. Ellwart Markus Guba Christiane J. Bruns Christopher Heeschen | 2007 | Cell Stem Cell2007，，3： | 1 |
| 6 | Linking Transgene Expression of Engineered Mesenchymal Stem Cells and Angiopoietin-1–induced Differentiation to Target Cancer Angiogenesis显示文摘 | Claudius Conrad Yves Hüsemann Hanno Niess Irene von Luettichau Ralf Huss Christian Bauer Karl-Walter Jauch Christoph A. Klein Christiane Bruns Peter J. Nelson | 2011 | Annals of Surgery2011，，3： | 1 |
| 7 | Analysis and Simulation of a 1-18 GHz BroadbandDouble-Ridged Horn Antenna显示文摘 | Bruns Christian Leuchtmann Pascal Vahldieck Ruediger | 2003 | IEEE Trans on Electromagnetic Compatibility2003，145，1： | 1 |
| 8 | Heat shock protein 27 as a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma显示文摘 | Claus Sch?fer Hendrik Seeliger Dominik C. Bader Gerald Assmann Denise Buchner Yang Guo Andreas Ziesch Andreas Palagyi Stephanie Ochs Rüdiger P. Laubender Andreas Jung Enrico N. De Toni Thomas Kirchner Burkhard G?ke Christiane Bruns Eike Gallmeier | 2012 | Journal of Cellular and Molecular Medicine2012，，8： | 1 |
| 9 | Human African trypanosomiasis显示文摘 | Reto Brun Johannes Blum Francois Chappuis Christian Burri | 2010 | The Lancet . 2010 (9709)2010，，： | 1 |
| 10 | A closer look at reverberation chambers 3-D simulation and experimental verification显示文摘 | Christian Bruns Ruediger Vahldieck | 2005 | IEEE Transactions on Electromagnetic Compatibility2005，47，5： | 1 |
| 11 | Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer显示文摘 | Patrick C. Hermann Stephan L. Huber Tanja Herrler Alexandra Aicher Joachim W. Ellwart Markus Guba Christiane J. Bruns Christopher Heeschen | 2007 | Cell Stem Cell2007，，3： | 1 |
| 12 | Effect of arbuseular mycorrhizal colonization and two levels of compost supply on nutrient uptake and flowering of pelargonium plants显示文摘 | Henrike Perner Dietmar Schwarz Christian Bruns | 2007 | Mycorrhiza2007，17，： | 1 |
| 13 | Software improvement for evaluation of laryngopharyngeal pH testing(Restech)——a comparison between Data View 3 and 4显示文摘BACKGROUND When gastroesophageal reflux contents reach above the upper esophageal sphincter,patients may,in addition to typical reflux symptoms,present with atypical,extraesophageal symptoms related to laryngopharyngeal reflux(LPR).Surgical treatment of LPR has shown to lead to 70%symptom improvement,however no gold standard for the diagnosis of LPR exists.In 2007,the Restech Dx-pH was released as a valid method to measure acid exposure above the upper esophageal sphincter.Recently,a new software update was introduced for analysis of measured pH data and calculation of composite scores.The effect of the changes applied to the new software version have not yet been analyzed.AIM To compare results generated by Data View 3 to the most recently released Data View 4.METHODS All patients with gastroesophageal reflux disease symptoms were seen in a specialized surgical outpatient clinic for gastrointestinal function testing.Retrospective chart review was performed of all patients presenting with suspected gastroesophageal reflux disease and extraesophageal reflux symptoms,who underwent laryngopharyngeal pH monitoring using the Restech Dx-pH system(Respiratory Technology Corp.,Houston,TX,United States)and simultaneous esophageal pH monitoring.Data View 3 and Data View 4 were used to evaluate Restech studies obtained.Diary entries such as mealtimes,supine and upright periods,and symptoms were entered manually to ensure accuracy and precise conversion of data between both software versions.Paired t test was performed for statistical analysis of results.RESULTS A total of 174 patients(63.8%female)met inclusion criteria,all suffering from extraesophageal reflux symptoms as well as typical gastroesophageal reflux disease symptoms.Mean RYAN score upright was 48.77 in Data View 3 compared to 22.17 in Data View 4,showing a significant difference(~aP=0.0001).Similar results were shown for supine period(mean RYAN Score Data View 35.29 vs 1.42 in Data View 4,~cP=0.0001).For upright periods 80 patients showed a decrease of value of the RYAN score with a mean of-58.9(mean 51.1%decrease).For supine position 25 patients showed a decrease of value of the RYAN score with a mean of-15.13[range(-153.44)–(-0.01)],which equals a mean decrease of value of 44.5%.Ten patients showed no oropharyngeal acid exposure in Data View 3,but mild/moderate(n=7)or severe(n=3)acid exposure in Data View 4.Correlation with positive esophageal pH measurement was improved in all 10 patients.CONCLUSION Results of both software versions cannot be compared to each other.However,our data suggests that Data View 4 may be an improvement of the Restech pH measurement in the evaluation of LPR. | Dolores Thea Müller Elena Schulte Benjamin Babic Laura Knepper Claudia Fuchs Wolfgang Schroder Christiane J Bruns Jessica M Leers Hans Friedrich Fuchs | 2020 | World Journal of Gastrointestinal Surgery2020，12，5： | 1 |
| 14 | Surgery for Metastasis to the Pancreas: Is it Safe and Effective?显示文摘 | Hanno Niess Claudius Conrad Axel Kleespies Florian Haas Qi Bao Karl‐Walter Jauch Christian Graeb Christiane J. Bruns | 2013 | J Surg Oncol2013，，8： | 1 |
| 15 | Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastasis 显示文摘 | CHRISTIANE J BRUN S WENBIAO L I U | 2000 | Cancer2000，1，89： | 1 |
| 16 | The molecular biology of pancreatic adenocarcinoma:translational challenges and clinical perspectives显示文摘Pancreatic cancer is an increasingly common cause of cancer mortality with a tight correspondence between disease mortality and incidence.Furthermore,it is usually diagnosed at an advanced stage with a very dismal prognosis.Due to the high heterogeneity,metabolic reprogramming,and dense stromal environment associated with pancreatic cancer,patients benefit little from current conventional therapy.Recent insight into the biology and genetics of pancreatic cancer has supported its molecular classification,thus expanding clinical therapeutic options.In this review,we summarize how the biological features of pancreatic cancer and its metabolic reprogramming as well as the tumor microenvironment regulate its development and progression.We further discuss potential biomarkers for pancreatic cancer diagnosis,prediction,and surveillance based on novel liquid biopsies.We also outline recent advances in defining pancreatic cancer subtypes and subtype-specific therapeutic responses and current preclinical therapeutic models.Finally,we discuss prospects and challenges in the clinical development of pancreatic cancer therapeutics. | Shun Wang Yan Zheng Feng Yang Le Zhu Xiao-Qiang Zhu Zhe-Fang Wang Xiao-Lin Wu Cheng-Hui Zhou Jia-Yan Yan Bei-Yuan Hu Bo Kong De-Liang Fu Christiane Bruns Yue Zhao Lun-Xiu Qin Qiong-Zhu Dong | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 1 |
| 17 | Clinical relevance and cellular source of elevated soluble urokinase plasminogen activator receptor (su PAR ) in acute liver failure显示文摘 | Alexander Koch Henning W. Zimmermann Nikolaus Gassler Christoph Jochum Ralf Weiskirchen Jan Bruensing Lukas Buendgens Hanna Dückers Tony Bruns Guido Gerken Ulf P. Neumann David H. Adams Christian Trautwein Ali Canbay Frank Tacke | 2014 | Liver Int2014，，9： | 1 |
| 18 | Role of mTOR in solid tumor systems: a therapeutical target against primary tumor growth, metastases, and angiogenesis显示文摘 | Hendrik Seeliger Markus Guba Axel Kleespies Karl-Walter Jauch Christiane J. Bruns | 2007 | Cancer and Metastasis Reviews (-)2007，，3： | 1 |
| 19 | A Clos- er Look at Reverberation Chambers-3-D Simulation and Ex- perimental Verification显示文摘 | CHRISTIAN BRUNS RUEDIGER VAHLDIECK | 2005 | IEEE transactions on electro- magnetic compatibility2005，47，5： | 1 |
| 20 | Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer显示文摘 | Patrick C. Hermann Stephan L. Huber Tanja Herrler Alexandra Aicher Joachim W. Ellwart Markus Guba Christiane J. Bruns Christopher Heeschen | 2007 | Cell Stem Cell2007，，3： | 1 |
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