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| 1 | Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study显示文摘Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,we report a novel batorigin CoV causing severe and fatal pneumonia in humans.Methods:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,China.Nucleic acids of the BAL were extracted and subjected to next-generation sequencing.Virus isolation was carried out,and maximum-likelihood phylogenetic trees were constructed.Results:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress syndrome.Chest radiography revealed diffuse opacities and consolidation.One of these patients died.Sequence results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the isolates.These isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate clade.Moreover,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin CoVs.However,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same receptor.Conclusion:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans. | Li-Li Ren Ye-Ming Wang Zhi-Qiang Wu Zi-Chun Xiang Li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-Jun Li Xing-Wang Li Hui Li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-Yang Xu Fan Yang Xin-Ming Wang Chao Wu Lan Chen Yi-Wei Liu Bo Liu Jian Yang Xiao-Rui Wang Jie Dong Li Li Chao-Lin Huang Jian-Ping Zhao Yi Hu Zhen-Shun Cheng Un-Lin Liu Zhao-Hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei Wang | 2020 | Chinese Medical Journal2020，，9： | 99 |
| 2 | Vaccination against hepatitis B: the Chinese experience显示文摘目的将在中国在肝炎 B 病毒感染的预防考察肝炎 B 疫苗和它的关键角色的集体种痘的实现。数据主要从 PubMed,中国医院知识数据库,和杂志从 1980 ~ 2008 出版了的另外的受欢迎的汉语的数据来源。搜索词是“肝炎 B 疫苗”。在主要调查者在中国在 hepatology 的领域里写作的中国和批评评论进行的学习选择原版研究被选择。结果汉语调查者开始开发在 1970 年代末疫苗的肝炎 B。第一支自制导出血浆的疫苗在 1986 变得可得到,它被国内生产的 recombinant (酵母或中国仓鼠卵巢房间) 完全代替了自从 2001 疫苗。中国健康权威建议种牛痘在 1992 的所有婴儿。从那时起,中国把巨大的努力放在集体种痘的实现。在婴儿疫苗的肝炎 B 的全面范围稳定地增加了并且到达了超过 95.0% 在城市并且在农村区域的 83.0%--97.0% 。在孩子的长期的 HBV 搬运人率 < 10 岁在 2006 在集体种痘前从 10.0% 减少了到 1.0%-2.0% ,并且那从 10.0% ~ 7.2% 在一般人口减少了;总的来说,全国集体的肝炎 B 种痘减少了超过 3000 万长期的 HBV 感染和 HBV 相关严重 sequlae。控制由集体种痘的肝炎 B 的中国成功的经验为任何 unindustrialized 国家为一个例子提供无论谁被承诺控制这疾病的结论。 | ZHOU Yi-hua WU Chao ZHUANG Hui | 2009 | Chinese Medical Journal2009，，1： | 67 |
| 3 | Genome-wide analysis of heat shock transcription factor families in rice and Arabidopsis显示文摘The heat shock transcription factors (HSFs) are the major heat shock factors regulating the heat stress response. They participate in regulating the expression of heat shock proteins (HSPs), which are critical in the protection against stress damage and many other important biological processes. Study of the HSF gene family is important for understanding the mechanism by which plants respond to stress. The completed genome sequences of rice (Oryza sativa) and Arabidopsis (Arabidopsis thaliana) constitute a valuable resource for comparative genomic analysis, as they are representatives of the two major evolutionary lineages within the angiosperms: the monocotyledons and the dicotyledons. The identification of phylogenetic relationships among HSF proteins in these species is a fundamental step to unravel the functionality of new and yet uncharacterized genes belonging to this family.In this study, the full complement of HSF genes in rice and Arabidopsis has probably been identified through the genome-wide scan. Phylogenetic analyses resulted in the identification of three major clusters of orthologous genes that contain members belonging to both species, which must have been represented in their common ancestor before the taxonomic splitting of the angiosperms. Further analysis of the phylogenetic tree reveals a possible dicot specific gene group. We also identified nine pairs of paralogs, as evidence for studies on the evolution history of rice HSF family and rice genome evolution. Expression data analysis indicates that HSF proteins are widely expressed in plants. These results provide a solid base for future functional genomic studies of the HSF gene family in rice and Arabidopsis. | Jingkang Guo Jian Wu Qian Ji Chao Wang Lei Luo Yi Yuan Yonghua Wang Jian Wang | 2008 | Journal of Genetics and Genomics2008，35，2： | 52 |
| 4 | Ideal cardiovascular health and incidence of atherosclerotic cardiovascular disease among Chinese adults:the China-PAR project显示文摘Existing evidence on the relationship between cardiovascular health(CVH) metrics and cardiovascular disease(CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics on preventing incident atherosclerotic CVD(ASCVD) in Chinese population. This study was conducted among 93,987 adults from the China-PAR project(Prediction for ASCVD Risk in China) who were followed up until 2015. Cox proportional hazard regression models were used to estimate the hazard ratios(HRs) and their corresponding 95% confidence intervals(CIs) of CVH metrics for the risk of ASCVD, including coronary heart disease(CHD), stroke and ASCVD death. We further estimated the population-attributable risk percentage(PAR%) of these metrics in relation to each outcome. We observed gradient inverse associations between the number of ideal CVH metrics and ASCVD incidence. Compared with participants having ≤2 ideal CVH metrics, the multivariable-adjusted HRs(95% CIs) of ASCVD for those with 3, 4, 5, 6 and 7 ideal CVH metrics were 0.83(0.74–0.93), 0.66(0.59–0.74), 0.55(0.48–0.61), 0.44(0.38–0.50) and 0.24(0.18–0.31), respectively(P for trend <0.0001). Approximately 62.1% of total ASCVD, 38.7% of CHD, 66.4% of stroke, and 60.5% of ASCVD death were attributable to not achieving all the seven ideal CVH metrics. After adjusting effects of ideal health factors, having four ideal health behaviors could independently bring adults health benefits in preventing 17.4% of ASCVD, 18.0% of CHD, 16.7% of stroke, and 10.1% of ASCVD death. Among all the seven CVH metrics, to keep with ideal blood pressure(BP) implied the largest public health gains against various ASCVD events(PAR% between 33.0% and 47.2%), while ideal diet was the metric most difficult to be achieved in the long term. Our study indicates that the more ideal CVH metrics adults have, the less ASCVD burden there is in China. Special efforts of health education and behavior modification should be made on keeping ideal BP and dietary habits in general Chinese population to prevent the epidemic of ASCVD. | Chao Han Fangchao Liu Xueli Yang Jichun Chen Jianxin Li Jie Cao Ying Li Chong Shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Dongshen Hu Xiangfeng Lu Xigui Wu Dongfeng Gu | 2018 | Science China(Life Sciences)2018，61，5： | 60 |
| 5 | Roux-en-Y choledochojejunostomy using novel magnetic compressive anastomats in canine model of obstructive jaundice显示文摘BACKGROUND:The traditional hand-sewn Roux-en-Y choledochojejunostomy is technically complicated,and the incidence of postoperative complications has remained high.A set of novel magnetic compressive anastomats was introduced to facilitate choledochojejunostomy and improve the prognosis of patients.METHODS:After ligating the common bile duct for 7 days,16 dogs were randomly divided into two groups (n=8 per group).Anastomats were used in the study group,and the traditional hand-sewn method was used in the control group for standard Roux-en-Y choledochojejunostomy.We compared the operation time,incidence of complications,gross appearance,and pathological disparity in stoma between the two groups in 1-month and 3-month follow-up examinations.RESULTS:The time spent on constructing the anastomosis for the study group was significantly shortened.Although no anastomotic stenosis occurred in the two groups,the narrowing rate of biliary-enteric anastomosis was much higher in the control group.There was one case of bile leakage in the control group,whereas no bile leakage occurred in the study group.A smoother surface,an improved layer apposition,and a lower local inflammatory response were identified in the anastomosis of the study group.CONCLUSION:The structures of the novel magnetic compressive anastomats are simple,and they are time-saving,safe and efficient for performing Roux-en-Y choledocho- jejunostomy procedures in a canine model of obstructive jaundice. | Chao Fan,Xiao-Peng Yan,Shi-Qi Liu,Chun-Bao Wang,Jian-Hui Li,Liang Yu,Zheng Wu and Yi Lv Department of Hepatobiliary Surgery and Department of Pathology,First Affiliated Hospital,School of Medicine,Xi’an Jiaotong University,Xi’an 710061,China Department of Surgical Oncology,Third Affiliated Hospital,School of Medicine,Xi’an Jiaotong University,Xi’an 710068,China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 49 |
| 6 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 7 | Early Paleozoic ridge subduction in the Chinese Altai: Insight from the abrupt change in zircon Hf isotopic compositions显示文摘Zircons were separated from granitoids, gneisses, and sedimentary rocks of the Chinese Altai. Those with igneous characteristics yielded U-Pb ages of 280-2800 Ma, recording a long history of magmatic activity in the region. Zircon Hf isotopic compositions show an abrupt change at ~420 Ma, indicating that prior to that time the magmas came from both ancient and juvenile sources, whereas younger magmas were derived mainly from juvenile material. This may imply that the lithosphere was signifi- cantly modified in composition by a rapid addition of melt from the mantle. We suggest that this dramatic change was due to the onset of ridge subduction, which can account not only for the formation of voluminous granitoids, mafic rocks with complex compositions, and the association of adakite + high-Mg andesite + boninite + Nb-enriched basalt, but also for the coeval high-T, low-P metamorphism. | SUN Min LONG XiaoPing CAI KeDa JIANG YingDe WANG BuYun YUAN Chao ZHAO GuoChun XIAO WenJiao WU FuYuan | 2009 | Science China Earth Sciences2009，52，9： | 33 |
| 8 | Influence of ambulance use on early reperfusion therapies for acute myocardial infarction显示文摘背景救护车使用帮助尖锐心肌的梗塞(AMI ) 的权威的处理。这研究的目的是在北京与 AMI 为病人在早灌注治疗的管理上评估救护车使用的效果, China.Methods 数据有希望地与圣举起心肌的梗塞( STEMI )从 498 个病人被收集在 12 小时症状发作以内被同意到 19 所医院进入在11月1,2005日和2006年12月31日之间的北京。基线特征和救护车用户和非救护车用户的起始的管理仅仅是 compared.Results 186 (37.3%) 病人们把一辆救护车用作交通到医院。平均,救护车用户更老并且在表示上的相对更高的风险比非救护车用户。在为病人和医院特征的调整以后,救护车使用与更大的早灌注率被联系,主要因为主要经皮的冠的干预的更大的发生。另外,救护车用户有显著地更短的中部的 door-to-balloon (120 与 145 相比纪录, P < 0.001 ) 并且症状 onset-to-balloon (223 与 300 相比纪录, P < 0.001 ) 时间比非救护车 users.Conclusions 救护车是由在北京的 AMI 病人的 underused。救护车使用可以导致早灌注治疗的更多的经常、更快的收据。新公共健康策略应该被开发由 AMI 病人便于救护车的增加的使用。 | SONG Li HU Da-yi YAN Hong-bing YANG Jin-gang SUN Yi-hong LI Chao LIU Shu-shan WU Dong FENG Qi | 2008 | Chinese Medical Journal2008，，9： | 31 |
| 9 | Uric acid stimulates endothelin-1 gene expression associated with NADPH oxidase in human aortic smooth muscle cells显示文摘瞄准:最近的试验性、人的研究证明了 hyperuricemia 与高血压和心血管的疾病被联系。endothelin-1 (ET-1 ) 的提高的层次被认为是心血管的疾病的最强大的独立预言者之一。为调查尿导致酸的脉管的疾病是否与 ET-1 有关,在人的大动脉的光滑的肌肉房间(HASMC ) 的尿导致酸的 ET-1 表示被检验。方法:与尿酸,房间增长和 ET-1 表示对待的有教养的 HASMC 被检验。尿导致酸的细胞外的调整信号的家族 ases (英皇家空军之阶级最低之兵) 上的抗氧化剂预告的处理 phosphorylation 被执行阐明在增长和 ET-1 基因表示的氧化还原作用敏感的小径。结果:尿酸被发现增加 HASMC 增长, ET-1 表示和反应的氧种类生产。N-acetylcysteine 和 apo-cynin 的能力(l-[4-hydroxy-3-methoxyphenyl ] ethanone,一个 NADPH oxidase 禁止者) 建议了细胞内部的氧化还原作用小径的参与禁止尿导致酸的 ET-1 分泌物和房间增长。而且, apocynin,和 p47 phox 击倒的禁止的 ET-1 分泌物和房间增长由尿酸导致了的小介入 RNA。由 U0126 的英皇家空军之阶级最低之兵的抑制(1,4-diamino-2,3-dicyano-1,4-bis [2-aminophenylthio ] 丁二烯) 显著地压制的尿导致酸的 ET-1 表示,含有在对尿酸的反应的这条小径。另外,尿酸增加了抄写因素使活跃之物 protein-1 (AP-1 ) 调停的记者活动,以及 ERK phosphorylation。ET-1 基因倡导者的 Mutational 分析证明 AP-1 有约束力的地点是在尿导致酸的 ET-1 基因表示的重要 cis 元素。结论:这是由在 HASMC 的尿酸的 ET-1 规定的第一观察,它含有在脉管的变化的尿酸的重要角色与高血压和脉管的疾病联系了。 | Hung-hsing CHAO Ju-chi LIU Jia-wei LIN Cheng-hsien CHEN Cheng-hsi WU Tzu-hurng CHENG | 2008 | Acta Pharmacologica Sinica2008，29，11： | 31 |
| 10 | Toll-like receptor 4/nuclear factor-kappa B signaling detected in brain after early subarachnoid hemorrhage显示文摘背景发炎和免疫在 subarachnoid 出血(SAH ) 以后在早大脑损害的致病起一个重要作用。原子 factor-kappa B (NF-KB ) 为发炎和免疫调整许多基因必需品并且被像使用费的受体(TLR ) 激活。这研究试图检测在早 SAH 以后在老鼠大脑发信号的像使用费的受体 4/nuclear factor-kappa B (TLR4/NF-KB ) 的表示。老鼠被将斩首的方法和他们的大脑在血的单个注射以后在 0, 2, 4, 6, 12, 24 和 48 个小时被移开进 prechiasmatic 水塘, TLR4 的 mRNA 表示被 immunohistochemistry 并且西方的弄污被 Taqman 即时 RT-PCR,和蛋白质表示测量。肿瘤坏死 factor-alpha (TNF-) 的 NF-KB 活动和集中, interleukin-lbeta (IL-) 和 intedeukin-6 (IL-6 ) 被试金(ELISA ).Results TaqMan 即时 RT-PCR 并且西方的弄污识别了的连接酶的 immunosorbent 测量在在 mRNA 和蛋白质的 TLR4 表示的一个 biphasic 变化:一座起始的山峰(2-6 小时) 和持续举起(12-48 小时) 。染色的 Immunohistochemical 在 glial 房间和脉管的内皮细胞层主要显示出 TLR4-1ike 免疫反应的可诱导的表示。在象 NF-KB-regulated proinflammatory cytokines (TNF- , IL-1 和 IL-6 ) 的生产一样的 NF-KB 子单元 p65 的激活的一个类似的 biphasic 变化被 ELISA 检测。结论这些数据建议试验性的 SAH 导致在早大脑损害发信号的 TLR4 表示和 NF-KB 的重要起来规定。发信号的 TLR4/NF-KB 的激活可以在 SAH 以后调整煽动性的回答。 | MA Chun-xiao YIN Wei-ning CAI Bo-wen WU Jian WANG Jun-yi HE Min SUN Hong DING Jun-li YOU Chao | 2009 | Chinese Medical Journal2009，，13： | 33 |
| 11 | Fracture development in shale and its relationship to gas accumulation显示文摘有高石英,长石和碳酸盐的页岩,将有低泊松比率,高幼仔模量和高易碎物。作为结果,页岩是导致的在外部力量下面生产自然、导致的破裂。一般来说,在在页岩和在场的易碎的矿物质的体积的破裂开发之间有好关联。有高 TOC 或反常地高的压力的页岩开发得好破裂。页岩破裂开发也与全部的煤气的累积和免费煤气的体积显示出积极关联,即,页岩破裂越更好被开发,越 greater 煤气的累积并且因此越多更高煤气的生产。破裂为天然气和形成水提供迁居水管和累积空格,它为免费天然气的容量的增加是有利的。在页岩的更宽的破裂导致煤气的损失。在北美洲,从在页岩的高角度的破裂地区有页岩气体探索和高煤气的生产的高成功比率。在在四川盆的更低的古生代的海洋的器官的充满事的岩石中的好天然气表演或低收益制片人是仔细与在易碎的页岩的破裂开发的度有关。 | Wenlong Ding Chao Li Chunyan Li Changchun Xu Kai Jiu Weite Zeng Liming Wu | 2012 | Geoscience Frontiers2012，3，1： | 32 |
| 12 | Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors显示文摘Multipotent 神经干细胞为房间治疗保持大诺言。到导致的 pluripotent 干细胞以及成熟神经原的成纤维细胞的 reprogramming 建议可能性没有首先建立 pluripotency,把一个严重地区分的体的房间变换成一个 multipotent 状态。这里,我们证明房间从中层导出的那 Sertoli 能直接被变换成拥有神经干细胞性质的一个 multipotent 状态。导致的神经干细胞(iNSCs ) 表示多重 NSC 特定的标记,展出类似于正常 NSC 的全球基因表示侧面,并且能够自强并且区分功能的神经原进神经胶质并且 electrophysiologically。为酷氨酸 hydroxylase (TH ) 积极的导出 iNSC 的神经原污点, γ -aminobutyric 酸,和胆碱 acetyltransferase。另外, iNSCs 能熬过并且产生跟随移植进有牙齿的回转的触处。iNSCs 的产生可以为疾病建模和再生药有重要含意。 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Libin Wang Wei Li Haijiang Zhang Xiao-Yang Zhao Lei Liu Ziwei Wang Changlong Guo Hua-Jun Wu Zhonghua Liu Liu Wang Shigang He Xiu-Jie Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，1： | 31 |
| 13 | Surface movement and deformation characteristics due to high- intensive coal mining in the windy and sandy region显示文摘 | Zhenqi Hu Chao Chen Wu Xiao Xinjing Wang Mingjie Gao | 2016 | International Journal of Coal Science & Technology2016，3，3： | 34 |
| 14 | Hot water-extracted Lycium barbarum and Rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells显示文摘瞄准:在老鼠或人的肝细胞癌(HCC ) 在房间增长和 apoptosis 上调查热提取水的 Lycium 倒刺海芋属植物(LBE ) 和 Rehmannia glutinosa (RGE ) 的效果房间。方法:老鼠(H-4-II-E ) 和 HCC (HA22T/VGH ) 房间衬里的人与热提取水的 LBE 和 RGE 的各种各样的集中(0-10 g/L ) 被孵化。在 6-24 h 孵化以后,房间增长(n = 6 ) 被比色法测量。apoptotic 房间(n = 6 ) 被流动血细胞计数检测。p53 蛋白质的表示(n = 3 ) 被 SDS 页并且西方的弄污决定。结果:粗略的 LBE (2-5 g/L ) 和 RGE (2-10 g/L ) dose-dependently 在 11% 禁止了 H-4-II-E 房间的增长(P <
0.05 ) 到 85%(P <
0.01 ) 在 6-24 h 处理以后。在 5 g/L 的剂量的粗略的 LBE 在 6-24 h 孵化以后比粗略的 RGE 更有效地压制了 H-4-II-E 房间的房间增长(P <
0.01 ) 。粗略的 LBE (2-10 g/L ) 和 RGE (2-5 g/L ) dose-dependently 也由 14%-43% 禁止了 HA22T/VGH 房间的增长(P <
0.01 ) 在 24 h 以后。在 10 g/L 的剂量的粗略的 LBE 比粗略的 RGE 更有效地禁止了 HA22T/VGH 房间的增长(56.8%+/-1.6% 对 70.3%+/-3.1% 控制, P = 0.0003 <
0.01 ) 。apoptotic 房间显著地与粗略的 LBE (2-5 g/L ) 和 RGE (5-10 g/L ) 的更高的剂量在 24 h 处理以后在 H-4-II-E 房间增加了(P <
0.01 ) 。在 H-4-II-E 房间的 p53 蛋白质的表达式是 119% 控制组和 143% 与相比对待 LBE (2, 5 g/L ) 组,和 110% 控制和 132% 组与 RGE 相比对待(5, 10 g/L ) 在 24 h 以后的组。结论:热提取水的粗略的 LBE (2-5 g/L ) 和 RGE (5-10 g/L ) 禁止增长并且在 HCC 房间刺激调停 p53 的 apoptosis。 | Jane C-J Chao Shih-Wen Chiang Ching-Chiung Wang Ya-Hui Tsai Ming-Shun Wu | 2006 | World Journal of Gastroenterology2006，12，28： | 30 |
| 15 | THE STUDY OF THE YELLOW SEA WARM CURRENT AND ITS SEASONAL VARIABILITY显示文摘The Yellow Sea Warm Current(YSWC) penetrates northward along the Yellow Sea Trough,and brings warm and saline water towards the Bohai Sea.The YSWC becomes much less intrusive in summer and is limited mostly in the southern trough,contrasting with a deep winter penetration well into the trough.The seasonal variability of the YSWC has prompted a debate regarding which controls the YSWC and its seasonal variability.In this article,the annual mean and seasonal variability of the YSWC was examined by using a 3-D ocean model together with several experiments.The results show that in the annual mean the YSWC is a compensating current firstly for the southward Korea Coastal Current(KCC),which is mainly caused by the Kuroshio Current(KC).The local wind-stress forcing plays an important but secondary role.However,the local monsoonal forcing plays a prominent role in modulating the seasonal variability.A deep northwestward intrusion of the YSWC in winter,for instance,is mainly due to a robustly developed China Coastal Current(CCC) which draws water along the Yellow Sea trough to feed a southward flow all the way from the Bohai Sea to the Taiwan Strait. | XU Ling-ling WU De-xing LIN Xiao-pei MA Chao | 2009 | Journal of Hydrodynamics2009，21，2： | 29 |
| 16 | Geological Characteristics and Ore-forming Time of the Dexing Porphyry Copper Ore Mine in Jiangxi Province显示文摘The Dexing porphyry copper ore mine is located in the Qin-Hang metallogenic belt between the Yangtze block and the Cathaysia block. It is a giant porphyry copper mine in China, including 3 ore districts: Tongchang, Fujiawu and Zhushahong. Our analyses of Re in molybdenite indicate that the ore-forming material of the copper ore deposits in Dexing should be mainly mantle-derived. Our study fills in a gap in the study of formation time of the Dexing copper mine, and further proves that the copper ore deposits in the three ore districts should be formed simultaneously, about 170 Ma, belonging to the early Yanshan period, and that the formation time of the copper ore deposits should be consistent with the formation time of granodiorite porphyry in which the copper ore deposits are hosted. Promising areas for seeking porphyry copper ore deposits is predicated to be the west or southwest of Dexing. | GUO Shuo ZHAO Yuany QU Huanchun WU Dexin XU Hong LI Chao LIU Yan ZHU Xiaoyun WANG Zengke | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 28 |
| 17 | Suppression of Jasmonic Acid-Mediated Defense by Viral-Inducible MicroRNA319 Facilitates Virus Infection in Rice显示文摘MicroRNAs (miRNAs ) 是植物开发和主人病毒相互作用的枢轴的调节的人。然而,角色和涉及病毒的感染和主人危险性的特定的 miRNAs 的行动模式仍然保持大部分不清楚。在这研究,我们给那瑞斯看引起 miR319 的增加的累积,但是减少的破旧绝技病毒(RRSV ) 感染调整 miR319 的 TCP (TEOSINTE BRANCHED/CYCLOIDEA/PCF ) 的表示基因,特别 TCP21,在米饭植物。转基因的米饭植物 overexpressing miR319 或 downregulating TCP21 展出了像疾病的显型并且与野类型的植物比较显示出显著地更高的危险性到 RRSV。相反,仅仅温和的疾病症状在感染 RRSV 的线 overexpressing TCP21 并且特别在转基因的植物 overexpressing 被观察 miR319 抵抗的 TCP21。miR319 的 RRSV 感染和 overexpression 在米饭与 JA 生合成和信号相关的基因的 downregulated 表示一起引起了减少的内长的 jasmonic 酸(JA ) 层次。然而,有甲基 jasmonate 的米饭植物的治疗减轻了 RRSV 引起并且减少了病毒累积的疾病症状。一起拿,我们的结果建议由在米饭的 RRSV 感染的 miR319 的正式就职压制调停 JA 的防卫便于病毒感染和症状开发。 | Chao Zhang Zuomei Ding Kangcheng Wu Liang Yang Yang Li Zhen Yang Shan Shi Xiaojuan Liu Shanshan Zhao Zhirui Yang Yu Wang Luping Zheng Juan Wei Zhenguo Du Aihong Zhang Hongqin Miao Yi Li Zujian Wu Jianguo Wu | 2016 | Molecular Plant2016，9，9： | 27 |
| 18 | Reversal of hyperglycemia in diabetic rats by portal vein transplantation of islet-like cells generated from bone marrow mesenchymal stem cells显示文摘AIM: To study the capacity of bone marrow mesenchymal stem cells (BM-MSCs) trans-differentiating into islet-like cells and to observe the effect of portal vein transplantation of islet-like cells in the treatment of streptozotocin-induced diabetic rat. METHODS: BM-MSCs were isolated from SD rats and induced to differentiate into islet-like cells under defined conditions. Differentiation was evaluated with electron microscopy, RT-PCR, immunofluorescence and flow cytometry. insulin release after glucose challenge was tested with ELiSA. Then allogeneic islet-like cells were transplanted into diabetic rats via portal vein. Blood glucose levels were monitored and islet hormones were detected in the liver and pancreas of the recipient by immunohistochemistry. RESULTS: BM-MSCs were spheroid adherent monolayers with high CD90, CD29 and very low CD45 expression. Typical islet-like cells clusters were formed after induction. Electron microscopy revealed that secretory granules were densely packed within the cytoplasm of the differentiated cells. The spheroid cells expressed islet related genes and hormones. The insulin-positive cells accounted for 19.8% and mean fluorescence intensity increased by 2.6 fold after induction. The cells secreted a small amount of insulin that was increased 1.5 fold after glucose challenge. After transplantation, islet-like cells could locate in the liver expressing islet hormones and lower the glucose levels of diabetic rats during d 6 to d 20.CONCLUSION: Rat BM-MSCs could be transdifferentiated into islet-like cells in vitro . Portal vein transplantation of islet-like cells could alleviate the hyperglycemia of diabetic rats. | Xiao-Hong Wu Cui-Ping Liu Kuan-Feng Xu Xiao-Dong Mao Jian Zhu Jing-Jing Jiang Dai Cui Mei Zhang Yu Xu Chao Liu | 2007 | World Journal of Gastroenterology2007，13，24： | 23 |
| 19 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang Norden E. Shen Zheng Long Steven R. Wu Manli C. Shih Hsing H. Zheng Quanan Yen Nai-Chyuan Tung Chi Chao Liu Henry H | 1998 | Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences . 1998 (1971)1998，，1971： | 22 |
| 20 | Clinical research advances in primary liver cancer显示文摘Primarylivercancer(PLC)isoneofthemostcommoncancersinChina.Accordingtothestatisticsofourcountry,primarylivercancerclaims2040l... | WU Meng Chao | 1998 | World Journal of Gastroenterology1998，4，6： | 23 |
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