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| 1 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 2 | Measurement of calprotectin in ascitic fluid to identify elevated polymorphonuclear cell count显示文摘AIM: To evaluate the diagnostic capability of calprotectin in ascitic fluid for detecting a polymorphonuclear (PMN) cell count > 250/μL ascites. METHODS: In this prospective observational study, a total of 130 ascites samples were analysed from 71 consecutive patients referred for paracentesis. Total and differential leukocyte cell counts were determined manually with a Neubauer chamber and gentianviolet stain. Calprotectin was measured in 1 mL ascetic fluid by enzyme-linked immunosorbent assay (ELISA) and a point-of-care (POC) lateral flow assay with the Quantum Blue Reader (Bühlmann Laboratories). All measurements were carried out in a central laboratory by senior personnel blinded to patient history. A PMN count > 250/μL was the primary endpoint of the study. The diagnostic value of ascitic calprotectin measurement was assessed by comparing to the final diagnosis of each patient that had been adjudicated by investigators blinded to calprotectin values. RESULTS: The PMN count was > 250/μL in 19 samples (14.6%) from 15 patients (21.1%) and varied widely among the study population (range 10-19 800/mL and 1-17 820/mL, respectively). Spontaneous bacterial peritonitis (SBP) was the final diagnosis in four patients (5.6%). All patients with PMN ≤ 250/μL had negative bacterial culture. PMN count was elevated in five patients with peritoneal carcinomatosis, three with lymphoma, one with neuroendocrine carcinoma, and two with secondary peritonitis due to abdominal perforation. PMN cell counts correlated with ascitic calprotectin values (Spearman's rho; r = 0.457 for ELISA, r = 0.473 for POC). A considerable range of ascitic calprotectin concentrations was detected by ELISA [median 0.43 μg/mL, interquartile range (IQR) 0.23-1.23 (range 0.10-14.93)] and POC [median 0.38 μg/mL, IQR 0.38-0.56 (range 0.38-13.31)]. Ascitic calprotectin levels were higher in samples with PMN > 250/μL, by both ELISA [median (IQR) 2.48 μg/mL (1.61-3.65) vs 0.10 μg/mL (0.10-0.36), P < 0.001] and POC [2.78 μg/mL (2.05-5.37) vs 0.38 μg/mL (0.38-0.41), P < 0.001]. The area under the receiver operating characteristics curve for identifying an elevated PMN count was 0.977 (95%CI: 0.933 to 0.995) for ELISA and 0.982 (95%CI: 0.942 to 0.997) for POC (P = 0.246 vs ELISA). Using the optimal cut-off value for ELISA (0.63 μg/mL), ascitic calprotectin had 94.8% sensitivity, 89.2% specificity, positive and negative likelihood ratios of 8.76 and 0.06 respectively, positive and negative predictive values of 60.0% and 99.0% respectively, and 90.0% overall accuracy. Using the optimal cut-off value for POC (0.51 μg/mL), the respective values were 100.0%, 84.7%, 6.53, 0.00, 52.8%, 100% and 87.7%. Correlation between ELISA and POC was excellent (r = 0.873, P < 0.001). The mean ± SD of the difference was -0.11 ± 0.48 μg/mL with limits of agreement of + 0.8 μg/mL (95%CI: 0.69 to 0.98) and -1.1 μg/mL (95%CI: -1.19 to -0.91). CONCLUSION: Ascitic calprotectin reliably predicts PMN count > 250/μL, which may prove useful in the diagnosis of SBP, especially with a readily available bedside testing device. | Emanuel Burri Felix Schulte Jürgen Muser Rémy Meier Christoph Beglinger | 2013 | World Journal of Gastroenterology2013，19，13： | 10 |
| 3 | Single-photon avalanche diode imagers in biophotonics:review and outlook显示文摘Single-photon avalanche diode(SPAD)arrays are solid-state detectors that offer imaging capabilities at the level of individual photons,with unparalleled photon counting and time-resolved performance.This fascinating technology has progressed at a very fast pace in the past 15 years,since its inception in standard CMOS technology in 2003.A host of architectures have been investigated,ranging from simpler implementations,based solely on off-chip data processing,to progressively“smarter”sensors including on-chip,or even pixel level,time-stamping and processing capabilities.As the technology has matured,a range of biophotonics applications have been explored,including(endoscopic)FLIM,(multibeam multiphoton)FLIM-FRET,SPIM-FCS,super-resolution microscopy,time-resolved Raman spectroscopy,NIROT and PET.We will review some representative sensors and their corresponding applications,including the most relevant challenges faced by chip designers and end-users.Finally,we will provide an outlook on the future of this fascinating technology. | Claudio Bruschini Harald Homulle Ivan Michel Antolovic Samuel Burri Edoardo Charbon | 2019 | Light(Science & Applications)2019，8，1： | 8 |
| 4 | ZrO_2基复合金属氧化物催化剂上CO_2温和氧化乙苯制苯乙烯(英文)显示文摘苯乙烯(SM)是聚合物化学中最重要的单体之一,由其生产的聚合物产品(如PS,SBR和ABS等)具有独特的性能,因而SM的需求逐年增加.乙苯(EB)催化脱氢工艺提供了90%的SM需求,该过程在K促进的氧化铁催化剂上于600-650℃进行.这是一个吸热且体积增大的反应,因此需要绝热反应器和大量的过热过饱和蒸汽以提供热量和降低反应分压,从而有利于反应平衡向SM方向移动,也可避免或消除积碳.同时,也造成大量潜热被浪费;热点也降低了整个反应活性和催化剂寿命.在蒸汽中加入空气或富氧空气,使得副产H_2与O_2反应,产生的热量可供随后乙苯脱氢反应,同时H_2的移除也有利于提高EB单程转化率,并保持高的SM选择性.但是,该过程需要2个催化剂,反应器的设计和催化剂的装填比较复杂,且存在爆炸的危险.因此,人们尝试了多种氧化剂和新型的催化剂.最近也有人提出软氧化剂的概念.这为开发新催化体系提供了可能.相对于O_2,CO_2的氧化性很弱,但可用作温和氧化剂去除脱氢单元中副产的H_2,降低了反应温度,且不影响反应活性和选择性;同时,具有较大的经济性和环保性,在工业上也是切实可行的.除了负载型的碱金属促进的氧化铁催化剂外,各种金属或金属氧化物也用于催化CO_2氧化EB脱氢反应中,如Fe,Cr,V和La的氧化物为活性金属,碳材料、MgO、SiO_2、Al_2O_3、Ga_2O_3、ZrO_2、TiO_2、水滑石类化合物及分子筛为载体.Park课题组研究了Fe,V和Cr基催化剂,即设计氧化还原的催化剂表面以解离CO_2,产生的O用于逆水汽反应.其中以Al_2O_3负载的V和V-Sb氧化物催化剂性能最为突出;但存在积碳失活和V物种的深度还原等问题.为了进一步提高催化剂性能,该课题组开发了多种ZrO_2基复合氧化物催化剂,包括MnO_2-ZrO_2,TiO_2-ZrO_2,CeO_2-ZrO_2和SnO_2-ZrO_2.这些催化剂具有酸碱特性,在反应中表现出较高的催化性能.因此,本文简要总结了用于CO_2氧化EB脱氢反应的ZrO_2基催化剂最新研究进展.研究发现,在CO_2氧化EB脱氢制SM反应中,CO_2在提高催化剂活性和稳定性方面起着非常重要的作用,可被定义为软氧化剂:氧化催化剂表面以保持其表面氧含量,移除催化剂表面产生的积碳和副产物H_2,为反应体系提供较高的热容以克服反应平衡限制,从而达到较高的转化率.ZrO_2基复合金属氧化物是具有改善的织构特性的纳米粒子,且具有酸碱两性和氧化还原性能.改性可提高催化体系的热稳定性和活性.其中CeO_2-V_2O_5/TiO_2-ZrO_2催化剂具有恰当的氧化还原性和酸碱两性,二者协同作用,因而催化性能最佳.氧化还原稳定剂Sb的添加进一步提高了其催化性能.碱金属和碱土金属可优化其酸碱性,增加比表面积,从而提高反应活性和选择性以及CO_2转化率.继续加强抑制积碳和促进CO_2活化方面的研究,可有望进一步提高单程转化率(75%以上)、选择性(98%)和CO_2转化率(30%).总之,CO_2氧化EB脱氢制SM是一个高度经济性和环境友好的新过程,在未来有望满足SM日益增长的需求.另外,该过程的开发可减少CO_2排放,其副产的CO还可用于多种化工过程.然而,该过程仍面临诸多挑战:如何抑制积碳,单程转化率和催化剂寿命有待进一步提高.这些挑战也给我们未来的研究提供了方向.深入理解反应机理、积碳机理和CO_2的活化过程也有利于我们开发出更适合工业应用的催化剂. | NanzheJiang Abhishek Burri Sang-Eon Park | 2016 | Chinese Journal of Catalysis2016，37，1： | 3 |
| 5 | 国际法和人工智能显示文摘本文就人工智能的主要领域及其对国际法的启发提出了五个论点。这些主要领域分别是自动化、法律人格、武器系统、控制和标准化。这些论点一起分析了一个问题,即为了应对正在进行的人工智能革命,国际法需要在哪些方面进行调整。这些观点还揭示了可以从国际法中获得的对人工智能治理的启发。 | 赖晨枫(译) 蔡伟(译) | 2021 | 法治论坛2021，，1： | 2 |
| 6 | Identification of Adropin as a Secreted Factor Linking Dietary Macronutrient Intake with Energy Homeostasis and Lipid Metabolism显示文摘 | K. Ganesh Kumar James L. Trevaskis Daniel D. Lam Gregory M. Sutton Robert A. Koza Vladimir N. Chouljenko Konstantin G. Kousoulas Pamela M. Rogers Robert A. Kesterson Marie Thearle Anthony W. Ferrante Randall L. Mynatt Thomas P. Burris Jesse Z. Dong Heathe | 2008 | Cell Metabolism2008，，： | 2 |
| 7 | Lactated Ringer's solution resuscitation causes neutrophil activation after hemorrhagic shock显示文摘 | RHEE CAP BURRI D KAUFMANN C | 1998 | J Trauma1998，44，： | 1 |
| 8 | Improvements in survival and clinical benefit with gemcitabine as firstline therapy for patients with advanced pancreatic cancer: a randomized trial显示文摘 | Burris HA Ⅲ Moore MJ Anderson J | 1997 | J Clin Oncol1997，15，6： | 1 |
| 9 | Umbilical artery acid-base status in the preterm infant显示文摘 | Ramin SM Gilstrap LC Leveno K J Burris J Little BB | 1989 | Obstet Gynecol1989，74，2： | 1 |
| 10 | Oxidative damage and defense 显示文摘 | Jacob RA Burri BJ | 1996 | Am J Clin Nutr1996，63，： | 1 |
| 11 | Improvements in sur- vival and clinical benefit with gemeitabine as first-line therapy for patients with advanced pancreas cancer:a randomized trial 显示文摘 | Burris HA 3^rd Moore MJ Andersen J | 1997 | J Clin Oncal1997，15，： | 1 |
| 12 | Improved wear resistance in aluminaPTFE nanocomposites with irregular shaped nanoparticles显示文摘 | Burris D L Sawyer W G | 2006 | Wear2006，260，91： | 1 |
| 13 | Vertex-distinguishing proper edge-colorings显示文摘 | BURRIS A C SCHELP R H | 1997 | J Graph Theory1997，26，2： | 1 |
| 14 | Efficacy and safety of intravenous amiodarone for incessant tachycardias in infant 显示文摘 | Burri S Hug M I Bauersfeld U | 2003 | Eur J Pediatr2003，162，8： | 1 |
| 15 | Nanoerythmpoietin is 10-times more effective than regular erythropo-etin in neuroprotection in a neonatal rat model of hypoxia and ischemia显示文摘 | Chen H Spagnoli F Burris M | 2012 | Stroke2012，43，3： | 1 |
| 16 | Carcinoma ofunknown primary site显示文摘 | Greco FA Burris HA 3rd Erland JB | 2000 | Cancer2000，89，12： | 1 |
| 17 | Improved wear resistance in alumina-PTFE nanocomposites with irregular shaped nanoparticles 显示文摘 | Burris D Sawyer W | 2006 | Wear2006，260，： | 1 |
| 18 | Leadership behavior and employee voice: Is the door really open?显示文摘 | Detert J R Burris E R | 2007 | Academy of Management Journal2007，50，4： | 1 |
| 19 | Caleaneal fractures:indirect re- ductlon and external fixation 显示文摘 | McGarvey W C Burris M W Clanton T O | 2006 | Foot Ankle Surg2006，27，7： | 1 |
| 20 | Fetal and postnatal development of the lung显示文摘 | Burri P H | 1984 | Annu Rev Physiol1984，46，： | 1 |
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