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| 1 | Therapeutic temperature modulation is associated with pulmonary complications in patients with severe traumatic brain injury显示文摘AIM: To examine complications associated with the use of therapeutic temperature modulation(mild hypothermia and normothermia) in patients with severe traumatic brain injury(TBI). METHODS: One hundred and fourteen charts were reviewed. Inclusion criteria were: severe TBI with Glasgow Coma Scale(GCS) < 9, intensive care unit(ICU) stay > 24 h and non-penetrating TBI. Patients were divided into two cohorts: the treatment group received therapeutic temperature modulation(TTM) with continuous surface cooling and indwelling bladder temperature probes. The control group received standard treatment with intermittent acetaminophen for fever. Information regarding complications during the time in the ICU was collected as follows: Pneumonia was identified using a combination of clinical and laboratory data. Pulmonary embolism, pneumothorax and deep venous thrombosis were identified based onimaging results. Cardiac arrhythmias and renal failure were extracted from the clinical documentation. acute respiratory distress syndrome and acute lung injury were determined based on chest imaging and arterial blood gas results. A logistic regression was conducted to predict hospital mortality and a multiple regression was used to assess number and type of clinical complications. RESULTS: One hundred and fourteen patients were included in the analysis(mean age = 41.4, SD = 19.1, 93 males), admitted to the Jackson Memorial Hospital Neuroscience ICU and Ryder Trauma Center(mean GCS = 4.67, range 3-9), were identified and included in the analysis. Method of injury included motor vehicle accident(n = 29), motor cycle crash(n = 220), blunt head trauma(n = 212), fall(n = 229), pedestrian hit by car(n = 216), and gunshot wound to the head(n = 27). Ethnicity was primarily Caucasian(n = 260), as well as Hispanic(n = 227) and African American(n = 223); four patients had unknown ethnicity. Patients received either TTM(43) or standard therapy(71). Within the TTM group eight patients were treated with normothermia after TBI and 35 patients were treated with hypothermia. A logistic regression predicting in hospital mortality with age, GCS, and TM demonstrated that GCS(Beta = 0.572, P < 0.01) and age(Beta =-0.029) but not temperature modulation(Beta = 0.797, ns) were significant predictors of in-hospital mortality [χ2(3) = 22.27, P < 0.01] A multiple regression predicting number of complications demonstrated that receiving TTM was the main contributor and was associated with a higher number of pulmonary complications(t =-3.425, P = 0.001). CONCLUSION: Exposure to TTM is associated with an increase in pulmonary complications. These findings support more attention to these complications in studies of TTM in TBI patients. | Kristine H O’Phelan Amedeo Merenda Katherine G Denny Kassandra E Zaila Cynthia Gonzalez | 2015 | World Journal of Critical Care Medicine2015，4，4： | 18 |
| 2 | Rheumatic manifestations of inflammatory bowel disease显示文摘This article reviews the literature concerning rheu-matic manifestations of inflammatory bowel disease (IBD),including common immune-mediated pathways,frequency,clinical course and therapy. Musculoskel-etal complications are frequent and well-recognized manifestations in IBD,and affect up to 33% of pa-tients with IBD. The strong link between the bowel and the osteo-articular system is suggested by many clinical and experimental observations,notably in HLA-B27 transgenic rats. The autoimmune pathogenic mechanisms shared by IBD and spondyloarthropathies include genetic susceptibility to abnormal antigen pre-sentation,aberrant recognition of self,the presence of autoantibodies against specific antigens shared by the colon and other extra-colonic tissues,and increased intestinal permeability. The response against microor-ganisms may have an important role through molecular mimicry and other mechanisms. Rheumatic mani-festations of IBD have been divided into peripheral arthritis,and axial involvement,including sacroiliitis,with or without spondylitis,similar to idiopathic anky-losing spondylitis. Other periarticular features can oc-cur,including enthesopathy,tendonitis,clubbing,peri-ostitis,and granulomatous lesions of joints and bones.Osteoporosis and osteomalacia secondary to IBD and iatrogenic complications can also occur. The manage-ment of the rheumatic manifestations of IBD consists of physical therapy in combination with local injection of corticosteroids and nonsteroidal anti-inflammatory drugs; caution is in order however,because of their possible harmful effects on intestinal integrity,perme-ability,and even on gut inflammation. Sulfasalazine,methotrexate,azathioprine,cyclosporine and lefluno-mide should be used for selected indications. In some cases,tumor necrosis factor-α blocking agents should be considered as first-line therapy. | Tatiana Sofía Rodríguez-Reyna Cynthia Martínez-Reyes Jesús Kazúo Yamamoto-Furusho | 2009 | World Journal of Gastroenterology2009，15，44： | 11 |
| 3 | Endoscopic retrograde cholangiography for pediatric choledocholithiasis: Assessing the need for endoscopic intervention显示文摘AIM:To assess pediatric patients for choledocholithiasis.We applied current adult guidelines to identify predictivefactors in children.METHODS:A single-center retrospective analysis was performed at a tertiary children's hospital.We evaluated 44 consecutive pediatric patients who underwent endoscopic retrograde cholangiography(ERCP) for suspected choledocholithiasis.Patients were stratified into those with common bile duct stones(CBDS) at ERCP vs those that did not using the American Society of Gastrointestinal Endoscopy(ASGE) guidelines(Very Strong and Strong criteria) for suspected CBDS.RESULTS:CBDS were identified in 84% at the time of ERCP.Abdominal ultrasound identified CBDS in 36% of patients.Conjugated bilirubin ≥ 0.5 mg/d L was an independent risk factor for CBDS(P = 0.003).The Very Strong(59.5%) and Strong(48.6%) ASGE criteria identified the majority of patients(P = 0.0001).A modified score using conjugated bilirubin had a higher sensitivity(81.2% vs 59.5%) and more likely to identify a stone than the standard criteria,odds ratio of 25.7 compared to 8.8.Alanine aminotransferase and gamma-glutamyl transferase values identified significant differences in a subset of patients with odds ratio of 4.1 and 3.25,respectively.CONCLUSION:Current adult guidelines identified the majority of pediatric patients with CBDS,but specific pediatric guidelines may improve detection,thus decreasing risks and unnecessary procedures. | Douglas S Fishman Bruno P Chumpitazi Isaac Raijman Cynthia Man-Wai Tsai E O’Brian Smith Mark V Mazziotti Mark A Gilger | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，11： | 6 |
| 4 | Metabolic Syndrome and Central Fat Distribution Are Related to Lower Serum Osteocalcin Concentrations显示文摘 | Bezerra Dos Santos Magalh?es Karina Moreira Magalh?es Marcelo Trov?o Diniz Erik Salgado Lucena Cynthia Griz Luiz Bandeira Francisco | 2013 | Annals of Nutrition & Metabolism2013，，3： | 1 |
| 5 | Microbicidal action of lactoferrin and lactoferricin and their synergistic effect with metronidazole in Entamoeba histolytica显示文摘 | Nidia L S Magda R L Cynthia O P | 2006 | Biochem Cell2006，84，： | 1 |
| 6 | Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands显示文摘 | Heather M. O’Hagan Wei Wang Subhojit Sen Christina DeStefano Shields Stella S. Lee Yang W. Zhang Eriko G. Clements Yi Cai Leander Van Neste Hariharan Easwaran Robert A. Casero Cynthia L. Sears Stephen B. Baylin | 2011 | Cancer Cell2011，，5： | 1 |
| 7 | Study of vertical transmission of fowl adenoviruses显示文摘 | HELENA G CYNTHIA P DAVPR O | 2006 | Can J Vet Res2006，70，： | 1 |
| 8 | Serologic monitoring of a broiler breeder flock previously affected by inclusion body hepatitis and testing of the progeny for vertical transmission of fowl adenoviruses显示文摘 | CYNTHIA P HELENA G DAVOR O | 2007 | Can J Vet Res2007，71，： | 1 |
| 9 | The Effects of Smoking Status on Walking Ability and Health-Related Quality of Life in Patients With Peripheral Arterial Disease显示文摘 | Cynthia Fritschi Eileen G. Collins Susan O’Connell Conor McBurney Jolene Butler Lonnie Edwards | 2013 | The Journal of Cardiovascular Nursing2013，，4： | 1 |
| 10 | Meconium aspiration produces airway hyperresponsiveness and eosinophilic inflammation in a murine model 显示文摘 | Khan A M Elidemir O Cynthia E | 2002 | Am J Physiol Lung Cell Mol Physiol2002，283，： | 1 |
| 11 | 肺动脉导管对重症患者的影响——随机临床试验汇总分析显示文摘背景:评估肺动脉导管(pulmonary artery catheter,PAC)的随机临床试验(randomized clinical trials,RCTs)一直受到研究样本量较小的限制。一些非随机研究表明,PAC的应用会增加患者的发病率和死亡率。
目的:评估PAC对重症患者的影响。数据来源:在MEDLINE(1985~2005年)数据库、Cochrane对照试验登记站(1988~2005年)、国立卫生研究院ClinicalTrials.gov网站数据库以及美国食品与药物管理局网站上对将患者随机分配至PAC组和非PAC组的RCTs进行检索。在重症心力衰竭患者中进行的ESCAPE试验结果也被纳入。检索词包括肺动脉导管、右心导管、导管和Swan-Ganz。
研究选择:符合条件的研究应包含如下患者:接受手术治疗的患者,进入重症监护病房(intensive care unit,ICU)的患者,因重度心力衰竭入院或者诊断为急性呼吸窘迫综合征和/或败血症的患者。作为观察指标,入选的研究报告了患者死亡、住院天数或ICU住院天数。
数据提取:各研究的入选标准、基线特征、干预措施、预后以及方法学质量的信息由2位作者提取。不同意见通过协商达成共识解决。
数据综合:13项RCTs共包含5051例随机患者。各试验的血流动力学目标和治疗策略各不相同。使用随机效应模型估计患者死亡、住院天数以及使用变力和静脉血管扩张药物的优势比(odds ratios,ORs)。死亡率的合并OR为1.04(95%可信区间[confidence interval,CI],0.90~1.20;P=0.59)。PAC组平均住院天数与非PAC组平均住院天数的差为0.11天(95%CI,-0.51~0.74;P=0.73)。PAC与变力药物(OR,1.58;95%CI,1.19~2.12;P=0.002)和静脉内血管扩张药物的使用率较高相关(OR,2.35;95%CI,1.75~3.15;P〈0.001)。
结论:对于重症患者而言,PAC的使用既不增加总体死亡率或住院天数,也没有给患者带来益处。尽管相关RCTs已进行了近20年,但是仍未得出可以提高患者存活率的明确的PAC使用策略。PAC对临床预后的中性作用可能为对其在各种重症患者的使用缺乏有效的循证治疗所致。 | Monica R. Shah Vic Hasselblad Lynne W. Stevenson Cynthia Binanay Christopher M. O'Connor George Sopko Robert M. Califf 陈益和(译) 唐福林(校) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 1 |
| 12 | Increasing the use of secondary fiber: an overview of deinking chemistry and stickies control 显示文摘 | Cynthia R O Marybth K L | 1992 | Appita1992，45，2： | 1 |
| 13 | Word-of-Mouth Communications: A Motivational Analysis显示文摘 | O S Sundaram Kaushik Mitra Cynthia Webster | 1998 | Advance in consumer Research1998，25，1： | 1 |
| 14 | Hispanics with Primary Biliary Cirrhosis Are More Likely to Have Features of Autoimmune Hepatitis and Reduced Response to Ursodeoxycholic Acid Than Non-Hispanics显示文摘 | Cynthia Levy Jahnavi Naik Christin Giordano Amar Mandalia Christopher O’Brien Kalyan R. Bhamidimari Eugene R. Schiff Paul Martin | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 15 | Increasing the use of secondary fiber: an overview of deinking ehemistry, and stickies eontrol显示文摘 | Cynthia R O Marybth K L | 1992 | Appita1992，45，2： | 1 |
| 16 | The application of signal detection theory to weather forecasting behavior显示文摘 | Harvey Lewis O Jr Kenneth R Hammond Cynthia M Lusk | 1992 | Mon Wea Rev1992，120，： | 1 |
| 17 | Characteristic brain magnetic resonance imaging pattern in patients with macrocephaly and PTEN mutations显示文摘 | Adeline Vanderver Davide Tonduti Ilana Kahn Johanna Schmidt Livija Medne Jodie Vento Kimberly A. Chapman Brendan Lanpher Phillip Pearl Andrea Gropman Charles Lourenco John‐Steven Bamforth Cynthia Sharpe Mercédes Pineda Jens Schallner Olaf Bodamer Simona O | 2014 | Genet2014，，3： | 1 |
| 18 | The association between meteorological events and acute heart failure: New insights from ASCEND-HF显示文摘 | Debraj Das Jeffery A. Bakal Cynthia M. Westerhout Adrian F. Hernandez Christopher M. O’Connor Dan Atar John J.V. McMurray Paul W. Armstrong Justin A. Ezekowitz | 2014 | International Journal of Cardiology2014，，3： | 1 |
| 19 | Randomized,controlled,double-blind,multicenter comparison of the cognitive effects of ziprasidone versus olanzapine in acutely ill inpatients with schizophrenia or schizoaffective disorder显示文摘 | Philip D Harvey Cynthia O | | 0，，： | 1 |
| 20 | Prefrontal cortex, negative symptoms, and schizophrenia: an MRI study显示文摘 | Cynthia G Wible Jane Anderson Martha E Shenton Ashley Kricun Yoshio Hirayasu Shin Tanaka James J Levitt Brian F O’Donnell Ron Kikinis Ferenc A Jolesz Robert W McCarley | 2001 | Psychiatry Research: Neuroimaging2001，，2： | 1 |
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