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| 1 | Cancer epigenetics: linking basic biology to clinical medicine显示文摘癌症进化根本,阶段被 epigenetic 畸形以及基因改变驾驶。epigenetic 控制事件的 Dysregulation 可以导致 DNA methylation 和染色质配置的反常模式,哪个是到癌症的致病的批评贡献者。这些 epigenetic 畸形被在他们的单个部件之间的多重蛋白质建筑群和相互影响包括 DNA methylation 机械放并且坚持说, histone 修饰词,特别地 polycomb (PcG ) 蛋白质,和染色质改变蛋白质。在染色体宽的技术的最近的进展表明了这些 dysregulated epigenetic 部件的参与看起来广泛。而且,作为为癌症的一个驱动力有关像茎的房间 subpopulations 在在癌症和概念的 epigenetic 畸形之间有一个成长连接。新兴的数据建议对正常胚胎、成年的干细胞固有的 epigenetic 风景的方面可以帮助促进在长期的发炎或积累的反应的氧种类的压力下面,恶意的 subpopulations 的进化。最后,理解在癌症的所有类型涉及 epigenetic 畸形的开始和维护的分子的机制为翻译目的有大潜力。这为 epigenetic biomarker 开发已经是明显的,并且为指向的药理学瞄准颠倒癌症特定的 epigenetic 改变。 | Hsing-Chen Tsai Stephen B Baylin | 2011 | Cell Research2011，21，3： | 18 |
| 2 | The Epigenomics of Cancer显示文摘 | Peter A. Jones Stephen B. Baylin | 2007 | Cell2007，，4： | 4 |
| 3 | Gene silencing in cancer in association with promoter hypermethylation 显示文摘 | Herman JG Baylin SB | 2003 | N Engl J Med2003，349，21： | 1 |
| 4 | Gene silencing in cancer association with promoter hypermethylation显示文摘 | Herman JG Baylin SB | 2003 | N EngI J Med2003，349，21： | 1 |
| 5 | Vitamin D deficien- cy and anthropometric indicators of adiposity in school-age children:a prospective study显示文摘 | Gilbert-Diamond D Baylin A Mora-Plazas M | 2010 | Am J Clin Nutr2010，92，6： | 1 |
| 6 | The fundamental role of epigenetic events in cancer显示文摘 | Jones PA Baylin SB | 2002 | Nat Rev Genet2002，3，： | 1 |
| 7 | The fundamental role of epigenetic events in cancer显示文摘 | Jones PA Baylin SB | 2002 | Nat Rev Genet2002，3，6： | 1 |
| 8 | Reversal of gene silencing as a therapeutic target for cancer-roles for DNA methylation and its interdigitation with chromatin显示文摘 | Baylin SB | 2004 | Novartis Found Symp2004，259，： | 1 |
| 9 | DNA hypermethylation in tumorigenesis:epigenetics joins genetics显示文摘 | Baylin S B Herman J G | | 0，，04： | 1 |
| 10 | Mechanisms of disease:Gene silencing in cancer in association with promoter hypermethylation显示文摘 | Herman J Baylin SB | 2003 | New Engl J Med2003，349，21： | 1 |
| 11 | Alcohol intake, drinking patterns, and risk of nonfatal acute myocardial infarction in Costa Rica显示文摘 | Edmond KK Ana Baylin Edward Ruiz-Narvaez | 2005 | Am J Clin Nutr2005，82，6： | 1 |
| 12 | Hypermethylation of the 5'region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies 显示文摘 | Baylin SB Fearon ER Vogelstein B | 1987 | Blood1987，70，： | 1 |
| 13 | Methylation-specific PCR:A novel PCR assay for methylation status of CpG islands显示文摘 | Herman JG Graff JR Baylin SB | 1996 | Proc Natl Acad Sci USA1996，93，： | 1 |
| 14 | DNA hypermethylation in tumorigenesis: epigenetics joins genetics 显示文摘 | Baylin S B Herman J G | 2000 | Trend Genet2000，16，4： | 1 |
| 15 | A gene hypermethyla-tion profile of human cancer显示文摘 | Esteller M Corn PG Baylin SB | 2001 | Cancer Res2001，61，8： | 1 |
| 16 | The fundamental role of epigenetic events in cancer显示文摘 | Jones PA Baylin SB | | 0，，06： | 1 |
| 17 | Epigenetic gene silencing in cancer-amechanism for early oncogenic pathway addiction显示文摘 | Baylin SB Ohm JE | 2006 | Nat RevCancer2006，6，2： | 1 |
| 18 | Vitamin d deficiency and anthropometric indicators of adiposity in school-age children:a prospective study显示文摘 | Gilbert-Diamond D Baylin A Mora-Plazas M | 2010 | Am J Clin Nutr2010，92，6： | 1 |
| 19 | The fundamental role of epigenetie events in cancer显示文摘 | Jones PA Baylin SB | 2002 | Nat Rev Genet2002，3，6： | 1 |
| 20 | Use of the polymerase chain reaction to detect yypermethylation in the calcitonin gene: a new sensitive approach to monitor tumoure cells in acute myelogenous leukemia显示文摘 | Fukuhara T Hooper WC Baylin SB | 1992 | Leukemia Res1992，16，10： | 1 |
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