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| 1 | 木瓜总三萜对幽门螺杆菌诱导小鼠胃炎的保护作用研究显示文摘观察木瓜总三萜对幽门螺杆菌(Helicobacter pylori,Hp)诱导小鼠胃炎保护作用,探寻其可能作用机制。将慢性萎缩性胃炎(chronic atrophic gastritis,CAG)模型制作成功小鼠随机分为模型组、木瓜总三萜不同剂量(50、100 mg·kg^(-1))组和三联疗法组,另取未感染Hp C57BL/6J小鼠作为正常组;治疗组小鼠分别给予相应的药物,每日1次,连续4周。然后取血和胃组织进行血液中活性氧自由基(reactive oxygen species,ROS)、单核细胞趋化蛋白1(monocyte chemotactic protein 1,MCP-1)、角质细胞趋化因子(keratinocyte chemokines,KC)、TNF-α、IL-1β、IL-6、IL-18、IL-4、IL-10含量,胃组织中LDH、MPO、SOD、GSH-Px、CAT和MDA活性和含量及血液、胃组织和溶酶体中β-葡萄糖醛酸酶、β-半乳糖苷酶、组织蛋白酶B和D活性的检测,HE染色法观察胃组织形态学改变;实时定量PCR法测定胃组织中Toll样受体4(Toll like receptor 4,TLR4)、髓样分化因子(myeloid differentiation factor 88,MyD88)、Bcl-2、Bcl-xl、Bax、Bad mRNA表达,Western blot法测定胃组织中TLR4、MyD88、p-IKKβ、p-IκBα、NOD样受体家族3(NOD-like receptor family 3,NLRP3)、凋亡相关斑点样蛋白(apoptosis-associated speck-like protein,ASC)、pro-caspase-1、caspase-1、硫氧还蛋白互作蛋白(thioredoxin-interacting protein,TXNIP)、pro-IL-1β、pro-IL-18、Bcl-2、Bcl-xl、Bax、Bad、cytochrome C、凋亡酶激活因子(apoptotic protease activating factor-1,Apaf-1)、pro-caspase-9、pro-caspase-3、cleaved-caspase-9、cleaved-caspase-3、聚腺苷二磷酸核糖聚合酶-1[poly(ADP-ribose)polymerase 1,PARP-1]、cleaved-PARP-1及胞浆和胞核中NF-κB p65蛋白表达。结果显示,木瓜总三萜可显著抑制Hp增殖,减轻胃黏膜损伤,改善淋巴细胞浸润和腺体萎缩;降低血液、胃组织中β-葡萄糖醛酸酶、β-半乳糖苷酶、组织蛋白酶B和D活性及溶酶体细胞器胞质中β-葡萄糖醛酸酶、组织蛋白酶D的活性,升高溶酶体细胞器溶酶体中β-葡萄糖醛酸酶、组织蛋白酶D活性;降低血液中ROS、MCP-1、KC、TNF-α、IL-1β、IL-6、IL-18和胃组织中MDA含量及MPO、LDH活性,升高血液中IL-4、IL-10含量和胃组织中SOD、CAT和GSH-Px活性;下调胃组织中TLR4、MyD88、Bax、Bad mRNA和蛋白表达,下调胃组织中p-IKKβ、p-IκBα、NLRP3、ASC、pro-caspase-1、caspase-1、TXNIP、pro-IL-1β、pro-IL-18、cytochrome C、Apaf-1、cleaved-caspase-9、cleaved-caspase-3、cleaved-PARP-1和胞核中NF-κB p65蛋白表达,降低p-IKKβ/IKKβ和p-IκBα/IκBα比值;上调胃组织中Bcl-2、Bcl-xl mRNA和蛋白表达,升高Bcl-2/Bax和Bcl-xl/Bad比值,上调胃组织中pro-caspase-9、pro-caspase-3和胞浆中NF-κB p65蛋白表达。以上研究表明木瓜总三萜对Hp诱导小鼠CAG有显著保护作用,其机制可能与增强内源性抗氧化系统功能、抑制Hp诱导CAG小鼠氧化应激、炎症反应、纠正溶酶体功能障碍及TLR4/NF-κB/NLRP3炎症小体信号通路炎性激活,进而抑制线粒体介导的细胞凋亡有关。 | 石孟琼 贺君宇 王晓 舒恒 NGWA Adeline Ngeng 陈烨韬 彭校 张继红 陈茂华 | 2021 | 中国中药杂志2021，46，18： | 12 |
| 2 | Functions and mechanisms of plant histone deacetylases显示文摘Lysine acetylation, one of the major types of post-translational modifications, plays critical roles in regulating gene expression and protein function. Histone deacetylases(HDACs) are responsible for removing acetyl groups from lysines of both histone and non-histone proteins. While tremendous progress has been made in understanding the function and mechanism of HDACs in animals in the past two decades, nearly half of the HDAC studies in plants were reported within the past five years. In this review,we summarize the major findings on plant HDACs, with a focus on the model plant Arabidopsis thaliana, and highlight the components, regulatory mechanisms, and biological functions of HDAC complexes. | Xiangsong Chen Adeline BDing Xuehua Zhong | 2020 | Science China(Life Sciences)2020，63，2： | 11 |
| 3 | Targeting natural killer cells in solid tumors显示文摘Natural killer(NK)cells are innate lymphoid cells endowed with cytolytic activity and a capacity to secrete cytokines and chemokines.Several lines of evidence suggest that NK cells play an important role in anti-tumor immunity.Some therapies against hematological malignacies make use of the immune properties of NK cells,such as their ability to kill residual leukemic blasts efficiently after conditioning during haploidentical hematopoietic stem cell transplantation.However,knowledge on NK cell infiltration and the status of NK cell responsiveness in solid tumors is limited so far.The pro-angiogenic role of the recently described NK cell-like type 1 innate lymphoid cells(ILC1s)and their phenotypic resemblance to NK cells are confounding factors that add a level of complexity,at least in mice.Here,we review the current knowledge on the presence and function of NK cells in solid tumors as well as the immunotherapeutic approaches designed to harness NK cell functions in these conditions,including those that aim to reinforce conventional anti-tumor therapies to increase the chances of successful treatment. | Guillaume Habif Adeline Crinier Pascale Andre Eric Vivier Emilie Narni-Mancinelli | 2019 | Cellular & Molecular Immunology2019，16，5： | 9 |
| 4 | The human TTAGGG repeat factors I and 2 bind to a subsetof interstitial telomeric sequences and satellite repeats显示文摘 | Thomas Simonet Laure-Emmanuelle Zaragosi Claude Philippe Kevin Lebrigand Cldmentine Schouteden Adeline Augereau Serge Bauwens Jing Ye Marco Santagostino Elena Giulotto Frederique Magdinier Beatrice Horard Pascal Barbry Rainer Waldmann Eric Gilson | 2011 | Cell Research2011，21，7： | 7 |
| 5 | Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia显示文摘Natural killer(NK)cells are innate cytotoxic lymphoid cells(ILCs)involved in the killing of infected and tumor cells.Among human and mouse NK cells from the spleen and blood,we previously identified by single-cell RNA sequencing(scRNAseq)two similar major subsets,NK1 and NK2.Using the same technology,we report here the identification,by single-cell RNA sequencing(scRNAseq),of three NK cell subpopulations in human bone marrow.Pseudotime analysis identified a subset of resident CD56^(bright) NK cells,NK0 cells,as the precursor of both circulating CD56dim NK1-like NK cells and CD56^(bright) NK2-like NK cells in human bone marrow and spleen under physiological conditions.Transcriptomic profiles of bone marrow NK cells from patients with acute myeloid leukemia(AML)exhibited stress-induced repression of NK cell effector functions,highlighting the profound impact of this disease on NK cell heterogeneity.Bone marrow NK cells from AML patients exhibited reduced levels of CD160,but the CD160high group had a significantly higher survival rate. | Adeline Crinier Pierre-Yves Dumas Bertrand Escalière Christelle Piperoglou Laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic Pierre Milpied Émilie Narni-Mancinelli Éric Vivier | 2021 | Cellular & Molecular Immunology2021，18，5： | 5 |
| 6 | Partyline显示文摘爱马仕主题派对神奇故事之旅爱马仕每年的主题派对都有叫人意想不到的地方。今年的派对Tales to be told'被传诵的故事'则以说故事为主题。除了更能发挥无穷的想象力,更有着代代承传的意味。较早前在巴黎举行的主题派对,爱马仕选择了位于巴黎第三区Le Marais的一间古老大宅举行。宾客走过长长的通道,遍历了不同刺激有趣的童话故事场景,视觉冲击一浪接一浪。最大的惊喜,莫过于把宴会大堂由伸手不见五指的漆黑环境,瞬间变成富丽堂皇的会场。神奇魔法果然是爱马仕的看家本领。 | L 谢浩然 Adeline Lai 陈铭恒 | 2010 | 明日风尚2010，0，5： | 4 |
| 7 | Rodent models of fatty liver diseases显示文摘Fatty liver diseases including alcoholic liver disease(ALD)and non-alcoholic fatty liver disease(NAFLD)are leading causes of chronic liver diseases worldwide.ALD and NAFLD encompass a broad spectrum of liver disorders ranging from simple steatosis to steatohepatitis,fibrosis,cirrhosis and superimposed hepatocellular carcinoma.Despite considerable advances in our understanding of the pathogenesis of fatty liver diseases over the past 40 years,effective diagnostic,prognostic,and therapeutic tools are still lacking.The use of animal models is crucial to investigate the cellular and molecular mechanisms underlying the development and progression of fatty liver diseases and develop novel therapeutic strategies.Although no animal model to date can faithfully replicate all the clinical and histological features of ALD or NAFLD,existing models can mimic specific aspects of human diseases.This review provides an overview of the most commonly used and recently developed rodent models of ALD and NAFLD and discusses their major strengths and shortcomings. | Adeline Bertola | 2018 | Liver Research2018，2，1： | 4 |
| 8 | Path-polarization hyperentangled and cluster states of photons on a chip显示文摘Encoding many qubits in different degrees of freedom(DOFs)of single photons is one of the routes toward enlarging the Hilbert space spanned by a photonic quantum state.Hyperentangled photon states(that is,states showing entanglement in multiple DOFs)have demonstrated significant implications for both fundamental physics tests and quantum communication and computation.Increasing the number of qubits of photonic experiments requires miniaturization and integration of the basic elements,and functions to guarantee the setup stability,which motivates the development of technologies allowing the precise control of different photonic DOFs on a chip.We demonstrate the contextual use of path and polarization qubits propagating within an integrated quantum circuit.We tested the properties of four-qubit linear cluster states built on both DOFs,and we exploited them to perform the Grover's search algorithm according to the one-way quantum computation model.Our results pave the way toward the full integration on a chip of hybrid multi-qubit multiphoton states. | Mario Arnolfo Ciampini Adeline Orieux Stefano Paesani Fabio Sciarrino Giacomo Corrielli Andrea Crespi Roberta Ramponi Roberto Osellame Paolo Mataloni | 2016 | Light(Science & Applications)2016，5，1： | 3 |
| 9 | Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6Chi and Ly6Clo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice显示文摘 | Christophe Combadière Stéphane Potteaux Mathieu Rodero Tabassome Simon Adeline Pezard Bruno Esposito Régine Merval Amanda Proudfoot Alain Tedgui Ziad Mallat | 2008 | Circulation2008，，13： | 2 |
| 10 | From traditional serrated adenoma to tubulovillous adenoma and beyond显示文摘It is well established that colorectal cancer develops from a series of precursor epithelial polyps, including tubular adenomas, villous/tubulovillous adenomas(VA/TVA), sessile serrated adenomas(SSA) and traditional serrated adenomas(TSA). Of these, TSAs are least common and account for only 5% of all serrated polyps. TSAs are characterised by the presence of a 'pinecone-like' architecture, granular eosinophilic cytoplasm, luminal serrations, ectopic crypt foci(ECF) and elongated, pencillate nuclei. However, the distinct slit-like luminal serrations, reminiscent of small bowel mucosa, appear to be the most unique and reproducible feature to distinguish TSAs from other polyps. There is a contention that TSAs are not inherently dysplastic and that the majority do not show cytological atypia. Two types of dysplasia are associated with TSA. Serrated dysplasia is less well recognised and less commonly encountered than adenomatous dysplasia. In addition, it is now becoming increasingly evident that TSAs can be admixed with HP, SSA and VA/TVA. At a genetic level, polyps may switch phenotype as they accumulate genetic changes, evolving from a serrated pathway to a more conventional one, which could be the basis for a spectrum theory starting out with a TSA with serration and ECF evolving into a TSA with conventional dysplasia and, eventually, to a well-developed conventional adenoma. Nevertheless, there is an exigency for future studies to provide further illumination and bridge the gaps in our present understanding. | Sangeetha N Kalimuthu Adeline Chelliah Runjan Chetty | 2016 | World Journal of Gastrointestinal Oncology2016，8，12： | 2 |
| 11 | Sepsis and serum cytokine concentrations显示文摘 | Pierre Damas Jean-Luc Canivet Donat De Groote Yvonne Vrindts Adelin Albert Paul Franchimont Maurice Lamy | 1997 | Critical Care Medicine1997，，3： | 1 |
| 12 | The sheitrooke reactive powder concrete footbridge显示文摘 | Aitcin P C Lachemi M Adeline R | 1998 | Structural Engineering International1998，8，2： | 1 |
| 13 | Lymphoma and Myeloma Cell Resistance to Cytotoxic Agents and Ionizing Radiations Is Not Affected by Exposure to Anti-IL-6 Antibody 显示文摘 | Angelique Gougelet Adeline Mansuy Jean-Yves Blay | 2009 | PLoS One2009，4，11： | 1 |
| 14 | The use of thenovosol process for the treatment of polluted marine sediment显示文摘 | ZOUBEIR L ADELINE S LAURENT C S | 2007 | JHazard Mater2007，148，3： | 1 |
| 15 | Processing and stabilization of cauliflower by ohmic heating technology innovative显示文摘 | Francois zuber Adeline Goullieux | 2001 | Food Science 8L Emerging Technologies2001，2，4： | 1 |
| 16 | The use of the Novosol process for the treatment of polluted marine sediment显示文摘 | Lafhaj Zoubeir Saliceto Adeline Cohen Solal Laurent | | 0，，： | 1 |
| 17 | Radiofrequency ablation of unresectable liver tumors: factors associated with incomplete ablation or local recurrence显示文摘 | Ahmet Ayav Adeline Germain Frederic Marchal Ioannis Tierris Valérie Laurent Christophe Bazin Yufeng Yuan Laurence Robert Laurent Brunaud Laurent Bresler | 2010 | The American Journal of Surgery2010，，4： | 1 |
| 18 | Parents of children in the pediatric inten- sive care unit:what are their needs显示文摘 | Jean W Adeline M | 1988 | Heart & Lung1988，17，5： | 1 |
| 19 | Correction:Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia显示文摘Correction to:Cellular&Molecular Immunology http://gffzzd3cc09b8251d45dfsfc56wf90cfvp6xuf.ffgz.tsg.suse.edu.cn/10.1038/S41423-020-00574-8,published online 25 November 2020 In the version of this article initially published,two unintended errors were made during manuscript preparation.(1)The figure legend for Panel 3B was missing;the correct legend is as follows. | Adeline Crinier Pierre-Yves Dumas Bertrand Escalière Christelle Piperoglou Laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic Pierre Milpied Émilie Narni-Mancinelli Éric Vivier | 2021 | Cellular & Molecular Immunology2021，18，11： | 1 |
| 20 | Diabetes mellitus and risk of colorectal cancer in the singapore Chinese health study 显示文摘 | ADELINE SEOW JIAN-MIN YUAN WOON-PUAY KOH | 2006 | Journal of the National Cancer Institute2006，2，98： | 1 |
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