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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | 新型除草剂快杀稗在水田环境中归宿的研究显示文摘快杀稗为新型选择性水田除草剂,正在世界各地实验推广.快杀稗在太阳光下,纯水中稳定,田水中光解较快.在模拟太阳光的紫外光下(即光解反应器内),在灭菌的田水中光解较慢,H_2O_2可大大加快光解速率,主要光解产物为3,7-二氯喹啉.在pH8的水中稳定,不易为微生物降解,几乎不与水田底泥结合,且不易挥发.在田间,快杀稗在30天内消解93—99%,其中第一天消解约50%.稻田底泥中快杀稗含量很低.可以推测,快杀稗污染环境的潜在危险性较小. | 王一茹 Crosby D G | 1992 | 环境科学学报1992，12，3： | 17 |
| 3 | 用键合硅柱和色谱技术分析水中快杀稗残留显示文摘本文提供了两种简便、快速、灵敏、经济的快杀稗残留分析方法。用C_8键合硅柱萃取、富集水中的快杀稗,与MTBSTFA衍生,用GC-FID测定。添加回收率为90—108%,检测极限为1ppb。HPLC法,水样不必净化可直接测定,检测极限为20ppb。水样浓度过低时,需用C_8键合硅柱萃取,富集后用HPLC测定,20ppb的添加回收率为101.3%,可检测到2ppb。 | 王一茹 Crosby D G | 1992 | 环境化学1992，11，1： | 12 |
| 4 | Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial显示文摘 | Tom Waddell Ian Chau David Cunningham David Gonzalez Alicia Frances Clare Okines Andrew Wotherspoon Claire Saffery Gary Middleton Jonathan Wadsley David Ferry Wasat Mansoor Tom Crosby Fareeda Coxon David Smith Justin Waters Timothy Iveson Stephen Falk Sar | 2013 | Lancet Oncology2013，，6： | 10 |
| 5 | Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial显示文摘 | Somnath Mukherjee Christopher N Hurt John Bridgewater Stephen Falk Sebastian Cummins Harpreet Wasan Tom Crosby Catherine Jephcott Rajarshi Roy Ganesh Radhakrishna Alec McDonald Ruby Ray George Joseph John Staffurth Ross A Abrams Gareth Griffiths Tim Maugh | 2013 | Lancet Oncology2013，，4： | 4 |
| 6 | 澳大利亚小麦品质分类标准概述显示文摘澳大利亚是世界主要小麦出口国,其小麦出口量占世界小麦出口总量的10%~15%。本文主要介绍澳大利亚小麦品质分类发展史、现有小麦分类及品质特性和小麦品种品质分类评定体系。澳大利亚小麦品质分类早期采用美国和加拿大执行的小麦品质分类标准,后期在西澳小麦咨询委员会、澳大利亚小麦品质目标项目群的建议和出口国家对小麦品质的要求下,最终形成了现有的8种小麦品质分类标准:优质硬麦(APH)、硬麦(AH)、优质白麦(APW)、标准白麦(ASW)、面条小麦(ANW)、优质面条白麦(APWN)、软麦(ASFT)和杜伦麦(ADR)。澳大利亚小麦品种品质分类着重于新品种的加工和最终使用性能,通过划分种植区域、设置对照品种、建立质量评定标准和贸易标准,最终形成了完整的小麦品种品质分类体系,保证了同类同等小麦质量的一致性和稳定性。 | 王旭琳 刘锐 吴桂玲 Graham Crosbie 闫美姣 | 2021 | 麦类作物学报2021，41，1： | 4 |
| 7 | Study to Determine Adequate Margins in Radiotherapy Planning for Esophageal Carcinoma by Detailing Patterns of Recurrence After Definitive Chemoradiotherapy显示文摘 | Michael R. Button Carys A. Morgan Elizabeth S. Croydon S. Ashley Roberts Thomas D.L. Crosby | 2009 | International Journal of Radiation Oncology, Biology, Physics2009，，3： | 2 |
| 8 | Genetic transformation of strawberry by Agrobacterium tumefaciens using a leaf disk regeneration system显示文摘 | Narender S. Nehra Ravindra N. Chibbar Kutty K. Kartha Raju S. S. Datla William L. Crosby Cecil Stushnoff | 1990 | Plant Cell Reports1990，，6： | 2 |
| 9 | Malignant Gastrointestinal Stromal Tumors of the Small Intestine: A Review of 50 Cases From a Prospective Database显示文摘 | Jacqueline A. Crosby MD Charles N. Catton MD Aileen Davis PhD Jean Couture MD Brian O'Sullivan MD Rita Kandel MD Carol J. Swallow MD PhD | 2001 | Annals of Surgical Oncology2001，，1： | 2 |
| 10 | Antisense Technology: An Emerging Platform for Cardiovascular Disease Therapeutics显示文摘 | Richard G. Lee Jeff Crosby Brenda F. Baker Mark J. Graham Rosanne M. Crooke | 2013 | Journal of Cardiovascular Translational Research2013，，6： | 2 |
| 11 | Root growth, yield, and fruit quality responses of reticulatus and inodorus melons ( Cucumis melo L.) to deficit subsurface drip irrigation显示文摘 | Sat Pal Sharma Daniel I. Leskovar Kevin M. Crosby Astrid Volder A.M.H. Ibrahim | 2014 | Agricultural Water Management2014，，： | 2 |
| 12 | Structure-selectivity studies on catalysts for the phase-transfer catalysed asymmetric alkylation of glycine imine esters 显示文摘 | LYGO B CROSBY J LOWDO T R | 2001 | Tetrahedron2001，57，12： | 2 |
| 13 | Diagnostic strategies in CADASIL显示文摘 | H. S. Markus R. J. Martin M. A. Simpson Y. B. Dong N. Ali A. H. Crosby J. F. Powell | 2002 | Neurology2002，，8： | 2 |
| 14 | Prognostic significance of endoluminal ultrasound-defined disease length and tumor volume (EDTV) for patients with the diagnosis of esophageal cancer显示文摘 | Christopher P. Twine S. Ashley Roberts Wyn G. Lewis B. Vicki Dave Claire E. Rawlinson David Chan Mark Robinson Tom D. Crosby | 2010 | Surgical Endoscopy2010，，4： | 2 |
| 15 | Enhancement of iron chelaation by desferrioxamine entrapped in red blood cell ghosts显示文摘 | Green BR Miller J Crosby W | 1981 | Blood1981，57，5： | 2 |
| 16 | 触摸屏技术的发展显示文摘触摸屏让人机交互更直截了当
DisplaySearch的预测表明到2016年整个触摸屏市场的价值将可能达到140亿美元,是去年的3倍多。目前很多新的应用领域开始看到触控技术的优势,从而产生巨大的滚雪球效应。一些电子设备和装置将这种直观方法用于其用户界面,并能够在竞争产品中脱颖而出。因此。OEM已经在关注这一技术,希望借此增加市场份额。下文介绍了触摸屏的“简短历史”一从最初的无足轻重,到今天几乎无处不在的地位。 | Ian Crosby | 2011 | 电子与电脑2011，，4： | 2 |
| 17 | 衡量营销投资回报率的三大方法显示文摘顾客体验的好坏与广告、促销、销售终端、产品、顾客服务、社区关系等众多品牌接触点的表现有关,因此,企业的诸多部门与营销投资回报率紧密相关。 | Lawrence A. Crosby 孟群华(译) | 2009 | 广告主2009，，8： | 2 |
| 18 | 柴油发动机新技术解析显示文摘本文译自美国《MOTOR》杂志,是针对美国汽修技师在柴油发动机维修技术中面临的一些新问题而进行的解析。那么,国内的汽修技师不久之后是否也会面临同样的问题呢?本文所介绍的柴油机的最新技术或许将对您有所帮助。 | Peter Crosby 韩建保 王勋 | 2008 | 汽车维修与保养2008，，2： | 2 |
| 19 | Relationship Quality in Services Selling:An Interpersonal Influence Perspective显示文摘 | CROSBY LAWRENCE A KENNETH R EVANS DEBORAH COWLES | 1990 | Journal of Marketing1990，，54： | 1 |
| 20 | Relationship Quality in Services Selling:An Interpersonal Influence Perspective显示文摘 | CROSBY L A EVANS K R COWLES D | 1990 | Journal of Marketing1990，54，3： | 1 |
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