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39篇 您的检索式：作者名="Mischel PS"

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	题名	作者	年代	出处	被引量
1	Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor	Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS	2003	癌症2003，22，7：	41
2	Molecular classi-fication of gliomas显示文摘	MASUI K MISCHEL PS REIFENBERGER G	2016	Handb Clin Neurol2016，134，：	1
3	Targeted molecular therapy of GBM显示文摘	Mischel PS Cloughesy TF	2003	Brain Pathol2003，13，：	1
4	Identification of molecular subtypes of glioblastoma by gene expression profiling显示文摘	Mischel PS Shai R Shi T	2003	Oncogene2003，22，15：	1
5	Glioblastoma : from molecular pathology to targeted treatment 显示文摘	Cloughesy TF Cavenee WK Mischel PS	2014	Annu Rev Pathol2014，9，1：	1
6	PTEN-mediated resistance to epidermal growth factor receptor kinase in- hibitors显示文摘	Mellinghoff IK Cloughesy TF Mischel PS	2007	Clin Cancer Res2007，13，21：	1
7	Charting the course across the blood-brainbarrier显示文摘	Nathanson D Mischel PS	2011	J Clin Invest2011，121，1：	1
8	Nerve growth factor signals via preexisting TrkA receptor oligomers显示文摘	Mischel PS Umbach JA Eskandari S		0，，02：	1
9	Targeted molecular therapy of GBM显示文摘	Mischel PS Cloughesy TF	2003	Brain Pathol2003，13，1：	1
10	Childhood generalized and mesial temporal epilepsies deminstrate different amounts and patterns of hippocampal neuron loss and mossy fiber synaptic reorganization 显示文摘	Mathern GW Babb TL Mischel PS	1996	Brain1996，119，3：	1
11	Charting the course across the blood-brain barrier 显示文摘	Nathanson D Mischel PS	2011	J Clin Invest2011，121，1：	1
12	Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B显示文摘	Mischel PS Vinters HV	2001	J Neuropathol Exp Neurol2001，60，7：	1
13	Childhood generalized and mesial temporal epilepsies demonstrate differentamounts and patterns of hippocampal neuron loss and mossy fibre synapticreorganization显示文摘	Mathem GW Babb TL Mischel PS		0，，3：	1
14	Lymphomatosis cerebri presenting as a rapidly progressive dementia:clinical,neuroimaging and pathologic findings显示文摘	Bakshi R Mazziotta JC Mischel PS	1999	Dement Geriatr CognDisord1999，10，：	1
15	Lymphomatosis cerebri presenting as a rapidly progressive dementia:clinical,neuroimaging and pathologic findings显示文摘	Bakshi R Mazziotta JC Mischel PS	1999	Dement Geriatr Cogn Disord1999，10，：	1
16	p53 disruption profoundly alters the response of human glioblastoma cells to DNA topoisomerase I inhibition显示文摘	Wang Y Zhu S Cloughesy TF Liau LM Mischel PS	2004	Oncogene2004，23，：	1
17	The extracellular domain of p75NTR is necessary to inhibit ueurotrophin-3 signaling through TrkA显示文摘	Mischel PS Smith SG Vining ER	2001	JBiolChem2001，276，11：	1
18	Glioblastoma: from molecular pathology to targeted treatment显示文摘	Cloughesy TF Cavenee WK Mischel PS	2014	Annu Rev Pathol2014，，：	1
19	Targeted molecular therapy of GBM显示文摘	Mischel PS Cloughesy TF	2003	Brain Pathol2003，13，1：	1
20	PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors显示文摘	Cloughesy TF Mischel PS	2007	Clin Cancer Res2007，13，21：	1

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