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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Scintigraphy in laryngopharyngeal and gastroesophageal reflux disease:A definitive diagnostic test?显示文摘AIM: To investigate the utility of scintigraphic studies in predicting response to laparoscopic fundoplication(LF) for chronic laryngopharyngeal reflux symptoms.METHODS: Patients with upper aero-digestive symptoms that remained undiagnosed after a period of 2 mo were studied with conventional p H and manometric studies. Patients mainly complained of cough, sore throat, dysphonia and globus. These patients were imaged after ingestion of 99m-technetium diethylene triamine pentaacetic acid. Studies were quantified with time activity curves over the pharynx, upper and lower oesophagus and background. Late studies of the lungs were obtained for aspiration. Patients underwent LF with post-operative review at 3 mo after surgery.RESULTS: Thirty four patients(20 F, 14 M) with an average age of 57 years and average duration of symptoms of 4.8 years were studied. Twenty four hour p H and manometry studies were abnormal in all patients. On scintigraphy, 27/34 patients demonstrated pharyngeal contamination and a rising or flat pharyngeal curve. Lung aspiration was evident in 50% of patients. There was evidence of pulmonary aspiration in 17 of 34 patients in the delayed study(50%). Pharyngeal contamination was found in 27 patients. All patients with aspiration showed pharyngeal contamination. In the 17 patients with aspiration, graphical time activity curve showed rising activity in the pharynx in 9 patients and a flat curve in 8 patients. In those 17 patients without pulmonary aspiration, 29%(5 patients) had either a rising or flat pharyngeal graph. A rising or flat curve predicted aspiration with a positive predictive value of 77% and a negative predictive valueof 100%. Over 90% of patients reported a satisfactory symptomatic response to LF with an acceptable sideeffect profile. CONCLUSION: Scintigraphic reflux studies offer a good screening tool for pharyngeal contamination and aspiration in patients with gastroesophageal reflux disease. | Gregory L Falk John Beattie Alvin Ing SE Falk Michael Magee Leticia Burton Hans Van der Wall | 2015 | World Journal of Gastroenterology2015，21，12： | 2 |
| 3 | Isoflurane-in- duced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures显示文摘 | Wise-Faberowski L Zhang H Ing R | 2005 | Anesth Analg2005，101，3： | 1 |
| 4 | Elevated expression ofFn14 in nonsmall cell lung cancer correlates with activatedEGFR and promotes tumor cell migration and invasion显示文摘 | Whitsett TG Cheng E Inge L | 2012 | Am JPathol2012，181，1： | 1 |
| 5 | Genetic epidemiological studies of early-onset deafness in the US school-age population显示文摘 | MARAZITA M L PLOUGHMAN L M RAWL INGS B | 1993 | Am J Med Genet1993，46，： | 1 |
| 6 | New index of combined systolic and diastolic myocardial performance:a simple and reproducible measure of cardiac function: a study in normals and dilated cardiomyopathy 显示文摘 | Tei C L ing LH Hodge DO | 1995 | J Cardiol1995，26，6： | 1 |
| 7 | On general principally injective rings显示文摘 | CHEN J L D ING N Q | 1999 | Comm ALGEBRA1999，27，5： | 1 |
| 8 | Beta-catenin regulates vascular endothelial growth factor expression in colon cancer显示文摘 | Easwaran V Lee S H Inge L | 2003 | Cancer Res2003，63，12： | 1 |
| 9 | The preparation of some bromodeoxyand dibromodeoxy pentonolactones 显示文摘 | Klaus B Inge L Christian P | 1981 | Carbohydr Res1981，90，： | 1 |
| 10 | New index of combined systolic and diastolic myocardial performance:a simple and re-producible measure of cardiac function-a study in no-rmals and dilated cardiomyopathy显示文摘 | Tei C L ing LH Hodge DO | 1995 | J Cardio1995，26，6： | 1 |
| 11 | Optimal and nonlinear decoupling control of systems with sandwiched backlash显示文摘 | TAO G MA X L ING Y | 2001 | Automatica2001，37，： | 1 |
| 12 | Auto- matic Monitoring of Slope Deformations Using Geoteehnieal Instruments显示文摘 | l)ing X L Ren D Y Montgomery B | 2000 | Journal of Survey- ing Engineering-Asce2000，126，2： | 1 |
| 13 | Salt tectonics driven by dif- ferential sediment loading:stability analysis and finite-element experi- ments显示文摘 | Gemmer L Ings S J Medvedev S | 2004 | Basin Research2004，16，： | 1 |
| 14 | Detection and characterization of long pulse low velocity impact damage in plastic bonded explosives显示文摘 | Chen P W Huang F L Dai K D I)ing Y S | 2005 | International Journal of Impact Engineering2005，31，49： | 1 |
| 15 | Dynamic modelling of passive margin salt tectonics:effects of water loading, sediment properties andsedimentation patterns显示文摘 | Gemmer L Beaumont C Ings S J | 2005 | Basin Research2005，17，： | 1 |
| 16 | Simple synthes is of (R)-Carnitine from D-galactono-1,4-lactone显示文摘 | Lundt Inge pedersen Christian L | 1992 | Te trahed ron1992，48，2： | 1 |
| 17 | beta-Catenin regulates vascular endothelial growth factorexpression in colon cancer 显示文摘 | Easwaran V Lee S H Inge L Guo L Goldbeck C Garrett E etal | 2003 | Cancer Res2003，63，： | 1 |
| 18 | Antibacterial properties of human amniotic membrances显示文摘 | Talmi YP Sigler L Inge E | 1991 | Plancenta1991，12，3： | 1 |
| 19 | Neonatal data on a cohort of 2889 infants born after ICSI (1991-1999) and of 2995 infants born after IVF (1983-1999)显示文摘 | Maryse B Inge L Veerle D | 2002 | Hum Reprod2002，17，3： | 1 |
| 20 | Evaluation of 99mTc-UBI 29-41 scintigraphy for specific detection of experimental Staphylococcus aureus prosthetic joint infections显示文摘 | Sarda-Mantel L Saleh-Mghir A Wel ing MM | | 0，，08： | 1 |
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