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| 1 | Collaboration for success:the value of strategic collaborations for precision medicine and biomarker discovery显示文摘Precision medicine aims to provide the precise treatment for the patient with the right dose at the right point of time.Biomarkers(BM)are vital for the identification of patients who would benefit the most from individualized treatment.In addition,they help to enable the prediction of prognosis,the detection of early therapeutic and adverse effects,and may serve as surrogate endpoints in clinical trials.BM are becoming essential tools to increase productivity in drug discovery and impressively enhance the way medicine is practiced.However,the identification,sufficient validation and implementation of such BM are challenging.This process requires expertise from different areas and high resource investments.Collaborations of different partners may be helpful to overcome these challenges.In the past decade,collaborations between diagnostics and pharmaceutical companies as well as industrial–academic collaborations have been increasingly pursued.Moreover,public funding may offer support and open new opportunities to form such consortia.Herein we give an overview of the different types of collaborations,their opportunities and challenges,and describe experiences in forming strategic partnerships with other companies. | Lilla Landeck Monika Lessl Joachim Reischl Andreas Busch Patricia Carrigan Matthias Gottwald Petra Reinke Khusru Asadullah | 2016 | Advances in Precision Medicine2016，1，1： | 3 |
| 2 | Neoadjuvant chemotherapy with cisplatin, 5-FU, and leucovorin (PLF) in locally advanced gastric cancer: a prospective phase II study显示文摘 | Katja Ott Andreas Sendler Karen Becker Hans-Joachim Dittler Hermann Helmberger Raimonde Busch Christian Kollmannsberger J. Rüdiger Siewert Ulrich Fink | 2003 | Gastric Cancer2003，，3： | 3 |
| 3 | CBM and CO2-ECBM related sorption processes in coal: A review显示文摘 | Andreas Busch Yves Gensterblum | 2011 | International Journal of Coal Geology2011，，2： | 2 |
| 4 | Sixteen-slice spiral CT versus MR imaging for the assessment of left ventricular function in acute myocardial infarction显示文摘 | Andreas H. Mahnken Ralf Koos Marcus Katoh Elmar Spuentrup Petra Busch Joachim E. Wildberger Harald P. Kühl Rolf W. Günther | 2005 | European Radiology2005，，4： | 2 |
| 5 | Experimental study of gas and water transport processes in the inter-cleat (matrix) system of coal: Anthracite from Qinshui Basin, China显示文摘 | Fengshuang Han Andreas Busch Niels van Wageningen Jianli Yang Zhenyu Liu Bernhard M. Krooss | 2009 | International Journal of Coal Geology2009，，2： | 2 |
| 6 | The role of smooth muscle in the pathogenesis of pelvic organ prolapse—an immunohistochemical and morphometric analysis of the cervical third of the uterosacral ligament显示文摘 | Christl Reisenauer Thomas Shiozawa Matthias Oppitz Christian Busch Andreas Kirschniak Tanja Fehm Ulrich Drews | 2008 | International Urogynecology Journal2008，，3： | 1 |
| 7 | 创新药物研发--拜耳先灵医药的发展方式显示文摘拜耳先灵医药全球研发部(GDD)的使命是用小分子和生物类创新药物来改善患者生活质量,关注心脏病、肿瘤、诊断影像和女性健康这四个领域内未被满足的医疗需求。在研究与开发活动中,与清华大学这样的顶级科研组织进行全球性创新合作是很重要的一部分。在研发所在地拥有整合性技术平台能够保证操作流程优化,这对于达到质量高标准和减少药品研发价值链损耗是必要的。通用机制协同效应会最大化在癌症、心脏病和女性健康方面候选药品的价值。最近实验室的成功案例是抗癌药物多吉美(索拉非尼)和口服抗凝药拜瑞妥(利伐沙班)。生物制药也是拜耳先灵医药的核心领域,各种项目正在向前推进,如靶向抗癌放射免疫疗法L19-SIP,以及做为分子影像工具的Florbetaben,能够在阿尔茨海默病早期在体内检测大脑β样淀粉酶斑块。成立'国际研发中心(中国)',以及'拜耳-清华创新药研究中心'就是为了完成拜耳先灵医药使命的最新举措。 | Andreas Busch | 2009 | 中国新药杂志2009，18，17： | 1 |
| 8 | Long-term outcome and quality of life after thyrnectomy for myasthenia gravis 显示文摘 | Christoph Busch Andreas Machens | 1996 | Ann Surg1996，224，2： | 1 |
| 9 | NHE-1 inhibition: from protection during acute ischaemia/reperfusion to prevention/reversal of myocardial remodelling显示文摘 | Wolfgang J. Linz Andreas E. Busch | 2003 | Naunyn - Schmiedeberg’s Archives of Pharmacology2003，，4： | 1 |
| 10 | Diagnostic Accuracy of Dual-Source Computed Tomography in the Diagnosis of Coronary Artery Disease显示文摘 | Thorsten R. C. Johnson Konstantin Nikolaou Stephanie Busch Alexander W. Leber Alexander Becker Bernd J. Wintersperger Carsten Rist Andreas Knez Maximilian F. Reiser Christoph R. Becker | 2007 | Investigative Radiology2007，，10： | 1 |
| 11 | Methane and CO 2 sorption and desorption measurements on dry Argonne premium coals: pure components and mixtures显示文摘 | Andreas Busch Yves Gensterblum Bernhard M. Krooss | 2003 | International Journal of Coal Geology2003，，2： | 1 |
| 12 | High- pressure Methane and Carbon Dioxide Sorption on Coal and Shale Samples from the Paran6 Basin, Brazil 显示文摘 | Philipp Weniger Wolfgang Kalkreuth Andreas Busch | 2010 | International Journal of Coal Geology2010，84，： | 1 |
| 13 | CBM and CO2 - ECBM related sorption processes in coal:A review显示文摘 | Andreas Busch Yves Gensterblum | 2011 | International Journal of Coal Geology2011，87，2： | 1 |
| 14 | Methane and carbon dioxide adsorption-diffusion experiments on coal:upscaling and modeling显示文摘 | Yves Gensterblum Bernhard M Krooss | 2004 | Coal Geology2004，60，： | 1 |
| 15 | Electrophysiological and antiarrhythmic effects of the novel I Kur channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I Kr blockers dofetilide, azimilide, d,l-sotalol and ibutilide显示文摘 | Karsten Knobloch Joachim Brendel Stefan Peukert Bj?rn Rosenstein Andreas E. Busch Klaus J. Wirth | 2002 | Naunyn - Schmiedeberg’s Archives of Pharmacology2002，，5： | 1 |
| 16 | Carbon dioxide storage potential of shales显示文摘 | Andreas Busch Sascha Alles Yves Gensterblum Dirk Prinz David N. Dewhurst Mark D. Raven Helge Stanjek Bernhard M. Krooss | 2008 | International Journal of Greenhouse Gas Control2008，，3： | 1 |
| 17 | High-pressure methane and carbon dioxide sorption on coal and shale samples from the Paraná Basin, Brazil显示文摘 | Philipp Weniger Wolfgang Kalkreuth Andreas Busch Bernhard M. Krooss | 2010 | International Journal of Coal Geology2010，，3： | 1 |
| 18 | Automated vs. manual assessment of left ventricular function in cardiac multidetector row computed tomography: comparison with magnetic resonance imaging显示文摘 | Andreas H. Mahnken Georg Mühlenbruch Ralf Koos Sven Stanzel Petra Simone Busch Mathias Niethammer Rolf W. Günther Joachim E. Wildberger | 2006 | European Radiology2006，，7： | 1 |
| 19 | A preliminary evaluation of the CO2 storage potential in unminable coal seams of the Munster Cretaceous Basin, Germany 显示文摘 | Alexander Kronimus Andreas Busch Sascha Alles | 2008 | International Journal of Greenhouse Gas Control2008，2，3： | 1 |
| 20 | Sixteen-slice spiral CT versus MR imaging for the assessment of left ventricular function in acute myocardial infarction显示文摘 | Andreas H. Mahnken Ralf Koos Marcus Katoh Elmar Spuentrup Petra Busch Joachim E. Wildberger Harald P. Kühl Rolf W. Günther | 2005 | European Radiology2005，，4： | 1 |
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