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| 1 | Prospective study of probiotic supplementation results in immune stimulation and improvement of upper respiratory infection rate显示文摘The human gut microbiota is an important environmental factor for human health with evolutionarily conserved roles in immunity,metabolism,development,and behavior of the host.Probiotic organisms are claimed to offer several functional properties including stimulation of immune system.The purpose of this study is to investigate the effects of a probiotic supplementation on adult volunteers who have contracted the common cold four or more times in the past year.This study is a single center,doubleblind,randomized,controlled,prospective trial.Subjects received a probiotic drink containing Lactobacillus paracasei(at least 3×10^7 colony forming units(CFU)ml^-1),Lactobacillus casei 431®(at least 3×10^7 CFU ml1)and Lactobacillus fermentium PCC®(at least 3×10^6 CFU ml^-1)or an identical placebo without probiotics for a 12-week study period.The consumption of probiotics significantly reduced the incidence of upper respiratory infection(p<0.023)and flu-like symptoms with an oral temperature higher than 38℃(p<0.034)as compared to the placebo group.Subjects that consumed probiotics demonstrated a significantly higher level of IFN-g in the serum(p<0.001)and sIgA in the gut(p<0.010)as compared to the placebo group and a significant higher level of serum IFN-g(p<0.001)and gut sIgA(p<0.001)as compared to their baseline test results.In contrast,there were no significant differences in the serum IL-4,IL-10,IgA,IgG or IgM between the probiotics and the placebo groups.Results of this study demonstrated that probiotics were safe and effective for fighting the common cold and influenza-like respiratory infections by boosting the immune system. | Hong Zhang Chiajung Yeh Zonglian Jin Liwei Ding Bryan Y.Liu Li Zhang H.Kathleen Dannelly | 2018 | Synthetic and Systems Biotechnology2018，3，2： | 5 |
| 2 | A Retrospective Cohort Mortality Study in Jinchang,the Largest Nickel Production Enterprise in China显示文摘Nickel is an essential trace metal used in the occupational setting,resulting in both occupational and nonoccupational exposures to individuals at varying levels.Exposure to nickel has been associated with several toxicities and the International Agency for Research on Cancer has concluded that there is sufficient evidence in humans associating exposure to nickel | MA Li BAI Ya Na PU Hong Quan HE Jie Bryan A.Bassig DAI Min ZHANG Ya Wei ZHENG Tong Zhang CHENG Ning | 2014 | Biomedical and Environmental Sciences2014，27，7： | 4 |
| 3 | Survival of patients with distal esophageal and gastric cardia tumors: A population-based analysis of gastroesophageal junction carcinomas显示文摘 | Bryan A. Whitson Shawn S. Groth Zhongze Li Robert A. Kratzke Michael A. Maddaus | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，1： | 2 |
| 4 | Metal Exposure and Risk of Diabetes and Prediabetes among Chinese Occupational Workers显示文摘Objective To study the association between metal exposure and risk of diabetes and prediabetes among Chinese workers exposed to metals.Methods We used data obtained from the baseline survey of the Jinchang Cohort Study of workers in Jinchang Industry,the largest nickel production company in China.A total of 42,122 workers ≥20 years of age were included in the study.A standardized,structured questionnaire was used to collect epidemiological information.Physical examinations and laboratory tests were conducted to evaluate the health status of the participants and to measure various biomarkers including blood sugar,lipids,and urinary metal concentrations.Logistic regression was used to study the association between occupational groups categorized according to the measured metal levels(office workers,low-level;mining/production workers,mid-level;and smelting/refining workers,high-level)and risk of diabetes and prediabetes.Results The overall prevalence of diabetes and prediabetes was 7.5% and 16.8%,respectively.The adjusted odds ratios for diabetes among mining/production workers and smelting/refining workers compared to office workers were 1.5(95% CI:1.3,1.7)and 3.8(95% CI:3.4,4.3),respectively.No association was observed between these occupational groups and prediabetes in this study.Conclusion Occupations associated with higher levels of metal exposure were associated with an increased risk of diabetes in this cohort.More studies are needed to confirm this observed association. | YANG Ai Min CHENG Ning PU Hong Quan LIU Si Min LI Juan Sheng BASSIG Bryan A. DAI Min LI Hai Yan HU Xiao Bin REN Xiao Wei ZHENG Tong Zhang BAI Ya Na | 2015 | Biomedical and Environmental Sciences2015，28，12： | 2 |
| 5 | Comparative outcomes of subcutaneous and transvenous cardioverter-defibrillators显示文摘Background: The comparative outcomes of subcutaneous implantable cardioverter-defibrillator (S-ICD) and transvenous (T-ICD) have not been well studied. The aim of this study was to evaluate the safety and efficacy of currently available S-ICD and T-ICD. Methods: The study included 86 patients who received an S-ICD and 1:1 matched to those who received single-chamber T-ICD by gender, age, diagnosis, left ventricular ejection fraction (LVEF), and implant year. The clinical outcomes and implant complications were compared between the two groups. Results: The mean age of the 172 patients was 45 years, and 129 (75%) were male. The most common cardiac condition was hypertrophic cardiomyopathy (HCM, 37.8%). The mean LVEF was 50%. At a mean follow-up of 23 months, the appropriate and inappropriate ICD therapy rate were 1.2% vs. 4.7%(X^2= 1.854, P=0.368) and 9.3% vs. 3.5%(X^2 = 2.428, P = 0.211) in S-ICD and T-ICD groups respectively. There were no significant differences in device-related major and minor complications between the two groups (7.0% vs. 3.5%, X^2 = 1.055, P = 0.496). The S-ICD group had higher T-wave oversensing than T-ICD group (9.3% vs. 0%, X^2 = 8.390, P=0.007). Sixty-five patients had HCM (32 in S-ICD and 33 in T-ICD). The incidence of major complications was not significantly different between the two groups. Conclusions: The efficacy of an S-ICD is comparable to that of T-ICD, especially in a dominantly HCM patient population. The S-ICD is assodated with fewer major complications demanding reoperation. | Jin-Jun Liang Hideo Okamura Roshini Asirvatham Andrew Schneider David O. Hodge Mei Yang Xu-Ping Li Ming-Yan Dai Ying Tian Pei Zhang Bryan C. Cannon Cong-Xin Huang Paul A. Friedman Yong-Mei Cha | 2019 | Chinese Medical Journal2019，，6： | 2 |
| 6 | Distribution and fractionation of phosphorus, cadmium, nickel, and lead in calcareous soils amended with composts显示文摘 | Zinati G M Li Y Bryan H H | 2004 | Journal of Envirenmental Science and Health2004，，1： | 1 |
| 7 | Advances in CO 2 capture technology: A patent review显示文摘 | Bingyun Li Yuhua Duan David Luebke Bryan Morreale | 2013 | Applied Energy2013，，： | 1 |
| 8 | Discovery of azetidinyl ketolides for the treatment of susceptible and muhidrug resistant community - acquired respiratory tract infections ~显示文摘 | Thomas V Magee Sharon L Ripp Bryan Li | 2009 | J Med Chem2009，52，： | 1 |
| 9 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 10 | CMC 2000 Chromatic Adaptation Transform: CMCCAT2000 显示文摘 | LI Chang-jun LUO M R BRYAN R | 2000 | Color Research and Application2000，27，1： | 1 |
| 11 | Fate of antimicrobials and antimicrobial resistance genes in simulated swine manure storage显示文摘 | Stacey R. Joy Xu Li Daniel D. Snow John E. Gilley Bryan Woodbury Shannon L. Bartelt-Hunt | 2014 | Science of the Total Environment2014，，： | 1 |
| 12 | 用于农业和食品工业的传感器显示文摘现代农业管理在很大程度上有赖于许多不同种类的传感方法,以提供关于作物、土壤、气候和环境条件的准确信息。几乎每一类传感技术都可以在农业和食品工业中得到应用。本文将对传感器在农业和食品工业中的应用作一简略评述。 | Suiqiong Li Aleksandr Simonian Bryan A. Chin | 2012 | 化学传感器2012，32，1： | 1 |
| 13 | Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections显示文摘 | Thomas V Magee Sharon L Ripp Bryan Li | | 0，，23： | 1 |
| 14 | Blocking tumorescape in hematologic malignancies:The anti-PD-1 strategy显示文摘 | Bryan LJ> Gordon LI | 2015 | Blood Rev2015，29，1： | 1 |
| 15 | Adipose tissue-derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor-derived factors显示文摘 | Constantin Jotzu Eckhard Alt Gabriel Welte Jie Li Bryan T. Hennessy Eswaran Devarajan Srinivasalu Krishnappa Severin Pinilla Lilly Droll Yao-Hua Song | 2010 | Analytical Cellular Pathology / Cellular Oncology2010，，2： | 1 |
| 16 | TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment显示文摘 | Yun Li Bryan W Luikart | 2008 | Neuron2008，59，3： | 1 |
| 17 | Histone Deacetylase 7 Maintains Vascular Integrity by Repressing Matrix Metalloproteinase 10显示文摘 | Shurong Chang Bryan D. Young Shijie Li Xiaoxia Qi James A. Richardson Eric N. Olson | 2006 | Cell2006，，2： | 1 |
| 18 | Opportunities to search for extraterrestrial intelligence with the FAST显示文摘The discovery of ubiquitous habitable extrasolar planets,combined with revolutionary advances in instrumentation and observational capabilities,has ushered in a renaissance in the search for extraterrestrial intelligence(SETI).Large scale SETI activities are now underway at numerous international facilities.The Five-hundred-meter Aperture Spherical radio Telescope(FAST)is the largest single-aperture radio telescope in the world,and is well positioned to conduct sensitive searches for radio emission indicative of exo-intelligence.SETI is one of the five key science goals specified in the original FAST project plan.A collaboration with the Breakthrough Listen Initiative was initiated in 2016 with a joint statement signed both by Dr.Jun Yan,the then director of National Astronomical Observatories,Chinese Academy of Sciences(NAOC),and Dr.Peter Worden,Chairman of the Breakthrough Prize Foundation.In this paper,we highlight some of the unique features of FAST that will allow for novel SETI observations.We identify and describe three different signal types indicative of a technological source,namely,narrow band,wide-band artificially dispersed and modulated signals.Here,we propose observations with FAST to achieve sensitivities never before explored.For nearby exoplanets,such as TESS targets,FAST will be sensitive to an EIRP of 1.9×1011 W,well within the reach of current human technology.For the Andromeda Galaxy,FAST will be able to detect any Kardashev type II or more advanced civilization there. | Di Li Vishal Gajjar Pei Wang Andrew Siemion Zhi-Song Zhang Hai-Yan Zhang You-Ling Yue Yan Zhu Cheng-Jin Jin Shi-Yu Li Sabrina Berger Bryan Brzycki Jeff Cobb Steve Croft Daniel Czech David DeBoer Julia DeMarines Jamie Drew J.Emilio Enriquez Nectaria Gizani Eric J.Korpela Howard Isaacson Matthew Lebofsky Brian Lacki David H.E.MacMahon Morgan Nanez Chen-Hui Niu Xin Pei Danny C.Price Dan Werthimer Pete Worden Yunfan Gerry Zhang Tong-Jie Zhang FAST Collaboration | 2020 | Research in Astronomy and Astrophysics2020，20，5： | 1 |
| 19 | Crystal structure of a single-chain trimer of human adiponectin globular domain显示文摘 | Xiaoshan Min Bryan Lemon Jie Tang Qiang Liu Richard Zhang Nigel Walker Yang Li Zhulun Wang | 2012 | FEBS Letters2012，，： | 1 |
| 20 | Sex steroids and their receptors in lampreys显示文摘 | Bryan M B Scott A P Li W | 2008 | Steroids2008，73，1： | 1 |
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