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| 1 | Gastric intestinal metaplasia is associated with gastric dysplasia but is inversely correlated with esophageal dysplasia显示文摘AIM To determine which clinical factors might be associated with gastric intestinal metaplasia(IM) in a North American population.METHODS Pathology and endoscopy databases at an academicmedical center were reviewed to identify patients with and without gastric IM on biopsies for a retrospective cohort study. Patient demographics, insurance status, and other clinical factors were reviewed.RESULTS Four hundred and sixty-eight patients with gastric IM(mean age: 61.0 years ± 14.4 years, 55.5% female) and 171 without gastric IM(mean age: 48.8 years ± 20.8 years, 55.0% female) were compared. The endoscopic appearance of atrophic gastritis correlated with finding gastric IM on histopathology(OR = 2.05, P = 0.051). Gastric IM was associated with histologic findings of chronic gastritis(OR = 2.56, P < 0.001), gastric ulcer(OR = 6.97, P = 0.015), gastric dysplasia(OR = 6.11, P = 0.038), and gastric cancer(OR = 6.53, P = 0.027). Histologic findings of Barrett's esophagus(OR = 0.28, P = 0.003) and esophageal dysplasia(OR = 0.11, P = 0.014) were inversely associated with gastric IM. Tobacco use(OR = 1.73, P = 0.005) was associated with gastric IM.CONCLUSION Patients who smoke or have the endoscopic finding of atrophic gastritis are more likely to have gastric IM and should have screening gastric biopsies during esophagogastroduodenoscopy(EGD). Patients with gastric IM are at increased risk for having gastric dysplasia and cancer, and surveillance EGD with gastric biopsies in these patients might be reasonable. | Justin M Gomez James T Patrie Wissam Bleibel Jeanetta W Frye Bryan G Sauer Vanessa M Shami Edward B Stelow Christopher A Moskaluk Andrew Y Wang | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 3 |
| 2 | Intestinal stem cells and the colorectal cancer microenvironment显示文摘Colorectal cancer(CRC)remains a highly fatal condition in part due to its resilience to treatment and its propensity to spread beyond the site of primary occurrence.One possible avenue for cancer to escape eradication is via stem-like cancer cells that,through phenotypic heterogeneity,are more resilient than other tumor constituents and are key contributors to cancer growth and metastasis.These proliferative tumor cells are theorized to possess many properties akin to normal intestinal stem cells.Not only do these CRC'stem'cells demonstrate similar restorative ability,they also share many cell pathways and surface markers in common,as well as respond to the same key niche stimuli.With the improvement of techniques for epithelial stem cell identification,our understanding of CRC behavior is also evolving.Emerging evidence about cellular plasticity and epithelial mesenchymal transition are shedding light onto metastatic CRC processes and are also challenging fundamental concepts about unidirectional epithelial proliferation.This review aims to reappraise evidence supporting the existence and behavior of CRC stem cells,their relationship to normal stem cells,and their possible dependence on the stem cell niche. | Bryan A Ong Kenneth J Vega Courtney W Houchen | 2014 | World Journal of Gastroenterology2014，20，8： | 2 |
| 3 | Climate Variability and the Frequency of Extreme Temperature Events for Nine Sites across Canada: Implications for Power Usage 显示文摘 | Colombo F Andrew David Etkin Bryan W Karney | 1999 | Journal of Climate1999，12，： | 1 |
| 4 | The use of the dog-whelk,Nucella lapillus,as an indicator of tributyltin contamination显示文摘 | GIBBS P E BRYAN G W PASCOE P L | 1987 | J Mar Biol Assoc UK1987，67，： | 1 |
| 5 | The Decline of the Gastropod Nucella Lapillus around Southwest England : Evidence for the Effect of Tributyhin from Antifouling Paints 显示文摘 | Bryan G W Gibbs P E Hummerstong L G | 1986 | Jottrnal of the Marine Biological Association of the United Kingdom1986，66，03： | 1 |
| 6 | Clinical evaluation of toxic effects of cis-diamminediehloroplatinum (NSC-119875)-phase & clinical study 显示文摘 | Talley R W O'Bryan R M Gutterman J U | 1973 | Cancer Chemother Rep1973，57，4： | 1 |
| 7 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 8 | An Exploratory Study of Environmental Attitudes and the Willingness to Pay for Environmental Certi- fication in Mexico 显示文摘 | Bryan W H Michael V R Carlos E B M etal | 2014 | Business Research2014，67，5： | 1 |
| 9 | Coumarin dyes for dye-sensitized solar cells:a long-range-corrected density functional study 显示文摘 | Bryan M W Joseph G C | 2008 | Journal of Chemical Physics2008，129，21： | 1 |
| 10 | Mineralogic variability of the uppermost mantle along mid-ocean ridges显示文摘 | Dick H J B Fisher R L Bryan W B | 1984 | Earth and Planetary Science Letters1984，69，88： | 1 |
| 11 | Bioavaility, accumulation and ef- fects of heavy metals in sediments with special reference to United Kingdom estuaries: a review显示文摘 | Bryan G W Langston W J | 1992 | Environmental Pollution1992，76，2： | 1 |
| 12 | Strategic Corporate Social Responsibility and Value Creation among Large Firms: Lessons from the Spanish Experience 显示文摘 | Husted Bryan W David B Alien | 2010 | Long Range Planning2010，40，6： | 1 |
| 13 | Strategic Corporate Social Responsibility and Value Creation among Large Firms: Lessions from the Spanish Experience 显示文摘 | Husted Bryan W David B Allen | 2007 | Long Range Planning2007，40，6： | 1 |
| 14 | The use of the dog- whelk, Nucella lapillus, as an indicator of tributyltin contamination显示文摘 | Gibbs P E Bryan G W Pascoe P L | 1987 | Journal of the Marine Biological Association of the United Kingdom1987，67，： | 1 |
| 15 | Creating safer workplaces: assessing the determinants and role of safety climate 显示文摘 | DAVID M D BRYAN S S MARK G W | 2004 | Journal of Safety Research2004，35，1： | 1 |
| 16 | Early-and late-season grazing of orchardgrass and fescue hayfields overseeded with red clover显示文摘 | PRIGGE A W BRYAN W B GOLDMEN-INNIS E S | 1999 | Agronomy journal1999，4，： | 1 |
| 17 | An outbreak of acute fascioliasis among Aymara Indians in the Bolivian Altiplano 显示文摘 | Bjorland J Bryan RT Strauss W | 1995 | Clin Infect Dis1995，21，5： | 1 |
| 18 | Pollution due to heavy metals and their com- pounds 显示文摘 | Bryan G W | 1984 | Marine Ecology1984，5，3： | 1 |
| 19 | Bioavailability, accumulation and effects of heavy metals in sediments with special references to UK estuaries: a review 显示文摘 | Bryan G W Langston W J | 1992 | Environmental Pollution1992，76，2： | 1 |
| 20 | EpichloO endophytes grow by intercalary hyphal extension in elongating grass leaves显示文摘 | Christensen M J Bennett R J Ansari H A Koga H Johnson R D Bryan G T Simpson W R Koolaard J P Nickless E M Voisey C R | 2008 | Fungal Genetics and Biology2008，45，2： | 1 |
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