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| 1 | Chemotherapy of glioblastoma in rats using doxorubicin - loaded nanoparticles显示文摘Glioblastomas belong to the most aggressive human cancers with short survival times.Due to the blood-brainbarrier,they are mostly inaccessible to traditional chemotherapy.We have recently shown that doxorubicin boundto polysorbate-coated nanoparticles crossed the intact blood-brain barrier,thus reaching therapeutic concentra-tions in the brain.Here,we investigated the therapeutic potential of this formulation of doxorubicin in vivo using ananimal model created by implantation of 101/8 glioblastoma tumor in rat brains.Groups of 5-8 glioblastoma- | Steiniger SC Kreuter J Khalansky AS Skidan IN Bobruskin I Smirnova ZS Severin SE Uhl R Kock M Geiger KD Gelperina SE | 2004 | 中国神经肿瘤杂志2004，2，1： | 13 |
| 2 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 1: Definitions and diagnosis显示文摘 | Axel Dignass Rami Eliakim Fernando Magro Christian Maaser Yehuda Chowers Karel Geboes Gerassimos Mantzaris Walter Reinisch Jean-Frederic Colombel Severine Vermeire Simon Travis James O. Lindsay Gert Van Assche | 2012 | Journal of Crohn’s and Colitis2012，，10： | 12 |
| 3 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 5 |
| 4 | A study on changes in surface chemistry during the initial stages of electroless Ni(P) deposition on alumina显示文摘 | Severin J W | 1993 | Ibid1993，140，3： | 4 |
| 5 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 2: Current management显示文摘 | Axel Dignass James O. Lindsay Andreas Sturm Alastair Windsor Jean-Frederic Colombel Mathieu Allez Gert D’Haens André D’Hoore Gerassimos Mantzaris Gottfried Novacek Tom ?resland Walter Reinisch Miquel Sans Eduard Stange Severine Vermeire Simon Travis Gert | 2012 | Journal of Crohn’s and Colitis2012，，10： | 4 |
| 6 | Pharmacogenetics in inflammatory bowel disease显示文摘遗传药理学是在在药反应的可变性之间的协会的学习并且(或) 在基因的药毒性和多型性。科学的这个领域的目标是使药适应一个病人的特定的基因背景因此使他们更有效、安全。在这篇文章,我们在影响的基因描述变体在煽动性的肠疾病( IBD )的治疗使用的普通的药的功效或毒性, ulcerative ( UC ),和 Crohn 包括 sulfasalazine 和 mesalazine 是疾病( CD ), azathioprine ( AZA )和 6-mercaptopurine ( 6-MP ), methotrexate ( MTX ), glucocorticosteroids ( CS )和 infliximab 。而且, pharmacogenetic 研究的困难一般来说并且更明确地在 IBD 被描述。尽管遗传药理学是已经贡献了一些药的行动的内在的机制的更好的理解的一个有希望的领域,在 IBD 使用,翻译直到现在成每日的实践的唯一的发现是在 thiopurine S-methyltransferase (TPMT ) 基因多型性和 thiopurine 治疗的 hematological 毒性之间的关系。在未来,在很好描绘的耐心的队组织研究是必要的谁一致地被对待并且系统地评估了以便测定药反应更客观地。一个努力应该被作从为 pharmacogenetic 研究在适当知情同意以后在临床的药试用注册的所有病人收集 genomic DNA。 | Marie Pierik Paul Rutgeerts Robert Vlietinck Severine Vermeire | 2006 | World Journal of Gastroenterology2006，12，23： | 3 |
| 7 | Biological Therapies for Inflammatory Bowel Diseases显示文摘 | Paul Rutgeerts Severine Vermeire Gert Van Assche | 2009 | Gastroenterology2009，，4： | 3 |
| 8 | Role of genetics in prediction of disease course and response to therapy显示文摘The clinical course of Crohn's disease and ulcerative colitis is highly variable between patients,and this has therapeutic implications.A number of clinical features have been identified,which predict a mild or more severe outcome.However,several of these are subjective and/or not persistent over time.With the progress in genetics research in inflammatory bowel disease(IBD),genetic markers are increasingly being proposed to improve stratification of patients.Genetics have the major advantage of being stable over time and not prone to subjective interpretation.Nevertheless,none of the genetic variants associated with particular outcomes have shown sufficient sensitivity or specificity to have been implemented in daily management.Along the same line of thinking,pharmacogenetics or the study of association between variability in drug response and genetic variation has also received more attention as part of the endeavor for personalized medicine.The ultimate goal in this area of medicine is to adapt medication to a patient's specific genetic background and therefore improve on efficacy and safety rates.Although pharmacogenetic studies have been performed for all classes of drugs applied in IBD,few have generated consistent findings or have been replicated.The only genetic test approved for clinical practice is thiopurine S-methyltransferase testing prior to starting treatment with thiopurine analogues.The other reported associations have suffered from lack of confirmation or still need replication efforts.Nevertheless,the importance and necessity of pharmacogenetic studies will increase further as more therapeutic classes are being developed. | Severine Vermeire Gert Van Assche Paul Rutgeerts | 2010 | World Journal of Gastroenterology2010，16，21： | 3 |
| 9 | Hepatitis delta virus: A fascinating and neglected pathogen显示文摘Hepatitis delta virus(HDV) is the etiologic agent of the most severe form of virus hepatitis in humans. Sharing some structural and functional properties with plant viroids, the HDV RNA contains a single open reading frame coding for the only virus protein, the Delta antigen. A number of unique features, including ribozyme activity, RNA editing, rolling-circle RNA replication, and redirection for a RNA template of host DNA-dependent RNA polymerase Ⅱ, make this small pathogen an excellent model to study virus-cell interactions and RNA biology. Treatment options for chronic hepatitis Delta are scarce and ineffective. The disease burden is perhaps largely underestimated making the search for new, specific drugs, targets, and treatment strategies an important public health challenge. In this review we address the main features of virus structure, replication, and interaction with the host. Virus pathogenicity and current treatment options are discussed in the light of recent developments. | Celso Cunha Jo?o Paulo Tavanez Severin Gudima | 2015 | World Journal of Virology2015，4，4： | 3 |
| 10 | Withdrawal of anti-tumour necrosis factor α therapy in inflammatory bowel disease显示文摘Anti-tumour necrosis factor α(anti-TNFα) therapy is an established treatment in inflammatory bowel disease.However, this treatment is associated with high costs and the possibility of severe adverse events representing a true challenge for patients, clinicians and health care systems.Consequently, a crucial question is raised namely if therapy can be stopped once remission is achieved and if so, how and in whom.Additionally, in a real-life clinical setting, discontinuation may also be considered for other reasons such as the patient's preference, pregnancy, social reasons as moving to countries or continents with less access, or different local policy or reimbursement.In contrast to initiation of anti-TNFα therapy guidelines regarding stopping of this treatment are missing.As a result, the decision of discontinuation is still a challenging aspect in the use of anti-TNFα therapy.Currently this is typically based on an estimated, case-by-case, benefit-risk ratio.This editorial is intended to provide an overview of recent data on this topic and shed light on the proposed drug withdrawal strategies. | Konstantinos Papamichael Severine Vermeire | 2015 | World Journal of Gastroenterology2015，21，16： | 2 |
| 11 | A Randomized Controlled Trial on Pharmacological Preconditioning in Liver Surgery Using a Volatile Anesthetic显示文摘 | Beatrice Beck-Schimmer Stefan Breitenstein Severin Urech Elisena De Conno Moritz Wittlinger Milo Puhan Wolfram Jochum Donat R. Spahn Rolf Graf Pierre-Alain Clavien | 2008 | Annals of Surgery2008，，6： | 2 |
| 12 | Antimicrobial resistance among commensal isolates of Escherichia coli and Staphylococcus aureus in the Indonesian population inside and outside hospitals显示文摘 | E. S. Lestari J. A. Severin P. M. G. Filius K. Kuntaman D. O. Duerink U. Hadi H. Wahjono H. A. Verbrugh | 2008 | European Journal of Clinical Microbiology & Infectious Diseases2008，，1： | 2 |
| 13 | Crustal structure beneath Cameroon from EGM2008显示文摘We used the Earth Gravitational Model( EGM2008) data sets to analyze the regional gravity anomalies and to study the underground structures in Cameroon. We first created a high-resolution Free-Air anomaly database,then corrected the gravity field of the topographic effect by using ETOPO1 DEM with a resolution of0.01° to obtain the Bouguer anomaly,then applied a multi-scale wavelet-analysis technique to separate the gravity-field components into different parts of shallow-to-deep origins,and finally used the logarithmic power spectrum technique to obtain detailed images and corresponding source depths as well as certain lateral inhomogeneity of structure density. The anomalies of shallow origin show successive elongated gravity 'highs'and'lows'attributable to subsurface Tertiary and lower Cretaceous undulations. Our results are in good agreement with previous investigations. | Ngatchou Heutchi Evariste Liu Genyou Tabod Charles Tabod Kamguia Joseph Nguiya Severin Tiedeu Alain KE Xiaoping | 2014 | Geodesy and Geodynamics2014，5，1： | 2 |
| 14 | Povidone iodine gel alcohol:A 30-second,onetime application preoperative skin preparation显示文摘 | Jeng DK Severin JE | 1998 | Am J Infect Contral1998，26，5： | 2 |
| 15 | Levels of C-reactive Protein Are Associated With Response to Infliximab Therapy in Patients With Crohn’s Disease显示文摘 | Matthias Jürgens Jestinah M. Mahachie John Isabelle Cleynen Fabian Schnitzler Herma Fidder Wouter van Moerkercke Vera Ballet Maja Noman Ilse Hoffman Gert van Assche Paul J. Rutgeerts Kristel van Steen Severine Vermeire | 2011 | Clinical Gastroenterology and Hepatology2011，，5： | 2 |
| 16 | Classification of inflammatory bowel disease: the old and the new显示文摘 | Severine Vermeire Gert Van Assche Paul Rutgeerts | 2012 | Current Opinion in Gastroenterology2012，，4： | 2 |
| 17 | Sa1922 Pilot Study on the Safety and Efficacy of Faecal Microbiota Transplantation in Refractory Crohn’s Disease显示文摘 | Severine Vermeire Marie Joossens Kristin Verbeke Falk Hildebrand Kathleen Machiels Karolien Van den Broeck Gert Van Assche Paul J. Rutgeerts Jeroen Raes | 2012 | Gastroenterology2012，，5： | 2 |
| 18 | Control of walking and running by means of electrical stimulation of the midbrain显示文摘 | Shik M L Severin F Orlovsky G IN | 1966 | Biofizika1966，11，： | 1 |
| 19 | Effects of operating conditions on oil loss and properties of products obtained by co-rotating twin-screw extrusion of fatty meal: preliminary study显示文摘 | Teresa De Pilli Carla Severin Antonietta Baiano | 2005 | Journal of Food Engineering2005，70，1： | 1 |
| 20 | Versatile EGFP reporter plasmids for cellular localization of recombinant gene products in filamentous fungi显示文摘 | Stefanie P?ggeler Sandra Masloff Birgit Hoff Severine Mayrhofer Ulrich Kück | 2003 | Current Genetics2003，，1： | 1 |
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