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| 1 | Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy显示文摘This review summarizes the safety and efficacy of statins in patients with cirrhosis.Due to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in cirrhosis.The most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver function.Rhabdomyolysis is the most serious and potentially life-threatening manifestation.It has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle injury.Likewise,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle injury.Due to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something useful.Through these effects,statins could prevent liver-related morbidity and mortality in cirrhotic patients.Observational studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and death.The few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic resistance.Another large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival rate.Despite these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies involved.Therefore,it is advisable to perform further randomized controlled trials on a large series of patients with hard clinical endpoints,using different statin types and varying doses.The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients. | Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero | 2021 | World Journal of Gastroenterology2021，27，28： | 4 |
| 2 | Transcatheter closure of patent foramen ovale in patients with cerebral ischemia显示文摘 | Braun MU Fassbender D Schoen SP | 2002 | J Am Coll Cardiol2002，39，12： | 2 |
| 3 | The integrin alpha(v)beta8mediates epithelial homeostasis through MT1-MMP-dependent activationof TGF-betal显示文摘 | Mu D Cambier S Fjellbirkeland L | 2002 | J Cell Biol2002，157，3： | 1 |
| 4 | Macrophage accumulation in human progressive diabetic nephropathy显示文摘 | Nguyen D Ping F Mu W | 2006 | Nephrology (Carlton)2006，11，3： | 1 |
| 5 | Strategic orientations and new product commercialization: Mediator, moderator, and interplay显示文摘 | Mu J F Benedetto C A D | 2011 | R&D Management2011，41，4： | 1 |
| 6 | Adaptive sliding - mode guidance of a homing missile 显示文摘 | D Zhou C Mu W Xu | 1999 | Journal of Guidance Control and Dynamics1999，22，4： | 1 |
| 7 | The effects of mixed MPEG-PLA/Pluronic copolymer micelles on the bioavailability and multidrug resistance of docetaxel 显示文摘 | Mu C F Balakrishnan P Cui F D | 2010 | Biomaterials2010，31，8： | 1 |
| 8 | Adaptive sliding mode guidance of ahoming missile显示文摘 | Zhou D Mu CD Xu W L | 1999 | Journal of Guidance Control and Dynamics1999，22，4： | 1 |
| 9 | Erythropoietin for neonatal brain injury: opportunity and challenge显示文摘 | Xiong T Qu Y Mu D | 2011 | International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience2011，29，6： | 1 |
| 10 | A microRNA polycistron as a potential human oncogene显示文摘 | He L Thomson JM Hemann MT Hernando-Monge E Mu D Goodson S Powers S Cordon-Cardo C.Lowe SW Hannon GJ | | 0，，： | 1 |
| 11 | Best model augmentation for varia- ble-structure multiple-model estimation 显示文摘 | Lan J Li X R Mu C D | 2011 | IEEE Transac- tions on Aerospace and Electronic Systems2011，47，3： | 1 |
| 12 | Equivalent water height extracted from GRACE gravity field model with robust independent component analysis显示文摘 | GUO J MU D LIU X | 2014 | Acta Geophysica2014，62，4： | 1 |
| 13 | Rescheduling with release dates to minimize makespan under a limit on the maximum sequence disruption显示文摘 | Yuan J J Mu Y D | 2007 | European Journal of Operation Research2007，182，2： | 1 |
| 14 | The outcome of poskrolater al fusion in highly sekeiod patients with diseogenie low back pain显示文摘 | PARKER L M MU NELL S E BODEN S D | 1996 | Spine1996，21，16： | 1 |
| 15 | Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke显示文摘 | Gonzalez FF Mc Quillen P Mu D | 2007 | Dev Neuro Sci2007，29，3： | 1 |
| 16 | A simple method for organotypic cultures of nervous tissue 显示文摘 | Stoppini L Buchs PA Mu|ler D | 1991 | J Neurosci Methods1991，37，2： | 1 |
| 17 | Fuzzy adaptive variable structureguidance for space interception 显示文摘 | Zhou D Mu C D Xu W L | 1999 | Tsinghua Science and Tech-nology1999，4，4： | 1 |
| 18 | Estimating the Willingness to Pay for Water Services in Developing Countries: A Case Study of the Use of Contingent Valuation Surveys in Southern Haiti显示文摘 | Whittington D Briscoe J Mu X | 1990 | Econom- ic Development and Cultural Change1990，38，2： | 1 |
| 19 | Rescheduling with release dates to minimize total sequence disruption under a limit on the makespan显示文摘 | Yuan J J Mu Y D Lu L F | 2007 | Asia-Pacific Journal of Operational Research2007，24，6： | 1 |
| 20 | Regulation of hypoxia-indncible fac- tor lalpha and induction of vascular endothelial growth factor in a rat neonatal stroke model 显示文摘 | Mu D Jiang X Sheldon RA | 2003 | Neurobiol Dis2003，14，3： | 1 |
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