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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | The design and fabrication of a 40 cm diameter,SiC coated,normal incidence telescope and spectrometer显示文摘 | Stephan R McCandliss Mel E Martinez Paul D Feldman | 1994 | SPIE1994，2011，： | 1 |
| 3 | Assessment of metal contamination in donana national park (spain) using crayfish (proeamburus elarkia) 显示文摘 | Sanchez Lopez F J Gil Garcia M D Martinez Vidal J | 2004 | Environmental Monitoring and Assessment2004，，93： | 1 |
| 4 | Food-web structure and network theory:The role of connectance and size显示文摘 | Dunne J A Williams R J Martinez N D | 2002 | Proceedings of the National Academy of Sciences2002，99，12： | 1 |
| 5 | Textural and physicochemical changes in salmon (Salmo salar) treated with commercial liquid smoke flavoudngs显示文摘 | MARTINEZ O SALMERON L GUILLEN M D | 2007 | Food Chemistry2007，100，2： | 1 |
| 6 | Textural and physicochemical changes in salmon (Salmo salar) treated with commercial liquid smoke flavourings显示文摘 | Martinez O Salmeron J Guillen M D | 2007 | Food Chemistry2007，100，2： | 1 |
| 7 | A rapid,sensitive method for the quantitation of specific metabolites of sulfur mustard in human urine using isotope-dilution gas chromatography-tandem mass spectrometry显示文摘 | YOUNG C L ASH D DRISKELL W J BOYER A E MARTINEZ R A SILKS L A BARR J R | 2004 | Anal Toxicol2004，28，5： | 1 |
| 8 | Two-microphone multi-speaker localization based on a laplacian mixture model显示文摘 | Cobos M Lopez J J and Martinez D | 2010 | Digital Signal Processing2010，21，1： | 1 |
| 9 | Seven novel point mulations in the uroporphyrinogen decarboxylase (UROD) gene in patients with familial porphyria cutanea larda (f-PCT) 显示文摘 | Cappellini MD Martinez di Montemuros F Tavazzi D | 2001 | Hum Murat2001，17，4： | 1 |
| 10 | Restoring p53tumor suppressor activity as an antican-cer therapeutic strategy显示文摘 | Martinez J D | 2010 | Future Oncol2010，6，： | 1 |
| 11 | Immunobiology of vasoactive intestinal peptide (VIP) 显示文摘 | Pozo D Delgado M Martinez M | 2000 | Immunol Today2000，21，1： | 1 |
| 12 | Computational prediction of novel components of lung transcription networks 显示文摘 | Martinez M J Smith A D Li B L | 2007 | Bioinformatics2007，23，1： | 1 |
| 13 | Obstructive sleep apnea and resistant hypertension: a case-control study 显示文摘 | Gonalves SC Martinez D Gus M | 2007 | Chest2007，132，6： | 1 |
| 14 | Syngas production in downdraft biomass gasifiers and its application using internal combustion engines显示文摘 | Martinez J D Mahkamov K Andrade R V | 2012 | Renewable Energy2012，38，7： | 1 |
| 15 | Development of wheezing disorders and asthma in preschool children显示文摘 | Martinez F D | 2002 | Pediatrics2002，109，3： | 1 |
| 16 | A highly efficient Echerichia col#based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA 显示文摘 | Lee EC Yu D Martinez de Velasco J | 2001 | Genomics2001，73，1： | 1 |
| 17 | Tobacco,alcohol, and illicit drug use in adolescents with diabetes mellitus显示文摘 | Martinez A A Araneda J C Fernandez D | 2007 | Pediatr Diabetes2007，8，5： | 1 |
| 18 | Deterruination of photoirradiated high polar benzoylureas in tomato by HPLC with luminol chemiluminescence detection显示文摘 | Martinez Galera M Gil Gareia M D Santiago Valverde R | 2008 | Talanta2008，76，4： | 1 |
| 19 | Rheological characteris- tics of ground the robber-modified bitumen显示文摘 | Navarro F J Partal P Martinez F et d | 2002 | Chemical Engi- neering Journal2002，89，13： | 1 |
| 20 | Improved heterogeneous distance functions显示文摘 | Wilson D R Martinez T R | 1997 | Journal of Artificial Intelligence Research1997，1，6： | 1 |
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