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| 1 | 以便秘和腹泻为主的肠易激综合征与5-羟色胺信号改变显示文摘Background &Aims: Evidence suggests that postprandial platelet-depleted plasma 5-hydroxytryptamine (5-HT) concentrations may be abnormal in irritable bowel syndrome (IBS). However, interpretation of the data has been hampered by the variable methodology and rather small numbers used in previous studies. Therefore, the aim of this study was to measure concentrations of platelet-depleted plasma 5-HT and its metabolite 5-HIAA under fasting and fed conditions in a large group of patients with diarrhea-predominant (d-) and constipation-predominant (c-) IBS, compared with controls. The ratio of plasma 5-HIAA:5-HT and platelet stores was also assessed. Methods: Twenty-nine c-IBS patients (aged, 19-53 years), 55 d-IBS patients (aged, 19-52 years), and 35 healthy volunteers (aged, 18-46 years) had platelet-depleted plasma 5-HT/5-HIAA concentrations measured using reverse-phase, high-performance liquid chromatography with fluorimetric detection before and after a standard meal. Results: d-IBS patients had raised platelet-depleted plasma 5-HT concentrations under fasting and fed conditions (P < .05). However, the postprandial relative to fasting concentration was similar to controls. In contrast, c-IBS patients failed to show an increase in platelet-depleted plasma 5-HT concentration with meal ingestion compared with controls (P < .01). c-IBS was associated with decreased 5-HIAA (P < .01) but normal 5-HIAA:5-HT ratio and d-IBS with normal 5-HIAA concentrations but reduced 5-HIAA:5-HT ratio (P < .005). c-IBS but not d-IBS patients had increased platelet 5-HT. Conclusions: These results support the concept that d-IBS is characterized by reduced 5-HT reuptake, whereas impaired release may be a feature of c-IBS. These results also provide a rational basis for current pharmacologic approaches involving modulation of different 5-HT receptors in c-and d-IBS. | Atkinson W. Lockhart S. Whorwell P. J. L.A. Houghton. 李宏宇(译) 郑世成(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，6： | 8 |
| 2 | Tracer diffusion studies in NiO bicrystals and polycrystals显示文摘 | A. Atkinson D. P. Moon D. W. Smart R. I. Taylor | 1986 | Journal of Materials Science1986，，5： | 1 |
| 3 | Selective electrodeposition of metals from simulated waste solutions显示文摘 | R. D. Armstrong M. Todd J. W. Atkinson K. Scott | 1996 | Journal of Applied Electrochemistry1996，，4： | 1 |
| 4 | Stereolithographic biomodelling in cranio-maxillofacial surgery: a prospective trial显示文摘 | Paul S. D’Urso Timothy M. Barker W. John Earwaker Lain J. Bruce R. Leigh Atkinson Michael W. Lanigan John F. Arvier David J. Effeney | 1999 | Journal of Cranio-Maxillofacial Surgery1999，，1： | 1 |
| 5 | Studies in humans using deuterium-labeled α- and γ-tocopherols demonstrate faster plasma γ-tocopherol disappearance and greater γ-metabolite production显示文摘 | Scott W. Leonard Elaine Paterson Jeffrey K. Atkinson Rajasekhar Ramakrishnan Carroll E. Cross Maret G. Traber | 2004 | Free Radical Biology and Medicine2004，，： | 1 |
| 6 | Vertebral Fractures Predict Subsequent Fractures显示文摘 | L. J. Melton III E. J. Atkinson C. Cooper W. M. O’Fallon B. L. Riggs | 1999 | Osteoporosis International1999，，3： | 1 |
| 7 | A combined spectral and object-based approach to transparent cloud removal in an operational setting for Landsat ETM+显示文摘 | Gary R. Watmough Peter M. Atkinson Craig W. Hutton | 2010 | International Journal of Applied Earth Observations and Geoinformation2010，，2： | 1 |
| 8 | The fate of nitrogen and phosphorus at the land-sea margin of the North Atlantic Ocean显示文摘 | S. W. Nixon J. W. Ammerman L. P. Atkinson V. M. Berounsky G. Billen W. C. Boicourt W. R. Boynton T. M. Church D. M. Ditoro R. Elmgren J. H. Garber A. E. Giblin R. A. Jahnke N. J. P. Owens M. E. Q. Pilson S. P. Seitzinger | 1996 | Biogeochemistry1996，，1： | 1 |
| 9 | Evaluation of methods for cultivating limbal mesenchymal stromal cells显示文摘 | Laura J. Bray Celena F. Heazlewood Kerry Atkinson Dietmar W. Hutmacher Damien G. Harkin | 2012 | Cytotherapy2012，，8： | 1 |
| 10 | The fate of nitrogen and phosphorus at the land-sea margin of the North Atlantic Ocean显示文摘 | S. W. Nixon J. W. Ammerman L. P. Atkinson V. M. Berounsky G. Billen W. C. Boicourt W. R. Boynton T. M. Church D. M. Ditoro R. Elmgren J. H. Garber A. E. Giblin R. A. Jahnke N. J. P. Owens M. E. Q. Pilson S. P. Seitzinger | 1996 | Biogeochemistry1996，，1： | 1 |
| 11 | Characterisation of microsatellites from Actinidia chinensis显示文摘 | Kurt Weising Raymond W. M. Fung D. Jeannette Keeling Ross G. Atkinson Richard C. Gardner | 1996 | Molecular Breeding1996，，2： | 1 |
| 12 | Cotransplantation of HLA-Identical Sibling Culture-Expanded Mesenchymal Stem Cells and Hematopoietic Stem Cells in Hematologic Malignancy Patients显示文摘 | Hillard M. Lazarus Omer N. Koc Steven M. Devine Peter Curtin Richard T. Maziarz H. Kent Holland Elizabeth J. Shpall Philip McCarthy Kerry Atkinson Brenda W. Cooper Stanton L. Gerson Mary J. Laughlin Fausto R. Loberiza Annemarie B. Moseley Andrea Bacigalup | 2005 | Biology of Blood and Marrow Transplantation2005，，5： | 1 |
| 13 | Cotransplantation of HLA-Identical Sibling Culture-Expanded Mesenchymal Stem Cells and Hematopoietic Stem Cells in Hematologic Malignancy Patients显示文摘 | Hillard M. Lazarus Omer N. Koc Steven M. Devine Peter Curtin Richard T. Maziarz H. Kent Holland Elizabeth J. Shpall Philip McCarthy Kerry Atkinson Brenda W. Cooper Stanton L. Gerson Mary J. Laughlin Fausto R. Loberiza Annemarie B. Moseley Andrea Bacigalup | 2005 | Biology of Blood and Marrow Transplantation2005，，5： | 1 |
| 14 | Clinical and Radiographic Features of Dural Arteriovenous Fistula, a Treatable Cause of Myelopathy显示文摘 | John L.D. Atkinson Gary M. Miller William E. Krauss W. Richard Marsh David G. Piepgras Patty Pate Atkinson Robert D. Brown John I. Lane | 2001 | Mayo Clinic Proceedings2001，，： | 1 |
| 15 | Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation显示文摘 | Richard S. Bruno Scott W. Leonard Jeffery Atkinson Thomas J. Montine Rajasekhar Ramakrishnan Tammy M. Bray Maret G. Traber | 2005 | Free Radical Biology and Medicine2005，，4： | 1 |
| 16 | Multi-functional landscapes in semi arid environments: implications for biodiversity and ecosystem services显示文摘 | P. J. O’Farrell B. Reyers D. C. Maitre S. J. Milton B. Egoh A. Maherry C. Colvin D. Atkinson W. Lange J. N. Blignaut R. M. Cowling | 2010 | Landscape Ecology2010，，8： | 1 |
| 17 | The fate of nitrogen and phosphorus at the land-sea margin of the North Atlantic Ocean显示文摘 | S. W. Nixon J. W. Ammerman L. P. Atkinson V. M. Berounsky G. Billen W. C. Boicourt W. R. Boynton T. M. Church D. M. Ditoro R. Elmgren J. H. Garber A. E. Giblin R. A. Jahnke N. J. P. Owens M. E. Q. Pilson S. P. Seitzinger | 1996 | Biogeochemistry1996，，1： | 1 |
| 18 | 肠易激综合征中基于IgG抗体的食物排除:一项随机对照研究 | Atkinson W. Sheldon T.A. Shaath N. Whorwell P.J. 杨瑗 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，3： | 0 |
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