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| 1 | Biolog方法在区分城市土壤与农村土壤微生物特性上的应用显示文摘通过利用环境微生物研究中比较可靠有效的Biolog方法研究了英国阿伯丁市城市土壤与邻近农村土壤的微生物群落结构和功能多样性,结果表明在重金属元素胁迫下,城市土壤的微生物群落结构与农村土壤相比已经发生了显著的改变,从而导致城市土壤微生物在利用能源碳方面包括消耗量、消耗速度、能源碳的利用种类等发生了一系列改变,使城市土壤显著区别于农村土壤。 | 杨元根 Paterson E Campbell C | 2002 | 土壤学报2002，39，4： | 50 |
| 2 | 重金属Cu的土壤微生物毒性研究显示文摘Cu进入土壤后的早期阶段 ,低浓度对土壤微生物生物量有刺激作用 ,而高浓度则起抑制作用 ;表现在微生物呼吸强度升高 ,微生物生理生态参数代谢商 qCO2 增大 ,微生物生物量碳与有机碳的比值 (Cmic/Corg)降低 ;但土壤对Cu高强的结合容量导致该效应随时间而变得不显著 ;Biolog数据表明 ,在Cu的胁迫下 ,不仅微生物的群落结构有所改变 ,而且对碳源的优先利用种类发生了转移 ,碳源消耗量增加 ,消耗速度变快 ,同时这样的损伤效应具有长期性。 | 杨元根 Paterson E Campbell C | 2002 | 土壤通报2002，33，2： | 23 |
| 3 | Genome Alignment Spanning Major Poaceae Lineages Reveals Heterogeneous Evolutionary Rates and Alters Inferred Dates for KeyEvolutionary Events显示文摘 | Xiyin Wa ng Jingpeng Wang Dianchuan Jin Hui Guo Tae-Ho Lee Tao Liu Andrew H. Paterson | 2015 | Molecular Plant2015，8，6： | 18 |
| 4 | 用土壤微生物方法评价重金属Cu的毒性及其时间效应显示文摘从微生物特征及其群落结构等方面研究了重金属Cu的土壤毒性及其时间效应。结果表明,Cu进入土壤早期阶段,低浓度对土壤微生物生物量有刺激作用,高浓度起抑制作用;微生物呼吸强度迅速增加,微生物生理生态参数qCO_2升高,C_(mic)/C_(org)降低;土壤溶液中Cu浓度很低,对发光菌E.Coli有轻度抑制作用,但随时间延长而更不显著;Biolog结果显示,在Cu胁迫下,微生物的群落结构有所改变,对碳源的消耗量增加,速度变快,这种损伤具有长期效应。 | 杨元根 Paterson E Campbell C | 2001 | 自然科学进展(国家重点实验室通讯)2001，11，3： | 12 |
| 5 | Endoscopic ultrasound-guided elastography in the nodal staging of oesophageal cancer显示文摘AIM:To assess quantitative endoscopic ultrasound (EUS)guided elastography in the nodal staging of oesophagogastric cancers.METHODS:This was a single tertiary centre study assessing 50 patients with established oesophago-gastric cancer undergoing EUS-guided fine needle aspiration biopsy (FNAB) of lymph nodes between July 2007 and July 2009.EUS-guided elastography of lymph nodes was performed before EUS-FNAB.Standard EUS characteristics were also described.Cytological determination of whether a lymph node was malignant or benign was used as the gold standard for this study.Comparisons of elastography and standard EUS characteristics were made between the cytologically benign and malignant nodes.The main outcome measure was the accuracy of elastography in differentiating between benign and malignant lymph nodes in oesophageal cancers.RESULTS:EUS elastography and FNAB were performed on 53 lymph nodes.Cytological malignancy was found in 23 nodes,one was indeterminate,one was found to be a gastrointestinal stromal tumor and 25 of the nodes were negative for malignancy.On 3 occasions insufficient material was obtained for analysis.The area under the curve for the receiver operating characteristic curve for elastography strain ratio was 0.87 (P<0.0001).Elastography strain ratio had a sensitivity 83%,specificity 96%,positive predictive value 95%,and negative predictive value 86% for distinguishing between malignant and benign nodes.The overall accuracy of elastography strain ratio was 90%.Elastography was more sensitive and specific in determining malignant nodal disease than standard EUS criteria.CONCLUSION:EUS elastography is a promising modality that may complement standard EUS and help guide EUS-FNAB during staging of upper gastrointestinal tract cancer. | Stuart Paterson Fraser Duthie Adrian J Stanley | 2012 | World Journal of Gastroenterology2012，18，9： | 10 |
| 6 | A rapid method for extraction of cotton ( Gossypium spp.) genomic DNA suitable for RFLP or PCR analysis显示文摘 | Andrew H. Paterson Curt L. Brubaker Jonathan F. Wendel | 1993 | Plant Molecular Biology Reporter1993，，2： | 9 |
| 7 | 北京西山房山岩体西北部强变形带的成因新解显示文摘北京西山房山岩体西北缘不对称发育一条弧形塑性强变形带,前人根据岩体东南部组构缓倾和岩体内部强应变分布特征提出岩浆斜向底辟侵位模式(王人镜等,1990;张吉顺和李志中,1990)。本文在前人研究的基础上,对房山岩体的组构进行系统观测,研究了西北缘固态塑性强变形带地质特征,着重探讨了岩体侵位时围岩热结构状态。文章认为岩浆同侵位固态塑性强变形带的形成需要早期岩浆进入准固态-固态和后期岩浆膨胀动力这两个必要条件。房山岩体西北部的强变形带是由于岩体侵位时西部围岩的温度较低,岩浆较早进入准固态-固态,后期岩浆侵位时膨胀动力双重因素造成的,提出了围岩热结构状态是房山岩体不对称的固态塑性强变形带的控制因素,而不是岩浆斜向底辟侵位的结果。这一研究成果不仅较合理地解释了房山岩体强变形带不对称发育特征,而且对研究同类花岗质岩体的定位机制有一定启示意义。 | 燕滨 何斌 徐义刚 Scott Paterson 张焘 | 2008 | 大地构造与成矿学2008，32，4： | 9 |
| 8 | 老年痴呆患者大小便失禁的初级卫生保健研究进展显示文摘大小便失禁是指不由自主的尿液或粪便泄漏。因大小便失禁带有社会耻辱感,所以大小便失禁患者及其家庭照顾者往往会采取各种措施来隐瞒大小便失禁〔1,2〕。有研究表明,它可通过初级卫生保健预防和治疗〔3〕,但目前仍然存在漏报和漏诊的情况。本文综述了老年痴呆和大小便失禁之间的关系及其初级卫生保健研究进展。1老年痴呆大小便失禁患者的影响因素在大小便失禁的众多潜在因素中,老年痴呆症是导致尿失禁(UI)和大便失禁(FI)的一个独立危险因素。 | 罗艳 王瑶 Jan Paterson 邹健 王婧 王媛媛 Lily Dongxia Xiao 何国平 | 2015 | 中国老年学杂志2015，35，19： | 9 |
| 9 | 对一类无证书签名方案的攻击及改进显示文摘给出了对一个已有的高效无证书签名方案的替换公钥攻击,表明了在该方案中,攻击者可以通过替换签名者公钥伪造签名;进而针对该攻击提出了改进方案.改进方案将用户单一公钥替换为公钥对,增加了公钥有效性验证,简化了签名产生算法,在随机预言机模型下具有存在性不可伪造性. | 曹雪菲 Kenneth. G. Paterson 寇卫东 | 2008 | 北京邮电大学学报2008，31，2： | 8 |
| 10 | Origin of raptorial feeding in juvenile euarthropods revealed by a Cambrian radiodontan显示文摘The rapid rise of arthropods during the Cambrian quickly established some clades, such as the euarthropod stem-group called Radiodonta, as the dominant and most diverse predators in marine ecosystems. Recent discoveries have shown that the size and dietary ecology of radiodontans are far more diverse than previously thought, but little is known about the feeding habits of juveniles. Here, we document a very small(~18-mm-long), near-complete specimen of the radiodontan Lyrarapax unguispinus from the early Cambrian Chengjiang Biota of China. This specimen is the smallest radiodontan individual known,representing a juvenile instar. Its adult-like morphology—especially the fully developed spinose frontal appendages and tetraradial oral cone—indicates that L. unguispinus was a well-equipped predator at an early developmental stage, similar to modern raptorial euarthropods, such as mantises, mantis shrimps and arachnids. This evidence, coupled with the basal phylogenetic position of radiodontans, confirms that raptorial feeding habits in juvenile euarthropods appeared early in the evolutionary history of the group. | Jianni Liu Rudy Lerosey-Aubril Michael Steiner Jason A. Dunlop Degan Shu John R. Paterson | 2018 | National Science Review2018，5，6： | 8 |
| 11 | 心脏外科术后肺部并发症危险因素分析显示文摘目的:分析心脏外科术后肺部并发症的围手术期危险因素及其影响。方法:分析1995年1月~2002年2月间连续2084例正中切口右房-升主动脉体外循环心脏外科手术术前、术中及术后相关因素,观察它们在围手术期肺部并发症中的作用。结果:共有136例肺部并发症(6.5%)。肺部并发症的术前危险因素包括女性(相对危险度OR=1.49)、吸烟(OR=1.64)、慢性阻塞性肺部疾病(OR=2.36),术中危险因素包括应用冷心脏停搏液(OR=1.56),术后危险因素包括需要血管活性药物支持(OR=2.00)、2次开胸(OR=2.08)、主动脉内球囊反搏(OR=2.39)、胸腔积液(OR=2.63)、术后脑血管意外(OR=5.45)、膈神经损伤(OR=8.09)、以及术后肾功能衰竭需用肾透析(OR=12.87)。围手术期肺部并发症不是围手术期死亡的危险因素。结论:心脏外科术后多种围手术期危险因素增加术后肺部并发症的发生,特别是术后脑血管意外、膈神经损伤、以及肾功能衰竭需要肾透析对围手术期肺部并发症的发生影响最为明显。对此类患者需特别注意保护肺功能,以减少并发症的发生。围手术期肺部并发症不是围手术期死亡的危险因素。 | 邓勇志 孙宗全 Hugh S Paterson | 2007 | 临床心血管病杂志2007，23，8： | 5 |
| 12 | 肥胖患病率及其对患者机械通气时间和在重症监护室住院时间的影响:单中心观察研究显示文摘目的:在重症监护室(ICU)患者样本中,为异常身体质量指数(BMI)的发生率提供概况;确定是否有任一医学专科与异常的BMI有关;分析BMI与ICU相关转归的关联。方法:选择2012年11月至2014年6月,在Sir Charles Gairdner医院的三级ICU(23张床位)住院的735例成年患者(年龄中位数为58岁),进行回顾性观察。首要结果测量指标是患者的BMI,低体质量(<18.5 kg/m^2)、正常体质量(18.5~24.99 kg/m^2)、超重(25~29.99 kg/m^2)、肥胖(30~39.99 kg/m^2)或重度肥胖(≥40 kg/m^2);其他测量指标包括性别、急性生理学与慢性健康状况评分系统Ⅱ评分、住院科室、机械通气(MV)时间、住院时间(LOS)和病死率。结果:与普通人群比较,研究队列中肥胖患者的比例更高,绝大部分患者超重(33.9%)或肥胖(36.5%),BMI的中位数为27.9(IQR为7.9)。不同专科患者的BMI无统计学差异(P=0.103)。未发现异常BMI对患者病死率有负面影响(ICU,P=0.373;医院,P=0.330);正常BMI患者比其他类型BMI患者的MV时间更短,BMI对患者ICU LOS的影响取决于MV时间。与正常体质量的患者比较,机械通气时间为5天或更长的超重患者,LOS更短;重度肥胖无机械通气的患者,LOS更长。结论:尽管肥胖-疾病关系日益复杂化,而现有数据只反映了单中心ICU住院患者的不同类别的BMI;但在研究队列中,考虑护理的成本影响仍然可能是重要的,尤其是对MV和LOS的影响。 | Diane M. Dennis Chrianna Bharat Timothy Paterson | 2017 | 中国护理管理2017，17，5： | 5 |
| 13 | 双侧乳内动脉π型桥全动脉化冠状动脉旁路移植术显示文摘目的 研究 π型桥全动脉化心肌血运重建的临床应用。 方法 1994年 9月到 2 0 0 2年 8月对 2 2例患者根据冠状动脉病变解剖特点选用π型桥进行全动脉化心肌血运重建 ,即 3支血管病变合并对角支 /中间支中段病变时 ,采用由左侧乳内动脉小 Y型桥与前降支和对角支 /中间支吻合 ,与双侧乳内动脉 T型桥共同构成 π型桥。 结果本组无围术期死亡 ,无心肌梗死、脑血管意外和胸骨感染发生 ;1例患者术后二次开胸止血。随访 6 0 .7± 2 3.0个月 ,无心绞痛复发需要冠脉介入治疗或手术治疗者 ,也无冠心病导致的死亡发生。 结论 对 3支血管病变合并对角支 /中间支中段冠脉病变的患者 ,双侧乳内动脉 π型桥可以顺利完成全动脉化心肌血运重建 ,中期效果良好。 | 邓勇志 孙宗全 Hugh S Paterson | 2005 | 中国胸心血管外科临床杂志2005，12，1： | 4 |
| 14 | Mediastinal node staging by positron emission tomographycomputed tomography and selective endoscopic ultrasound with fine needle aspiration for patients with upper gastrointestinal cancer:Results from a regional centre显示文摘AIM To investigate the impact of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) and positron emission tomography-computed tomography(PET-CT) in the nodal staging of upper gastrointestinal(GI) cancer in a tertiary referral centre.METHODS We performed a retrospective review of prospectively recorded data held on all patients with a diagnosis of upper GI cancer made between January 2009 and December 2015. Only those patients who had both a PET-CT and EUS with FNA sampling of a mediastinal node distant from the primary tumour were included. Using a positive EUS-FNA result as the gold standard for lymph node involvement, the sensitivity, specificity, positive and negative predictive values(PPV and NPV) and accuracy of PET-CT in the staging of mediastinal lymph nodes were calculated. The impact on therapeutic strategy of adding EUS-FNA to PET-CT was assessed.RESULTS One hundred and twenty one patients were included. Sixty nine patients had a diagnosis of oesophageal adenocarcinoma(Thirty one of whom were junctional), forty eight had oesophageal squamous cell carcinoma and four had gastric adenocarcinoma. The FNA results were inadequate in eleven cases and the PET-CT findings were indeterminate in two cases, therefore thirteen patients(10.7%) were excluded from further analysis. There was concordance between PET-CT and EUS-FNA findings in seventy one of the remaining one hundred and eight patients(65.7%). The sensitivity, specificity, PPV and NPV values of PET-CT were 92.5%, 50%, 52.1% and 91.9% respectively. There was discordance between PET-CT and EUS-FNA findings in thirty seven out of one hundred and eight patients(34.3%). MDT discussion led to a radical treatment pathway in twenty seven of these cases, after the final tumour stage was altered as a direct consequence of the EUS-FNA findings. Of these patients, fourteen(51.9%) experienced clinical remission of a median of nine months(range three to forty two months). CONCLUSION EUS-FNA leads to altered staging of upper GI cancer, resulting in more patients receiving radical treatment that would have been the case using PET-CT staging alone. | Chris Harrington Lyn Smith Jennifer Bisland Elisabet López González Neil Jamieson Stuart Paterson Adrian John Stanley | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，1： | 4 |
| 15 | Acinetobacter baumannii Emergence of a Successful Pathogen显示文摘 | Peleg AY Seifert H Paterson DL | 2008 | Clin Microbiol Rev2008，21，3： | 4 |
| 16 | 人工智能只是开始 科技将不断改变会计人员的工作方式显示文摘人工智能技术的出现是社会发展变革带来的巨大转变,这几乎是离岸外包下一步的合理发展。一些大公司的常规会计业务的流程操作都已经被取代人力资本的技术程序所替代。自动化的破坏是巨大的,它摧毁了赛场,很快对澳大利亚每位会计人员的盈利能力产生了影响。接下来有什么影响呢?我们该作何准备?我们该如何适应新的商业环境? | Chris Paterson | 2018 | 新理财(公司理财)2018，0，12： | 3 |
| 17 | 基于自动测量的诊室血压高血压诊断标准与心血管病风险显示文摘与血压相关的心血管事件风险很大程度是基于台式水银血压计的人群测量数据。考虑到电子血压计逐步替代台式水银血压计,该研究采用全自动血压计在研究对象独自安静休息时多次读取数据,以探讨导致心血管风险显著增加的血压水平。方法:纳入〉65岁的未经治疗的高血压社区居民3627例。从社区药店和家庭医生获得受试者未受干扰时的坐位自动诊室血压数据。针对致命性及非致命性心血管事件,受试者随访(4.9±1.0)年。 | Myers MG Kaczorowski J Paterson JM Dolovich L Tu K 赵狄 练桂丽 | 2015 | 中华高血压杂志2015，23，8： | 3 |
| 18 | Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper显示文摘 | Matthias G. Friedrich Udo Sechtem Jeanette Schulz-Menger Godtfred Holmvang Pauline Alakija Leslie T. Cooper James A. White Hassan Abdel-Aty Matthias Gutberlet Sanjay Prasad Anthony Aletras Jean-Pierre Laissy Ian Paterson Neil G. Filipchuk Andreas Kumar Ma | 2009 | Journal of the American College of Cardiology2009，，17： | 2 |
| 19 | Sediment phosphorus cycling in a large shallow lake: spatio-temporal variation in phosphorus pools and release显示文摘 | Bryan M. Spears Laurence Carvalho Rupert Perkins Alex Kirika David M. Paterson | 2007 | Hydrobiologia2007，，1： | 2 |
| 20 | Enrichment of retinal ganglion and Müller glia progenitors from retinal organoids derived from human induced pluripotent stem cells-possibilities and current limitations显示文摘BACKGROUND Retinal organoids serve as excellent human-specific disease models for conditions affecting otherwise inaccessible retinal tissue from patients.They permit the isolation of key cell types affected in various eye diseases including retinal ganglion cells(RGCs)and Müller glia.AIM To refine human-induced pluripotent stem cells(hiPSCs)differentiated into threedimensional(3D)retinal organoids to generate sufficient numbers of RGCs and Müller glia progenitors for downstream analyses.METHODS In this study we described,evaluated,and refined methods with which to generate Müller glia and RGC progenitors,isolated them via magnetic-activated cell sorting,and assessed their lineage stability after prolonged 2D culture.Putative progenitor populations were characterized via quantitative PCR and immunocytochemistry,and the ultrastructural composition of retinal organoid cells was investigated.RESULTS Our study confirms the feasibility of generating marker-characterized Müller glia and RGC progenitors within retinal organoids.Such retinal organoids can be dissociated and the Müller glia and RGC progenitor-like cells isolated via magnetic-activated cell sorting and propagated as monolayers.CONCLUSION Enrichment of Müller glia and RGC progenitors from retinal organoids is a feasible method with which to study cell type-specific disease phenotypes and to potentially generate specific retinal populations for cell replacement therapies. | Kristine Karla Freude Sarkis Saruhanian Alanna McCauley Colton Paterson Madeleine Odette Annika Oostenink Poul Hyttel Mark Gillies Henriette Haukedal Miriam Kolko | 2020 | World Journal of Stem Cells2020，12，10： | 2 |
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