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您的检索式：作者名="Lockhart S."
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| 1 | 以便秘和腹泻为主的肠易激综合征与5-羟色胺信号改变显示文摘Background &Aims: Evidence suggests that postprandial platelet-depleted plasma 5-hydroxytryptamine (5-HT) concentrations may be abnormal in irritable bowel syndrome (IBS). However, interpretation of the data has been hampered by the variable methodology and rather small numbers used in previous studies. Therefore, the aim of this study was to measure concentrations of platelet-depleted plasma 5-HT and its metabolite 5-HIAA under fasting and fed conditions in a large group of patients with diarrhea-predominant (d-) and constipation-predominant (c-) IBS, compared with controls. The ratio of plasma 5-HIAA:5-HT and platelet stores was also assessed. Methods: Twenty-nine c-IBS patients (aged, 19-53 years), 55 d-IBS patients (aged, 19-52 years), and 35 healthy volunteers (aged, 18-46 years) had platelet-depleted plasma 5-HT/5-HIAA concentrations measured using reverse-phase, high-performance liquid chromatography with fluorimetric detection before and after a standard meal. Results: d-IBS patients had raised platelet-depleted plasma 5-HT concentrations under fasting and fed conditions (P < .05). However, the postprandial relative to fasting concentration was similar to controls. In contrast, c-IBS patients failed to show an increase in platelet-depleted plasma 5-HT concentration with meal ingestion compared with controls (P < .01). c-IBS was associated with decreased 5-HIAA (P < .01) but normal 5-HIAA:5-HT ratio and d-IBS with normal 5-HIAA concentrations but reduced 5-HIAA:5-HT ratio (P < .005). c-IBS but not d-IBS patients had increased platelet 5-HT. Conclusions: These results support the concept that d-IBS is characterized by reduced 5-HT reuptake, whereas impaired release may be a feature of c-IBS. These results also provide a rational basis for current pharmacologic approaches involving modulation of different 5-HT receptors in c-and d-IBS. | Atkinson W. Lockhart S. Whorwell P. J. L.A. Houghton. 李宏宇(译) 郑世成(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，6： | 8 |
| 2 | Diagnosis and Management of Pseudoaneurysms: An Update显示文摘 | Baljendra S. Kapoor Heather L. Haddad Souheil Saddekni Mark E. Lockhart | 2009 | Current Problems in Diagnostic Radiology2009，，4： | 1 |
| 3 | Disaster triage after the Haitian earthquake显示文摘 | R.M. Smith G.S.M. Dyer K. Antonangeli N. Arredondo H. Bedlion A. Dalal G.M. Deveny G. Joseph D. Lauria S.H. Lockhart S. Lucien S. Marsh S.O. Rogers H. Salzarulo S. Shah R.J. Toussaint J. Wagoner | 2011 | Injury2011，，11： | 1 |
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