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| 1 | 急性缺血性卒中静脉阿替普酶溶栓治疗的纳入和排除标准的科学依据美国心脏协会/美国卒中协会对医疗卫生专业人员发布的声明(续前)显示文摘19 颅内出血史
根据最初的 FDA 标签和2013年AHA/ASA指南,颅内出血史是静脉阿替普酶治疗缺血性卒中的一项额外禁忌证或排除标准。最近修订后的标签仅将近期 ICH 列为一项警告,并且在禁忌证中删除了ICH史。与前面讨论的静脉阿替普酶治疗排除标准相似,文献回顾仅在大样本回顾性研究中发现了少量这类病例。缺乏相关数据可能是修订后的FDA 标签不再将 ICH 史作为禁忌证而仅将近期ICH 列为一项警告的原因。在这种情况下,FDA 如何定义“近期”一词尚不清楚。有趣的是,对在静脉阿替普酶治疗前通过 MRI 检测脑微出血( cerebral microbleed, CMBs)存在情况进行的研究可为这个卒中亚组患者提供更多的见解。从病理生理学角度,这种微出血的原因尚不清楚,可能反映再灌注损伤或脑血管自动调节功能破坏。因此,在静脉阿替普酶治疗后出现这些损害可能没有意义或是人为信号。 | Dawn O. Kleindorfer Opeolu M. Adeoye Andrew M. Demchuk Jennifer E. Fugate James C. Grotta Alexander A. Khalessi Elad I. Levy Yuko Y. Palesch Shyam Prabhakaran Gustavo Saposnik Jeffrey L. Saver Eric E. Smith 高圆圆 顾雨铖 徐欣 徐曼曼 张佳慧 李韶雅 冒萧萧 陈歆 徐运 | 2016 | 国际脑血管病杂志2016，24，5： | 98 |
| 2 | Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging. | Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert | 2022 | Stroke & Vascular Neurology2022，7，2： | 7 |
| 3 | Hyperfibrinogenemia and Functional Outcome From Acute Ischemic Stroke显示文摘 | Gregory J. del Zoppo David E. Levy Warren W. Wasiewski Arthur M. Pancioli Andrew M. Demchuk James Trammel Bart M. Demaerschalk Markku Kaste Gregory W. Albers Eric B. Ringelstein | 2009 | Stroke2009，，5： | 1 |
| 4 | Hyperfibrinogenemia and Functional Outcome From Acute Ischemic Stroke显示文摘 | Gregory J. del Zoppo David E. Levy Warren W. Wasiewski Arthur M. Pancioli Andrew M. Demchuk James Trammel Bart M. Demaerschalk Markku Kaste Gregory W. Albers Eric B. Ringelstein | 2009 | Stroke2009，，5： | 1 |
| 5 | Transcranial doppler in acute stroke显示文摘 | Andrew M Demchuk M D Maher Saqqur M D | 2005 | Neuroi Clin North Am2005，15，： | 1 |
| 6 | What Causes Disability After Transient Ischemic Attack and Minor Stroke?: Results From the CT And MRI in the Triage of TIA and minor Cerebrovascular Events to Identify High Risk Patients (CATCH) Study显示文摘 | Shelagh B. Coutts Jayesh Modi Shiel K. Patel Heidi Aram Andrew M. Demchuk Mayank Goyal Michael D. Hill | 2012 | Stroke2012，，11： | 1 |
| 7 | Thrombolysis in brain ischemia(TIBI) transcranial Doppler flow grades predict clinical severity,early recovery,and mortality in patients treated with intravenous tissue plasminogen activator显示文摘 | Andrew M Demchuk MD Scott MD | 2001 | Stroke2001，32，： | 1 |
| 8 | Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study显示文摘 | Andrew M Demchuk Dar Dowlatshahi David Rodriguez-Luna Carlos A Molina Yolanda Silva Blas Imanuel Dzialowski Adam Kobayashi Jean-Martin Boulanger Cheemun Lum Gord Gubitz Vasantha Padma Jayanta Roy Carlos S Kase Jayme Kosior Rohit Bhatia Sarah Tymchuk Sures | 2012 | Lancet Neurology2012，，： | 1 |
| 9 | Addition of Brain Infarction to the ABCD2 Score (ABCD2I): A Collaborative Analysis of Unpublished Data on 4574 Patients显示文摘 | Matthew F. Giles Greg W. Albers Pierre Amarenco Murat M. Arsava Andrew Asimos Hakan Ay David Calvet Shelagh Coutts Brett L. Cucchiara Andrew M. Demchuk S. Claiborne Johnston Peter J. Kelly Anthony S. Kim Julien Labreuche Philippa C. Lavallee Jean-Louis Ma | 2010 | Stroke2010，，9： | 1 |
| 10 | Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison显示文摘 | Julio A Chalela Chelsea S Kidwell Lauren M Nentwich Marie Luby John A Butman Andrew M Demchuk Michael D Hill Nicholas Patronas Lawrence Latour Steven Warach | 2007 | The Lancet2007，，9558： | 1 |
| 11 | Cavitation After Acute Symptomatic Lacunar Stroke Depends on Time, Location, and MRI Sequence显示文摘 | Francois Moreau Shiel Patel M. Louis Lauzon Cheryl R. McCreary Mayank Goyal Richard Frayne Andrew M. Demchuk Shelagh B. Coutts Eric E. Smith | 2012 | Stroke2012，，7： | 1 |
| 12 | Role of CT Angiography in Thrombolysis Decision-Making for Patients With Presumed Seizure at Stroke Onset显示文摘 | P N. Sylaja Imanuel Dzialowski Andrea Krol Jayanta Roy Paolo Federico Andrew M. Demchuk | 2006 | Stroke2006，，3： | 1 |
| 13 | Noninvasive imaging is improving but digital subtraction angiography remains the gold standard显示文摘 | Michael D. Hill Andrew M. Demchuk Richard Frayne | 2007 | Neurology2007，，： | 1 |
| 14 | Thrombolysis in Brain Ischemia (TIBI) Transcranial Doppler Flow Grades Predict Clinical Severity, Early Recovery, and Mortality in Patients Treated With Intravenous Tissue Plasminogen Activator显示文摘 | Andrew M. Demchuk W. Scott Burgin Ioannis Christou Robert A. Felberg Philip A. Barber Michael D. Hill Andrei V. Alexandrov | 2001 | Stroke: Journal of the American Heart Association2001，，： | 1 |
| 15 | Speed of Intracranial Clot Lysis With Intravenous Tissue Plasminogen Activator Therapy: Sonographic Classification and Short-Term Improvement显示文摘 | Andrei V. Alexandrov W. Scott Burgin Andrew M. Demchuk Ashraf El-Mitwalli James C. Grotta | 2001 | Circulation: Journal of the American Heart Association2001，，： | 1 |
| 16 | Alberta Stroke Program Early CT Score in Acute Stroke Triage 显示文摘 | Andrew M Demchuk MD Shelagh B | 2005 | Neuroimag Clin N Am2005，15，： | 1 |
| 17 | Low Rates of Acute Recanalization With Intravenous Recombinant Tissue Plasminogen Activator in Ischemic Stroke: Real-World Experience and a Call for Action显示文摘 | Rohit Bhatia Michael D. Hill Nandavar Shobha Bijoy Menon Simerpreet Bal Puneet Kochar Tim Watson Mayank Goyal Andrew M. Demchuk | 2010 | Stroke2010，，10： | 1 |
| 18 | Specific Transcranial Doppler Flow Findings Related to the Presence and Site of Arterial Occlusion显示文摘 | Andrew M. Demchuk Ioannis Christou Theodore H. Wein Robert A. Felberg Marc Malkoff James C. Grotta Andrei V. Alexandrov | 2000 | Stroke: Journal of the American Heart Association2000，，1： | 1 |
| 19 | Yield of Transcranial Doppler in Acute Cerebral Ischemia显示文摘 | Andrei V. Alexandrov Andrew M. Demchuk Theodore H. Wein James C. Grotta | 1999 | Stroke: A Journal of Cerebral Circulation1999，，8： | 1 |
| 20 | Endovascular Stroke Trials: Why We Must Enroll All Eligible Patients显示文摘 | Mayank Goyal Michel Shamy Bijoy K. Menon Jeffrey L. Saver Hans-Christoph Diener J. Mocco Vitor Mendes Pereira Tudor G. Jovin Osama Zaidat Elad I. Levy Antoni Davalos Andrew Demchuk Michael D. Hill | 2013 | Stroke2013，，： | 1 |
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