|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Brain stem cells as the cell of origin in glioma显示文摘Glioma incidence rates in the United States are near 20000 new cases per year, with a median survival time of 14.6 mo for high-grade gliomas due to limited therapeutic options. The origins of these tumors and their many subtypes remain a matter of investigation. Evidence from mouse models of glioma and human clinical data have provided clues about the cell types and initiating oncogenic mutations that drive gliomagenesis, a topic we review here. There has been mixed evidence as to whether or not the cells of origin are neural stem cells, progenitor cells or differentiated progeny. Many of the existing murine models target cell populations defined by lineage-specific promoters or employ lineagetracing methods to track the potential cells of origin. Our ability to target specific cell populations will likely increase concurrently with the knowledge gleaned from an understanding of neurogenesis in the adult brain. The cell of origin is one variable in tumorigenesis, as oncogenes or tumor suppressor genes may differentially transform the neuroglial cell types. Knowledge of key driver mutations and susceptible cell types will allow us to understand cancer biology from a developmental standpoint and enable early interventional strategies and biomarker discovery. | Aram S Modrek N Sumru Bayin Dimitris G Placantonakis | 2014 | World Journal of Stem Cells2014，6，1： | 12 |
| 2 | Total pancreatectomy and islet autotransplantation: A decade nationwide analysis显示文摘AIM: To investigate outcomes and predictors of inhospital morbidity and mortality after total pancreatectomy(TP) and islet autotransplantation. METHODS: The nationwide inpatient sample(NIS) database was used to identify patients who underwent TP and islet autotransplantation(IAT) between 2002-2012 in the United States. Variables of interest were inherent variables of NIS database which included demographic data(age, sex, and race), comorbidities(such as diabetes mellitus, hypertension, and deficiency anemia), and admission type(elective vs nonelective). The primary endpoints were mortality and postoperative complications according to the ICD-9 diagnosis codes which were reported as the second to 25 th diagnosis of patients in the database. Risk adjusted analysis was performed to investigate morbidity predictors. Multivariate regression analysis was used to identify predictors of in-hospital morbidity.RESULTS: We evaluated a total of 923 patients who underwent IAT after pancreatectomy during 2002-2012. Among them, there were 754 patients who had TP + IAT. The most common indication ofsurgery was chronic pancreatitis(86%) followed by acute pancreatitis(12%). The number of patients undergoing TP + IAT annually significantly increased during the 11 years of study from 53 cases in 2002 to 155 cases in 2012. Overall mortality and morbidity of patients were 0% and 57.8 %, respectively. Postsurgical hypoinsulinemia was reported in 42.3% of patients, indicating that 57.7% of patients were insulin independent during hospitalization. Predictors of inhospital morbidity were obesity [adjusted odds ratio(AOR): 3.02, P = 0.01], fluid and electrolyte disorders(AOR: 2.71, P < 0.01), alcohol abuse(AOR: 2.63, P < 0.01), and weight loss(AOR: 2.43, P < 0.01). CONCLUSION: TP + IAT is a safe procedure with no mortality, acceptable morbidity, and achieved high rate of early insulin independence. Obesity is the most significant predictor of in-hospital morbidity. | Reza Fazlalizadeh Zhobin Moghadamyeghaneh Aram N Demirjian David K Imagawa Clarence E Foster Jonathan R Lakey Michael J Stamos Hirohito Ichii | 2016 | World Journal of Transplantation2016，6，1： | 9 |
| 3 | Impact of obesity treatment on gastroesophageal refluxdisease显示文摘Gastroesophageal reflux disease(GERD) is a frequently encountered disorder. Obesity is an important risk factor for GERD, and there are several pathophysiologic mechanisms linking the two conditions. For obese patients with GERD, much of the treatment effort is focused on weight loss and its consistent benefit to symptoms, while there is a relative lack of evidence regarding outcomes after novel or even standard medical therapy is offered to this population. Physicians are hesitant to recommend operative anti-reflux therapy to obese patients due to the potentially higher risks and decreased efficacy, and these patients instead are often considered for bariatric surgery. Bariatric surgical approaches are broadening, and each technique has emerging evidence regarding its effect on both the risk and outcome of GERD. Furthermore, combined antireflux and bariatric options are now being offered to obese patients with GERD. However, currently Rouxen-Y gastric bypass remains the most effective surgical treatment option in this population, due to its consistent benefits in both weight loss and GERD itself. This article aims to review the impact of both conservative and aggressive approaches of obesity treatment on GERD. | Abraham Khan Aram Kim Cassandra Sanossian Fritz Francois | 2016 | World Journal of Gastroenterology2016，22，4： | 9 |
| 4 | 粉末冶金自润滑Cu/MoS_2复合材料的摩擦行为(英文)显示文摘研究MoS_2含量对纯铜的显微组织、密度、硬度和耐磨性能的影响。采用纯铜粉和MoS_2粉末,通过机械球磨和热压法,制备含0~10%(质量分数)MoS_2颗粒的铜基复合材料。在干滑动摩擦条件下,采用销-盘式磨损实验装置,测试材料的耐磨性能,固定滑动速率为0.2 m/s。硬度测试结果显示,MoS_2含量为2.5%的复合材料的硬度达到峰值。当载荷一定时,Cu/2.5MoS_2复合材料具有最低的摩擦因数和磨损量。当载荷从1 N增加到4 N,不同含量增强相复合材料的摩擦因数均减小,同时,磨损量增大。磨损表面和磨屑的SEM照片显示,Cu/MoS_2复合材料的磨损机理由纯铜的粘着磨损为主转变为磨粒磨损和剥层磨损相结合的机制。 | Mohammad MOAZAMI-GOUDARZI Aram NEMATI | 2018 | Transactions of Nonferrous Metals Society of China2018，28，5： | 8 |
| 5 | Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease显示文摘AIM To determine how the auto-antibodies(Abs) profiles overlap in chronic hepatitis C infection(CHC) and autoimmune hepatitis(AIH) and correlate to liver disease.METHODS Levels of antinuclear Ab, smooth muscle antibody(SMA) and liver/kidney microsomal-1(LKM-1) Ab and markers of liver damage were determined in the sera of 50 patients with CHC infection, 20 AIH patients and 20 healthy controls using enzyme linked immunosorbent assay and other immune assays. RESULTS We found that AIH patients had more severe liver disease as determined by elevation of total Ig G, alkaline phosphatase, total serum bilirubin and serum transaminases and significantly higher prevalence of the three non-organ-specific autoantibodies(auto-Abs) than CHC patients. Antinuclear Ab, SMA and LKM-1 Ab were also present in 36% of CHC patients and related to disease severity. CHC cases positive for auto-Abs were directly comparable to AIH in respect of most markers of liver damage and total Ig G. These cases had longer disease duration compared with auto-Ab negative cases, but there was no difference in gender, age or viral load. KLM-1+ Ab CHC cases showed best overlap with AIH. CONCLUSION Auto-Ab levels in CHC may be important markers of disease severity and positive cases have a disease similar to AIH. Auto-Abs might have a pathogenic role as indicated by elevated markers of liver damage. Future studies will unravel any novel associations between these two diseases, whether genetic or other. | Kawa Amin Aram H Rasool Ali Hattem Taha AM Al-Karboly Taher E Taher Jonas Bystrom | 2017 | World Journal of Gastroenterology2017，23，8： | 5 |
| 6 | Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure显示文摘 | Aram V. Chobanian George L. Bakris Henry R. Black William C. Cushman Lee A. Green Joseph L. Izzo Daniel W. Jones Barry J. Materson Suzanne Oparil Jackson T. Wright Edward J. Roccella | 2003 | Hypertension: Journal of The American Heart Association2003，，6： | 4 |
| 7 | Glioblastoma stem cells:Molecular characteristics and therapeutic implications显示文摘Glioblastoma Multiforme(GBM)is a grade IV astrocytoma,with a median survival of 14.6 mo.Within GBM,stem-like cells,namely glioblastoma stem cells(GSCs),have the ability to self-renew,differentiate into distinct lineages within the tumor and initiate tumor xenografts in immunocompromised animal models.More importantly,GSCs utilize cell-autonomous and tumor microenvironment-mediated mechanisms to overcome current therapeutic approaches.They are,therefore,very important therapeutic targets.Although the functional criteria defining GSCs are well defined,their molecular characteristics,the mechanisms whereby they establish the cellular hierarchy within tumors,and their contribution to tumor heterogeneity are not well understood.This review is aimed at summarizing current findings about GSCs and their therapeutic importance from a molecular and cellular point of view.A better characterization of GSCs is crucial for designing effective GSCtargeted therapies. | Nermin Sumru Bayin Aram Sandaldjian Modrek Dimitris George Placantonakis | 2014 | World Journal of Stem Cells2014，6，2： | 3 |
| 8 | Stereotactic Hypofractionated Radiation Therapy as a Bridge to Transplantation for Hepatocellular Carcinoma: Clinical Outcome and Pathologic Correlation显示文摘 | Alan W. Katz Sheema Chawla Zhenhong Qu Randeep Kashyap Michael T. Milano Aram F. Hezel | 2012 | International Journal of Radiation Oncology Biology Physics2012，，3： | 2 |
| 9 | Networking and growth of young technology-intensive ventures in China显示文摘 | Zhao Li-ming Aram J D | 1995 | Journal of Business Venturing1995，10，5： | 1 |
| 10 | Networking and growth of young technology-intensive ventures in China显示文摘 | Zhao L Aram J D | 1995 | Journal of Business Venturing1995，10，5： | 1 |
| 11 | Transplantation of embryonic retina to adult retina in rabbits显示文摘 | Seiler M J Aramant RB Ehinger B | 1991 | Exp Eye Res1991，51，： | 1 |
| 12 | Selected properties of high- volume fly ash concretes 显示文摘 | Sivasund Aram V Carette G G Malhotra V M | 1990 | Concrete Inst: design con- struction1990，12，10： | 1 |
| 13 | Prognostic classifica- tions of lymph node involvement in lung cancer and current International Association for the Study of Lung Cancer de- scriptive classification in zones 显示文摘 | Riquet M Arame A Foueault C | 2010 | Interact Cardiovasc Tho- rac Surg2010，11，3： | 1 |
| 14 | Cooperative Profit Sharing in Coalition-based Resource Allocation in Wireless Networks 显示文摘 | Singh C Sarkar S Aram A | 2012 | IEEE/ACM Transactions on Networking2012，20，1： | 1 |
| 15 | Networking and growth of young technology-intensive ventures in China显示文摘 | Zhao L and Aram J D | 1995 | Journal of Busi- ness Venturing1995，11，10： | 1 |
| 16 | Optimized dispersive liquid-liquid micro- extraction and determination of sorbic acid and benzoic acid in beverage samples by gas chromatography显示文摘 | Taher Ahmadzadeh Kokya Khalil Farhadi Aram Alimo- hammad Kalhori | 2012 | Food Ana- lytical Methods2012，5，3： | 1 |
| 17 | Effects of angiotensinⅡinfusionand inhibition of nitric oxide synthase on the rat aorta显示文摘 | Kato H Hou J Aram V | 1996 | J Hypertens1996，28，2： | 1 |
| 18 | Requirements for BIM platforms in the concrete reinforcement supply chain显示文摘 | Aram S Eastman C Sacks R | | 0，，： | 1 |
| 19 | IdentificationandexpressionoftroponinT,anewmarkeronthesurfaceofculturedtumorendo-thelialcellsbyaptamerligand显示文摘 | AraM HyodoM OhgaN etal | 2014 | CancerMed2014，3，4： | 1 |
| 20 | Differential lineage restriction of rat retinal progenitor cells in vitro and in vivo显示文摘 | Yang P Seiler MJ Aramant RB Whittemore SR | 2002 | Nerosci Res2002，69，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员