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| 1 | Thymoquinone suppresses migration of Lo Vo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation显示文摘AIM To identify potential anti-cancer constituents in natural extracts that inhibit cancer cell growth and migration.METHODS Our experiments used high dose thymoquinone(TQ) as an inhibitor to arrest Lo Vo(a human colon adenocarcinoma cell line) cancer cell growth, which was detected by cell proliferation assay and immunoblotting assay. Low dose TQ did not significantly reduce Lo Vo cancer cell growth. Cyclooxygenase 2(COX-2) is an enzyme that is involved in the conversion of arachidonic acid into prostaglandin E2(PGE2) in humans. PGE2 can promote COX-2 protein expression and tumor cell proliferation and was used as a control.RESULTS Our results showed that 20 μmol/L TQ significantly reduced human LoV o colon cancer cell proliferation. TQ treatment reduced the levels of p-PI3 K, p-Akt, p-GSK3β, and β-catenin and thereby inhibited the downstream COX-2 expression. Results also showed that the reduction in COX-2 expression resulted in a reduction in PGE2 levels and the suppression of EP2 and EP4 activation. Further analysis showed that TG treatment inhibited the nuclear translocation of β-catenin in LoV o cancer cells. The levels of the cofactors LEF-1 and TCF-4 were also decreased in the nucleus following TQ treatment in a dose-dependent manner. Treatment with low dose TQ inhibited the COX-2 expression at the transcriptional level and the regulation of COX-2 expression efficiently reduced LoV o cell migration. The results were further verified in vivo by confirming the effects of TQ and/or PGE2 using tumor xenografts in nude mice.CONCLUSION TQ inhibits LoV o cancer cell growth and migration, and this result highlights the therapeutic advantage of using TQ in combination therapy against colorectal cancer. | Hsi-Hsien Hsu Ming-Cheng Chen Cecilia Hsuan Day Yueh-Min Lin Shin-Yi Li Chuan-Chou Tu Viswanadha Vijaya Padma Hui-Nung Shih Wei-Wen Kuo Chih-Yang Huang | 2017 | World Journal of Gastroenterology2017，23，7： | 12 |
| 2 | Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats显示文摘Objective:To assess the effect of quercetin(flavonoid) against lindane induced alterations in lipid profile of wistar rats.Methods:Rats were administered orally with lindane(100 mg/kg body weight) and quercetin(10 mg/kg body weight) for 30 days.After the end of treatment period lipid profile was estimated in serum and tissue.Results:Elevated levels of serum cholesterol, triglycerides,low density lipoprotein(LDL),very Low Density Lipoprotein(VLDL) and tissue triglycerides,cholesterol with concomitant decrease in serum HDL and tissue phospholipids were decreased in lindane treated rats were found to be significantly decreased in the quercetin and lindane co-treated rats.Conclusions:Our study suggests that quercetin has hypolipidemic effect and offers protection against lindane induced toxicity in liver by restoring the altered levels of lipids.The quercetin cotreatment along with lindane for 30 days reversed these biochemical alterations in lipids induced by lindane. | Viswanadha Vijaya Padma Gurusamy Lalitha Nichokon Puthanveedu Shirony Rathinasamy Baskaran | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，11： | 9 |
| 3 | Helicobacter pylori eradication in patients with chronic immune thrombocytopenic purpura显示文摘AIM:To assess the effect of Helicobacter pylori(H.pylori)eradication on platelet counts in patients with chronic immune thrombocytopenic purpura(cITP).METHODS:A total of 36 cITP patients were included in the study.The diagnosis of H.pylori was done by rapid urease test and Giemsa staining of the gastric biopsy specimen.All H.pylori positive patients received standard triple therapy for 14 d and were subjected for repeat endoscopy at 6 wk.Patients who continued to be positive for H.pylori on second endoscopyreceived second line salvage therapy.All the patients were assessed for platelet response at 6 wk,3rd and 6th months.RESULTS:Of the 36 patients,17 were positive for H.pylori infection and eradication was achieved in16 patients.The mean baseline platelet count in the eradicated patients was 88615.38±30117.93/mm3and platelet count after eradication at 6 wk,3 mo and6 mo was 143230.77±52437.51/mm3(P=0.003),152562.50±52892.3/mm3(P=0.0001),150187.50±41796.68/mm3(P=0.0001)respectively and in the negative patients,the mean baseline count was71000.00±33216.46/mm3 and at 6 wk,3rd and 6th month follow up was 137631.58±74364.13/mm3(P=0.001),125578.95±71472.1/mm3(P=0.005),77210.53±56892.28/mm3(P=0.684)respectively.CONCLUSION:Eradication of H.pylori leads to increase in platelet counts in patients with cITP and can be recommended as a complementary treatment with conventional therapy. | Ravinder Naik Noonavath Chandrasekharan Padma Lakshmi Tarun Kumar Dutta Vikram Kate | 2014 | World Journal of Gastroenterology2014，20，22： | 6 |
| 4 | Plant-Based Rasayana Drugs from Ayurveda显示文摘Rasayana tantra is one of the eight specialties of Ayurveda.It is a specialized practice in the form of rejuvenative recipes,dietary regimen,special health promoting behaviour and drugs.Properly administered Rasayana can bestow the human being with several benefits like longevity,memory,intelligence,freedom from diseases,youthful age,excellence of luster,complexion and voice,optimum strength of physique and sense organs,respectability and brilliance.Various types of plant based Rasayana recipes are mentioned in Ayurveda. Review of the current literature available on Rasayanas indicates that anti-oxidant and immunomodulation are the most studied activities of the Rasayana drugs.Querying in Pubmed database on Rasayanas reveals that single plants as well as poly herbal formulations have been researched on.This article reviews the basics of Rasayana therapy and the published research on different Rasayana drugs for specific health conditions.It also provides the possible directions for future research. | Subramani Paranthaman Balasubramani Padma Venkatasubramanian Subrahmanya Kumar Kukkupuni Bhushan Patwardhan | 2011 | Chinese Journal of Integrative Medicine2011，17，3： | 6 |
| 5 | Antimicrobial Profile of Lactic Acid Bacteria Isolated from Vegetables and Indigenous Fermented Foods of India against Clinical Pathogens Using Microdilution Method显示文摘In dairy and food industries lactic acid bacteria(LAB)have been used in form of starter culture that plays vital role in fermentation;as flavouring and texturizing or as preservative agents.There is increasing evidence that lactobacilli which inhabit the gastrointestinal tract develop antimicrobial activities and participatein the host’s defence system[1].During fermentation,most of the LAB produces a number of different compounds like organic acids,hydrogen peroxide,diacetyl,acetaldehyde,carbon dioxide,polysaccharides,and proteinaceous compounds called bacteriocins or bacteriocinogenic peptides[2-3].Such metabolites exert antimicrobial activity and | Ami PATEL Nihir SHAH Padma AMBALAM J. B. PRAJAPATI Olle HOLST Asa LJUNGH | 2013 | Biomedical and Environmental Sciences2013，26，9： | 4 |
| 6 | ^137Cs tracing dynamics of soil erosion,organic carbon,and total nitrogen in terraced fields and forestland in the Middle Mountains of Nepal显示文摘The Middle Mountains is one of the regions of Nepal most vulnerable to water erosion, where fragile geology, steep topography, anomalous climatic conditions, and intensive human activity have resulted in serious soil erosion and enhanced land degradation. Based on the 137 Cs tracing method, spatial variations in soil erosion, organic carbon, and total nitrogen(TN) in terraced fields lacking field banks and forestland were determined. Soil samples were collected at approximately 5 m and 20 m intervals along terraced field series and forestland transects respectively. Mean 137 Cs inventories of the four soil cores from the reference site was estimated at 574.33 ± 126.22 Bq m-2(1 Bq(i.e., one Becquerel) is equal to 1 disintegration per second(1 dps)). For each terrace, the 137 Cs inventory generally increased fromupper to lower slope positions, accompanied by a decrease in the soil erosion rate. Along the entire terraced toposequence, 137 Cs data showed that abrupt changes in soil erosion rates could occur between the lower part of the upper terrace and the upper part of the immediate terrace within a small distance. This result indicated that tillage erosion is also a dominant erosion type in the sloping farmland of this area. At the same time, we observed a fluctuant decrease in soil erosion rates for the whole terraced toposequence as well as a net deposition at the toe terrace. Although steep terraces(lacking banks and hedgerows) to some extent could act to limit soil sediment accumulation in catchments, soil erosion in the terraced field was determined to be serious. For forestland, with the exception of serious soil erosion that had taken place at the top of slopes due to concentrated flows from a country road situated above the forestland site, spatialvariation in soil erosion was similar to the 'standard' water erosion model. Soil organic carbon(SOC) and TN inventories showed similar spatial patterns to the 137 Cs inventory for both toposequences investigated. However, due to the different dominant erosion processes between the two, we found similar patterns between the <0.002 mm soil particle size fraction(clay sized) and 137 Cs inventories in terraced fields, while different patterns could be found between 137 Cs inventories and the <0.002 mm soil particle size fraction in the forestland site. Such results confirm that 137 Cs can successfully trace soil erosion, SOC and soil nitrogen dynamics in steep terraced fields and forestland in the Middle Mountains of Nepal. | SU Zheng-an XIONG Dong-hong DENG Wei DONG Yi-fan MA Jing PADMA C Poudel GURUNG B Sher | 2016 | Journal of Mountain Science2016，13，10： | 4 |
| 7 | Adaptive immunity at the crossroads of autophagy and metabolism显示文摘The function of lymphocytes is dependent on their plasticity,particularly their adaptation to energy availability and environmental stress,and their protein synthesis machinery.Lymphocytes are constantly under metabolic stress,and macroautophagy/autophagy is the primary metabolic pathway that helps cells overcome stressors.The intrinsic role of autophagy in regulating the metabolism of adaptive immune cells has recently gained increasing attention.In this review,we summarize and discuss the versatile roles of autophagy in regulating cellular metabolism and the implications of autophagy for immune cell function and fate,especially for T and B lymphocytes. | Shree Padma Metur Daniel J.Klionsky | 2021 | Cellular & Molecular Immunology2021，18，5： | 3 |
| 8 | In Vivo Myocardial Protection From Ischemia/Reperfusion Injury by the Peroxisome Proliferator–Activated Receptor-γ Agonist Rosiglitazone显示文摘 | Tian-li Yue Jun Chen Weike Bao Padma K. Narayanan Antoine Bril Wen Jiang Paul G. Lysko Juan-Li Gu Rogely Boyce Dawn M. Zimmerman Timothy K. Hart Robin E. Buckingham Eliot H. Ohlstein | 2001 | Circulation: Journal of the American Heart Association2001，，21： | 2 |
| 9 | Effect of angiotensin converting enzyme gene I/D polymorphism in South Indian children with nephrotic syndrome显示文摘Nephrotic syndrome is one of the most common childhood kidney diseases. It is mostly found in the age group of 2 to 8 years. Around 10%-15% of nephrotic syndrome cases are non-responders of steroid treatment(SRNS).Angiotensin converting enzyme(ACE)(I/D) gene association studies are important for detecting kidney disease and herein we assessed the association of ACE(I/D) polymorphism with nephrotic syndrome in South Indian children. We recruited 260 nephrotic syndrome(162 boys and 98 girls) and 218(140 boys and 78 girls) control subjects. ACE I/D polymorphism was analyzed by PCR using genotype allele specific primers. In ACE(I/D), we did not find significant association for the ungrouped data of nephrotic syndrome children and the control subjects. Kidney biopsies were done in 86 nephrotic syndrome cases(minimal change disease, n = 51;focal segmental glomerulosclerosis, n = 27;diffuse mesangial proliferation, n = 8). We segregated them into the minimal change disease/focal segmental glomerulosclerosis groups and observed that the ACE’D’ allele was identified with borderline significance in cases of focal segmental glomerulosclerosis and the ’Ⅰ’ allele was assessed as having very weak association in cases of minimal change disease. ’Ⅱ’ genotype was weakly associated with minimal change disease. Gender specific analysis revealed weak association of’ID’ genotype with female nephrotic syndrome in females. Dominant expression of DD genotype was observed in males with nephrotic syndrome. Our finding indicated that ACE(I/D) has moderate association with focal segmental glomerulosclerosis. However, due to the limited number of biopsy proven focal segmental glomerulosclerosis subjects enrolled, further studies are required to confirm these results. | Aravind Selvin Kumar Ramanathan Balakrishnan Karuppiah Murali Vijayan Kamaraj Raju Dhivakar Mani Rathika Chinniah Manikandan Thirunavukkarasu Padma Malini Ravi Jeyaram Illiayaraja Krishnan Prabha Senguttuvan | 2019 | The Journal of Biomedical Research2019，33，3： | 2 |
| 10 | Utility of B-Natriuretic Peptide in Detecting Diastolic Dysfunction: Comparison With Doppler Velocity Recordings显示文摘 | Emily Lubien Anthony DeMaria Padma Krishnaswamy Paul Clopton Jen Koon Radmila Kazanegra Nancy Gardetto Erin Wanner Alan S. Maisel | 2002 | Circulation: Journal of the American Heart Association2002，，5： | 2 |
| 11 | A rapid B-type natriuretic peptide assay accurately diagnoses left ventricular dysfunction and heart failure: A multicenter evaluation显示文摘 | Stacey J. Wieczorek Alan H.B. Wu Robert Christenson Padma Krishnaswamy Stephen Gottlieb Thomas Rosano David Hager Nancy Gardetto Albert Chiu Kathryn R. Ba illy Alan Maisel | 2002 | American Heart Journal2002，，5： | 2 |
| 12 | Utility of B-type natriuretic peptide in the diagnosis of congestive heart failure in an urgent-care setting显示文摘 | Quyen Dao Padma Krishnaswamy Radmila Kazanegra Alex Harrison Rambod Amirnovin Leslie Lenert Paul Clopton Joel Alberto Patricia Hlavin Alan S Maisel | 2001 | Journal of the American College of Cardiology2001，，2： | 2 |
| 13 | Detection of AmpC beta lactamases production in Escherichia coli & Klebsiella by an inhibitor based method 显示文摘 | Hemalatha V Padma M Sekar U | 2007 | Indian J Med Res2007，126，3： | 1 |
| 14 | PET/CT in the evalua- tion of anti-NMDA-receptor encephalitis: What we need to know as a NM physician显示文摘 | Padma S Sundaram PS Marmattom BV | 2011 | IndianJ Nucl Med2011，26，2： | 1 |
| 15 | Despite snags and skepticism,Thai vaccine trial lumbers on显示文摘 | Padma TV | 2004 | Nature medicine2004，10，12： | 1 |
| 16 | Protective effect of Phyllanthus fraternus against thioacetamide induced mitochondrial dysfunction 显示文摘 | Padma R Setty OH | 1997 | J Clinic Biochem Nutri1997，22，2： | 1 |
| 17 | Application of soft computing techniques to induction motor design显示文摘 | S. Padma R. Bhuvaneswari S. Subramanian | 2007 | COMPEL: The International Journal for Computation and Mathematics in Electrical and Electronic Engineering2007，，5： | 1 |
| 18 | Management of obstructive sleep apnea: a dental perspective 显示文摘 | Padma A Ramakrishnan N Narayanan V | 2007 | Indian J Dent Res2007，18，4： | 1 |
| 19 | Protective effect of Phyllanthus fraternus against carbon tetra chloride induced mitochondrial dysfunction 显示文摘 | Padma P Setty OH | 1999 | Life Sci1999，64，25： | 1 |
| 20 | Development of a new steering mechanism for automobiles 显示文摘 | VENKATACHALAM R PADMA R A | 2012 | Advances in Reconfigurable Mechanisms and Robots2012，2012，： | 1 |
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