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| 1 | Contrasting trends of PM2.5 and surface-ozone concentrations in China from 2013 to 2017显示文摘Although much attention has been paid to investigating and controlling air pollution in China,the trends of air-pollutant concentrations on a national scale have remained unclear.Here,we quantitatively investigated the variation of air pollutants in China using long-term comprehensive data sets from 2013 to 2017,during which Chinese government made major efforts to reduce anthropogenic emission in polluted regions.Our results show a significant decreasing trend in the PM2.5 concentration in heavily polluted regions of eastern China,with an annual decrease of〜7%compared with measurements in 2013.The measured decreased concentrations of SO2>NO2 and CO(a proxy for anthropogenic volatile organic compounds)could explain a large fraction of the decreased PM2.5 concentrations in different regions.As a consequence;the heavily polluted days decreased significantly in corresponding regions.Concentrations of organic aerosol;nitrate;sulfate,ammonium and chloride measured in urban Beijing revealed a remarkable reduction from 2013 to 2017;connecting the decreases in aerosol precursors with corresponding chemical components closely.However;surface-ozone concentrations showed increasing trends in most urban stations from 2013 to 2017;which indicates stronger photochemical pollution.The boundary-layer height in capital c让ies of eastern China showed no significant trends over the Beijing-Tianjin-Hebei,Yangtze River Delta and Pearl River Delta regions from 2013 to 2017;which confirmed the reduction in anthropogenic emissions.Our results demonstrated that the Chinese government was successful in the reduction of particulate matter in urban areas from 2013 to 2017,although the ozone concentration has increased significantly;suggesting a more complex mechanism of improving Chinese air quality in the future. | Yonghong Wang Wenkang Gao Shuai Wang Tao Song Zhengyu Gong Dongsheng Ji Lili Wang Zirui Liu Guiqian Tang Yanfeng Huo Shili Tian Jiayun Li Mingge Li Yuan Yang Biwu Chu Tuukka Petaja Veli-Matti Kerminen Hong He Jiming Hao Markku Kulmala Yuesi Wang Yuanhang Zhang | 2020 | National Science Review2020，7，8： | 51 |
| 2 | 基于表面肌电信号变化的慢性下背痛诊断和运动疗效评价显示文摘目的分析研究慢性非特异性下背痛(LBP)患者腰部肌肉活动的sEMG信号特征及其主动运动治疗效应。方法19名正常人对照组和19名非特异性LBP患者分别于主动运动治疗前、后在等惯性力腰部肌肉测试与训练系统上依次完成“等长-动态-等长”运动负荷试验,采集双测L5-S1部位的sEMG信号,计算并比较不同被试者平均肌电值(AEMG)、平均功率频率(MPF)、复杂度[C(n)]和确定性线段百分比(%DET)均值和斜率变化。结果动态运动负荷过程中LBP患者的C(n)下降率明显快于正常人,MPF和C(n)均值明显低于正常人,而%DET均值明显高于正常人;主动运动治疗后,患者MPF和C(n)均值提高,而%DET均值下降。结论运动负荷试验过程中LBP患者腰部肌肉sEMG有多种不同于正常人的信号特征,这些信号特征有望成为LBP诊断和疗效评价的有效指标。 | 王健 方红光 Markku Kankaanpaa | 2005 | 航天医学与医学工程2005，18，4： | 33 |
| 3 | 多重劣化机制作用下混凝土的性能和耐久性(英文)显示文摘基于近年来芬兰VT技术研究中心在混凝土性能和耐久性方面的研究成果,对多重劣化机制共同作用下混凝土耐久性能表现进行了综述。这些研究是建立在30余年来有关混凝土耐久性的研究结果之上,包括15年的现场暴露实验数据,有关混凝土耐久性能是通过实验室加速实验结果和现场暴露实验结果共同评价的。结果显示,实验室的单一因素作用下的混凝土耐久性加速劣化结果与多因素共同作用下的暴露实验和工程现场测试结果有很大的差异。现场测试能够获得较长期的混凝土耐久性结果,这可以用来校准和验证混凝土耐久性和寿命预测模型,并引导继续对多因素共同作用下混凝土的耐久性能进行更全面深入的研究。 | Erika HOLT Miguel FERREIRA Hannele KUOSA Markku LEIVO | 2015 | 硅酸盐学报2015，43，10： | 13 |
| 4 | Gastrointestinal stromal tumors – definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis显示文摘 | Markku Miettinen Jerzy Lasota | 2001 | Virchows Archiv2001，，1： | 8 |
| 5 | Quality of life following laparoscopic Nissen fundoplication: Assessing short-term and long-term outcomes显示文摘AIM: To investigate the quality of life following lapa-roscopic Nissen fundoplication by assessing short-term and long-term outcomes. METHODS: From 1992 to 2005, 249 patients under-went laparoscopic Nissen fundoplication. Short-term outcome data including symptom response, side effects of surgery, endoscopy, and patient's perception of over-all success were collected prospectively. Long-term out-comes were investigated retrospectively in patients witha median follow-up of 10 years by assessment of reflux symptoms, side effects of surgery, durability of antire-flux surgery, need for additional treatment, patient's perception of success, and quality of life. Antireflux sur-gery was considered a failure based on the following criteria: moderate to severe heartburn or regurgitation; moderate to severe dysphagia reported in combination with heartburn or regurgitation; regular proton pump inhibitor medication use; endoscopic evidence of erosive esophagitis Savary-Miller grade 1-4; pathological 24-h pH monitoring; or necessity to undergo an additional surgery. The main outcome measures were short-and long-term cure rates and quality of life, with patient sat-isfaction as a secondary outcome measure. RESULTS: Conversion from laparoscopy to open sur-gery was necessary in 2.4% of patients. Mortality was zero and the 30-d morbidity was 7.6% (95%CI: 4.7%-11.7%). The median postoperative hospital stay was 2 d [interquartile range (IQR) 2-3 d]. Two hundred and forty-seven patients were interviewed for short-term analysis following endoscopy. Gastro-esophageal reflux disease was cured in 98.4% (95%CI: 95.9%-99.6%) of patients three months after surgery. New-onset dysphagia was encountered postoperatively in 13 patients (6.7%); 95% reported that the outcome was better after antireflux surgery than with preopera-tive medical treatment. One hundred and thirty-nine patients with a median follow-up of 10.2 years (IQR 7.2-11.6 years) were available for a long-term evalu-ation. Cumulative long-term cure rates were 87.7% (81.0%-92.2%) at 5 years and 72.9% (64.0%-79.9%) at 10 years. Gastrointestinal symptom rating scores and RAND-36 quality of life scores of patients with treatment success were similar to those of the general population but significantly lower in those with failed antireflux surgery. Of the patients available for long-term follow-up, 83% rated their operation a success. CONCLUSION: For the long-term, our results indicate decreasing effectiveness of laparoscopic antirefluxsurgery, although most of the patients seem to have an overall quality of life similar to that of the general population. | Ilmo Kellokumpu Markku Voutilainen Caj Haglund Martti Frkkil Peter J Roberts Hannu Kautiainen | 2013 | World Journal of Gastroenterology2013，19，24： | 7 |
| 6 | Irritable bowel syndrome symptom severity improves equally with probiotic and placebo显示文摘AIM To determine the effects of Lactobacillus acidophilus NCFM on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS In this randomized triple-blind trial, adult IBS volunteerswho were recruited according to Rome Ⅲ criteria received 109 or 1010 colony-forming units of NCFM or placebo daily for 12 wk. IBS Symptom Severity Score(IBS-SSS), which constituted the primary outcome, and secondary outcomes, including individual IBS symptoms, IBS-related QoL questionnaire, anxiety and depression, defecation frequency, and stool consistency, were assessed at baseline at the end of the 8-wk runin period, after 4 and 12 wk of intervention, and after a 4-wk washout.RESULTS A total of 340 of 391 randomized volunteers completed the trial. IBS-SSS improved over 12 wk of treatment in all treatment groups, decreasing by a mean ± SD of 44.0 ± 80.2, 50.8 ± 82.4, and 48.3 ± 72.2 in the placebo, active low-dose, and active high-dose groups, respectively. Similarly, secondary outcomes did not differ between treatment groups. However, in a post hoc analysis of volunteers with moderate to severe abdominal pain at baseline(VAS > 35/100), the treatment significantly reduced the sensation of abdominal pain. Pain scores fell by 20.8 ± 22.8, 29.4 ± 17.9, and 31.2 ± 21.9 in the placebo, active low-dose, and active high-dose groups, respectively(P value for placebo vs combined active doses = 0.0460).CONCLUSION NCFM alleviates moderate to severe abdominal pain, consistent with earlier observations of this strain mitigating visceral pain through increased analgesic receptor expression. | Anna Lyra Markku Hillila Teppo Huttunen Sofia Mannikko Mikko Taalikka Julia Tennila Anneli Tarpila Sampo Lahtinen Arthur C Ouwehand Lea Veijola | 2016 | World Journal of Gastroenterology2016，22，48： | 7 |
| 7 | Diagnosis of gastrointestinal stromal tumors: A consensus approach显示文摘 | Christopher D.M. Fletcher Jules J. Berman Christopher Corless Fred Gorstein Jerzy Lasota B.Jack Longley Markku Miettinen Timothy J. O’Leary Helen Remotti Brian P. Rubin Barry Shmookler Leslie H. Sobin Sharon W. Weiss | 2002 | Human Pathology2002，，5： | 7 |
| 8 | Vegetation structural characteristics and topographic factors in the remnant moist Afromontane forest of Wondo Genet, south central Ethiopia显示文摘For forest ecosystem management to be effective, knowledge of the horizontal and vertical structural diversity of a forest is essential. The moist Afromontane highlands of Wondo Genet in south-central Ethiopia present an opportunity to restore and rehabilitate and enhance the ecosystem services to be obtained from this forest sustainably. We focused on the forest structural characteristics to better understand the current forest conditions to assist in the sustainable management of this resource. A total of 75 (20 m × 20 m) quadrats were sampled and diameter at breast height (DBH)≥2 cm and stem height≥2 m were measured. Species identity and abundance, elevation, slope, and aspect were recorded for each plot. Structural characteristics were computed for each plot. Relationship of topographic factors with vegetation characteristics was conducted using R-Software. A total of 72 woody species was recorded. Whereas, the overall diameter distribution shows an inverted J-shaped curve, the basal area followed a bell-shaped pattern. Five types of population structures are revealed. The mean tree density and basal area was 397.3 stems ha-1 and 31.4 m2·ha-1 , respectively. Only 2.8% of the tree species have densities of≥25 stems ha-1 and the percentage distribution of trees show 56.2% in the DBH class 2-10 cm, indicating that the forest is dominated by medium-sized trees. Celtis africana (8.81 m2·ha-1 ) and Pouteria adolfi-friedericii (5.13 m2·ha-1 ) make the highest contribution to the basal area and species importance value index. The families/species with the highest importance value index are Ulmaceae, Fabacea and Sapotaceae. Species abundance (r2 = 0.32, p <0.001) and species richness (r2 =0.50, p <0.001) are positively related with tree density. Tree density is negatively related with elevation (r2 = -0.36, p <0.001), slope (r2 =-0.15, p <0.001) and aspect (r2 = -0.07, p <0.05). While basal area is negatively related with elevation (r2 =-0.14, p <0.001), it has a positive relationship with tree density (r2 =0.28, p <0.001 and species richness (r2 =0.098). Species with poor population structure should be assisted by restoration tasks and further anthropogenic disturbance such as illegal logging and fuel wood extraction should be restricted. | Mamo Kebede Markku Kanninen Eshetu Yirdaw Mulugeta Lemenih | 2013 | Journal of Forestry Research2013，24，3： | 6 |
| 9 | Gastrointestinal stromal tumors: Pathology and prognosis at different sites显示文摘 | Markku Miettinen Jerzy Lasota | 2006 | Seminars in Diagnostic Pathology2006，，2： | 5 |
| 10 | 中国农林复合经营系统的现状及其未来潜力显示文摘在中国,主要的农林复合经营系统占地大约4500万 hm^2。主要的经营模式是农林复合经营。淡水养殖林业复合经营如林-渔-次作物及林-渔-畜禽复合系统是湿地的土地利用方式。林牧复合系统在北部和西部地区很普遍。与单一栽培模式相比,经营良好的系统会产生许多效益。残留物的再循环可望能提高自然资源的有效利用。中国主要的农林复合经营系统中植被的碳汇达179Tg/a。据报道,农林复合经营对土壤保护和生物多样性有积极的影响作用。限制农林复合经营的主要因素在于因缺少技术支持而使大多数系统管理水平低下。尽管如此,中国农林复合经营具有巨大的发展潜力。本文提出了一些农林复合经营中有关政策取向、技术支持、推广及市场开发的建议。 | 黄文丁 Markku Kanninen 许其芬 黄宝龙 王燕 | 1997 | 人类环境杂志1997，26，6： | 4 |
| 11 | Frequency and Clinical Determinants of Poststroke Depression显示文摘 | Tarja Pohjasvaara Antero Leppavuori Irina Siira Risto Vataja Markku Kaste Timo Erkinjuntti | 1998 | Stroke: A Journal of Cerebral Circulation1998，，11： | 4 |
| 12 | Musa chunii Hkkinen,a new species (Musaceae) from Yunnan,China and taxonomic identity of Musa rubra显示文摘The center of diversity of the genus Musa (Musaceae) is in Southeast Asia, a region not studied in detail and where new species and varieties continue to be reported. A new wild banana species, M. chunii Hkkinen from Yunnan, China is described and illustrated based on observed morphological characteristics in the field. This extremely rare new species was only found in Tongbiguan Nature Reserve, Dehong District, West Yunnan. A key to M. chunii and related taxa is provided. In addition, critical notes regarding M. rubra Kurz identity are given. | Markku HKKINEN | 2009 | Journal of Systematics and Evolution2009，47，1： | 4 |
| 13 | Post-ERCP pancreatitis: Reduction by routine antibiotics显示文摘 | Sari R?ty M.D. Juhani Sand M.D. Markku Pulkkinen S.R.N. Martti Matikainen M.D. Isto Nordback M.D | 2001 | Journal of Gastrointestinal Surgery2001，，4： | 3 |
| 14 | Gastrointestinal stromal tumors – definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis显示文摘 | Markku Miettinen Jerzy Lasota | 2001 | Virchows Archiv2001，，1： | 3 |
| 15 | Long-term observation of air pollution-weather/climate interactions at the SORPES station: a review and outlook显示文摘 | Aijun Ding Wei Nie Xin Huang Xuguang Chi Jianning Sun Veli-Matti Kerminen Zheng Xu Weidong Guo Tuukka Petaja Xiuqun Yang Markku Kulmala Congbin Fu | 2016 | Frontiers of Environmental Science & Engineering2016，10，5： | 3 |
| 16 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 17 | A taxonomic revision of Musa aurantiaca (Musaceae) in Southeast Asia显示文摘Since the initial description, the name Musa aurantiaca Baker (1893) has been unclear to most botanists. The aim of this study is to settle its true identity and to update the description. The plant is distributed in the regions of Upper Assam and Arunachal Pradesh, India, Northern Myanmar and Tibet, China where it occurs commonly but it is not mentioned in Chinese literature at all. In this paper, the authors also review the description and the literature history of M. aurantiaca from 1893 to the present. Musa aurantiaca Baker is typified here. | Markku HKKINEN Henry VRE | 2008 | 植物分类学报2008，46，1： | 3 |
| 18 | 服用抗氧化剂降低老年人血清脂质过氧化物——随机双盲临床试验显示文摘给某老年人护理院的45位老人服用β-胡萝卜素,维生素B_6,维生素C,维生素E,锌和硒,或者相应的安慰剂作为日常食物的补充,为期一年。开始时,这些老年人的血清脂质过氧化物水平(2.7±0.7μmol/L)高于作为对照组的年轻健康成年人(2.3±0.6μmol/L),P<0.01。服药三个月后,老年人的血清脂质过氧化物已降至2.2±0.6μmol/L,并且保持这一低水平直到研究结束,而服安慰剂者血清脂质过氧化物无变化。 血清脂质过氧化物与全血硒浓度呈显著负相关(r=-0.428,P<0.01),但只有在血硒高于200μg/L时才可见血清脂质过氧化物的降低。血清α-维生素E浓度也与血清脂质过氧化物呈负相关,但相关程度(r=-0.273,P<0.76)低于与血硒间的相关。 从生物化学角度看,25%的老年人可观察到维生素B_6缺乏;每天补充2mg维生素B_6彻底治愈了全部的病例。服药组经几项心理学检验有轻微改善,而服用安慰剂的对照组无变化或者恶化。护士报告在服药组中见有临床改善,未见有毒性副作用。老年人服用抗氧化剂从生物化学和临床上都是有益的。 | Matti Tolonen Seppo Sarna Tuomas Westermarck Markku Halme Ulla-Riitta Nordberg Mirja Keinonen Jaap Schrijver Seppo E.J.Tuominen 杨旭冬 | 1989 | 营养学报1989，11，1： | 3 |
| 19 | On secondary new particle formation in China显示文摘新大气的喷雾器粒子的形成是被观察了发生在甚至重重地弄脏的环境的全球现象。然而,在所有环境,看起来是冷凝作用水池的阀值价值(由于先存在喷雾器粒子) 在哪个以后 3 个 nm 粒子的形成率不再被检测。在中国,新粒子生产在很高的污染层次被观察了(冷凝作用水池在几个大城市,包括的北京,上海和南京以及在珀尔河三角洲(PRD ) 的大约 0.1 s -1) 。这里,我们总结从这些研究获得的最近的调查结果并且讨论这些调查结果将在未来研究和政策上有的各种各样的含意。 | Markku Kulmala Tuukka Petaja Veli-Matti Kerminen Joni Kujansuu Taina Ruuskanen Aijun Ding Wei Nie Min HU Zhibin Wang Zhijun Wu Lin Wang Douglas R. Worsnop | 2016 | Frontiers of Environmental Science & Engineering2016，10，5： | 3 |
| 20 | Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): a review显示文摘 | Markku Miettinen Mourad Majidi Jerzy Lasota | 2003 | European Journal of Cancer2003，，： | 3 |
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