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| 1 | 急性缺血性卒中静脉阿替普酶溶栓治疗的纳入和排除标准的科学依据美国心脏协会/美国卒中协会对医疗卫生专业人员发布的声明(续前)显示文摘19 颅内出血史
根据最初的 FDA 标签和2013年AHA/ASA指南,颅内出血史是静脉阿替普酶治疗缺血性卒中的一项额外禁忌证或排除标准。最近修订后的标签仅将近期 ICH 列为一项警告,并且在禁忌证中删除了ICH史。与前面讨论的静脉阿替普酶治疗排除标准相似,文献回顾仅在大样本回顾性研究中发现了少量这类病例。缺乏相关数据可能是修订后的FDA 标签不再将 ICH 史作为禁忌证而仅将近期ICH 列为一项警告的原因。在这种情况下,FDA 如何定义“近期”一词尚不清楚。有趣的是,对在静脉阿替普酶治疗前通过 MRI 检测脑微出血( cerebral microbleed, CMBs)存在情况进行的研究可为这个卒中亚组患者提供更多的见解。从病理生理学角度,这种微出血的原因尚不清楚,可能反映再灌注损伤或脑血管自动调节功能破坏。因此,在静脉阿替普酶治疗后出现这些损害可能没有意义或是人为信号。 | Dawn O. Kleindorfer Opeolu M. Adeoye Andrew M. Demchuk Jennifer E. Fugate James C. Grotta Alexander A. Khalessi Elad I. Levy Yuko Y. Palesch Shyam Prabhakaran Gustavo Saposnik Jeffrey L. Saver Eric E. Smith 高圆圆 顾雨铖 徐欣 徐曼曼 张佳慧 李韶雅 冒萧萧 陈歆 徐运 | 2016 | 国际脑血管病杂志2016，24，5： | 98 |
| 2 | Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging. | Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert | 2022 | Stroke & Vascular Neurology2022，7，2： | 7 |
| 3 | Defining hematoma expansion in intracerebral hemorrhage: Relationship with patient outcomes显示文摘 | D. Dowlatshahi A.M. Demchuk M.L. Flaherty M. Ali P.L. Lyden E.E. Smith | 2011 | Neurology2011，，14： | 2 |
| 4 | Accuracy and criteria for localizing arterial occlusion with transcranial Doppler 显示文摘 | Demchuk AM Christou L Wein TH | 2000 | Neuroimaging2000，10，1： | 1 |
| 5 | Rebleeding leads to poor outcome in ultra-early craniotomy for incracerebral hemorrhage显示文摘 | Morgenstem LB Demchuk AM Kim DH | 2001 | Neurology2001，56，5： | 1 |
| 6 | Pre- diction of haematoma growth and outcome in patients with in- tracerebral haemorrhage using the CT-angiography spot sign (PREDICT) a prospective observational study显示文摘 | Demchuk A M Dowlatshahi D Rodriguez Luna D | 2012 | Lancet Neu- rol2012，11，4： | 1 |
| 7 | Thrombolysis in brain ischemia (TIBI) transcranial Doppler flow grades predict clinical severity, early recovery, and mortality in patients treated with intravenous tissue plasminogen activator 显示文摘 | Demchuk AM Burgin WS Christou I | 2001 | Stroke2001，32，： | 1 |
| 8 | High rate of complete recanalization and dramatic clinical recovery during tpA infusion when continuously monitored with 2 - WHz transcranial doppler monitoring显示文摘 | ALexandrov AV Demchuk AM Felberg RA | 2000 | Stroke2000，31，： | 1 |
| 9 | Accuracy and criteria for localizing arterial occlusion with transcranial Doppler显示文摘 | Demchuk AM Christou I Wein TH | 2000 | J Neuroimaging2000，10，1： | 1 |
| 10 | Noninvasive imaging is improving but digital subtraction angiography remains the Gold standard显示文摘 | Hill HD Demchuk AM Frayne R | 2007 | Neurology2007，68，： | 1 |
| 11 | Noninvasive imaging is improving but digital subtraction angiography remains the gold standard显示文摘 | Hill MD Demchuk AM Frayne R | 2007 | Neurology2007，68，24： | 1 |
| 12 | Early clinical and radiological predictors of fatal brain swelling in ischemic stroke显示文摘 | Krieger DW Demchuk AM Kasner SE | 1999 | Stroke1999，30，： | 1 |
| 13 | Hyperfibrinogenemia and Functional Outcome From Acute Ischemic Stroke显示文摘 | Gregory J. del Zoppo David E. Levy Warren W. Wasiewski Arthur M. Pancioli Andrew M. Demchuk James Trammel Bart M. Demaerschalk Markku Kaste Gregory W. Albers Eric B. Ringelstein | 2009 | Stroke2009，，5： | 1 |
| 14 | Carbon-nanofibre-reinforced poly(ether ether ketone) composites显示文摘 | Jan Sandler Philipp Werner Milo S.P Shaffer Vitaly Demchuk Volker Altst?dt Alan H Windle | 2002 | Composites Part A2002，，8： | 1 |
| 15 | Building a'brain attack'eam to administer thrombolytic therapy for acute ischemic stroke显示文摘 | Barber P A Demchuk A M | 2000 | CMAJ2000，162，11： | 1 |
| 16 | Vscoelastic properties of magnetorheological elastomers in the regime of dynamic deformation显示文摘 | Demchuk S A Kuz'min V A | 2002 | Journal of Engineering Physics and Thermophysics2002，75，2： | 1 |
| 17 | Pre- dictors of fatal brain oedema in massive hemispheric isehemic stroke显示文摘 | KASNER S E DEMCHUK A M BERROUSCHOT J | 2001 | Stroke2001，32，9： | 1 |
| 18 | Accuracy and criteria for localizing arterial occlusion with trans-cranial Doppler显示文摘 | Demchuk AM Christou I Wein TH | | 0，，01： | 1 |
| 19 | Emergency Noninvasive Angiography for Acute Intracerebral Hemorrhage显示文摘 | H. Khosravani S.A. Mayer A. Demchuk B.S. Jahromi D.J. Gladstone M. Flaherty J. Broderick R.I. Aviv | 2013 | American Journal of Neuroradiology2013，，8： | 1 |
| 20 | Rebleeding leads to poor outcome in ultra-early craniotomy for intracerebral hemorrhage显示文摘 | Morgenstern LB Demchuk AM Kim DH | 2001 | Neurology2001，56，10： | 1 |
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