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| 1 | Small artery structure and hypertension: adaptive changes and target organ damage显示文摘 | Ashley S Izzard Damiano Rizzoni Enrico Agabiti-Rosei Anthony M Heagerty | 2005 | Journal of Hypertension2005，，2： | 5 |
| 2 | Oxidative stress-mediated effects of angiotensin Ⅱ in the cardiovascular system显示文摘Angiotensin Ⅱ(Ang Ⅱ), an endogenous peptide hormone, plays critical roles in the pathophysiological modulation of cardiovascular functions. Ang Ⅱ is the principle effector of the renin-angiotensin system for maintaining homeostasis in the cardiovascular system, as well as a potent stimulator of NAD(P)H oxidase, which is the major source and primary trigger for reactive oxygen species(ROS) generation in various tissues. Recent accumulating evidence has demonstrated the importance of oxidative stress in Ang Ⅱ-induced heart diseases. Here, we review the recent progress in the study on oxidative stress-mediated effects of Ang Ⅱ in the cardiovascular system. In particular, the involvement of Ang Ⅱ-induced ROS generation in arrhythmias, cell death/heart failure, ischemia/reperfusion injury, cardiac hypertrophy and hypertension are discussed. Ca2+/calmodulin-dependent protein kinase Ⅱ is an important molecule linking Ang Ⅱ, ROS and cardiovascular pathological conditions. | Hairuo Wen Judith K Gwathmey Lai-Hua Xie | 2012 | World Journal of Hypertension2012，2，4： | 3 |
| 3 | Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”显示文摘Uncontrolled high blood pressure is a major risk factor for heart attack, stroke, and kidney failure and contributes to an estimated 25% of deaths worldwide. Despite numerous treatment options, estimates project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Improvements in the detection and management of hypertension will undoubtedly be accomplished through a better understanding of the complex etiology of this disease and a more comprehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(primarily in pre-clinical models) indicate that the small GTPase Rho A and its downstream target, Rho kinase, play an important role in regulating BP homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current(albeit limited) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients. | Xue Bai Rachel Dee Kevin D Mangum Christopher P Mack Joan M Taylor | 2016 | World Journal of Hypertension2016，6，1： | 3 |
| 4 | Pulse pressure and aortic pulse wave are markers of cardiovascular risk in hypertensive populations显示文摘 | Roland Asmar Annie Rudnichi Jacques Blacher Gérard M London Michel E Safar | 2001 | American Journal of Hypertension2001，，2： | 3 |
| 5 | Relationship between splanchnic vasodilation and postprandial hypotension in patients with primary autonomic failure显示文摘 | Jaspal S. Kooner Sarah Raimbach Laura Watson Roger Bannister Stanley Peart Christopher J. Mathias | 1989 | Journal of Hypertension1989，，： | 2 |
| 6 | Reduced levels of N-terminal-proatrial natriuretic peptide in hypertensive patients with metabolic syndrome and their relationship with left ventricular mass显示文摘 | Speranza Rubattu Sebastiano Sciarretta Giuseppino Massimo Ciavarella Vanessa Venturelli Paola De Paolis Giuliano Tocci Luciano De Biase Andrea Ferrucci Massimo Volpe | 2007 | Journal of Hypertension2007，，4： | 2 |
| 7 | Role of oxidative stress in cardiovascular diseases显示文摘 | Naranjan S. Dhalla Rana M. Temsah Thomas Netticadan | 2000 | Journal of Hypertension2000，，6： | 2 |
| 8 | The β-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke显示文摘 | Christa Th?ne-Reineke Christian Neumann Pawel Namsolleck Kristin Schmerbach Maxim Krikov Jan H Schefe Kristin Lucht Heide H?rtnagl Michael Godes Susanne Müller Kay Rumschüssel Heiko Funke-Kaiser Arno Villringer U Muscha Steckelings Thomas Unger | 2008 | Journal of Hypertension2008，，12： | 2 |
| 9 | Regression of cardiovascular remodeling in hypertension:Novel relevant mechanisms显示文摘Asymptomatic organ damage due to progressive kidney damage, cardiac hypertrophy and remodeling put hypertensive patients at high risk for developing heart and renal failure, myocardial infarction and stroke. Current antihypertensive treatment normalizes high blood pressure, partially reverses organ damage, and reduces the incidence of heart and renal failure. Activation of the renin-angiotensin system(RAS) is a primary mechanism of progressive organ damage and, specifically, a major cause of both renal and cardiovascular fibrosis. Currently, inhibition of the RAS system [mainly with angiotensin I converting enzyme inhibitors or angiotensin II(Ang II) receptor antagonists] is the most effective antihypertensive strategy for normalizing blood pressure and preventing target organ damage. However, residual organ damage and consequently high risk for cardiovascular events and renal failure still persist. Accordingly, in hypertension, it is relevant to develop new therapeutic perspectives, beyond reducing blood pressure to further prevent/reduce target organ damage by acting on pathways that trigger and maintain cardiovascular and renal remodeling. We review here relevant novel mechanisms of target organ damage in hypertension, their role and evidence in prevention/regression of cardiovascular remodeling and their possible clinical impact as well. Specifically, we focus on the signaling pathway Rho A/Rho kinase, on the impact of the vasodilatory peptides from the RAS and some insights on the role of estrogens and myocardial chymase in cardiovascular hypertensive remodeling. | Jorge E Jalil María P Ocaranza | 2016 | World Journal of Hypertension2016，6，1： | 2 |
| 10 | Ambulatory blood pressure monitoring and development of cardiovascular events in high-risk patients included in the Spanish ABPM registry: the CARDIORISC Event study显示文摘 | Alejandro de la Sierra José R. Banegas Julián Segura Manuel Gorostidi Luis M. Ruilope | 2012 | Journal of Hypertension2012，，4： | 2 |
| 11 | Orthostatic hypotension: a common, serious and underrecognized problem in hospitalized patients显示文摘 | Carlos Feldstein Alan B. Weder | 2012 | Journal of the American Society of Hypertension2012，，1： | 2 |
| 12 | Effects of prostaglandin E1α cyclodestrin treatment on endothelial dysfunction in patients with systemic sclerosis显示文摘 | Cristina Giannattasio MariaRosa Pozzi Marco Gradinali Elisabetta Montemerlo Francesca Citterio Silvia Maestroni Elena Fantini Monica Failla Maria Robuschi Salvatore Bianco Giuseppe Mancia | 2007 | Journal of Hypertension2007，，4： | 2 |
| 13 | Tempol Attenuates the Development of Hypertensive Renal Injury in Dahl Salt-Sensitive Rats显示文摘 | Ryohei Hisaki Hirotaka Fujita Fumio Saito Toshio Kushiro | 2005 | American Journal of Hypertension2005，，5： | 2 |
| 14 | Geographic variations in the prevalence, awareness, treatment and control of hypertension in China显示文摘 | Kristi Reynolds Dongfeng Gu Paul Muntner Xigui Wu Jing Chen Guanyong Huang Xiufang Duan Paul K Whelton Jiang He | 2003 | Journal of Hypertension2003，，7： | 2 |
| 15 | Association of high-sensitivity C-reactive protein with carotid artery intima-media thickness in hypertensive older adults显示文摘 | Moatassem S. Amer Amal E. Elawam Mohamed S. Khater Omar H. Omar Randa A. Mabrouk Hend M. Taha | 2011 | Journal of the American Society of Hypertension2011，，5： | 2 |
| 16 | Endocrine hypertension:An overview on the current etiopathogenesis and management options显示文摘Endocrine causes of secondary hypertension include primary aldosteronism,pheochromocytoma,cushing's syndrome,hyperparathyroidism and hypo-and hyperthyroidism.They comprise 5%-10% of the causes of secondary hypertension.Primary hyperaldosteronism,the most common of the endocrine cause of hypertension often presents with resistant or difficult to control hypertension associated with either normo-or hypokalemia.Pheochromocytoma,a great mimicker of many conditions,is associated with high morbidity and mortality if left untreated.A complete history including pertinent family history,physical examination along with a high index of suspicion with focused biochemical and radiological evaluation is important to diagnose and effectively treat these conditions.The cost effective targeted genetic screening for current known mutations associated with pheochromocytoma are important for early diagnosis and management in family members.The current review focuses on the most recent evidence regarding causes,clinical features,methods of diagnosis,and management of these conditions.A multidisciplinary approach involving internists,endocrinologists and surgeons is recommended in optimal management of these conditions. | Reena M Thomas Ewa Ruel Prapimporn Ch Shantavasinkul Leonor Corsino | 2015 | World Journal of Hypertension2015，5，2： | 2 |
| 17 | Reninoma: case report and literature review显示文摘 | Lara Wong Thomas HS Hsu Mark G Perlroth Lawrence V Hofmann Claudia M Haynes Laurence Katznelson | 2008 | Journal of Hypertension2008，，2： | 2 |
| 18 | Diabetic patients and kidney protection: an attainable target显示文摘 | David Barit Mark E Cooper | 2008 | Journal of Hypertension2008，，： | 2 |
| 19 | Clinical implication of hematological indices in the essential hypertension显示文摘Prognostic value of haematological indices,especially red cell distribution width,neutrophil lymphocyte ratio and mean platelet volume,was reported with numerous investigations in miscellaneous cardiovascular settings.Their major prognostic value was linked to oxidative stress and inflammation since their level was correlated with major inflammatory markers such as high sensitive C-reactive protein and interleukins.Oxidative stress and chronic inflammation are also postulated as the main pathophysiologic mechanism of essential hypertension(HT) and its vascular complication.Recently,correlation between HT and haematological parameters was searched in numerous studies,which has made the topic more popular.Herein,we reveal the correlation between haematological indices and HT and we also demonstrate the clinical implication of this correlation.Impaired haematological parameters may strongly indicate hypertensive end-organ damage. | Ahmet Karabulut Aytac Karadag | 2015 | World Journal of Hypertension2015，5，2： | 2 |
| 20 | Obesity, Alcohol Consumption and Blood Pressure in Australian Men and Women The National Heart Foundation of Australia Risk Factor Prevalence Study显示文摘 | Stephen W. MacMahon Ralph B. Blacket Graham J. Macdonald Wayne Hall | 1984 | Journal of Hypertension1984，，1： | 2 |
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