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| 1 | Diffusion-weighted MRI in a liver protocol: Its role in focal lesion detection显示文摘AIM: To evaluate the role of diffusion-weighted imaging (DWI) in the detection of focal liver lesions (FLLs), using a conventional magnetic resonance imaging (MRI) protocol. METHODS: Fifty-two patients (22 males, average age 55.6 years, range: 25-82 years), studied using a 1.5 Tesla magnetic resonance scanner, were retrospectively analyzed; detection of FLLs was evaluated by considering the number of lesions observed with the following sequences: (1) respiratory-triggered diffusion-weighted single-shot echo-planar (DW SS-EP) sequences; (2) fat-suppressed fast spin-echo (fs-FSE) T2 weighted sequences; (3) steady-state free precession (SSFP) images; and (4) dynamic triphasic gadolinium-enhanced images, acquired with three-dimensional fast spoiled gradient-echo (3D FSPGR). Two radiologists independently reviewed the images: they were blinded to their respective reports. DW SS-EP sequences were compared to fs-FSE, SSFP and dynamic gadolinium-enhanced acquisitions using a t -test. Pairs were compared for the detection of: (1) all FLLs; (2) benign FLLs; (3) malignant FLLs; (4) metastases; and (5) hepatocellular carcinoma (HCC). RESULTS: Interobserver agreement was very good (weighted = 0.926, CI = 0.880-0.971); on the consensus reading, 277 FLLs were detected. In the comparison with fs-FSE, DW SS-EP sequences had a significantly higher score in the detection of all FLLs, benign FLLs, malignant FLLs and metastases; no statistical difference was observed in the detection of hepatocellular carcinoma (HCCs). In the comparison with SSFP sequences, DW SS-EP had significantly higher scores (P < 0.05) in the detection of all lesions, benign lesions, malignant lesions, metastases and HCC. All FLLs were better detected by dynamic 3D FSGR enhanced acquisition, with P = 0.0023 for reader 1 and P = 0.0086 for reader 2 in the comparison with DW SS-EP sequences; with reference to benign FLLs, DW SS-EP showed lower values than 3D FSPGR enhanced acquisition (P < 0.05). No statistical differences were observed in the detection of malignant lesions and metastases; considering HCCs, a very slight difference was reported by reader 1 (P = 0.049), whereas no difference was found by reader 2 (P = 0.06). CONCLUSION: In lesion detection, DWI had higher scores than T2 sequences; considering malignant FLLs, no statistical difference was observed between DWI and dynamic gadolinium images. | Stefano Palmucci Letizia Antonella Mauro Martina Messina Brunella Russo Giovanni Failla Pietro Milone Massimiliano Berretta Giovanni Carlo Ettorre | 2012 | World Journal of Radiology2012，4，7： | 11 |
| 2 | The Or Gene Enhances Carotenoid Accumulation and Stability During Post-Harvest Storage of Potato Tubers显示文摘在主食庄稼的维生素原 A 类胡萝卜素不在存储期间是很稳定的,他们的损失损害营养的质量。阐明位于类胡萝卜素累积和稳定性下面的基本机制,我们调查了表示了花椰菜橘子的转基因的土豆 tubers (或) 基因。我们发现 Or transgene 不仅支持了叶红素水平的保留,而且连续地在冷存储的 5months 期间刺激了它的累积。相反,类胡萝卜素的增加的层次都没在存储的一样的时期期间在向量唯一的控制或一个黄肉的变化的 tubers 被观察。增加的类胡萝卜素累积被发现与扣押的 lipoproteincarotenoid 的形成被联系结构,以及与提高的许多 phytoene synthase,在类胡萝卜素 biosynthetic 小径的关键酶。而且,存储的维生素原 A 类胡萝卜素被显示在模仿的消化期间稳定并且为由人的肠的吸收性的房间的举起可存取。Proteomic 分析识别了蛋白质的三个主要的功能的组(即热吃惊蛋白质, glutathione-S-transferases,和糖类新陈代谢的蛋白质) 那在或调整类胡萝卜素累积是潜在地重要的。我们的结果证明类胡萝卜素隐遁能力的那条规定是类胡萝卜素稳定性被调整的重要机制。我们的调查结果建议在主食庄稼的合适的水池结构形成的那正式就职可以向庄稼提供在植物生长和收获以后的存储期间支持或稳定维生素原 A 累积的一个唯一的能力。 | Li Li Yong Yang Qiang Xu Katherine Owsiany Ralf Welsch Chureeporn Chitchumroonchokchai Shan Lu Joyce Van Eck Xiu-Xin Deng Mark Failla Theodore W. Thannhauser | 2012 | Molecular Plant2012，5，2： | 8 |
| 3 | Effects of prostaglandin E1α cyclodestrin treatment on endothelial dysfunction in patients with systemic sclerosis显示文摘 | Cristina Giannattasio MariaRosa Pozzi Marco Gradinali Elisabetta Montemerlo Francesca Citterio Silvia Maestroni Elena Fantini Monica Failla Maria Robuschi Salvatore Bianco Giuseppe Mancia | 2007 | Journal of Hypertension2007，，4： | 2 |
| 4 | Alterations radial artery compliance in patients with congestive heart failure显示文摘 | Failla M Stella ML | 1995 | Am J Cardiol1995，76，： | 1 |
| 5 | Granulocyle/macrophage colonystimulating factor treatment of human chronic ulcers promotes angiogenesis associated with de novo vascular endothelial growth factor transcription in the ulcer bed显示文摘 | Cianfarani F Tommasi R Failla CM | 2006 | Br J Dcrmatol2006，154，1： | 1 |
| 6 | Redesigning the substrate specificity of the hepatitis C virus NS3 protease显示文摘 | Failla C Pizzi E | 1996 | Folding Design1996，1，： | 1 |
| 7 | Altered intercellular in lung fibroblast cultures from patients with idiopathic pulmonary fibrosis显示文摘 | Trovato-Salinaro A Trovato-Salinaro E Failla M | 2006 | Respir Res2006，27，7： | 1 |
| 8 | Carotid and aortic distensibility in congestive heart failure:Effects of high-dose angiotensin-converting enzyme inhibitor or low-dose association with angiotensin type Ⅰ receptor blockade显示文摘 | Achilli F Failla M | 2002 | J Am Coll Cardiol2002，39，： | 1 |
| 9 | Granulocyte/macrophage colony-stimu-lating factor treatment of human chromic ulcers promotes angiogenesis associated with de novo vascular endothelial growth faeeor transcription in the ulcer bed显示文摘 | Cianfarani F Tommasi R Failla CM | 2006 | Br J Dermatol2006，154，1： | 1 |
| 10 | Impact of the stage of ripening and dietary fat on in vitro bioaccessibility ofβ- carotene in 'ataulfo mango显示文摘 | Ornelas-Paz J D J Failla M L Yahia E M et aI | 2008 | Journal of Agricultural and Food Chemistry2008，56，4： | 1 |
| 11 | IL- 113 associations with posttraumatic epilepsy development: A geneties and biomarker co- hort study显示文摘 | Diamond ML Ritter AC Failla MD | 2015 | Epilepsia2015，56，7： | 1 |
| 12 | Linear Viscoelasticity and Structure of Polypropylene-montmorillonite Nanocomposites显示文摘 | Rohlmann C O Failla M D Quinzani L M | 2006 | Polymer2006，，47： | 1 |
| 13 | Transport and metabolism of equol by Caco-2 human intestinal cells 显示文摘 | WALSH K R FAILLA M L | 2009 | Agric Food Chem2009，57，： | 1 |
| 14 | Relative bioavailability of β-carotene from supplement sources显示文摘 | FULLER C J BUTTERFOSS D N FAILLA M L | 2001 | Nutr Res2001，21，： | 1 |
| 15 | Al-tered intercellular communication in lung fibroblast cul- tures from patients with idiopathic pulmonary fibrosis 显示文摘 | TROVATO S A TROVATO S E FAILLA M | 2006 | Respiratory Research2006，27，7： | 1 |
| 16 | Wavelets : Theoretical concepts and vibrations related applications 显示文摘 | SPANONS POL D FAILLA | 2005 | Shock & Vibration Digest2005，37，5： | 1 |
| 17 | Steroid versus placebo injection for trigger finger显示文摘 | Murphy D Failla J M Koniuch MP | 1995 | J Hand Surg(Am)1995，20，： | 1 |
| 18 | Sequence analysis and expression of the hostproteetive immunogen VP2 of a variant strain of infectious bursal disease virus which can circumvent vaccination with standard type I strains 显示文摘 | Heine H G Haritou M Failla P | 1991 | J Gen Virol1991，72，： | 1 |
| 19 | Sequence analysis and expression of the host-protective immunogen VP2 of a variant strain of infectious bursal disease virus which can circumvent vaccination with standard type I strains 显示文摘 | Heine H G Haritou M Failla P | 1991 | J Gen Virol1991，72，8： | 1 |
| 20 | Injection accuracy andclinical relief of de Quervain's tendinitis显示文摘 | Zhingas C Failla J M Van Holsbeeck M | 1998 | J Hand surg(Am)1998，23，： | 1 |
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