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| 1 | Gastric emptying, postprandial blood pressure, glycaemia and splanchnic flow in Parkinson's disease显示文摘AIM: To determine gastric emptying, blood pressure, mesenteric artery blood flow, and blood glucose responses to oral glucose in Parkinson's disease. METHODS: Twenty-one subjects(13 M, 8 F; age 64.2 ± 1.6 years) with mild to moderate Parkinson's disease(Hoehn and Yahr score 1.4 ± 0.1, duration of known disease 6.3 ± 0.9 years) consumed a 75 g glucose drink, labelled with 20 MBq 99mTc-calcium phytate. Gastric emptying was quantified with scintigraphy, blood pressure and heart rate with an automated device, superior mesenteric artery blood flow by Doppler ultrasonography and blood glucose byglucometer for 180 min. Autonomic nerve function was evaluated with cardiovascular reflex tests and upper gastrointestinal symptoms by questionnaire. RESULTS: The mean gastric half-emptying time was 106 ± 9.1 min, gastric emptying was abnormally delayed in 3 subjects(14%). Systolic and diastolic blood pressure fell(P < 0.001) and mesenteric blood flow and blood glucose(P < 0.001 for both) increased, following the drink. Three subjects(14%) had definite autonomic neuropathy and 8(38%) had postprandial hypotension. There were no significant relationships between changes in blood pressure, heart rate or mesenteric artery blood flow with gastric emptying. Gastric emptying was related to the score for autonomic nerve function(R = 0.55, P < 0.01). There was an inverse relationship between the blood glucose at t = 30 min(R =-0.52, P < 0.05), while the blood glucose at t = 180 min was related directly(R = 0.49, P < 0.05), with gastric emptying. CONCLUSION: In mild to moderate Parkinson's disease, gastric emptying is related to autonomic dysfunction and a determinant of the glycaemic response to oral glucose. | Laurence G Trahair Thomas E Kimber Katerina Flabouris Michael Horowitz Karen L Jones | 2016 | World Journal of Gastroenterology2016，22，20： | 5 |
| 2 | 老年人餐后低血压研究进展显示文摘餐后低血压(PPH)是老年人常见而特有的疾病。从帕金森症患者中发现第一例PPH后〔1〕,又在自主神经功能障碍、多系统萎缩、糖尿病患者中相继发现PPH。近年来发现,PPH是老年人全因死亡的一个独立预测因子〔2〕。PPH患者大多数无明显临床症状,但其与晕厥、心绞痛、脑血管意外等严重心脑血管事件存在明显相关性〔3〕。1流行病学及相关影响因素PPH可发生于健康老年人〔4〕,但更常见于合并高血压〔5〕、 | 祝岩岩 王祥 郝守艳 李冰 郑杨 | 2015 | 中国老年学杂志2015，35，9： | 3 |
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