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| 1 | Sentinel Node Mapping for Gastric Cancer: A Prospective Multicenter Trial in Japan显示文摘 | Yuko Kitagawa Hiroya Takeuchi Yu Takagi Shoji Natsugoe Masanori Terashima Nozomu Murakami Takashi Fujimura Hironori Tsujimoto Hideki Hayashi Nobunari Yoshimizu Akinori Takagane Yasuhiko Mohri Kazuhito Nabeshima Yoshikazu Uenosono Shinichi Kinami Junichi S | 2013 | Journal of Clinical Oncology2013，，29： | 11 |
| 2 | New Sentinel Node Mapping Technologies for Early Gastric Cancer显示文摘 | Hiroya Takeuchi Yuko Kitagawa | 2013 | Annals of Surgical Oncology2013，，2： | 5 |
| 3 | Cutting edge of endoscopic full-thickness resection for gastric tumor显示文摘Recently,several studies have reported local full-thickness resection techniques using flexible endoscopy for gastric tumors,such as gastrointestinal stromal tumors,gastric carcinoid tumors,and early gastric cancer(EGC). These techniques have the advantage of allowing precise resection lines to be determined using intraluminal endoscopy. Thus,it is possible to minimize the resection area and subsequent deformity. Some of these methods include:(1) classical laparoscopic and endoscopic cooperative surgery(LECS);(2) inverted LECS;(3) combination of laparoscopic and endoscopic approaches to neoplasia with non-exposure technique; and(4) non-exposed endoscopic wall-inversion surgery. Furthermore,a recent prospective multicenter trial of the sentinel node navigation surgery(SNNS) for EGC has shown acceptable results in terms of sentinel node detection rate and the accuracy of nodal metastasis. Endoscopic full-thickness resection with SNNS is expected to become a treatment option that bridges the gap between endoscopic submucosal dissection and standard surgery for EGC. In the future,the indications for these procedures for gastric tumors could be expanded. | Tadateru Maehata Osamu Goto Hiroya Takeuchi Yuko Kitagawa Naohisa Yahagi | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，16： | 4 |
| 4 | Pre-hepatectomy type Ⅳ collagen 7S predicts post-hepatectomy liver failure and recovery显示文摘BACKGROUND Liver resection is an effective treatment for benign and malignant liver tumors.However,a method for preoperative evaluation of hepatic reserve has not yet been established.Previously reported assessments of preoperative hepatic reserve focused only on liver failure in the early postoperative period and did not consider the long-term recovery of hepatic reserve.When determining eligibility for hepatectomy,the underlying pathophysiology needs to be considered to determine if the functional hepatic reserve can withstand both surgery and any postoperative therapy.AIM To identify pre-hepatectomy factors associated with both early postoperative liver failure and long-term postoperative liver function recovery.METHODS This study was a retrospective cohort study.We retrospectively investigated 215 patients who underwent hepatectomy at our hospital between May 2013 and December 2016.Early post-hepatectomy liver failure(PHLF)was defined using the International Study Group of Liver Surgery’s definition of PHLF.Long-term postoperative recovery of liver function was defined as the time taken for serum total bilirubin and albumin levels to return to levels of<2 mg/dL and>2.8 g/dL,respectively,and the time taken for Child-Pugh score to return to Child-Pugh class A.RESULTS Preoperative type IV collagen 7S was identified as a significant independent factor associated with both PHLF and postoperative long-term recovery of liver function.Further analysis revealed that the time taken for the recovery of Child-Pugh scores and serum total bilirubin and albumin levels was significantly shorter in patients with type IV collagen 7S≤6 ng/mL than in those with type IV collagen 7S>6 ng/mL.In additional analyses,similar results were observed in patients without chronic viral hepatitis associated with fibrosis.CONCLUSION Preoperative type IV collagen 7S is a preoperative predictor of PHLF and longterm postoperative liver function recovery.It can also be used in patients without chronic hepatitis virus. | Masatsugu Ishii Osamu Itano Masahiro Shinoda Minoru Kitago Yuta Abe Taizo Hibi Hiroshi Yagi Ayano Takeuchi Hanako Tsujikawa Tokiya Abe Yuko Kitagawa | 2020 | World Journal of Gastroenterology2020，26，7： | 3 |
| 5 | Current status and challenges in sentinel node navigation surgery for early gastric cancer显示文摘As an optimal surgical procedure to accurately evaluate lymph node(LN)metastasis during surgery with minimal surgical resection,we have been developing sentinel node(SN)biopsy for early gastric cancer since the 1990s.Twelve institutions from the Japanese Society of Sentinel Node Navigation Surgery(SNNS),including Keio University Hospital,conducted a multicenter prospective trial to validate the SN concept using the dual-tracer method with blue dye and a radioisotope.According to the results,397 patients were included in the final analysis,and the overall accuracy in detecting LN metastasis using SN biopsy was 99%(383 of 387).Based on the validation study,we are targeting cT1N0 with a primary tumor of≤4 cm in diameter as an indication for SN biopsy for gastric cancer.We are currently running a multicenter nonrandomized phaseⅢtrial to assess the safety and efficacy of SN navigation surgery.The Korean group has reported the result of a multicenter randomized phaseⅢtrial.Since meticulous gastric cancer in the remnant stomach was rescued by subsequent gastrectomy,the disease-specific survival was comparable between the two techniques,implying that SN navigation surgery can be an alternative to standard gastrectomy.With the development of SN biopsy procedure and treatment modalities,the application of SN biopsy will be expanded to achieve an individualized minimally invasive surgery. | Satoru Matsuda Tomoyuki Irino Hirofumi Kawakubo Hiroya Takeuchi Yuko Kitagawa | 2021 | Chinese Journal of Cancer Research2021，33，2： | 3 |
| 6 | Current status of minimally invasive esophagectomy for patients with esophageal cancer显示文摘 | Hiroya Takeuchi Hirofumi Kawakubo Yuko Kitagawa | 2013 | General Thoracic and Cardiovascular Surgery2013，，： | 2 |
| 7 | Multicenter study evaluating the clinical performance of the OSNA assay for the molecular detection of lymph node metastases in gastric cancer patients显示文摘 | Koshi Kumagai Noriko Yamamoto Isao Miyashiro Yasuhiko Tomita Hitoshi Katai Ryoji Kushima Hitoshi Tsuda Yuko Kitagawa Hiroya Takeuchi Makio Mukai Masayuki Mano Hidetaka Mochizuki Yo Kato Nariaki Matsuura Takeshi Sano | 2014 | Gastric Cancer2014，，2： | 2 |
| 8 | Gastric carcinogenesis and the cancer stem cell hypothesis显示文摘 | Yoshiro Saikawa Kazumasa Fukuda Tsunehiro Takahashi Rieko Nakamura Hiroya Takeuchi Yuko Kitagawa | 2010 | Gastric Cancer2010，，1： | 1 |
| 9 | Association of anastomotic leakage with long-term oncologic outcomes of patients with esophagogastric junction cancer显示文摘BACKGROUND Despite improvements in surgical procedures and peri-operative patients management,the postoperative complications in esophagogastric junction(EGJ)cancer remain high because of technical aspects.Several studies have indicated the negative influence of postoperative infectious complications on long-term survival after gastrointestinal surgery.However,no study has shown the association between postoperative complications and long-term survival of patients with EGJ cancer.AIM To elucidate influence of postoperative complications on the long-term outcomes of patients with EGJ cancer.METHODS A total of 122 patients who underwent surgery for EGJ cancer at the Keio University were included in this study.We examined the association between complications and long-term oncologic outcomes.RESULTS In all patients,the 3-year overall survival(OS)rate was 71.9%,and the recurrencefree survival(RFS)rate was 67.5%.Compared with patients without anastomotic leakage,those with anastomotic leakage had poor median OS(8 mo vs not reached,P=0.028)and median RFS(5 mo vs not reached,P=0.055).Among patients with cervical anastomosis,there were not significant differences between patients with and without anastomotic leakage.However,among patients who underwent intrathoracic anastomosis,patients with anastomotic leakage had significantly worse OS(P=0.002)and RFS(P=0.005).CONCLUSION Anastomotic leakage was significantly associated with long-term oncologic outcomes of patients with EGJ cancer,especially those who underwent intrathoracic anastomosis.Cervical anastomosis with subtotal esophagectomy may be an option for the patients who are at high risk for anastomotic leakage. | Masashi Takeuchi Hirofumi Kawakubo Satoru Matsuda Shuhei Mayanagi Tomoyuki Irino Jun Okui Kazumasa Fukuda Rieko Nakamura Norihito Wada Hiroya Takeuchi Yuko Kitagawa | 2022 | World Journal of Gastrointestinal Surgery2022，14，1： | 1 |
| 10 | Accumulation of Pathogenesis-Related Proteins in Tobacco Leaves Irradiated with UV-B显示文摘 | Takahiro Fujibe Kaori Watanabe Nobuyoshi Nakajima Yuko Ohashi Ichiro Mitsuhara Kotaro T Yamamoto Yuichi Takeuchi | 2000 | Journal of Plant Research2000，，4： | 1 |
| 11 | Primary hepatic leiomyosarcoma with liver metastasis of rectal cancer显示文摘Primary hepatic leiomyosarcoma is a particularly rare tumor with a poor prognosis. Curative resection is currently the only effective treatment, and the efficacy of chemotherapy is unclear. This represents the first case report of a patient with primary hepatic leiomyosarcoma co-existing with metastatic liver carcinoma. We present a 59-year-old man who was diagnosed preoperatively with rectal cancer with multiple liver metastases. He underwent a curative hepatectomy after a series of chemotherapy regimens with modified FOLFOX6 consisting of 5-fluorouracil, leucovorin and oxaliplatin plus bevacizumab, FOLFIRI consisting of 5-fluorouracil, leucovorin and irinotecan plus bevacizumab, and irinotecan plus cetuximab. One of the liver tumors showed a different response to chemotherapy and was diag-nosed as a leiomyosarcoma following histopathological examination. This case suggests that irinotecan has the potential to inhibit the growth of hepatic leiomyosarcomas. The possibility of comorbid different histological types of tumors should be suspected when considering the treatment of multiple liver tumors. | Kiyoto Takehara Hideki Aoki Yuko Takehara Rie Yamasaki Kohji Tanakaya Hitoshi Takeuchi | 2012 | World Journal of Gastroenterology2012，18，38： | 1 |
| 12 | New Sentinel Node Mapping Technologies for Early Gastric Cancer显示文摘 | Hiroya Takeuchi Yuko Kitagawa | 2013 | Annals of Surgical Oncology2013，，2： | 1 |
| 13 | Is Lymphadenectomy a Predictor or Savior for Patients with Gastric Cancer?显示文摘 | Hiroya Takeuchi Yuko Kitagawa | 2010 | Annals of Surgical Oncology2010，，5： | 1 |
| 14 | Molecular Detection of Sentinel Node Micrometastases in Patients with Clinical N0 Gastric Carcinoma with Real-time Multiplex Reverse Transcription-Polymerase Chain Reaction Assay显示文摘 | Yoshimasa Shimizu MD Hiroya Takeuchi MD PhD Yasuhiko Sakakura PhD Yoshiro Saikawa MD PhD Tadaki Nakahara MD PhD Makio Mukai MD PhD Masaki Kitajima MD PhD Yuko Kitagawa MD PhD | 2012 | Annals of Surgical Oncology2012，，2： | 1 |
| 15 | Clinical Significance of Circulating Tumor Cells in Blood from Patients with Gastrointestinal Cancers显示文摘 | Kunihiko Hiraiwa MD Hiroya Takeuchi MD PhD Hirotoshi Hasegawa MD PhD Yoshiro Saikawa MD PhD Koichi Suda MD PhD Takashi Ando MD Koshi Kumagai MD Tomoyuki Irino MD Takahisa Yoshikawa MD Sachiko Matsuda PhD Masaki Kitajima MD PhD Yuko Kitagawa MD PhD | 2008 | Annals of Surgical Oncology2008，，11： | 1 |
| 16 | Validation Study of Radio-Guided Sentinel Lymph Node Navigation in Esophageal Cancer显示文摘 | Hiroya Takeuchi Hirofumi Fujii Nobutoshi Ando Soji Ozawa Yoshiro Saikawa Koichi Suda Takashi Oyama Makio Mukai Tadaki Nakahara Atsushi Kubo Masaki Kitajima Yuko Kitagawa | 2009 | Annals of Surgery2009，，5： | 1 |
| 17 | Molecular Detection of Sentinel Node Micrometastases in Patients with Clinical N0 Gastric Carcinoma with Real-time Multiplex Reverse Transcription-Polymerase Chain Reaction Assay显示文摘 | Yoshimasa Shimizu Hiroya Takeuchi Yasuhiko Sakakura Yoshiro Saikawa Tadaki Nakahara Makio Mukai Masaki Kitajima Yuko Kitagawa | 2012 | Annals of Surgical Oncology2012，，2： | 1 |
| 18 | Factors associated with regular dental visits among hemodialysis patients显示文摘AIM To investigate awareness and attitudes about preventive dental visits among dialysis patients; to clarify thebarriers to visiting the dentist. METHODS Subjects included 141 dentate outpatients receiving hemodialysis treatment at two facilities, one with a dental department and the other without a dental department. We used a structured questionnaire to interview participants about their awareness of oral health management issues for dialysis patients, perceived oral symptoms and attitudes about dental visits. Bivariate analysis using the χ2 test was conducted to determine associations between study variables and regular dental check-ups. Binominal logistic regression analysis was used to determine factors associated with regular dental checkups.RESULTS There were no significant differences in patient demographics between the two participating facilities, including attitudes about dental visits. Therefore, we included all patients in the following analyses. Few patients(4.3%) had been referred to a dentist by a medical doctor or nurse. Although 80.9% of subjects had a primary dentist, only 34.0% of subjects received regular dental check-ups. The most common reasons cited for not seeking dental care were that visits are burdensome and a lack of perceived need. Patients with gum swelling or bleeding were much more likely to be in the group of those not receiving routine dental check-ups(χ2 test, P < 0.01). Logistic regression analysis demonstrated that receiving dental check-ups was associated with awareness that oral health management is more important for dialysis patients than for others and with having a primary dentist(P < 0.05). CONCLUSION Dialysis patients should be educated about the importance of preventive dental care. Medical providers are expected to participate in promoting dental visits among dialysis patients. | Masami Yoshioka Yasuhiko Shirayama Issei Imoto Daisuke Hinode Shizuko Yanagisawa Yuko Takeuchi Takashi Bando Narushi Yokota | 2016 | World Journal of Nephrology2016，5，5： | 1 |
| 19 | A voxel-based morphometry study of gray and white matter correlates of a need for uniqueness显示文摘 | Hikaru Takeuchi Yasuyuki Taki Rui Nouchi Atsushi Sekiguchi Yuka Kotozaki Carlos Makoto Miyauchi Ryoichi Yokoyama Kunio Iizuka Hiroshi Hashizume Seishu Nakagawa Keiko Kunitoki Yuko Sassa Ryuta Kawashima | 2012 | Neuroimage2012，，3： | 1 |
| 20 | Regional gray and white matter volume associated with Stroop interference: Evidence from voxel-based morphometry显示文摘 | Hikaru Takeuchi Yasuyuki Taki Yuko Sassa Hiroshi Hashizume Atsushi Sekiguchi Tomomi Nagase Rui Nouchi Ai Fukushima Ryuta Kawashima | 2011 | Neuroimage2011，，3： | 1 |
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