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| 1 | 柴达木北缘超高压变质带中的岛弧火山岩显示文摘青藏高原北部柴北缘发育一套与超高压变质带并行的早古生代岛弧火山岩带,岛弧火山岩以玄武岩类为主,包括一些中酸性岩类,岩石以普遍遭受绿片岩相蚀变为特征,区别于该地区普遍遭受角闪岩相区域变质的元古代的基性火山岩。该早古生代的岛孤火山岩显示三组地球化学特征:①VTG-Ⅰ,岛弧拉斑玄武岩(IAT);②VTG-Ⅱ,高Al次钙碱性-碱性过渡型玄武岩;③VTG-Ⅲ,较N-MORB更亏损的拉斑玄武岩(异常MORB)。研究认为前两组火山岩是成熟岛弧两个发育阶段的特征性产物:洋壳俯冲到陆壳的初用,由俯冲洋壳和地幔楔的部分熔融形成岛弧拉斑玄武岩(IAT),随着俯冲板块的速度加快和岛弧周围地壳的加厚,则形成钙碱性玄武岩(CA)、高Al玄武岩。第三组火山岩形成于弧间盆地,由亏损的地幔楔高度部分熔融形成比N-MORB亏损的的火山岩(异常MORB)。岛弧火山岩的锆石LA-ICP-MS法U-Pb年龄为514.2±8.5 Ma,说明柴北缘在早古生代发生过洋壳向陆壳的俯冲作用。鉴于该地区代表陆-陆俯冲作用的柴北缘超高压变质岩石也是形成于早古生代(494Ma),认为陆-陆俯冲作用发生在洋-陆俯冲作用之后,二者时间和空间相伴随。 | 史仁灯 杨经绥 吴才来 Tsuyoshi IIZUKA Takafumi HIRATA | 2004 | 地质学报2004，78，1： | 116 |
| 2 | Can endoscopic submucosal dissection be safely performed in a smaller specialized clinic?显示文摘AIM:To investigate whether endoscopic submucosal dissection(ESD) can be safely performed at small clinics,such as the Shirakawa Clinic.METHODS:One thousand forty-seven ESDs to treat gastrointestinal tumors were performed at the Shirakawa Clinic from April 2006 to March 2011.The efficacy,technical feasibility and associated complications of the procedures were assessed.The ESD procedures were performed by five endoscopists.Sedation was induced with propofol for esophagogastorduodenal ESD.RESULTS:One thousand forty-seven ESDs were performed to treat 64 patients with esophageal cancer(E),850 patients with gastric tumors(G:764 patients with cancer,82 patients with adenomas and four others),four patients with duodenal cancer(D) and 129 patients with colorectal tumors(C:94 patients with cancer,21 patients with adenomas and 14 others).The en bloc resection rate was 94.3%(E:96.9%,G:95.8%,D:100%,C:79.8%).The median operation time was 46 min(range:4-360 min) and the mean size of the resected specimens was 18 mm(range:2-150 mm).No mortal complications were observed in association with the ESD procedures.Perforation occurred in 12 cases(1.1%,E:1 case,G:9 cases,D:1 case,C:1 case) and postoperative bleeding occurred in 53 cases(5.1%,G:51 cases,D:1 case,C:1 case);however,no case required either emergency surgery or blood transfusion.All of the perforations and postperative bleedings were resolved by endoscopic clipping or hemostasis.The other problematic complication observed was pneumonia,which was treated with conservative therapy.CONCLUSION:ESD can be safely performed in a clinic with established therapeutic methods and medical services to address potential complications. | Naondo Sohara Satoshi Hagiwara Riki Arai Haruhisa Iizuka Yasuhiro Onozato Satoru Kakizaki | 2013 | World Journal of Gastroenterology2013，19，4： | 15 |
| 3 | Wound healing of intestinal epithelial cells显示文摘The intestinal epithelial cells(IECs) form a selective permeability barrier separating luminal content from underlying tissues.Upon injury,the intestinal epithelium undergoes a wound healing process.Intestinal wound healing is dependent on the balance of three cellular events;restitution,proliferation,and differentiation of epithelial cells adjacent to the wounded area.Previous studies have shown that various regulatory peptides,including growth factors and cytokines,modulate intestinal epithelial wound healing.Recent studies have revealed that novel factors,which include toll-like receptors(TLRs),regulatory peptides,particular dietary factors,and some gastroprotective agents,also modulate intestinal epithelial wound repair.Among these factors,the activation of TLRs by commensal bacteria is suggested to play an essential role in the maintenance of gut homeostasis.Recent studies suggest that mutations and dysregulation of TLRs could be major contributing factors in the predisposition and perpetuation of inflammatory bowel disease.Additionally,studies have shown that specific signaling pathways are involved in IEC wound repair.In this review,we summarize the function of IECs,the process of intestinal epithelial wound healing,and the functions and mechanisms of the various factors that contribute to gut homeostasis and intestinal epithelial wound healing. | Masahiro Iizuka Shiho Konno | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 4 | Analysis of colonoscopic perforations at a local clinic and a tertiary hospital显示文摘AIM:To define the clinical characteristics,and to assess the management of colonoscopic complications at a local clinic.METHODS:A retrospective review of the medical records was performed for the patients with iatrogenic colon perforations after endoscopy at a local clinic between April 2006 and December 2010.Data obtained from a tertiary hospital in the same region were also analyzed.The underlying conditions,clinical presentations,perforation locations,treatment types(operative or conservative) and outcome data for patients at the local clinic and the tertiary hospital were compared.RESULTS:A total of 10 826 colonoscopies,and 2625 therapeutic procedures were performed at a local clinic and 32 148 colonoscopies,and 7787 therapeutic procedures were performed at the tertiary hospital.The clinic had no perforations during diagnostic colonoscopy and 8(0.3%) perforations were determined to be related to therapeutic procedures.The perforation rates in each therapeutic procedure were 0.06%(1/1609) in polypectomy,0.2%(2/885) in endoscopic mucosal resection(EMR),and 3.8%(5/131) in endoscopic submucosal dissection(ESD).Perforation rates for ESD were significantly higher than those for polypectomy or EMR(P < 0.01).All of these patients were treated conservatively.On the other hand,three(0.01%) perforation cases were observed among the 24 361 diagnostic procedures performed,and these cases were treated with surgery in a tertiary hospital.Six perforations occurred with therapeutic endoscopy(perforation rate,0.08%;1 per 1298 procedures).Perforation rates for specific procedure types were 0.02%(1 per 5500) for polypectomy,0.17%(1 per 561) for EMR,2.3%(1 per 43) for ESD in the tertiary hospital.There were no differences in the perforation rates for each therapeutic procedure between the clinic and the tertiary hospital.The incidence of iatrogenic perforation requiring surgical treatment was quite low in both the clinic and the tertiary hospital.No procedure-related mortalities occurred.Performing closure with endoscopic clipping reduced the C-reactive protein(CRP) titers.The mean maximum CRP titer was 2.9 ± 1.6 mg/dL with clipping and 9.7 ± 6.2 mg/dL without clipping,respectively(P < 0.05).An operation is indicated in the presence of a large perforation,and in the setting of generalized peritonitis or ongoing sepsis.Although we did not experience such case in the clinic,patients with large perforations should be immediately transferred to a tertiary hospital.Good relationships between local clinics and nearby tertiary hospitals should therefore be maintained.CONCLUSION:It was therefore found to be possible to perform endoscopic treatment at a local clinic when sufficient back up was available at a nearby tertiary hospital. | Toshihiko Sagawa Satoru Kakizaki Haruhisa Iizuka Yasuhiro Onozato Naondo Sohara Shinichi Okamura Masatomo Mori | 2012 | World Journal of Gastroenterology2012，18，35： | 5 |
| 5 | 胶东烟台磁山花岗岩的形成时代及其成矿意义显示文摘利用激光探针等离子体质谱测年技术(LA-ICP-MS)对胶东烟台磁山花岗岩的锆石进行了U-Pb年龄测定,8粒锆石的年龄为199~149 Ma,可分成3组:192 199 Ma(3粒)、178~185 Ma(2粒)和149 154 Ma(3粒),第3组年龄可能代表岩体的最终侵位时代,表明岩体形成于晚侏罗世,为燕山期花岗岩.另外4粒早元古代的继承锆石年龄为2110~2 467 Ma,平均年龄为2 252±41 Ma,反映其源岩有早元古代粉子山群的物质.该岩体的形成年龄为探讨南张家金矿的成因提供了重要依据. | 孟繁聪 史仁灯 Tsuyoshi Iizuka 杨经绥 Takafumi Hirata | 2005 | 岩石矿物学杂志2005，24，5： | 4 |
| 6 | Feasibility and safety of laparoscopic and endoscopic cooperative surgery for gastric submucosal tumors, including esophagogastric junction tumors显示文摘 | Shu Hoteya Shusuke Haruta Hisashi Shinohara Akihiro Yamada Tsukasa Furuhata Satoshi Yamashita Daisuke Kikuchi Toshifumi Mitani Osamu Ogawa Akira Matsui Toshiro Iizuka Harushi Udagawa Mitsuru Kaise | 2014 | Digestive Endoscopy2014，，4： | 4 |
| 7 | HFW管线钢管焊缝的高可靠性技术显示文摘为了解决HFW管线钢管焊缝可靠性问题,通过使用高速摄像机实现了HFW焊接过程的动态可视化,并构建了一个HFW数值分析模型,从而优化HFW焊接条件并实现焊缝区域的均匀加热。试验结果表明,焊接条件优化后开发出的HFW钢管焊缝金属的夏比韧脆转变温度达到-90℃,且具有较高的低温吸收能量值。此外,开发的点融合串列束超声波检验方法实现了焊缝区氧化物的实时连续检测,其灵敏度为常规方法的10倍以上。 | 孙宏 王志太 刘振伟 OKABE Takatoshi IIZUKA Yukinori IGI Satoshi | 2015 | 焊管2015，38，12： | 3 |
| 8 | Diagnostic algorithm of magnifying endoscopy with narrow band imaging for superficial non‐ampullary duodenal epithelial tumors显示文摘 | Daisuke Kikuchi Shu Hoteya Toshiro Iizuka Ryusuke Kimura Mitsuru Kaise | 2014 | Digestive Endoscopy2014，，： | 3 |
| 9 | Endoscopic submucosal dissection for early gastric cancers and large flat adenomas显示文摘 | Y. Onozato H. Ishihara H. Iizuka N. Sohara S. Kakizaki S. Okamura M. Mori | 2006 | Endoscopy2006，，10： | 3 |
| 10 | Endoscopic submucosal dissection and preoperative assessment with endoscopic ultrasonography for the treatment of rectal carcinoid tumors显示文摘 | Naoki Ishii Noriyuki Horiki Toshiyuki Itoh Masataka Maruyama Michitaka Matsuda Takeshi Setoyama Shoko Suzuki Shino Uchida Masayo Uemura Yusuke Iizuka Katsuyuki Fukuda Koyu Suzuki Yoshiyuki Fujita | 2010 | Surgical Endoscopy2010，，6： | 3 |
| 11 | Display Method for Online Bookstore Emulating Real Bookstore by WebGL显示文摘Thanks to the spread of the Internet, opportunities to use online bookstores have been increasing in recent years. However, it is difficult for the typical customer to intuitively grasp which book sells well or which book is recommended by the shop. We have therefore developed a display system for virtual bookstores in which an image of books arranged in a bookshelf or stacked on a table is reproduced by using WebGL. Since the amount of book stock that is managed by the server side needs to be changed as orders come in from clients, we introduce a server side technology using a hypertext preprocessor(PHP). | Kazuhisa Yanaka Terumichi Iizuka | 2014 | Journal of Electronic Science and Technology2014，12，1： | 2 |
| 12 | CD74 Is a Novel Prognostic Factor for Patients with Pancreatic Cancer Receiving Multimodal Therapy显示文摘 | Shigenori Nagata Yu-Fen Jin Katsuhiko Yoshizato Miki Tomoeda Misa Song Norishige Iizuka Masanori Kitamura Hidenori Takahashi Hidetoshi Eguchi Hiroaki Ohigashi Osamu Ishikawa Yasuhiko Tomita | 2009 | Annals of Surgical Oncology2009，，： | 2 |
| 13 | Cytapheresis re-induces high-rate steroid-free remission in patients with steroid-dependent and steroid-refractory ulcerative colitis显示文摘BACKGROUND It is a crucial issue for patients with refractory ulcerative colitis(UC),including steroid-dependent and steroid-refractory patients,to achieve and maintain steroid-free remission.However,clinical studies focused on the achievement of steroid-free remission in refractory UC patients are insufficient.Cytapheresis(CAP)is a non-pharmacological extracorporeal therapy that is effective for active UC with fewer adverse effects.This study comprised UC patients treated with CAP and suggested the efficacy of CAP for refractory UC patients.AIM To clarify the efficacy of CAP in achieving steroid-free remission in refractory UC patients.METHODS We retrospectively reviewed the collected data from 55 patients with refractory UC treated with CAP.We analyzed the following points:(1)Efficacy of the first course of CAP;(2)Efficacy of the second,third,and fourth courses of CAP in patients who experienced relapses during the observation period;(3)Efficacy of CAP in colonic mucosa;and(4)Long-term efficacy of CAP.Clinical efficacy was evaluated using Lichtiger’s clinical activity index or Sutherland index(disease activity index).Mucosal healing was evaluated using Mayo endoscopic subscore.The primary and secondary endpoints were the rate of achievement of steroidfree remission and the rate of sustained steroid-free remission,respectively.Statistical analysis was performed using the paired t-test and chi-squared test.RESULTS The rates of clinical remission,steroid-free remission,and poor effectiveness after CAP were 69.1%,45.5%,and 30.9%,respectively.There were no significant differences in rate of steroid-free remission between patients with steroiddependent and steroid-refractory UC.The mean disease activity index and Lichtiger’s clinical activity index scores were significantly decreased after CAP(P<0.0001).The rates of steroid-free remission after the second,third,and fourth courses of CAP in patients who achieved steroid-free remission after the first course of CAP were 83.3%,83.3%,and 60%,respectively.Mucosal healing was observed in all patients who achieved steroid-free remission after the first course of CAP.The rates of sustained steroid-free remission were 68.0%,60.0%,and 56.0%at 12,24,and 36 mo after the CAP.Nine patients(36%)had maintained steroid-free remission throughout the observation period.CONCLUSION Our results suggest that CAP effectively induces and maintains steroid-free remission in refractory UC and re-induces steroid-free remission in patients achieving steroid-free remission after the first course of CAP. | Masahiro Iizuka Takeshi Etou Yosuke Shimodaira Takashi Hatakeyama Shiho Sagara | 2021 | World Journal of Gastroenterology2021，27，12： | 2 |
| 14 | Acute respiratory distress syndrome associated with severe ulcerative colitis显示文摘Various extraintestinal manifestations including pulmonary abnormalities have been reported in patients with ulcerative colitis. Acute respiratory distress syndrome (ARDS) is a serious and fatal pulmonary manifestation. We have experienced a 67-year-old male patient with ARDS associated with a severe type of ulcerative colitis (UC). Severe dyspnea symptoms occurred during the treatment of UC in a previous hospital and the patient was transferred to our hospital on June 27, 2007. Both blood and sputa cultures for bacteria and fungi were negative. Cytomega-lovirus antigenemia was also not detected. From the clinical and radiological [Chest X-ray, computed tomography (CT)] findings, the patient was diagnosed with ARDS on the basis of the def inition of ARDS developed by the European-American Consensus Conference on ARDS. Both colonic inflammations and ARDS symptoms of the patient were resistant to any medical treatment includingcorticosteroids and antibiotics. However, ARDS symptoms were dramatically improved after surgical colectomy. We believe that severe colonic inflammation from UC was closely associated with the onset of ARDS of the patient. Our case report suggests that a severe type of ulcerative colitis might be taken into consideration as one of the predisposing factors of ARDS. | Shiho Sagara Yasuo Horie Yumiko Anezaki Hideaki Miyazawa Masahiro Iizuka | 2010 | World Journal of Gastroenterology2010，16，19： | 2 |
| 15 | Global mapping of urban built-up areas of year 2014 by combining MODIS multispectral data with VIIRS nighttime light data显示文摘An improved methodology for the extraction and mapping of urban built-up areas at a global scale is presented in this study.The Moderate Resolution Imaging Spectroradiometer(MODIS)-based multispectral data were combined with the Visible Infrared Imager Radiometer Suite(VIIRS)-based nighttime light(NTL)data for robust extraction and mapping of urban built-up areas.The MODIS-based newly proposed Urban Built-up Index(UBI)was combined with NTL data,and the resulting Enhanced UBI(EUBI)was used as a single master image for global extraction of urban built-up areas.Due to higher variation of the EUBI with respect to geographical regions,a region-specific threshold approach was used to extract urban built-up areas.This research provided 500-m-resolution global urban built-up map of year 2014.The resulted map was compared with three existing moderate-resolution global maps and one high-resolution map in the United States.The comparative analysis demonstrated finer details of the urban built-up cover estimated by the resultant map. | Ram C.Sharma Ryutaro Tateishi Keitarou Hara Saeid Gharechelou Kotaro Iizuka | 2016 | International Journal of Digital Earth2016，9，10： | 2 |
| 16 | Usefulness of Magnifying Endoscopy with Narrow-Band Imaging for Determining Tumor Invasion Depth in Early Gastric Cancer显示文摘 | Daisuke Kikuchi Toshiro Iizuka Shu Hoteya Akihiro Yamada Tsukasa Furuhata Satoshi Yamashita Kaoru Domon Masanori Nakamura Akira Matsui Toshifumi Mitani Osamu Ogawa Sumio Watanabe Mitsuru Kaise Guido Schumacher | 2013 | Gastroenterology Research and Practice2013，，： | 2 |
| 17 | Endoscopic submucosal dissection for nonampullary large superficial adenocarcinoma/adenoma of the duodenum: feasibility and long-term outcomes显示文摘 | Shu Hoteya Naohisa Yahagi Toshiro Iizuka Daisuke Kikuchi Toshifumi Mitani Akira Matsui Osamu Ogawa Satoshi Yamashita Tsukasa Furuhata Akihiro Yamada Ryusuke Kimura Kosuke Nomura Yasutaka Kuribayashi Mitsuru Kaise | 2013 | EIO2013，，01： | 2 |
| 18 | Typical gastroduodenal endoscopic findings in a Crohn's disease patient in remission stage显示文摘A 39-year-old patient with Crohn's disease (CD) was referred to our hospital for maintenance treatment of CD.He was diagnosed as having CD of the small and large intestines at 32 years old.He underwent partial resection of the ileum at 35 years old because of ileal perforation.He had received enteral nutritional supplement (1200 kcal/d) and metronidazole preparation (500 mg/d),and was in remission Crohn's disease activity index 73.We performed a routine gastroduodenal endoscopic examination,which revealed the representative endoscopic findings of gastroduodenal lesions in CD,namely,bamboo-joint-like appearance of the gastric body and cardia and a notched sign in the duodenum.These findings were clearly observed by using indigo carmine dye spraying.In our patient,typical gastroduodenal findings were observed even in the remission stage,suggesting that these findings would contribute to the early diagnosis of CD not only in the active stage but also during remission. | Masahiro Iizuka Taku Harada Hiro-o Yamano Takeshi Etou Shiho Sagara | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，3： | 2 |
| 19 | Hepatocellular carcinoma and nonalcoholic steatohepatitis developing during long-term administration of valproic acid显示文摘 | Katsuaki Sato Yoshimichi Ueda Keiichi Ueno Kazuya Okamoto Hideaki Iizuka Shogo Katsuda | 2005 | Virchows Archiv2005，，6： | 2 |
| 20 | Dendritic cell-based vaccination in metastatic melanoma patients: PhaseII clinical trial显示文摘 | Chie Oshita Masako Takikawa Akiko Kume Haruo Miyata Tadashi Ashizawa Akira Iizuka Yoshio Kiyohara Shusuke Yoshikawa Ryuji Tanosaki Naoya Yamazaki Akifumi Yamamoto Kazutoh Takesako Ken Yamaguchi Yasuto Akiyama | 2012 | Oncology Reports2012，，4： | 2 |
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