|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Isolation and characterization of H7N9 viruses from live poultry markets--Implication of the source of current H7N9 infection in humans显示文摘On March 31, 2013, the National Health and Family Planning Commission announced that human infections with a previously undescribed influenza A (H7N9) virus had occurred in Shanghai and Anhui Province, China. To investigate the possible origins of the H7N9 viruses causing these human infections, we collected 970 samples, including drinking water, soil, and cloacal and tracheal swabs of poultry from live poultry markets and poultry farms in Shanghai and Anhui Province. Twenty samples were positive for the H7N9 influenza virus. Notably, all 20 viruses were isolated from samples collected from live poultry markets in Shanghai. Phylogenetic analyses showed that the six internal genes of these novel human H7N9 viruses were derived from avian H9N2 viruses, but the ancestor of their HA and NA genes is uncertain. When we examined the phylogenetic relationship between the H7N9 isolates from live poultry markets and the viruses that caused the human infections, we found that they shared high homology across all eight gene segments. We thus identified the direct avian origin of the H7N9 influenza viruses that caused the human infections. Importantly, we observed that the H7N9 viruses isolated from humans had acquired critical mutations that made them more 'human-like'. It is therefore imperative to take strong measures to control the spread of H7N9 viruses in birds and humans to prevent further threats to human health. | SHI JianZhong DENG GuoHua LIU PeiHong ZHOU JinPing GUAN LiZheng LI WenHui LI XuYong GUO Jing WANG GuoJun FAN Jun WANG JinLiang LI YuanYuan JIANG YongPing LIU LiLing TIAN GuoBin LI ChengJun CHEN HuaLan | 2013 | Chinese Science Bulletin2013，58，16： | 85 |
| 2 | Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules显示文摘由病毒的 transduction 的四抄写因素 Oct4, Klf4, Sox2 和 c-Myc 的介绍能导致体的房间的 reprogramming 进导致的 pluripotent 干细胞(iPSCs ) ,但是 iPSCs 的使用被病毒的交货系统的使用妨碍。导致化学药品的 reprogramming 把一条新奇途径提供给没有任何病毒的基于向量的基因修正,产生 iPSCs。尽管,以前的报告证明几个小分子能代替一些 reprogramming 因素至少二个抄写因素, Oct4 和 Klf4,仍然被要求从老鼠产生 iPSCs 胚胎的成纤维细胞。这里,我们识别特定的化学联合,它是足够的面对一个单个抄写因素从胚胎的老鼠和成年成纤维细胞允许 reprogramming, Oct4 在 20 天以内,代替 Sox2, Klf4 和 c-Myc。用这个处理产生的 iPSCs 类似于胚胎的干细胞以全球基因表示介绍的老鼠,在 vitro 并且在 vivo 的 epigenetic 地位和 pluripotency。我们也发现那 8 天 Oct4 正式就职是足够的面对小分子启用导致 Oct4 的 reprogramming,它建议 reprogramming 在开始的 8 天以内被开始并且独立于连续外长的 Oct4 表示。没有基因修正,这些发现将帮助 iPSCs 的未来产生,以及阐明位于 reprogramming 过程下面的分子的机制。 | Yanqin Li Qiang Zhang Xiaolei Yin Weifeng Yang Yuanyuan Du Pingping Hou Jian Ge Chun Liu Weiqi Zhang Xu Zhang Yetao Wu Honggang Li Kang Liu Chen Wu Zhihua Song Yang Zhao Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，1： | 51 |
| 3 | Characteristics of volatile organic compounds,NO_2,and effects on ozone formation at a site with high ozone level in Chengdu显示文摘Chengdu is a megacity in the southwest of China with high ozone(O_3) mixing ratio.Observation of volatile organic compounds(VOCs), NO_2 and O_3 with high temporal resolution was conducted in Chengdu to investigate the chemical processes and causes of high O_3 levels. The hourly mixing ratios of VOCs, NO2, and O_3 were monitored by an online system from 28 August to 7 October, 2016. According to meteorological conditions,Chengdu, with relative warm weather and low wind speed, is favorable to O_3 formation.Part of the O_3 in Chengdu may be transported from the downtown area. In O_3 episodes,the average mixing ratios of NO_2 and O_3 were 20.20 ppbv and 47.95 ppbv, respectively. In non-O_3 episodes, the average mixing ratios of NO_2 and O_3 were 16.38 ppbv and 35.15 ppbv,respectively. The average mixing ratio of total VOCs(TVOCs) was 40.29 ppbv in non-O_3 episodes, which was lower than that in O_3 episodes(53.19 ppbv). Alkenes comprised51.7% of the total O_3 formation potential(OFP) in Chengdu, followed by aromatics which accounted for 24.2%. Ethylene, trans-pentene, propene, and BTEX(benzene, ethylbenzene,toluene, m/p-xylene, o-xylene) were also major contributors to the OFP in Chengdu. In O_3 episodes, intensive secondary formations were observed during the campaign. Oxygenated VOCs(OVOCs), such as acetone, Methylethylketone(MEK), and Methylvinylketone(MVK)were abundant. Isoprene rapidly converted to MVK and Methacrolein(MACR) during O_3 episodes. Acetone was mainly the oxidant of C3-C5 hydrocarbons. | Yuanyuan Deng Jing Li Yaqi Li Rongrong Wu Shaodong Xie | 2019 | Journal of Environmental Sciences2019，31，1： | 29 |
| 4 | SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy. | Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 5 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 6 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 7 | Gold nanoflowers for 3D volumetric molecular imaging of tumors by photoacoustic tomography显示文摘By binding molecular probes that target tumor cells, gold nanoparticles (AuNPs) with superior characteristics have shown great potential in tumor molecular imaging studies. The non-invasive, high-resolution, and three-dimensional imaging of the targeted AuNPs within the tumor is desirable for both diagnosis and therapy. In this study, gold nanoflowers (AuNFs) are presented as a novel contrast agent for photoacoustic tomography (PAT). By binding to folic acid, the molecular probe, the tail-vein injected AuNFs concentrated within the tumor site in mice; this was clearly visualized by three-dimensional (3D) PAT imaging. In addition, toxicity assay proved that AuNFs were harmless to living cells and animals. Our results demonstrate that AuNFs have great potential in tumor molecular imaging. | Yuanyuan Jiang Zijian Deng Dan Yang Xin Deng Qi Li Yinlin Sha Changhui Li Dongsheng Xu | 2015 | Nano Research2015，8，7： | 8 |
| 8 | Research on Relationships Between Built Environment and Criminal Behavior in Parking Areas: A Case Study on Pudong New Area, Shanghai | MAO Yuanyuan, PhD Candidate, School of Architecture & Urban Planning, Tongji University, Shanghai, P. R. China. DAI Shenzhi, Professor, School of Architecture & Urban Planning, Tongji University, Shanghai, P. R. China. DENG Tian, China Overseas Property Group Co., Ltd (Eastern China), Shanghai, P. R. China. XU Bin, Off icer, Shanghai Municipal Public Security Bureau Pudong Branch, Shanghai, P. R. China. ZHU Wei, PhD, Eindhoven University of Technology, Eindhoven, the Netherlands. DONG Hengping, Postgraduate student, School of Architecture & Urban Planning, Tongji University, Shanghai, P. R. China. | 2009 | China City Planning Review2009，18，2： | 7 |
| 9 | The application of perovskite materials in solar water splitting显示文摘Solar water splitting is a promising strategy for sustainable production of renewable hydrogen,and solving the crisis of energy and environment in the world.However,large-scale application of this method is hampered by the efficiency and the expense of the solar water splitting systems.Searching for non-toxic,low-cost,efficient and stable photocatalysts is an important way for solar water splitting.Due to the simplicity of structure and the flexibility of composition,perovskite based photocatalysts have recently attracted widespread attention for application in solar water splitting.In this review,the recent developments of perovskite based photocatalysts for water splitting are summarized.An introduction including the structures and properties of perovskite materials,and the fundamentals of solar water splitting is first provided.Then,it specifically focuses on the strategies for designing and modulating perovskite materials to improve their photocatalytic performance for solar water splitting.The current challenges and perspectives of perovskite materials in solar water splitting are also reviewed.The aim of this review is to summarize recent findings and developments of perovskite based photocatalysts and provide some useful guidance for the future research on the design and development of highly efficient perovskite based photocatalysts and the relevant systems for water splitting. | Yanbin Huang Jun Liu Yanchun Deng Yuanyuan Qian Xiaohao Jia Mengmeng Ma Cheng Yang Kong Liu Zhijie Wang Shengchun Qu Zhanguo Wang | 2020 | Journal of Semiconductors2020，41，1： | 6 |
| 10 | Effect of the degree of milling on the physicochemical properties,pasting properties and in vitro digestibility of Simiao rice显示文摘Simiao rice is a variety of long-grain Indica rice popular in South China.However,researches on the milling technology of Simiao rice are limited.The effect of different degrees of milling(DOMs)of Simiao rice(0-12%)were evaluated in terms of the physicochemical properties and in vitro starch digestibility of the rice.The results showed that,as the DOM increased from 0 to 12%,the head rice yield(HRY)and the content of protein,lipid,dietary fiber,vitamin B1,vitamin E and niacin nonlinearly decreased,while the content of total starch and amylose and paste viscosity parameters nonlinearly increased.The differences in chemical constituents between the brown and milled Simiao rice with different DOMs lead to the variation in their pasting properties and in vitro digestibility.Because of lower content of slowly digestible starch(SDS)and resistant starch(RS),milled Simiao rice exhibited greater digestibility and a higher estimated glycaemic index(EGI).The EGI of Simiao rice ranged from 77.98 to 85.55,and remained almost constant(approximately 84)when the DOM was above 4%.Correlation analysis indicated that the EGI had strong negative correlations with lipid,protein,dietary fiber and RS,but a positive correlation with amylose.These results provide theoretical guidance for the production of Simiao rice with desired physicochemical properties and digestibility by adjusting the DOM. | Zhiming Wang Mingwei Zhang Guang Liu Yuanyuan Deng Yan Zhang Xiaojun Tang Ping Li Zhencheng Wei | 2021 | Grain & Oil Science and Technology2021，4，2： | 5 |
| 11 | Microstructure evolution of an Mg-Zn-Nd-Zr magnesium alloy during recrystallization and partial remelting process显示文摘To obtain a spheroidal microstructure of a semi-solid Mg-Zn-Nd-Zr alloy,which is favorable for the subsequent thixocasting process,the recrystallization and partial remelting(RAP)method was used in this study,and the microstructure evolution of the alloy and the mechanism of the shape factor change during the RAP process were invesigated.The as-cast Mg-Zn-Nd-Zr alloy was prepared in a metal mold and then extruded into bars with an extrusion ratio of 16:1.Partial remelting was carried out on the extruded samples at 589℃(at a heating rate of 0.5℃·s-1)for different holding times ranging from 0 to 90 min.To examine the effect of heating rate,partial remelting of samples at the heating rate of 2℃·s-1was also performed.Results show that the extruded microstructure rapidly evolutes into recrystallized grains in the semi-solid state;the liquid f ilm initially forms at grain boundaries during the partial remelting,and then gradually changes from continuous into discontinuous state with the increase of holding time;this results in the agglomeration of adjacent grains and the decrease in shape factor.The value of shape factor increases continuously with holding time at f irst and reaches the maximum 0.62 when holding for 60 min,while decreases rapidly after a prolonged holding time.Moreover,local melting,mainly due to the inhomogeneous deformation during extrusion,becomes more signif icant and less uniformly distributed at a relatively higher reheating rate.The Mg-Zn-Nd-Zr magnesium alloy components have been thixo-cast successfully using the RAP method,which strongly proves the feasibility of RAP process in Mg-Zn-Nd-Zr alloy. | Tao Jianquan Wan Yuanyuan Sun Changjian Su Zhiquan Deng Tianquan Huang Jing | 2013 | China Foundry2013，10，4： | 4 |
| 12 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 13 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 14 | Fasting-induced hormonal regulation of lysosomal function显示文摘 | Chen, Liqun Wang, Ke Long, Aijun Jia, Liangjie Zhang, Yuanyuan Deng, Haiteng Li, Yu Han, Jinbo Wang, Yiguo | 2017 | Cell Research2017，27，6： | 3 |
| 15 | Sex Differences in Diagnosis and Clinical Phenotypes of Chinese Children with Autism Spectrum Disorder显示文摘The aim of this study was to explore the differences between boys and girls in the diagnosis and clinical phenotypes of autism spectrum disorder(ASD) in China's mainland. Children diagnosed with ASD(n = 1064, 228 females) were retrospectively included in the analysis. All children were assessed using the Autism Diagnostic Interview-Revised(ADI-R) and Autism Diagnostic Observation Schedule(ADOS). The results showed that girls scored significantly higher in ADI-R socioemotional reciprocity than boys, and also scored lower in ADI-R and ADOS restricted and repetitive behaviors(RRBs). Meanwhile, the proportions of girls who satisfied the diagnostic cut-off scores in the ADI-R RRBs domain were lower than in boys(P \ 0.05). Our results indicated that girls with ASD show greater socio-emotional reciprocity than boys. Girls also tended to show fewer RRBs than boys, and the type of RRBs in girls differ from those in boys. The ADI-R was found to be less sensitive in girls, particularly for assessment in the RRBs domain. | Shihuan Wang Hongzhu Deng Cong You Kaiyun Chen Jianying Li Chun Tang Chaoqun Ceng Yuanyuan Zou Xiaobing Zou | 2017 | Neuroscience Bulletin2017，33，2： | 3 |
| 16 | Research advances in forensic diatom testing显示文摘In forensic practice,it is difficult to determine whether a dead body in the water resulted from drowning or from disposal after death.Diatom testing is currently an important supporting technique for the determination of death by drowning and of drowning sites,even though it is a time-consuming and laborious task.This article reviews the development of diatom testing over the decades and discusses a new method for the potential application of deep learning in diatom testing. | Yuanyuan Zhou Yongjie Cao Jiao Huang Kaifei Deng Kaijun Ma Tianye Zhang Liqin Chen Ji Zhang Ping Huang | 2020 | Forensic Sciences Research2020，5，2： | 3 |
| 17 | Branched-chain amino acids regulate plant growth by affecting the homeostasis of mineral elements in rice显示文摘Dear Editor,Branched-chain amino acids(BCAAs)are essential amino acids that must be obtained from the diet for humans and animals.Branched-chain amino acid transaminases(BCATs)catalyze a key step in the BCAA synthesis pathway,however,little is known about their biological roles in planta.In this study,we functionally characterized two BCATs,OsBCAT4 and OsBCAT5,in rice and showed that they regulate the development of rice roots by affecting the levels of mineral elements. | Cheng Jin Yangyang Sun Yuheng Shi Yuanyuan Zhang Kai Chen Yuan Li Guige Liu Fang Yao Deng Cheng Jie Li Junjie Zhou Lianghuan Qu Xianqing Liu Jie Luo | 2019 | Science China(Life Sciences)2019，62，8： | 3 |
| 18 | Comparing overall survival between first generation EGFR-TKIs and chemotherapy in lung cancer patients with Del19/L858R显示文摘Objective: Combined overall survival(OS) analysis of Lux-Lung 3 and Lux-Lung 6 demonstrated that patients with epidermal growth factor receptor(EGFR) exon 19 deletions(Del19) would benefit from first-line second generation EGFR tyrosine kinase inhibitors(TKIs) afatinib but not for those with L858 R. This study was to investigate the survival difference between first-line first generation EGFR-TKIs and chemotherapy in patients with either Del19 or L858 R, and to directly compare OS in these two mutation groups.Methods: Eligibles were all prospective and retrospective studies comparing EGFR-TKIs with conventional chemotherapy or receiving single agent EGFR-TKIs and demonstrating survival analysis based on mutation types. The primary outcome was OS measured as pooled hazard ratios(HRs). All measures were pooled using randomeffects models and 95% confidential interval(95% CI) was calculated.Results: A total of 14 studies incorporating 1,706 patients with either Del19 or L858 R were included. Enrolling patients with Del19 or L858 R in randomized controlled trials(RCTs), first-line first generation EGFR-TKIs were associated with no OS benefit, compared with chemotherapy(pooled HR_(TKI/Chemo) for Del19: 0.82, 95% CI: 0.64-1.06, P=0.14; pooled HR_(TKI/Chemo) for L858R: 1.15, 95% CI: 0.85-1.56, P=0.38). Direct comparison of Del19 with L858 R receiving with first-line first generation EGFR-TKIs demonstrated no significant survival difference(pooled HR_(19/21): 0.88, 95% CI: 0.67-1.16, P=0.37).Conclusions: Among patients with advanced non-small cell lung cancer(NSCLC) harboring Del19 and L858 R, first-line first generation EGFR-TKIs demonstrated no survival benefit comparing with chemotherapy. Direct comparison between Del19 and L858 R revealed no significant survival difference after first-line first generation EGFR-TKIs. | Wei Deng Yuanyuan Lei Siyang Liu Jinji Yang Haiyan Tu Honghong Yan Yilong Wu | 2016 | Chinese Journal of Cancer Research2016，28，3： | 3 |
| 19 | Genome-wide profiling of RNA editing sites in sheep显示文摘Background: The widely observed RNA-DNA differences(RDDs) have been found to be due to nucleotide alteration by RNA editing. Canonical RNA editing(i.e., A-to-I and C-to-U editing) mediated by the adenosine deaminases acting on RNA(ADAR) family and apolipoprotein B mRNA editing catalytic polypeptide-like(APOBEC)family during the transcriptional process is considered common and essential for the development of an individual.To date, an increasing number of RNA editing sites have been reported in human, rodents, and some farm animals;however, genome-wide detection of RNA editing events in sheep has not been reported. The aim of this study was to identify RNA editing events in sheep by comparing the RNA-seq and DNA-seq data from three biological replicates of the kidney and spleen tissues.Results: A total of 607 and 994 common edited sites within the three biological replicates were identified in the ovine kidney and spleen, respectively. Many of the RDDs were specific to an individual. The RNA editing-related genes identified in the present study might be evolved for specific biological functions in sheep, such as structural constituent of the cytoskeleton and microtubule-based processes. Furthermore, the edited sites found in the ovine BLCAP and NEIL1 genes are in line with those in previous reports on the porcine and human homologs, suggesting the existence of evolutionarily conserved RNA editing sites and they may play an important role in the structure and function of genes.Conclusions: Our study is the first to investigate RNA editing events in sheep. We screened out 607 and 994 RNA editing sites in three biological replicates of the ovine kidney and spleen and annotated 164 and 247 genes in the kidney and spleen, respectively. The gene function and conservation analysis of these RNA editing-related genes suggest that RNA editing is associated with important gene function in sheep. The putative functionally important RNA editing sites reported in the present study will help future studies on the relationship between these edited sites and the genetic traits in sheep. | Yuanyuan Zhang Deping Han Xianggui Dong Jiankui Wang Jianfei Chen Yanzhu Yao Hesham Y.A.Darwish Wansheng Liu Xuemei Deng | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 2 |
| 20 | PM_(2.5) exposure associated with microbiota gut-brain axis:Multi-omics mechanistic implications from the BAPE study显示文摘Recent studies have shown that PM_(2.5) may activate the hypothalamus-pituitary-adrenal(HPA)axis by inducing hormonal changes,potentially explaining the increase in neurological and cardiovascular risks.In addition,an association between PM_(2.5) and gut microbiota and metabolites was established.The above evidence represents crucial parts of the gut-brain axis(GBA).In view of this evidence. | Tiantian Li Jianlong Fang Song Tang Hang Du Liang Zhao Yanwen Wang Fuchang Deng Yuanyuan Liu Yanjun Du Liangliang Cui Wanying Shi Yan Wang Jiaonan Wang Yingjian Zhang Xiaoyan Dong Ying Gao Yu Shen Li Dong Huichan Zhou Qinghua Sun Haoran Dong Xiumiao Peng Yi Zhang Meng Cao Hong Zhi Jingyang Zhou Xiaoming Shi | 2022 | The Innovation2022，3，2： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员