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| 1 | MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2显示文摘新兴的证据与肿瘤开发和前进显示出异常地表示的 microRNAs (miRNAs ) 的协会。然而,很少在胃的 carcinogenesis 对 miRNAs 的潜在的角色被知道。这里,我们执行了 miRNA microarray 屏蔽在配对的胃的癌症和他们的邻近的 nontumor 纸巾表示并且发现 miR-375 是的 miRNAs 差别极大地在胃的癌症纸巾的 downregulated。量的即时 PCR 分析证实那 miR-375 表情显著地从经历胃的切除术的病人与他们的 nontumor 对应物相比在超过 90% 主要胃的癌症被减少。miR-375 的 Overexpression 显著地在 vitro 并且在 vivo 禁止了胃的癌症房间增长。在胃的癌症房间的 miR-375 的强迫的表示显著地减少了 Janus kinase 的蛋白质水平 2 ( JAK2 )并且镇压带 JAK2 的 3 鈥? untranslated 区域的一个酶记者的活动,被预言的 miR-375-binding 地点的变化废除,显示那 JAK2 可以是 miR-375 目标基因。由由 RNAi 的 JAK2 的 AG490 或 silencing 的 JAK2 活动的任何一个抑制压制了类似于 miR-375 overexpression 的胃的癌症房间增长。而且, JAK2 的宫外的表示能部分颠倒 miR-375 引起的房间增长的抑制。最后,我们在胃的癌症发现了在 miR-375 表示和 JAK2 蛋白质水平之间的重要反的关联。因此,这些数据建议 miR-375 可以作为肿瘤 suppressor 工作由指向 JAK2 oncogene 潜在地调整胃的癌症房间增长,含有在胃的癌症的致病的 miR-375 的一个角色。 | Ling Ding Yanjun Xu Wei Zhang Yujie Deng Misi Si Ying Du Haomi Yao Xuyan Liu Yuehai Ke Jianmin Si Tianhua Zhou | 2010 | Cell Research2010，20，7： | 59 |
| 2 | Acupuncture and moxibustion reduces neuronal edema in Alzheimer's disease rats显示文摘To examine the possible correlation of aberrant Wnt signaling and pathological changes in Alzheimer's disease, we established a rat model of Alzheimer's disease and measured axin and β-catenin expression in the hippocampus. Rats were pretreated with moxibustion or electroacu-puncture, or both, at Baihui(GV20) and Shenshu(BL23). Axin expression was lower, β-catenin expression was greater, and neuronal cytoplasmic edema was visibly prevented in the rats that had received the pretreatments. Our results suggest that the mechanism underlying the neuro-protective effect of acupuncture and moxibustion in Alzheimer's disease is associated with axin and β-catenin expression in the Wnt signal transduction pathway. | Hua Zhou Guojie Sun Lihong Kong Yanjun Du Feng Shen Shuju Wang Bangguo Chen Xiaoling Zeng | 2014 | Neural Regeneration Research2014，9，9： | 8 |
| 3 | Enzyme@silica nanoflower@metal-organic framework hybrids: A novel type of integrated nanobiocatalysts with improved stability显示文摘一个新奇综合 nanobiocatalyst 系统基于 enzyme@silica,有改进稳定性的 nanoflower@metal 器官的框架(enzyme@SNF@ZIF-8 ) 结构第一次被制作。这个系统的通用性作为模型酶用青霉素 G acylase (针网阵列) 和过氧化氢酶(猫) 被验证。多微孔的 ZIF-8 层能被改变 ZIF-8 涂层周期的数字控制,它与不同 ZIF-8 层厚度生产 PGA@SNF@ZIF-8 nanobiocatalysts。在第二个 ZIF-8 涂层周期以后, PGA@SNF@ZIF-8 (2 ) 结构与一同类并且 well-intergrown ZIF-8 层被形成,它拥有优秀机械、化学的稳定性。而且, PGA@SNF@ZIF-8 (2 ) 表演与在硅石 nanoflowers (PGA@SNF ) 上使不能调动的免费针网阵列和针网阵列相比改进了 thermal/storage 稳定性和可重用性。获得的基于猫的 nanobiocatalysts (CAT@SNF@ZIF-8 (2 )) 也显示出优秀催化性能。 | Yingjie Du Jing Gao Huajiao Liu Liya Zhou Ying He Zhihong Huang Yanjun Jiang | 2018 | Nano Research2018，11，8： | 5 |
| 4 | Acupoint combinations used for treatment of Alzheimer's disease: A data mining analysis显示文摘OBJECTIVE: To identify the acupoint combinations used in the treatment of Alzheimer's disease(AD).METHODS: The clinical literature regarding acupuncture and moxibustion for AD was searched and collected from databases including Chinese Biomedical Medicine, China National Knowledge Infrastructure, Wanfang Database and PubMed. The database of acupuncture and moxibustion prescriptions for AD was established by using Excel software so as to conduct the descriptive analysis, association analysis on the data.RESULTS: Baihui(GV 20), Sishencong(EX-HN 1),Shenmen(HT 7), Zusanli(ST 36), Neiguan(PC 6),Fengchi(GB 20), Taixi(KI 3), Dazhui(GV 14), Shenshu(BL 23), Sanyinjiao(SP 6), Shenting(GV 24), Fenglong(ST 40), Xuanzhong(GB 39), Shuigou(GV 26)and Taichong(LR 3) were of higher frequency in the treatment of AD with acupnucture and moxibustion. Most acupoints were selected from the Governor Vessel. The commonly used acupoints were located on the head, face, neck and lower limbs. The combination of the local acupoints with the distal ones was predominated. The crossing points among the specific points presented the advantage in the treatment. The association analysis indicated that the correlation among Fengchi(GB 20)-Baihui(GV 20) was the strongest, followed by combinations of Dazhui(GV 14)-Baihui(GV 20), Shenshu(BL 23)-Baihui(GV 20) and Neiguan(PC 6)-Baihui(GV 20) and indicated the common rules of the clinical acupoint selection and combination for AD.CONCLUSION: Our findings provide a reference for acupoints selection and combination for AD in clinical acupuncture practice. | Yu Chaochao Wang Li Kong Lihong Shen Feng Ma Chaoyang Du Yanjun Zhou Hua | 2018 | Journal of Traditional Chinese Medicine2018，38，6： | 4 |
| 5 | Numerical simulation of seepage flow field in groundwater source heat pump system and its influence on temperature field显示文摘Energy utilization in the aquifers is a new technology closely related to development of heat pump technique. It is significant for the flow distribution to be predicted in the aquifer surrounding the Groundwater Source Heat Pump System (GSHPS). The authors presented a new concept of 'flow transfixion' by analyzing general features of aquifers, and then discussed interaction of the flow transfixion with the heat transfixion, which has practical significance to projects. A numerical model of groundwater flow was established based on the basic tenets of water-heat transferring in the aquifer. On this basis the flow field and the temperature field of GSHPS for a site in Shenyang City were numerically simulated. The basis of the flow transfixion was obtained; it was discussed for the influence of the flow transfixion on the heat transfixion. To a certain extent, the study offers some reference for the projects' design of GSHP in the studied area. | Jihua HU Yanjun ZHANG Danyan DU Gang WU Ziwang YU Chen WANG Fuquan NI | 2008 | Global Geology2008，11，3： | 4 |
| 6 | Pre-moxibustion and moxibustion prevent Alzheimer's disease显示文摘The Alzheimer's disease model in Wistar rats was established by injection of amyloid β-peptide(Aβ1–42) into the hippocampal CA1 region. Rats were treated with suspended moxibustion on Baihui(GV20) and Shenshu(BL23) acupoints. Prior to and post Aβ1–42exposure. Results showed no evidence of apoptosis in hippocampal neurons, a significantly reduced apoptosis rate of neurons and improved learning and memory abilities were observed in the Alzheimer's disease model. In particular, moxibustion prior to Aβ1–42exposure was more effective than moxibustion after Aβ1–42exposure in protecting the neuronal structure and lowering the apoptosis rate. Our findings indicate that a combination of preventive and therapeutic moxibustion has a beneficial effect for the prevention of Alzheimer's disease development. | Yanjun Du Ruolan Liu Guojie Sun Peiyan Meng Jie Song | 2013 | Neural Regeneration Research2013，8，30： | 4 |
| 7 | Orthogonal resource sharing scheme for device-to-device communication overlaying cellular networks: a cooperative relay based approach显示文摘In this paper, we propose a device-to-device(D2D) communication scheme to improve local services in cellular networks. By employing cooperative relay(CR) technology, D2 D and cellular communications can operate in orthogonal resource sharing(ORS) mode with the aim of optimizing the data rates for local D2 D users while fulfilling the minimum rate requirements for prioritized cellular users. In the proposed CR-based ORS scheme, we consider a cellular communication that is willing to share part of the occupied bandwidth resource with some D2 D communications. Hence, the newly-obtained resource can be used by a D2 D communication for the following two purposes, i.e., to compensate the rate loss of the cellular communication through cooperative relaying and to communicate its own information so as to increase its own rate. We formulated this CR-based ORS problem as a non-convex optimization problem. Hence, a global maximizer may not exist for the problem.To find the optimal solution for the problem, an effective heuristic algorithm is developed. Simulation results show that the proposed D2 D communication scheme can significantly increase the rates of local D2 D users and also fulfill the minimum rate requirements of cellular users. | ZHANG GuoPeng LIU Peng YANG Kun DU Yao HU YanJun | 2015 | Science China(Information Sciences)2015，58，10： | 3 |
| 8 | PM_(2.5) exposure associated with microbiota gut-brain axis:Multi-omics mechanistic implications from the BAPE study显示文摘Recent studies have shown that PM_(2.5) may activate the hypothalamus-pituitary-adrenal(HPA)axis by inducing hormonal changes,potentially explaining the increase in neurological and cardiovascular risks.In addition,an association between PM_(2.5) and gut microbiota and metabolites was established.The above evidence represents crucial parts of the gut-brain axis(GBA).In view of this evidence. | Tiantian Li Jianlong Fang Song Tang Hang Du Liang Zhao Yanwen Wang Fuchang Deng Yuanyuan Liu Yanjun Du Liangliang Cui Wanying Shi Yan Wang Jiaonan Wang Yingjian Zhang Xiaoyan Dong Ying Gao Yu Shen Li Dong Huichan Zhou Qinghua Sun Haoran Dong Xiumiao Peng Yi Zhang Meng Cao Hong Zhi Jingyang Zhou Xiaoming Shi | 2022 | The Innovation2022，3，2： | 2 |
| 9 | A two-level relaxed bound method for a nonlinear class of 0-1 knapsack problems显示文摘 | Gao Yuelin Wang Yanjun and Du Xuewu | 2005 | Intelligent Information Management Systems and Technologies2005，3，： | 1 |
| 10 | Nano-enabled solar driven-interfacial evaporation:Advanced design and opportunities显示文摘Solar-driven interfacial evaporation(SDIE)is emerging as a promising pathway to solving the worldwide water shortage and water pollution.Nanomaterials(e.g.,plasmonic metals,inorganic/organic semiconductors,and carbon nanomaterials)and related nanochemistry have attracted increasing attention for the solar-to-vapor process in terms of broadband absorption,electronic structure adjustment,and surface/interface chemistry manipulation.Furthermore,the assembly of nanomaterials can contribute to the mass transfer,heat management,and enthalpy regulation of water during solar evaporation.To date,numerous nano-enabled materials and structures have been developed to improve the solar absorption,heat management(i.e.,heat confinement and heat transfer),and water management(i.e.,activation,evaporation,and replenishment).In this review,we focus on a systematical summary about the composition and structure engineering of nanomaterials in SDIE,including size and morphology effects,nanostructure optimizations,and structure-property relationship decoupling.This review also surveys recent advances in nanochemistry(e.g.,preparation chemistry and structural chemistry)deployed to conceptual design of nanomaterials.Finally,the key challenges and future perspectives of nanomaterials for solar evaporation are overviewed.This review aims at providing guidance for the design and construction of nanomaterials for high-efficiency SDIE on the basis of the aspects of materials science and chemical engineering. | Xin Zhao Xiangtong Meng Hongqi Zou Yanjun Zhang Yangjun Ma Yadong Du Yuan Shao Jun Qi Jieshan Qiu | 2023 | Nano Research2023，16，5： | 1 |
| 11 | Some factors controlling diffusive transportof potassium ion through clayey soils显示文摘 | Du Yanjun Liu Songyu | 2006 | Journal of Southeast University2006，22，1： | 1 |
| 12 | Swelling shrinkage properties and soil improvement of compacted expansive soil in NingIiang Highway 显示文摘 | LI Shenglin | 1999 | Chin Eng Geology1999，53，3： | 1 |
| 13 | Swelling-shrinkage properties and soil improvement of compacted expansive soil,Ning-Liang highway,China显示文摘 | Yanjun Du Shenglin Li Shigenori Hayashi | 1999 | Engineering Geology1999，53，： | 1 |
| 14 | Earth reinforcement using soil bags 显示文摘 | Xu Yongfu Huang Jian Du Yanjun | 2008 | Geotextiles and Geomembranes2008，，26： | 1 |
| 15 | Bi-channel near-and far-field optical vortex generator based on a single plasmonic metasurface显示文摘With the recent development of the metasurface,generating an optical vortex in optical far or near fields is realized in various ways.However,to generate vortices in both the near and far fields simultaneously is still a challenge,although it has great potential in the future compact and versatile photonic system.Here,a bi-channel optical vortex generator in both the near and far fields is proposed and demonstrated within a single metasurface,where the surface plasmon vortex and the far-field optical vortex can be simultancously generated under circularly polarized light.The ability of generating vortices with arbitrary topological charges is experimentally demon-strated,which agrces well with simulations.This approach provides great freedom to integrate different vortex generators in a single device and ofers new opprtunities for integrated optical communications,trapping,and other related fields. | QIAO JIANG YANJUN BAO JING LI LIFENG TIAN ToNG CUI LIN SUN BOWEN DU BOWEN LI BENFENG BAI JIA WANG HONGBO SUN Bo SHEN HAN ZHANG FENG LIN XING ZHU ZHEYU FANG | 2020 | Photonics Research2020，8，6： | 1 |
| 16 | Characteristics of aerobic biogranules from membrane bioreactor system显示文摘 | Xiufen Li Yanjun Li He Liu Zhaozhe Hua Guocheng Du Jian Chen | 2006 | Journal of Membrane Science2006，，2： | 1 |
| 17 | Protective effects of berberine against amyloid beta-induced toxicity in cultured rat cortical neurons显示文摘Berberine,a major constituent of Coptidis rhizoma,exhibits neural protective effects.The present study analyzed the potential protective effect of berberine against amyloid β-induced cytotoxicity in rat cerebral cortical neurons.Alzheimer's disease cell models were treated with 0.5 and 2 μmol/L berberine for 36 hours to inhibit amyloid β-induced toxicity.Methyl thiazolyl tetrazolium assay and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling staining results showed that berberine significantly increased cell viability and reduced cell apoptosis in primary cultured rat cortical neurons.In addition,western blot analysis revealed a protective effect of berberine against amyloid β-induced toxicity in cultured cortical neurons,which coincided with significantly decreased abnormal up-regulation of activated caspase-3.These results showed that berberine exhibited a protective effect against amyloid β-induced cytotoxicity in cultured rat cortical neurons. | Wang, Jing Zhang, Yanjun Du, Shuai Zhang, Mixia | 2011 | Neural Regeneration Research2011，6，3： | 1 |
| 18 | An Improved Neural Network Utilized in Stereo Matching 显示文摘 | Xu Yanjun Du Limin Hou Ziqiang | 1998 | Journal of Image and Graphics1998，103，10： | 1 |
| 19 | Near-in- frared determination of polyphenols using linear and non- linear regression algorithms显示文摘 | HUANG Yue DU Guorong MA Yanjun | 2015 | Optik International Jour- nal for Light and Electron Optics2015，126，： | 1 |
| 20 | High-speed Stokes vector receiver enabled by a spin-dependent optical grating显示文摘Stokes vector direct detection is a promising,cost-effective technology for short-distance communication applications.Here,we design and fabricate a spin-dependent liquid crystal grating to detect light polarization states.By separating the circular and linear components of incident light,the polarization states can be resolved with accuracy of up to 0.25°.We achieved Stokes vector direct detection of quadrature phase-shift keying(QPSK),8 PSK,and16-ary quadrature amplitude modulation signals with 32,16,and 16 GBd rates,respectively.We integrated the system,including the grating,photodetectors,and optical elements,on a miniaturized printed circuit board and demonstrated high-speed optical communications with 16 GBd rate QPSK signals. | YOUPENG XIE TING LEI DAWEI WANG JIANXIN REN YANMENG DAI YANJUN CHEN LUPING DU BO LIU ZHAOHUI LI XIAOCONG YUAN | 2021 | Photonics Research2021，9，8： | 1 |
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