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| 1 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 2 | Detection of BRAF V600E Mutation in Colorectal Cancer显示文摘 | Susana Benlloch Artemio Payá Cristina Alenda Xavier Bessa Montserrat Andreu Rodrigo Jover Antoni Castells Xavier Llor F. Ignacio Aranda Bartomeu Massutí | 2006 | The Journal of Molecular Diagnostics2006，，5： | 1 |
| 3 | Chemoembolization of hepatocellular carcinoma with drug eluting beads: Efficacy and doxorubicin pharmacokinetics显示文摘 | María Varela María Isabel Real Marta Burrel Alejandro Forner Margarita Sala Mercé Brunet Carmen Ayuso Lluis Castells Xavier Monta?á Josep M. Llovet Jordi Bruix | 2007 | Journal of Hepatology2007，，3： | 1 |
| 4 | Acute phase response in laparoscopic and open colectomy in colon cancer显示文摘 | Salvadora Delgado M.D. Dr. Antonio M. Lacy M.D. Xavier Filella M.D. Antoni Castells M.D. Juan C. García-Valdecasas M.D. Josep M. Pique M.D. Dulce Momblán M.D. Josep Visa M.D | 2001 | Diseases of the Colon & Rectum2001，，5： | 1 |
| 5 | Chemoembolization of hepatocellular carcinoma with drug eluting beads: Efficacy and doxorubicin pharmacokinetics显示文摘 | María Varela María Isabel Real Marta Burrel Alejandro Forner Margarita Sala Mercé Brunet Carmen Ayuso Lluis Castells Xavier Monta?á Josep M. Llovet Jordi Bruix | 2007 | Journal of Hepatology2007，，3： | 1 |
| 6 | Effects of compression stockings during exercise and recovery on blood lactate kinetics显示文摘 | Diana Rimaud Laurent Messonnier Josiane Castells Xavier Devillard Paul Calmels | 2010 | European Journal of Applied Physiology2010，，2： | 1 |
| 7 | Chemoembolization of hepatocellular carcinoma with drug eluting beads: Efficacy and doxorubicin pharmacokinetics显示文摘 | María Varela María Isabel Real Marta Burrel Alejandro Forner Margarita Sala Mercé Brunet Carmen Ayuso Lluis Castells Xavier Monta?á Josep M. Llovet Jordi Bruix | 2007 | Journal of Hepatology2007，，3： | 1 |
| 8 | Imaging of hepatitis C virus infection in liver grafts after liver transplantation<!-- Doctopic: TAS -->显示文摘 | Laura Mensa Sofía Pérez-del-Pulgar Gonzalo Crespo George Koutsoudakis Carlos Fernández-Carrillo Mairene Coto-Llerena Rosa Miquel Helena Allende Lluís Castells Miquel Navasa Xavier Forns | 2013 | Journal of Hepatology2013，，2： | 1 |
| 9 | Laparoscopic-assisted vs. open colectomy for colorectal cancer: Influence on neoplastic cell mobilization显示文摘 | Xavier Bessa M.D. Dr. Antoni Castells M.D. Antonio M. Lacy M.D. J. Ignasi Elizalde M.D. Salvadora Delgado M.D. Loreto Boix Ph.D. Virginia Pi?ol M.D. Maria Pellisé M.D. Juan C. García-Valdecasas M.D. Josep M. Piqué M.D | 2001 | Journal of Gastrointestinal Surgery2001，，1： | 1 |
| 10 | Cell microarrays in drug discovery 显示文摘 | David Castel Amandine Pitaval Marie-Anne Debily and Xavier Gidrol | 2006 | Drug Discovery Today2006，11，1314： | 1 |
| 11 | Chemoembolization of hepatocellular carcinoma with drug eluting beads: Efficacy and doxorubicin pharmacokinetics显示文摘 | María Varela María Isabel Real Marta Burrel Alejandro Forner Margarita Sala Mercé Brunet Carmen Ayuso Lluis Castells Xavier Monta?á Josep M. Llovet Jordi Bruix | 2007 | Journal of Hepatology2007，，3： | 1 |
| 12 | Aberrant DNA Methylation in Hereditary Nonpolyposis Colorectal Cancer Without Mismatch Repair Deficiency显示文摘 | Ajay Goel Rosa M. Xicola Thuy–Phuong Nguyen Brian J. Doyle Vanessa R. Sohn Prathap Bandipalliam Laura S. Rozek Josep Reyes Carmen Cordero Francesc Balaguer Antoni Castells Rodrigo Jover Montserrat Andreu Sapna Syngal C. Richard Boland Xavier Llor | 2010 | Gastroenterology2010，，5： | 1 |
| 13 | Sofosbuvir compassionate use program for patients with severe recurrent hepatitis C after liver transplantation显示文摘 | Xavier Forns Michael Charlton Jill Denning John G. McHutchison William T. Symonds Diana Brainard Theo Brandt‐Sarif Paul Chang Valerie Kivett Lluís Castells Martín Prieto Robert J. Fontana Thomas F. Baumert Audrey Coilly Maria Carlota Londo?o Fran?ois Habe | 2015 | Hepatology2015，，5： | 1 |
| 14 | The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status显示文摘 | Rodrigo Jover Pedro Zapater Antoni Castells Xavier Llor Montserrat Andreu Joaquín Cubiella Francesc Balaguer Laura Sempere Rosa M. Xicola Luis Bujanda Josep M. Re?é Juan Clofent Xavier Bessa Juan D. Morillas David Nicolás-Pérez Elisenda Pons Artemio Payá | 2008 | European Journal of Cancer2008，，3： | 1 |
| 15 | Antimicrobial Activity of Stainless Steel with a Modified Tin Upperlayer on Meat Related Contaminants显示文摘 | Frederic De Nardi David Delaunay Roland Talibart Xavier Castel Laurent Le Gendre Amaud Castillo Christine Pissavin | 2016 | Journal of Food Science and Engineering2016，6，6： | 0 |
| 16 | Colorectal cancer prognosis twenty years later显示文摘AIM:To evaluate changes in colorectal cancer(CRC) survival over the last 20 years.METHODS:We compared two groups of consecutive CRC patients that were prospectively recruited:Group Ⅰincluded 1990 patients diagnosed between 1980 and 1994.GroupⅡincluded 871 patients diagnosed in 2001.RESULTS:The average follow up time was 21 mo(1-229)for GroupⅠand 50 mo(1-73.4)for GroupⅡ.Overall median survival was significantly longer in Group Ⅱthan in GroupⅠ(73 mo vs 25 mo,P<0.001)and the difference was significant for all tumor stages.Post surgical mortality was 8% for GroupⅠand 2% for Group Ⅱ(P<0.001).Only 17% of GroupⅠpatients received chemotherapy compared with 50% of GroupⅡpatients(P<0.001).CONCLUSION:Survival in colorectal cancer patients has doubled over the past 20 years.This increase seems to be partly due to the generalization in the administration of chemotherapy and to the decrease of post surgical mortality. | Luis Bujanda Cristina Sarasqueta Elisabeth Hijona Lander Hijona Angel Cosme Ines Gil Jose Luis Elorza Jose I Asensio Santiago Larburu José M Enríquez-Navascués Rodrigo Jover Francesc Balaguer Xavier Llor Xavier Bessa Montserrat Andreu Artemio Paya Antoni Castells Gastrointestinal Oncology Group of the Spanish Gastroenterological Association | 2010 | World Journal of Gastroenterology2010，16，7： | 0 |
| 17 | Analyzing the genomic and transcriptomic architecture of milk traits in Murciano-Granadina goats显示文摘Background:In this study,we aimed to investigate the molecular basis of lactation as well as to identify the genetic factors that influence milk yield and composition in goats.To achieve these two goals,we have analyzed how the mRNA profile of the mammary gland changes in seven Murciano-Granadina goats at each of three different time points,i.e.78 d(T1,early lactation),216 d(T2,late lactation)and 285 d(T3,dry period)after parturition.Moreover,we have performed a genome-wide association study(GWAS)for seven dairy traits recorded in the 1st lactation of 822 Murciano-Granadina goats.Results:The expression profiles of the mammary gland in the early(T1)and late(T2)lactation were quite similar(42 differentially expressed genes),while strong transcriptomic differences(more than one thousand differentially expressed genes)were observed between the lactating(T1/T2)and non-lactating(T3)mammary glands.A large number of differentially expressed genes were involved in pathways related with the biosynthesis of amino acids,cholesterol,triglycerides and steroids as well as with glycerophospholipid metabolism,adipocytokine signaling,lipid binding,regulation of ion transmembrane transport,calcium ion binding,metalloendopeptidase activity and complement and coagulation cascades.With regard to the second goal of the study,the performance of the GWAS allowed us to detect 24 quantitative trait loci(QTLs),including three genome-wide significant associations:QTL1(chromosome 2,130.72-131.01 Mb)for lactose percentage,QTL6(chromosome 6,78.90-93.48 Mb)for protein percentage and QTL17(chromosome 17,11.20 Mb)for both protein and dry matter percentages.Interestingly,QTL6 shows positional coincidence with the casein genes,which encode 80%of milk proteins.Conclusions:The abrogation of lactation involves dramatic changes in the expression of genes participating in a broad array of physiological processes such as protein,lipid and carbohydrate metabolism,calcium homeostasis,cell death and tissue remodeling,as well as immunity.We also conclude that genetic variation at the casein genes has a major impact on the milk protein content of Murciano-Granadina goats. | Dailu Guan Vincenzo Landi María Gracia Luigi-Sierra Juan Vicente Delgado Xavier Such Anna Castelló Betlem Cabrera Emilio Mármol-Sánchez Javier Fernández-Alvarez JoséLuis Ruiz de la Torre Casañas Amparo Martínez Jordi Jordana Marcel Amills | 2020 | Journal of Animal Science and Biotechnology2020，11，3： | 0 |
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