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| 1 | Low-dose metformin treatment in the subacute phase improves the locomotor function of a mouse model of spinal cord injury显示文摘Metformin,a first-line drug for type-2 diabetes,has been shown to improve locomotor recovery after spinal cord injury.However,there are studies reporting no beneficial effect.Recently,we found that high dose of metformin(200 mg/kg,intraperitoneal)and acute phase administration(immediately after injury)led to increased mortality and limited locomotor function recovery.Consequently,we used a lower dose(100 mg/kg,i.p.)metformin in mice,and compared the effect of immediate administration after spinal cord injury(acute phase)with that of administration at 3 days post-injury(subacute phase).Our data showed that metformin treatment starting at the subacute phase significantly improved mouse locomotor function evaluated by Basso Mouse Scale(BMS)scoring.Immunohistochemical studies also revealed significant inhibitions of microglia/macrophage activation and astrogliosis at the lesion site.Furthermore,metformin treatment at the subacute phase reduced neutrophil infiltration.These changes were in parallel with the increased survival rate of spinal neurons in animals treated with metformin.These findings suggest that low-dose metformin treatment for subacute spinal cord injury can effectively improve the functional recovery possibly through anti-inflammation and neuroprotection.This study was approved by the Institute Animal Care and Use Committee at the University of Texas Medical Branch(approval No.1008041C)in 2010. | Wen-Ye Song Han Ding Tiffany Dunn Jun-Ling Gao Javier Allende Labastida Caitlin Schlagal Guang-Zhi Ning Shi-Qing Feng Ping Wu | 2021 | Neural Regeneration Research2021，16，11： | 12 |
| 2 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 3 | 中药、针灸为主的综合干预介入肿瘤患者的临终关怀(英文)显示文摘目的:探讨中药、针灸为主的综合干预介入肿瘤患者临终关怀的策略及临床研究。方法:选取上海某医院中医科医院已确诊的肝癌患者作为研究对象,应用数字化四诊合参辅助诊疗仪采集受试者数字化四诊数据,进行辨证论治。从而对肝癌患者采取中药、针灸为主的综合干预措施。结果:将受试者的四诊数据与该医院中医科的诊断资料对比,相吻合。中药、针灸为主的综合干预介入肝癌患者的临终关怀,显著延长了术后患者的生存时间和生活质量。结论:数字化的四诊合参辅助诊疗仪的诊断符合率较高。中药、针灸以及心理干预对仅有6个月左右生存期的肝癌晚期患者可以提高其存活期和生活质量。 | 徐荣廷 牛婷立 马良宵 RO-berto González Silvia Allende Emma Verastegui 芦煜 张尚尚 张健 杨学智 牛欣 | 2017 | 中华中医药杂志2017，32，5： | 3 |
| 4 | The reference genetic linkage map for the multinational Brassica rapa genome sequencing project显示文摘 | Su Ryun Choi Graham R. Teakle Prikshit Plaha Jeong Hee Kim Charlotte J. Allender Elena Beynon Zhong Yun Piao Pilar Soengas Tae Ho Han Graham J. King Guy C. Barker Paul Hand Derek J. Lydiate Jacqueline Batley David Edwards Dal Hoe Koo Jae Wook Bang Beom-Se | 2007 | Theoretical and Applied Genetics2007，，6： | 2 |
| 5 | Suitability of aqueous chlorine dioxide versus sodium hypochlorite as an effective sanitizer for preserving quality of fresh-cut lettuce while avoiding by-product formation显示文摘 | Francisco López-Gálvez Ana Allende Pilar Truchado Ascensión Martínez-Sánchez Juan A. Tudela María V. Selma María I. Gil | 2009 | Postharvest Biology and Technology2009，，1： | 2 |
| 6 | Risk for esophageal neoplasia in B arrett’s esophagus patients with mucosal changes indefinite for dysplasia显示文摘 | Bela Horvath Prabhdeep Singh Hao Xie Prashanthi N Thota Daniela S Allende Rish K Pai Deepa T Patil Thomas P Plesec John R Goldblum Xiuli Liu | 2015 | J Gastroenterol Hepatol2015，，： | 2 |
| 7 | Molecularly imprinted polymers:a bridge to advanced drug delivery显示文摘 | SELLERGREN B ALLENDER C J | 2005 | Adv Drug Deliv Rev2005，57，12： | 1 |
| 8 | An enzyme-linked immunosorbent assay for the detection of vesicular stomatitis virus antibodies 显示文摘 | Allende R Sepulveda L Mendes da Silva A | 1992 | Prev Vet Med1992，14，： | 1 |
| 9 | Mutations in the genome of porcine reproductive and respiratory syndrome virus responsible for the attenuation phenotype 显示文摘 | Allende R Kutish G F Laegreid W | 2000 | Arch Virol2000，145，： | 1 |
| 10 | Angiostatin supress maligant glioma growth in vivo 显示文摘 | Strasser J Allende R | 1998 | Cancer Res1998，58，： | 1 |
| 11 | Effectiveness of two-sided UV-C treatments in inhibiting natural microflora and extending the shelf-life of minimally processed 'Red Oak Leaf' lettuce显示文摘 | Allende A McEvoy J L Luo Y | 2006 | Food Microbiology2006，23，： | 1 |
| 12 | OzonedepletionandincreasedUV-Bradiation:istherearealthreattophotosynthesis显示文摘 | AllenD Nogue′sS BakerNR | 1998 | JExpBot1998，49，： | 1 |
| 13 | North American and European porcine reproductive and respiratory syndrome viru- ses differ in nonstructural protein coding regions显示文摘 | ALLENDE R LEWIS T L LU Z | 1999 | J Gen Virol1999，80，2： | 1 |
| 14 | Bacterial identificationbased on protein mass spectrometry: A new insight at the micro-biology of the 21st century显示文摘 | Garcia P Allende F Legarraga P | 2012 | Rev Chilena lnfectol2012，29，3： | 1 |
| 15 | Combined ultraviolet-C and modified atmosphere packaging treatments for reducing microbial growth of fresh processed lettuce 显示文摘 | Allende A Art s F | 2003 | Food Science and Technology2003，36，： | 1 |
| 16 | Mutations in the ge- nome of porcine reproductive and respiratory syndrome virus responsible for the attenuation phenotype 显示文摘 | Allende R Kutish G F Laegreid W | 2006 | Archives of Vi- rology2006，145，： | 1 |
| 17 | Porcine reproductive and respiratory syndrome virus: description of persistence in individual pigs upon experimental infection显示文摘 | Allende R Laegreid WWL Kutish GF | 2000 | J Virol2000，，10： | 1 |
| 18 | Mutations in the genome of porcine reproductive and respiratory syndrome virus responsible for the attenuation phenotype 显示文摘 | Allende R Kutish G F Laegreid W | 2000 | Archives of Virology2000，145，6： | 1 |
| 19 | North American and European porcine reproductive and respiratory syndrome viruses differ in nonzst ructural protein coding regions显示文摘 | ALLENDE R LEWIS T L LU Z | 1999 | J Gen Virol1999，80，： | 1 |
| 20 | Cross- hypersensitivity syndrome between antiepileptic drugs : report of a case显示文摘 | Allende B M Izuel R M Urbieta S E | 2004 | FarmHosp2004，28，1： | 1 |
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