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| 1 | 波前像差引导的LASIK手术的临床效果观察显示文摘目的 :观察波前像差引导的LASIK手术矫正近视性散光的效果。方法 :2 8例 35只眼 ,平均术前球镜屈光度为 (- 4.8± 2 .3)D ,柱镜屈光度为 (- 1.1± 0 .9)D。手术前和手术后均使用Tscherning像差计测量 ,分析波前像差。应用 1.0mm光斑、频率 2 0 0Hz的飞点扫描准分子激光进行屈光手术。结果 :术后 3个月 ,6 8.0 %的眼屈光度在± 0 .5D(正视眼 )内 ,93.5 %眼在± 1.0D内。 93.5 %的裸眼视力为 2 0 / 2 0或更好。裸眼超常视力(BSCVA在 2 0 / 10或更好 )占 16 .0 %。高阶像差 (球差 ,彗差 )矫正不足 ,而波前像差全部均方根增加值为 1.44± 0 .74,彗差的矫正好于球差。结论 :波前像差引导的LASIK手术是一种很可靠的技术 ,可有效地矫正屈光不正 ,改善视觉敏感度 ,提高视觉质量 ,尤其是提高夜间视力的视觉质量。 | Michael Mrochen Maik Kaemmerer Theo Seiler | 2001 | 眼视光学杂志2001，3，2： | 63 |
| 2 | 从采矿迹地到景观公园显示文摘对矿区景观类型,矿区景观重建的概念、要素和目标以及矿区景观重建的实施进行了系统的分析研究.得出,通过对采矿迹地的合理整治和景观重建,采矿业对景观环境的损害是可以恢复的.最后以德国鲁尔区为例,阐述了景观规划对矿区景观重建的作用和意义. | 常江 Theo Koetter | 2005 | 煤炭学报2005，30，3： | 23 |
| 3 | Multi-state supernetworks:recent progress and prospects显示文摘Supernetworks have long been adopted to address multi-dimensional choice problems,which are thorny to solve for classic singular networks.Originated from combining transport mode and route choice into a multi-modal network,supernetworks have been extended into multi-state networks to include activity-travel scheduling,centered around activity-based models of travel demand.A key feature of the network extensions is that multiple choice facets pertaining to conducting a full activity program can be modeled in a consistent and integrative fashion.Thus,interdependencies and constraints between related choice facets can be readily captured.Given this advantage of integrity,the modeling of supernetwork has become an emerging topic in transportation research.This paper summarizes the recent progress in modeling multi-state supernetworks and discusses future prospects. | Feixiong Liao Theo Arentze Harry Timmermans | 2014 | Journal of Traffic and Transportation Engineering(English Edition)2014，1，1： | 16 |
| 4 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 5 | Ghrelin在大鼠神经系统中的表达对胃黏膜的保护作用显示文摘目的:研究大鼠脑、小肠肌间神经丛神经元和血浆内Ghrelin的表达,探讨Ghrelin在水浸加束缚应激性胃溃疡中的作用及机制.方法:选择健康♂Wiater大鼠76只,随机分为 6组:水浸加束缚组(10只);侧脑室注射Ghrelin 组(24只);皮下注射L-NAME+侧脑室注射 Ghrelin组(8只)和相应的3个对照组(正常大鼠组18只,侧脑室注射生理盐水组8只,皮下注射 L-NAME+侧脑室注射生理盐水组8只).采用放射免疫分析、荧光免疫组化双染和神经生理学等实验方法,观察脑、小肠肌间神经丛和血浆内Ghrelin的表达,探讨Ghrelin对大鼠束缚加水浸诱导的应激性胃溃疡的影响及机制.结果:在正常大鼠小肠肌间神经丛内和原代培养的肠肌间神经丛神经元均可见有Ghrelin 样免疫反应阳性物(Ghrelin-IR)的表达,且 Ghrelin-IR与胆碱乙酰转移酶(CHAT)共同表达于同一神经元内,但Ghrelin-IR不与一氧化碳合酶(NOS)和消化道感觉性神经元内特有的钙结合蛋白(Calbindin,Calb)共存.在大鼠应激性胃溃疡产生的同时,其血浆内Ghrelin- IR的含量明显减少(198.3±29.6 ng/L vs 141.7 ±26.5 ng/L.P=0.026).而下丘脑、延脑、垂体和肌间神经丛神经元内Ghrelin-IR的含量明显升高(分别为96.2±18.1 pg/mg vs 153.2 ±11.6 pg/mg.P=0.006;89.8±16.5 pg/mg vs 144.4±13.9 pg/mg,P=0.007;108.3± 11.9 pg/mg vs 198.2±23.3 pg/mg,P=0.002; 48.8±12.8 pg/mg vs 86.2±21.5 pg/mg.P= 0.02);侧脑室注射Ghrelin大鼠应激性胃溃疡的产生明显减少,且呈明显的量效依赖关系(溃疡指数:生理盐水,86.7±6.2;50 ng Ghrelin,79.3±10.7 P=2.18;500 ng Ghrelin, 61.3±11.7,P=0.04;5 000 ng Ghrelin,35.6 ±10.8,P=0.005),经sc一氧化氮合酶抑制剂 L-NAME后,Ghrelin的胃黏膜细胞保护作用消失.结论:Ghrelin与ChAT共存表达于肠肌间神经丛胆碱能神经元;应激性胃溃疡发生时,中枢神经系统和血浆内Ghrelin的表达发生变化; 中枢Ghrelin对胃黏膜细胞具有保护作用,且呈明显的量效依赖关系. | 徐珞 孙向荣 韩晓华 钟凤 Inge Depoortere Theo Peeters | 2006 | 世界华人消化杂志2006，14，8： | 14 |
| 6 | 藏毛窦发病率和远期复发率现况及其影响因素分析显示文摘目的调查德国部队中藏毛窦的发病率和术后远期复发率的现状及其发展变化趋势,分析不同手术治疗方法、体格状况和吸烟量等因素对藏毛窦的发病率和术后远期复发率的影响。方法对德国三家部队医院1980至1996年收治的所有藏毛窦患者的资料进行统计,随机抽取其中500例患者进行随访。结果德国部队中藏毛窦的发病率由1985年的0.3/1000上升到2007年的2.4/1000。随机抽取的500例患者中2例死亡,498例接受了随访。其术后复发率从1981年的33%,到1986年的23%,再到1996年的12%,呈明显下降趋势(P=0.01)。藏毛窦切除后行开放愈合的复发率为16.8%,显著低于行一期缝合的复发率31.0%(P〈0.01)。部队中人均体质量每十年增加1kg,德国国民人均体质量每十年增加1.9kg,但是体质量的增加与藏毛窦复发率之间无显著相关性(P=0.72)。每天吸烟20支以上者藏毛窦的复发率比吸烟≤20支者显著升高(P=0.015)。结论在藏毛窦的术后复发率下降,特别是切除后开放愈合的术后复发率下降的同时,藏毛窦的发病率上升了近十倍。 | Theo Evers Dietrich Doll Edouard Matevossian Sebastian Noe Konrad Neumann 李挥力 Norbert Huser Rainer Ludde Sebastian Hoffmann Bjorn Dirk Krapohl | 2011 | 中华外科杂志2011，49，9： | 14 |
| 7 | Comparative Transcriptional Profiling and Preliminary Study on Heterosis Mechanism of Super-Hybrid Rice显示文摘杂种优势比也是从二父母表演的后代改善了的生物现象和优异性能生来的父母线。混合米饭是在利用杂种优势的庄稼的最成功的 apotheoses 之一。由基因表示(半自动地面防空系统)的连续分析 F1 超级混血儿的米饭 Liangyou-2186 和它的父母介绍的 Transcriptional 表明 1183 差别表示了基因( DG ),在哪个之中 DG 被发现显著地在象光合作用和碳固定那样的小径充实,并且大多数涉及碳固定小径的关键基因在 F1 混合米饭展出了起来调整的表示。而且,相应的酶的增加的分解代谢的活动和光合的效率也被检测,它联合了显示那碳固定可能在 F1 混血儿,和力量被提高在超级混血儿的米饭与收益活力和杂种优势被联系。由有收益相关的量的特点 loci (QTL ) 的相关 DG,在微分基因表示和 phenotypic 变化之间的一种潜在的关系也被发现。另外,当以前在 Arabidopsis 报导了,包含生理节奏节奏、轻的发信号的小径的一个规章的网络也被发现,它建议如此的一个网络可能也与在混合米饭的杂种优势是相关的。总的来说,现在的学习为理解在米饭位于杂种优势下面的分子的机制提供另一个看法。 | Gui-Sheng Song Hong-Li Zhai Yong-Gang Peng Lei Zhang Gang Wei Xiao- Ying Chen Yu-Guo Xiao Lili Wang Yue-Jun Chen Bin Wu Bin Chen Yu Zhang Hua Chen Xiu-Jing Feng Wan-Kui Gong Yao Liu Zhi-Jie Yin Feng Wang Guo-Zhen Liu Hong-Lin Xu Xiao-Li Wei Xiao-Ling Zhao Pieter B.F. Ouwerkerk Thomas Hankemeier Theo Reijmers Rob van der Heijden Cong-Ming Lu Mei Wang Jan van der Greef Zhen Zhu | 2010 | Molecular Plant2010，3，6： | 12 |
| 8 | Scavenger receptor BI: A multi-purpose player in cholesterol and steroid metabolism显示文摘Scavenger receptor class B type Ⅰ (SR-BI) is an important member of the scavenger receptor family of integral membrane glycoproteins. This review highlights studies in SR-BI knockout mice, which concern the role of SR-BI in cholesterol and steroid metabolism. SR-BI in hepatocytes is the sole molecule involved in selective uptake of cholesteryl esters from high-density lipoprotein (HDL). SR-BI plays a physiological role in binding and uptake of native apolipoprotein B (apoB)-containing lipoproteins by hepatocytes, which identif ies SR-BI as a multipurpose player in lipid uptake from the blood circulation into hepatocytes in mice. In adrenocortical cells, SR-BI mediates the selective uptake of HDL-cholesteryl esters, which is eff iciently coupled to the synthesis of glucocorticoids (i.e. corticosterone). SR-BI knockout mice suffer from adrenal glucocorticoid insuff iciency, which suggests that functional SR-BI protein is necessary for optimal adrenal steroidogenesis in mice. SR-BI in macrophages plays a dual role in cholesterol metabolism as it is able to take up cholesterol associated with HDL and apoBcontaining lipoproteins and can possibly facilitate cholesterol efflux to HDL. Absence of SR-BI is associated with thrombocytopenia and altered thrombosis susceptibility, which suggests a novel role for SR-BI in regulating platelet number and function in mice. Transgenic expression of cholesteryl ester transfer protein in humanized SR-BI knockout mice normalizes hepatic delivery of HDL-cholesteryl esters. However, other pathologies associated with SR-BI def iciency, i.e. increased atherosclerosis susceptibility, adrenal glucocorticoid insuffi ciency, and impaired platelet function are not normalized, which suggests an important role for SR-BI in cholesterol and steroid metabolism in man. In conclusion, generation of SR-BI knockout mice has signif icantly contributed to our knowledge of the physiological role of SR-BI. Studies using these mice have identif ied SR-BI as a multi-purpose player in cholesterol and steroid metabolism because it has distinct roles in reverse cholesterol transport, adrenal steroidogenesis, and platelet function. | Menno Hoekstra Theo JC Van Berkel Miranda Van Eck | 2010 | World Journal of Gastroenterology2010，16，47： | 11 |
| 9 | 中欧铁路班列在中欧贸易运输中的作用显示文摘为明确中欧班列作为独立的洲际贸易运输方式的作用与地位,把中欧间贸易运输的时间划分为在途时间、装卸时间和等待时间,把运输费用划分为运输过程费用、运输期间的库存费用、占用资金的机会成本和货物随时间的贬值成本;然后,基于运输方式划分模型、中欧间贸易货物和贸易运输数据,标定9类中欧间贸易货物的时间价值,并基于敏感性分析研究货物的时间价值及中欧班列发班频率对三种运输方式在9种货物运输市场上的份额影响.计算结果表明,增加发班频率可极大提升中欧班列对纸制品、纺织产品、珠宝类产品和机电类产品的吸引力;植物产品、珠宝类产品和机电类产品时间价值的增加会促使人们更多地使用铁路运输. | 赵怡然 杨忠振 Theo Notteboom | 2018 | 大连海事大学学报2018，44，3： | 11 |
| 10 | 波前像差引导的LASIK术矫正眼球像差显示文摘目的 :观察波前像差引导的LASIK术矫正人眼像差后的效果 ,以确定人眼是否可获得超过一般的视敏度。方法 :波前像差引导的LASIK手术对 15只眼矫正近视和散光 ,同时矫正眼球的像差。结果 :手术后 1个月时 ,4只眼 (占 2 7% )获得了 2 0 /10以上的超常视力。波前像差的均方根值从 0 .6增加到 2 .3,与视觉敏感度的提高呈显著性相关 (P <0 .0 5 )。结论 :像差的矫正虽然还不能最令人满意 ,但这些结果表明 ,眼球的像差使人眼视敏度受限制 ,而通过手术矫正可获得超过一般的视敏度。 | Theo Seiler Michael Mrochen Maik Kaemmerer | 2001 | 眼视光学杂志2001，3，2： | 11 |
| 11 | 真实评价设计的五维框架显示文摘真实性(authenticity)是新型评价模式的核心要素之一。然而,对于什么是真实评价,学术界还未予以充分具体的探索,更远未达成共识。本文在评述有关真实评价的研究文献基础上,讨论了教学、学习与评价的关系,论述了基于真实能力评价的意义,探讨了真实性和真实评价的定义,建构了面向专业实践能力发展的真实教学和真实评价设计的五维框架。结合真实教学的五维框架,重点论述了真实评价的五个维度:真实任务、物理情境、社会情境、评价结果/形式和评价标准,并且提出了设计或开发真实评价应当考虑的三大问题。 | Judith T.M.Gulikers Theo J.Bastiaens Paul A.Kirschner 钟志贤(编译) 刘春燕(编译) 范志忠(编译) | 2009 | 远程教育杂志2009，27，4： | 11 |
| 12 | 小麦赤霉菌绿色荧光蛋白标记突变体的侵染研究显示文摘【目的】赤霉病是危害大麦、小麦生产的世界性病害,研究病原菌的致病过程对于病害的控制有重要意义。【方法】本研究利用绿色荧光蛋白(GFP)标记的禾谷镰刀菌回复突变体以单花滴注方法进行人工接种研究不同突变体的致病力差异及其在小麦穗部的侵染过程。【结果】269株回复突变体的致病力存在明显分化。接种6d后,致病力明显降低的突变体,只有接种小穗发病,致病力明显增强的突变体,病症可扩展至5个小穗。GFP荧光信号检测表明,弱致病突变体在接种后仅在接种小穗内生长、延伸,并终止于小穗基部的致密组织处。而强致病力突变体在接种小穗内生长2d后,即能够通过小穗基部的致密组织到达小麦穗轴,并沿着穗轴内部微管束组织和皮层组织向上和下延伸,侵入邻近小穗。【结论】病原菌在接种小穗中生长后,沿着柱头、子房或内、外稃内表面,经过靠近穗轴的致密组织,侵入邻近小穗,感染整个麦穗,直至到达茎秆。 | 张旭 Theo van de Lee 陆维忠 喻大昭 马鸿翔 | 2008 | 中国农业科学2008，41，10： | 9 |
| 13 | Metastatic prostate cancer remains incurable, why?显示文摘Metastatic prostate cancer patients present in two waysdwith already disseminated disease at the time of presentation or with disease recurrence after definitive local therapy.Androgen deprivation therapy is given as the most effective initial treatment to patients.However,after the initial response,almost all patients will eventually progress despite the low levels of testosterone.Disease at this stage is termed castration resistant prostate cancer(CRPC).Before 2010,the taxane docetaxel was the first and only life prolonging agent for metastatic CRPC(mCRPC).The last decade has witnessed robust progress in CRPC therapeutics development.Abiraterone,enzalutamide,apalutamide and sipuleucel-T have been evaluated as first-and second-line agents in mCRPC patients,while cabazitaxel was approved as a second-line treatment.Radium-223 dichloride was approved in symptomatic patients with bone metastases and no known visceral metastases pre-and post-docetaxel.However,despite significant advances,mCRPC remains a lethal disease.Both primary and acquired resistance have been observed in CRPC patients treated by these new agents.It could be solely cell intrinsic or it is possible that the clonal heterogeneity in treated tumors may result from the adaptive responses to the selective pressures within the tumor microenvironment.The aim of this review is to list current treatment agents of CRPC and summarize recent findings in therapeutic resistance mechanisms. | Liang Dong Richard C.Zieren Wei Xue Theo M.de Reijke Kenneth J.Pienta | 2019 | Asian Journal of Urology2019，6，1： | 9 |
| 14 | APP and APLP1 are degraded through autophagy in response to proteasome inhibition in neuronal cells显示文摘Amyloid beta(Aβ)precursor protein(APP)is a key protein in the pathogenesis of Alzheimer’s disease(AD).Both APP and its paralogue APLP1(amyloid beta precursor-like protein 1)have multiple functions in cell adhesion and proliferation.Previously it was thought that autophagy is a novel beta-amyloid peptide(Aβ)-generating pathway activated in AD.However,the protein proteolysis of APLP1 is still largely unknown.The present study shows that APLP1 is rapidly degraded in neuronal cells in response to stresses,such as proteasome inhibition.Activation of the endoplasmic reticulum(ER)stress by proteasome inhibitors induces autophagy,causing reduction of mature APLP1/APP.Blocking autophagy or JNK stress kinase rescues the protein expression for both APP and APLP1.Therefore,our results suggest that APP/APLP1 is degraded through autophagy and the APLP1 proteolysis is mainly mediated by autophagy-lysosome pathway. | Fangfang Zhou Theo van Laar Huizhe Huang Long Zhang | 2011 | Protein & Cell2011，2，5： | 8 |
| 15 | Vanishing bile duct syndrome in human immunodeficiency virus infected adults:A report of two cases显示文摘Vanishing bile duct syndrome(VBDS) is a group of rare disorders characterized by ductopenia,the progressive destruction and disappearance of intrahepatic bile ducts leading to cholestasis.Described in association with medications,autoimmune disorders,cancer,transplantation,and infections,the specific mechanisms of disease are not known.To date,only 4 cases of VBDS have been reported in human immunodeficiency virus(HIV) infected patients.We report 2 additional cases of HIV-associated VBDS and review the features common to the HIV-associated cases.Presentation includes hyperbilirubinemia,normal liver imaging,and negative viral and autoimmune hepatitis studies.In HIV-infected subjects,VBDS occurred at a range of CD4+ T-cell counts,in some cases following initiation or change in antiretroviral therapy.Lymphoma was associated with two cases;nevirapine,antibiotics,and viral co-infection were suggested as etiologies in the other cases.In HIV-positive patients with progressive cholestasis,early identification of VBDS and referral for transplantation may improve outcomes. | Ana Paula Oppenheimer Christopher Koh Mary McLaughlin John C Williamson Thomas D Norton Jennifer Laudadio Theo Heller David E Kleiner Kevin P High Caryn G Morse | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 16 | Driving-Cycle-Aware Energy Management of Hybrid Electric Vehicles Using a Three-Dimensional Markov Chain Model显示文摘This study developed a new online driving cycle prediction method for hybrid electric vehicles based on a three-dimensional stochastic Markov chain model and applied the method to a driving-cycle-aware energy management strategy.The impacts of different prediction time lengths on driving cycle generation were explored.The results indicate that the original driving cycle is compressed by 50%,which significantly reduces the computational burden while having only a slight effect on the prediction performance.The developed driving cycle prediction method was implemented in a real-time energy management algorithm with a hybrid electric vehicle powertrain model,and the model was verified by simulation using two different testing scenarios.The testing results demonstrate that the developed driving cycle prediction method is able to efficiently predict future driving tasks,and it can be successfully used for the energy management of hybrid electric vehicles. | Bolin Zhao Chen Lv Theo Hofman | 2019 | Automotive Innovation2019，2，2： | 7 |
| 17 | A Review on Surface?Functionalized Cellulosic Nanostructures as Biocompatible Antibacterial Materials显示文摘As the most abundant biopolymer on the earth,cellulose has recently gained significant attention in the development of antibacterial biomaterials.Biodegradability,renewability,strong mechanical properties,tunable aspect ratio,and low density offer tremendous possibilities for the use of cellulose in various fields.Owing to the high number of reactive groups(i.e.,hydroxyl groups)on the cellulose surface,it can be readily functionalized with various functional groups,such as aldehydes,carboxylic acids,and amines,leading to diverse properties.In addition,the ease of surface modification of cellulose expands the range of compounds which can be grafted onto its structure,such as proteins,polymers,metal nanoparticles,and antibiotics.There are many studies in which cellulose nano-/microfibrils and nanocrystals are used as a support for antibacterial agents.However,little is known about the relationship between cellulose chemical surface modification and its antibacterial activity or biocompatibility.In this study,we have summarized various techniques for surface modifications of cellulose nanostructures and its derivatives along with their antibacterial and biocompatibility behavior to develop non-leaching and durable antibacterial materials.Despite the high effectiveness of surface-modified cellulosic antibacterial materials,more studies on their mechanism of action,the relationship between their properties and their effectivity,and more in vivo studies are required. | Mandana Tavakolian Seid Mahdi Jafari Theo GMvan de Ven | 2020 | Nano-Micro Letters2020，12，6： | 7 |
| 18 | 美国规模化猪场零污染循环生产系统应用研究显示文摘传统的养猪模式,人们把家庭废料喂给猪,然后把猪粪作为农作物的肥料。尽管当时人们还没有意识到这种循环利用方式的作用,但实际上,这种方式保证了许多矿物质元素(比如磷)的持续利用,从而有效地避免了因某些营养物的流失而引起的诸多环境问题。 | Theo van Kempen | 2006 | 中国畜牧杂志2006，42，6： | 6 |
| 19 | Enhancing endogenous stem cells in the newborn via delayed umbilical cord clamping显示文摘There is currently no consensus among clinicians and scientists over the appropriate or optimal timing for umbilical cord clamping. However, many clinical studies have suggested that delayed cord clamping is associated with various neonatal benefits including increased blood volume, reduced need for blood transfusion, increased cerebral oxygenation in pre-term infants, and decreased frequency of iron deficiency anemia in term infants. Human umbilical cord blood contains significant amounts of stem and progenitor cells and is currently used in the treatment of several life-threatening diseases. We propose that delayed cord clamping be encouraged as it enhances blood flow from the placenta to the neonate, which is accompanied by an increase supply of valuable stem and progenitor cells, as well as may improve blood oxygenation and increase blood volume, altogether reducing the infant's susceptibility to both neonatal and age-related diseases. | Christopher Lawton Sandra Acosta Nate Watson Chiara Gonzales-Portillo Theo Diamandis Naoki Tajiri Yuji Kaneko Paul R.Sanberg Cesar V.Borlongan | 2015 | Neural Regeneration Research2015，10，9： | 6 |
| 20 | A Variable Stiffness Soft Gripper Using Granular Jamming and Biologically Inspired Pneumatic Muscles显示文摘 | Loai AI Abeach Samia Nefti-Meziani Theo Theodoridis Steve Davis | 2018 | Journal of Bionic Engineering2018，15，2： | 6 |
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