|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dementia and osteoporosis in a geriatric population: Is there a common link?显示文摘AIM To determine the existence of a common pathological link between dementia and osteoporosis through reviewing the current evidence base. METHODS This paper reviews the current literature on osteoporosis and dementia in order to ascertain evidence of a common predisposing aetiology. A literature search of Ovid MEDLINE(1950 to June 2016) was conducted. The keywords 'osteoporosis', 'osteoporotic fracture', 'dementia' and 'Alzheimer's disease'(AD) were used to determine the theoretical links with the most significant evidence base behind them. The key links were found to be vitamins D and K, calcium, thyroid disease, statins, alcohol and sex steroids. These subjects were then searched in combination with the previous terms and the resulting papers manually examined. Theoretical, in vitro and in vivo research were all used to inform this review which focuses on the most well developed theoretical common causes for dementia(predominantly Alzheimer's type) and osteoporosis.RESULTS Dementia and osteoporosis are multifaceted disease processes with similar epidemiology and a marked increase in prevalence in elderly populations. The existence of a common link between the two has been suggested despite a lack of clear pathological overlap in our current understanding. Research to date has tended to be fragmented and relatively weak in nature with multiple confounding factors reflecting the difficulties of in vivo experimentation in the population of interest. Despite exploration of various possible mechanisms in search for a link between the two pathologies, this paper found that it is possible that these associations are coincidental due to the nature of the evidence available. One finding in this review is that prior investigation into common aetiologies has found raised amyloid beta peptide levels in osteoporotic bone tissue, with a hypothesis that amyloid beta disorders are systemic disorders resulting in differing tissue manifestations. However, our findings were that the most compelling evidence of a common yet independent aetiology lies in the APOE4 allele, which is a well-established risk for AD but also carries an independent association with fracture risk. The mechanism behind this is thought to be the reduced plasma vitamin K levels in individuals exhibiting the APOE4 allele which may be amplified by the nutritional deficiencies associated with dementia, which are known to include vitamins K and D. The vitamin theory postulates that malnutrition and reduced exposure to sunlight in patients with AD leads to vitamin deficiencies. CONCLUSION Robust evidence remains to be produced regarding potential links and regarding the exact aetiology of these diseases and remains relevant given the burden of dementia and osteoporosis in our ageing population. Future research into amyloid beta, APOE4 and vitamins K and D as the most promising aetiological links should be welcomed. | Candice L Downey Adam Young Emily F Burton Simon M Graham Robert J Macfarlane Eva-Maria Tsapakis Eleftherios Tsiridis | 2017 | World Journal of Orthopedics2017，8，5： | 6 |
| 2 | 合生素治疗(长双歧杆菌/Synergy1)可促进活动性溃疡性结肠炎患者炎症消退:一项随机对照初步试验 | Furrie E. Macfarlane S. Kennedy A. 陈云茹 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，7： | 6 |
| 3 | Arthritis and the role of endogenous glucocorticoids显示文摘Rheumatoid arthritis and osteoarthritis,the most common forms of arthritis,are chronic,painful,and disabling conditions.Although both diseases differ in etiology,they manifest in progressive joint destruction characterized by pathological changes in the articular cartilage,bone,and synovium.While the potent anti-inflammatory properties of therapeutic(i.e.,exogenous)glucocorticoids have been heavily researched and are widely used in clinical practice,the role of endogenous glucocorticoids in arthritis susceptibility and disease progression remains poorly understood.Current evidence from mouse models suggests that local endogenous glucocorticoid signaling is upregulated by the pro-inflammatory microenvironment in rheumatoid arthritis and by aging-related mechanisms in osteoarthritis.Furthermore,these models indicate that endogenous glucocorticoid signaling in macrophages,mast cells,and chondrocytes has anti-inflammatory effects,while signaling in fibroblast-like synoviocytes,myocytes,osteoblasts,and osteocytes has pro-inflammatory actions in rheumatoid arthritis.Conversely,in osteoarthritis,endogenous glucocorticoid signaling in both osteoblasts and chondrocytes has destructive actions.Together these studies provide insights into the role of endogenous glucocorticoids in the pathogenesis of both inflammatory and degenerative joint disease. | Eugenie Macfarlane Markus J.Seibel Hong Zhou | 2020 | Bone Research2020，8，3： | 4 |
| 4 | 重症监护室内患者睡眠的自评和护士评估:一项探索性描述研究显示文摘目的:描述ICU患者的睡眠自评报告,检测患者的睡眠自评报告和床旁护士的睡眠评估报告之间的关系;描述患者建议的促进睡眠的对策。方法:对2014-2015年间连续纳入的能进行交流的成年患者,进行了探索性描述研究。患者睡眠情况采用理查兹-坎贝尔(Richards-Campbell)睡眠问卷(评分范围为0~100 mm;得分越高,表明睡眠质量越好)进行自评,同时护士以5级递进形式记录患者睡眠情况,进行评估。要求患者每日描述辅助或妨碍睡眠的因素。研究已获得伦理委员会批准。进行描述性统计分析[中位数(四分位间距)];用Spearman等级相关分析相关关系,用Kruskal-Wallis检验进行差异检验;P<0.05时,认为差异有显著性。结果:151名受试者纳入研究,年龄为60(46~71)岁,ICU停留时间为4(2~9)天,完成了356份睡眠自评报告。自我感知的睡眠质量为46(26~65)mm。睡眠的患者自评和护士评估之间存在中度相关(Spearman等级相关系数为0.39~0.50;P<0.001)。经患者认可的改善睡眠的对策包括适当的止痛和镇静药物,平和舒适的环境,以及集群护理、耳塞等物理措施。结论:患者在ICU期间,完成睡眠自评的中位数为2(1~3)日,表明常规使用自评是可行的。自评报告显示患者的睡眠质量低。在患者自评的多种辅助或妨碍睡眠的因素中,环境因素和影响患者舒适度的因素是最常见的。应实施针对这些因素的干预,以改善患者睡眠状况。 | Leanne M.Aitken Rosalind Elliott Marion Mitchell Chelsea Davis Bonnie Macfarlane Amanda Ullman Krista Wetzig Ashika Datt Sharon McKinley | 2017 | 中国护理管理2017，17，4： | 3 |
| 5 | 澳大利亚联邦政府数字信息管理的十年显示文摘数字时代,文件档案管理数字转型已成必然趋势。澳大利亚联邦政府于2011年发布了首个数字信息政策,目前正在制定2021年第三项政策。10年来,澳大利亚国家档案馆以支持联邦政府数字转型为导向,在数字信息管理方面取得了重要进展,逐步实现从纸质信息管理到数字信息管理的转型,但也在治理、互操作、存储和处置等方面面临着新的挑战。 | Linda Macfarlane 何思源 马林青(译) | 2020 | 档案学通讯2020，0，2： | 3 |
| 6 | Osteoblastic glucocorticoid signaling exacerbates high-fat-diet-induced bone loss and obesity显示文摘Chronic high-fat diet(HFD)consumption not only promotes obesity and insulin resistance,but also causes bone loss through mechanisms that are not well understood.Here,we fed wild-type CD-1 mice either chow or a HFD(43%of energy from fat)for 18 weeks;HFD-fed mice exhibited decreased trabecular volume(-28%)and cortical thickness(-14%)compared to chow-fed mice.In HFD-fed mice,bone loss was due to reduced bone formation and mineral apposition,without obvious effects on bone resorption.HFD feeding also increased skeletal expression of sclerostin and caused deterioration of the osteocyte lacunocanalicular network(LCN).In mice fed HFD,skeletal glucocorticoid signaling was activated relative to chow-fed mice,independent of serum corticosterone concentrations.We therefore examined whether skeletal glucocorticoid signaling was necessary for HFD-induced bone loss,using transgenic mice lacking glucocorticoid signaling in osteoblasts and osteocytes(HSD2^(OB/OCY)-tg mice).In HSD2^(OB/OCY)-tg mice,bone formation and mineral apposition rates were not suppressed by HFD,and bone loss was significantly attenuated.Interestingly,in HSD2^(OB/OCY)-tg mice fed HFD,both Wnt signaling(less sclerostin induction,increased P | Sarah Kim Holger Henneicke Lauryn L.Cavanagh Eugenie Macfarlane Lee Joanne Thai Daphne Foong Sylvia J.Gasparini Colette Fong-Yee Michael M.Swarbrick Markus J.Seibel Hong Zhou | 2021 | Bone Research2021，9，4： | 2 |
| 7 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | The Lancet2010，，9716： | 2 |
| 8 | Randomised controlled trial of combined spinal epidural vs. spinal anaesthesia for elective caesarean section: vasopressor requirements and cardiovascular changes显示文摘 | Alan JR Macfarlane Artur Pryn Kerry N Litchfield Fiona Bryden Steven Young Christopher Weir Elizabeth M McGrady | 2009 | European Journal of Anaesthesiology2009，，1： | 2 |
| 9 | Psychosocial risk markers for new onset irritable bowel syndrome – Results of a large prospective population-based study显示文摘 | B.I. Nicholl S.L. Halder G.J. Macfarlane D.G. Thompson S. O’Brien M. Musleh J. McBeth | 2007 | Pain2007，，1： | 2 |
| 10 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | The Lancet2010，，9716： | 2 |
| 11 | TRAIL-induced signalling and apoptosis 显示文摘 | MacFarlane M | 2003 | Toxicol Lett2003，139，： | 1 |
| 12 | Rubus chlorotic mottle virus, a new sobemovirus infecting raspberry and bramble 显示文摘 | Mcgavin W J Macfarlane S A | 2009 | Virus Research2009，139，： | 1 |
| 13 | An investigation of the opacity of high-Z mixture and implications for inertial confinement fusion hohlra um design显示文摘 | Wang P Macfarlane J J Orzechowski T J | 1997 | Rev Sci Instrum1997，68，1： | 1 |
| 14 | Risk factors for sudden death inmidde-aged British men显示文摘 | Wannamethee G Shaper AG Macfarlane PW | 1995 | Circulation1995，91，： | 1 |
| 15 | Methanesulfonate and p-toluenesulfonate salts of the N-methyl-Nalkylpyrrolidinium and quaternary ammonium cations:novel low cost ionic liquids显示文摘 | Golding J Forsyth S MacFarlane D R | 2002 | Green Chemistry2002，4，： | 1 |
| 16 | Study of community acquired pneumonia aetiology(SCAPA) in adults admitted to hospital:Implicationa for management guidelines显示文摘 | LIM W S MACFARLANE J T BOSWELL T C | 2001 | Thorax2001，56，4： | 1 |
| 17 | Probiotics, infection and immunity 显示文摘 | Macfarlane GT Cummings JH | 2002 | Curr Opin Infect Dis2002，15，5： | 1 |
| 18 | Characreridtic frequence-gain design study of an automatic flight control system显示文摘 | Kouraritakis B Murray W MacFarlane A G J | 1979 | International Journal of Control1979，29，2： | 1 |
| 19 | Lithium-doped plastic crystal electrolytes exhibiting fast ion conduction for secondary batteries 显示文摘 | Macfarlane D R Huang J Forsyth M | 1999 | Nature1999，402，： | 1 |
| 20 | Protein complexes ac- tivate distinct caspase cascades in death receptor and stress-in- duced apoptosis显示文摘 | Bratton SB Macfarlane M Cain K | 2000 | Exp Cell Res2000，256，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员