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| 1 | Role of matricellular proteins in cardiac tissue remodeling after myocardial infarction显示文摘After onset of myocardial infarction(MI),the left ventricle(LV) undergoes a continuum of molecular,cellular,and extracellular responses that result in LV wall thinning,dilatation,and dysfunction.These dynamic changes in LV shape,size,and function are termed cardiac remodeling.If the cardiac healing after MI does not proceed properly,it could lead to cardiac rupture or maladaptive cardiac remodeling,such as further LV dilatation and dysfunction,and ultimately death.Although the precise molecular mechanisms in this cardiac healing process have not been fully elucidated,this process is strictly coordinated by the interaction of cells with their surrounding extracellular matrix(ECM) proteins.The components of ECM include basic structural proteins such as collagen,elastin and specialized proteins such as fibronectin,proteoglycans and matricellular proteins.Matricellular proteins are a class of non-structural and secreted proteins that probably exert regulatory functions through direct binding to cell surface receptors,other matrix proteins,and soluble extracellular factors such as growth factors and cytokines.This small group of proteins,which includesosteopontin,thrombospondin-1/2,tenascin,periostin,and secreted protein,acidic and rich in cysteine,shows a low level of expression in normal adult tissue,but is markedly upregulated during wound healing and tissue remodeling,including MI.In this review,we focus on the regulatory functions of matricellular proteins during cardiac tissue healing and remodeling after MI. | Yutaka Matsui Junko Morimoto Toshimitsu Uede | 2010 | World Journal of Biological Chemistry2010，1，5： | 7 |
| 2 | Endoscopic ultrasonography can diagnose distal biliary strictures without a mass on computed tomography显示文摘AIM:To assess the diagnostic ability of endoscopic ultrasonography(EUS)for evaluating causes of dista biliary strictures shown on endoscopic retrograde chol angiopancreatography(ERCP)or magnetic resonance cholangiopancreatography(MRCP),even without iden tifiable mass on computed tomography(CT). METHODS:The diagnostic ability of EUS was retro spectively analyzed and compared with that of routine cytology(RC)and tumor markers in 34 patients with distal biliary strictures detected by ERCP or MRCP a Dokkyo Medical School Hospital from December 2005 to December 2008,without any adjacent mass or ec centric thickening of the bile duct on CT that could cause biliary strictures.Findings considered as benign strictures on EUS included preservation of the normasonographic layers of the bile duct wall,irrespective of the presence of a mass lesion.Other strictures were considered malignant.Final diagnosis of underlying diseases was made by pathological examination in 18 cases after surgical removal of the samples,and by clinical follow-up for>10 mo in 16 cases. RESULTS:Seventeen patients(50%)were finally di- agnosed with benign conditions,including 6'normal' subjects,while 17 patients(50%)were diagnosed with malignant disease.In terms of diagnostic ability,EUS showed 94.1%sensitivity,82.3%specificity,84.2% positive predictive value,93.3%negative predictive value(NPV)and 88.2%accuracy for identifying ma- lignant and benign strictures.EUS was more sensi- tive than RC(94.1%vs 62.5%,P=0.039).NPV was also better for EUS than for RC(93.3%vs 57.5%,P= 0.035).In addition,EUS provided significantly higher sensitivity than tumor markers using 100 U/mL as the cutoff level of carbohydrate antigen 19-9(94.1%vs 53%,P=0.017).On EUS,biliary stricture that was fi- nally diagnosed as malignant showed as a hypoechoic, irregular mass,with obstruction of the biliary duct and invasion to surrounding tissues. CONCLUSION:EUS can diagnose biliary strictures caused by malignant tumors that are undetectable on CT.Earlier detection by EUS would provide more therapeutic options for patients with early-stage pancreaticobiliary cancer. | Yasuyuki Saifuku Michiko Yamagata Takero Koike Genyo Hitomi Kazunari Kanke Hidetaka Watanabe Toshimitsu Murohisa Masaya Tamano Makoto Iijima Keiichi Kubota Hideyuki Hiraishi | 2010 | World Journal of Gastroenterology2010，16，2： | 5 |
| 3 | Ice-Shielding Models for Self-Preservation of Gas Hydrates显示文摘 | Tsutomu Uchlda Toshimitsu Sakurai Takeo Hondoh | 2011 | Journal of Chemistry and Chemical Engineering2011，5，8： | 4 |
| 4 | Single-port laparoscopic hepatectomy: technique, safety, and feasibility in a clinical case series显示文摘 | Masayasu Aikawa Mitsuo Miyazawa Kojun Okamoto Yasuko Toshimitsu Katsuya Okada Yosuke Ueno Shigeki Yamaguchi Isamu Koyama | 2012 | Surgical Endoscopy2012，，6： | 3 |
| 5 | Effects of brazing filler on properties of brazed joints between TiAl and metallic materials 显示文摘 | Toshimitsu T | 2001 | Intermetallics2001，9，3： | 3 |
| 6 | An oral fluoropyrimidine agent S-1 induced interstitial lung disease:A case report显示文摘A 66-year-old Japanese man with pancreatic cancer received eleven courses of gemcitabine monotherapy.The tumor responded to gemcitabine until metastatic liver tumors progressed.Subsequently,he was treated with S-1,an oral fluoropyrimidine anticancer agent,as salvage chemotherapy.Forty-two days after initiating S-1,he presented with dyspnea and fever.Chest computed tomography showed diffuse interstitial lesions with thickening of the alveolar septa and ground glass opacity.Serum KL-6 level was elevated to 1,230 U/mL and he did not use any other drugs except insulin.Thus,the development of interstitial lung disease(ILD)was considered to be due to S-1.Arterial blood oxygen pressure was 49.6 Torr in spite of oxygen administration(5 L/min).Steroid therapy improved his symptoms and the interstitial shadows on chest radiograph.Although S-1-induced ILD has mostly been reported to be mild,clinicians should be aware that S-1 has the potential to cause fatal ILD. | Hiromichi Yamane Masahide Kinugawa Shigeki Umemura Yasuhiro Shiote Kenichiro Kudo Toshimitsu Suwaki Haruhito Kamei Nagio Takigawa Katsuyuki Kiura | 2011 | World Journal of Clinical Oncology2011，2，7： | 3 |
| 7 | A three-dimensional prediction system for water quality polluction in coastal waters显示文摘The hydrodynamics and water quality in Hakata Bay, Japan are strongly affected by the seasonal variations in both the gravitational circulation and the stratification in the bay. The three\|dimensional hydrodynamics and water quality model has been developed to simulate the long\|term transport and fate of pollutants in the system. The model is unique in that it completely integrates the refined modelling of the hydrodynamics, biochemical reactions and the ecosystem in the coastal waters. It is a 3\|dimensional segmented model which is capable of resolving mean daily variations in all the parameters relevant to pollution control. It predicts daily fluctuations in the oxygen content at different depths in water throughout the year. It takes into account transport and settling of pollutant particles. It predicts light penetration from computed turbidity variations. It includes interactions between the ecosystem and water quality through nutrient cycling and photosynthesis. The model has been calibrated well against the data set of historical water quality observations in Hakata Bay. | SHEN Yong\|ming\+1, ZHENG Yong\|hong\+1, Toshimitsu KOMATSU\+2 (1. State Key Laboratory of Coastal and Offshore Engineering, Dalian University of Technology, Dalian 116023, China 2. Department of Civil Engineering, Kyushu University, Fukuoka 812 85 | 2000 | Journal of Environmental Sciences2000，12，4： | 3 |
| 8 | Swine-origin influenza-virus-induced acute lung injury:Novel or classical pathogenesis?显示文摘Influenza viruses are common respiratory pathogens in humans and can cause serious infection that leads to the development of pneumonia.Due to their hostrange diversity,genetic and antigenic diversity,and potential to reassort genetically in vivo,influenza A viruses are continual sources of novel influenza strains that lead to the emergence of periodic epidemics and outbreaks in humans.Thus,newly emerging viral diseases are always major threats to public health.In March 2009,a novel influenza virus suddenly emerged and caused a worldwide pandemic.The novel pandemic influenza virus was genetically and antigenically distinct from previous seasonal human influenza A/H1N1 viruses;it was identified to have originated from pigs,and further genetic analysis revealed it as a subtype of A/H1N1,thus later called a swine-origin influenza virus A/H1N1.Since the novel virus emerged,epidemiological surveys and research on experimental animal models have been conducted,and characteristics of the novel influenza virus have been determined but the exact mechanisms of pulmonary pathogenesis remain to be elucidated.In this editorial,we summa-rize and discuss the recent pandemic caused by the novel swine-origin influenza virus A/H1N1 with a focus on the mechanism of pathogenesis to obtain an insight into potential therapeutic strategies. | Naoyoshi Maeda Toshimitsu Uede | 2010 | World Journal of Biological Chemistry2010，1，5： | 3 |
| 9 | STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury显示文摘AIM To elucidate the role of STAT3 in hepatocarcinogenesis and biliary ductular proliferation following chronic liver injury. METHODS We investigated thioacetamide(TAA)-induced liver injury, compensatory hepatocyte proliferation, and hepatocellular carcinoma(HCC) development in hepatic STAT3-deficient mice. In addition, we evaluated TAAinduced biliary ductular proliferation and analyzed the activation of sex determining region Y-box9(SOX9) and Yes-associated protein(YAP), which regulate the transdifferentiation of hepatocytes to cholangiocytes.RESULTS Both compensatory hepatocyte proliferation and HCC formation were significantly decreased in hepatic STAT3-deficient mice as compared with control mice. STAT3 deficiency resulted in augmentation of hepatic necrosis and fibrosis. On the other hand, biliary ductular proliferation increased in hepatic STAT3-deficient livers as compared with control livers. SOX9 and YAP were upregulated in hepatic STAT3-deficient hepatocytes.CONCLUSION STAT3 may regulate hepatocyte proliferation as well as transdifferentiation into cholangiocytes and serve as a therapeutic target for HCC inhibition and biliary regeneration. | Mitsuhiko Abe Takafumi Yoshida Jun Akiba Yu Ikezono Fumitaka Wada Atsutaka Masuda Takahiko Sakaue Toshimitsu Tanaka Hideki Iwamoto Toru Nakamura Michio Sata Hironori Koga Akihiko Yoshimura Takuji Torimura | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 10 | Persistence of gene expression changes in noninflamed and inflamed colonic mucosa in ulcerative colitis and their presence in colonic carcinoma显示文摘AIM: A few studies have applied genomic-wide gene expression analysis in inflamed colon tissue sample in ulcerative colitis (UC). We reported the first study of non-inflamed mucosal gene expression in UC and explored its clinical implication.METHODS: Non-inflamed mucosa was obtained from 6 UC patients who received total colectomy. The gene expression of UC in noninfliamed mucosa was monitored with a microarray. For a selected gene, RT-PCR was performed to verify array results and to further examine expression pattern in inflamed mucosa of UC, colorectal cancer tissue and normal mucosa using additional matched pairs.RESULTS: Two genes showing 2.5-fold decreased expression with significance set at in UC samples were bomeo box a4 (HOXa4) and mads box transcription enhancer factor 2, polypeptide B (MEF2b). RT-PCR showed that MEF2b expression in non-inflamed mucosa was significantly downregulated, whereas the expression of MEF2b increased in accordance with the severity of mucosal inflammation. HOXa4 expression both in inflamed and non-inflamed mucosa in UC was consistently downregulated, and the downregulation of HOXa4 was also found in colorectal carcinoma.CONCLUSION: It is suggested that the MEF2b expression in UC which increase in accordance with inflammation may be induced by the inflammatory mediator. In contrast the downregulation of HOXa4 may be partly involved in the pathogenesis of disease including UC and UC-related carcinogenesis. | Yuji Toiyama Akira Mizoguchi Kazushi Kimura Toshimitsu Araki Shigeyuki Yoshiyama Kouhei Sakaguchi Chikao Miki Masato Kusunoki | 2005 | World Journal of Gastroenterology2005，11，33： | 2 |
| 11 | PIV Measurements of Flows around the Wind Turbines with a Flanged-Diffuser Shroud显示文摘当高效之一由 Ohya 等弯屈汽轮机,有称为“风透镜汽轮机”的凸缘弥漫的笼罩这样的风汽轮机被开发。以便调查流动特征和流动加速,纸论述流动速度大小一长类型并且紧缩类型的风有由粒子图象 velocimetry 的凸缘弥漫的笼罩的汽轮机。在长类型风汽轮机的情况中,内部流动的速度向量回答为汽轮机片旋转和旋转的没有片更弥漫在雷纳兹数字被介绍, 0.9 × 1 05。而且,流动回答在之间有或没有旋转被比较。通过 PIV 测量结果,一个人能认识到旋转的汽轮机片是影响在内部墙附近压制骚乱和流动分离更弥漫。时间平均速度向量在即时速度数据的一般水准上被做。在下游的区域有二个大旋涡更弥漫。在凸缘后面的一个旋涡是行动吸在风中到更弥漫并且提起入口流动速度。另一个大旋涡出现在 downstream。它可能作为主要流动的阻塞旋涡是行为。大阻塞旋涡不在即时速度向量是清楚的,然而,它在时间一般水准流动地里清楚地存在。在有紧缩类型的凸缘弥漫的笼罩的风汽轮机附近的流动地也被调查。在紧缩类型的汽轮机的凸缘后面的流动模式与长类型的一样。它意味着流动加速的效果被不稳定的旋涡在凸缘后面引起。有南方的时间一般水准的 CFD 和 PIV 结果的比较优化在以后紧缩类型更弥漫也被介绍。 | Kazuhiko Toshimitsu Koutarou Nishikawa Wataru Haruki Shinichi Oono Manabu Takao Yuji Ohya | 2008 | Journal of Thermal Science2008，17，4： | 2 |
| 12 | Oral treatment with nicorandil at discharge is associated with reduced mortality after acute myocardial infarction显示文摘 | Yasuhiko Sakata Daisaku Nakatani Masahiko Shimizu Shinichiro Suna Masaya Usami Sen Matsumoto Masahiko Hara Satoru Sumitsuji Shigeo Kawano Katsuomi Iwakura Toshimitsu Hamasaki Hiroshi Sato Shinsuke Nanto Masatsugu Hori Issei Komuro | 2011 | Journal of Cardiology2011，，： | 2 |
| 13 | Experimental Study of Improved HAWT Performance in Simulated Natural Wind by an Active Controlled Multi-Fan Wind Tunnel显示文摘The effects of turbulent intensity and vortex scale of simulated natural wind on performance of a horizontal axis wind turbine(HAWT) are mainly investigated in this paper. In particular, the unsteadiness and turbulence of wind in Japan are stronger than ones in Europe and North America in general. Hence, Japanese engineers should take account of the velocity unsteadiness of natural wind at installed open-air location to design a higher performance wind turbine. Using the originally designed five wind turbines on the basis of NACA and MEL blades, the dependencies of the wind frequency and vortex scale of the simulated natural wind are presented. As the results, the power coefficient of the newly designed MEL3-type rotor in the simulated natural wind is 130% larger than one in steady wind. | Kazuhiko Toshimitsu Takahiko Narihara Hironori Kikugawa Arata Akiyoshi Yuuya Kawazu | 2017 | Journal of Thermal Science2017，26，2： | 2 |
| 14 | A tissue-engi neered artificial bile duct grown to resemble the native bile duct 显示文摘 | Miyazawa M Torii T Toshimitsu Y | 2005 | AmJ Transplant2005，5，： | 1 |
| 15 | Addition of dexmedetomidine prolongs duration of vasodilation induced by sympathetic block with mepivacaine in dogs显示文摘 | Masatomo T Toshimitsu K Shigeki Y | 2004 | Reg Anesth Pain Med2004，29，4： | 1 |
| 16 | Age-related and zonal anatomical changes of apparent diffusion coefficient values in normal human prostatic tissues显示文摘 | Tamada T Sone T Toshimitsu S | 2008 | J Magn Reson Imaging2008，27，3： | 1 |
| 17 | Strengthening a High-Strength TiAl Alloy by Hot-Forging显示文摘 | Toshimitsu Tetsuia Kentaro Shindoa Satoru Kobayashib | 2003 | Intermetallics2003，，11： | 1 |
| 18 | Control of Traction and Levitation of Linear Induction Motor Driven by Power Source With Frequency Component Synchronous With the Motor Speed显示文摘 | Toshimitsu Morizane Kousuke Tsujikawa Noriyuki Kimura | 2011 | 1EEE Transactions on Magnetics2011，47，10： | 1 |
| 19 | Correlation of CCL20 expression in rectal mucosa with the developmentof ulcerative colitis?associated neoplasia显示文摘 | Kiyoshi Hashimoto Susumu Saigusa Toshimitsu Araki Koji Tanaka Yoshiki Okita Hiroyuki Fujikawa Mikio Kawamura Yoshinaga Okugawa Yuji Toiyama Yasuhiro Inoue Keiichi Uchida Yasuhiko Mohri Masato Kusunoki | 2013 | Oncology Letters2013，，5： | 1 |
| 20 | FDG-PET is effective in the detection of granulocytic sarcoma in patients with myeloid malignancy显示文摘 | Koki Ueda Motoshi Ichikawa Miwako Takahashi Toshimitsu Momose Kuni Ohtomo Mineo Kurokawa | 2010 | Leukemia Research2010，，9： | 1 |
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