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| 1 | Prognosis of metastatic splenic hilum lymph node in patients with gastric cancer after total gastrectomy and splenectomy显示文摘AIM:To clarify the significance of combined resection of the spleen to dissect the No.10 lymph node(LN). METHODS:We studied 191 patients who had undergone total gastrectomy with splenectomy,excluding non-curative cases,resection of multiple gastric cancer, and those with remnant stomach cancer.Various clinico-pathological factors were evaluated for any independent contributions to No.10 LN metastasis,usingχ 2 test. Significant factors were extracted for further analysis, carried out using a logistic regression method.Furthermore,lymph node metastasis was evaluated for any independent contribution to No.10 LN metastasis,using the same methods.The cumulative survival rate was calculated using the Kaplan-Meier method.The significance of any difference between the survival curves was determined using the Cox-Mantel test,and any difference was considered significant at the 5%level. RESULTS:From the variables considered to be potentially associated with No.10 LN metastasis,age, depth,invasion of lymph vessel,N factor,the numberof lymph node metastasis,Stage,the number of sites, and location were found to differ significantly between those with metastasis(the Positive Group)and those without(the Negative Group).A logistic regression analysis showed that the localization and Stage were significant parameters for No.10 LN metastasis.There was no case located on the lesser curvature in the Posi-tive Group.The numbers of No.2,No.3,No.4sa,No. 4sb,No.4d,No.7,and No.11 LN metastasis were each found to differ significantly between the Positive Group and the Negative Group.A logistic regression analysis showed that No.4sa,No.4sb,and No.11 LN metastasis were each a significant parameter for No.10 LN metastasis.There was no significant difference in survival curves between the Positive Group and the Negative Group. CONCLUSION:Splenectomy should be performed to dissect No.10 LN for cases which have No.4sa,No. 4sb or No.11 LN metastasis.However,in cases where the tumor is located on the lesser curvature,splenectomy can be omitted. | Keishiro Aoyagi Kikuo Kouhuji Motoshi Miyagi Takuya Imaizumi Junya Kizaki Kazuo Shirouzu | 2010 | World Journal of Hepatology2010，2，2： | 26 |
| 2 | Molecular targeting therapy using bevacizumab for peritoneal metastasis from gastric cancer显示文摘AIM: To clarify the significance of vascular endothelial growth factor(VEGF) in peritoneal metastasis from gastric cancer, using the gastric cancer cell line MKN-45 compared with the high potential peritoneal dissemination gastric cancer cell line MKN-45 P. METHODS: The supernatant of culture medium of MKN-45 cells or MKN-45 P cells was collected and the concentrations were measured of various cytokines, matrix metalloproteinases, growth factor and angiogenic factors, including VEGF. We performed an initial pilot study to explore whether bevacizumab, a humanized monoclonal antibody against VEGF, had any suppressive effect on the peritoneal dissemination from gastric cancer in an experimental nude mouse modelof peritoneal metastasis. RESULTS: The concentrations of interleukin-6(IL-6), IL-8, VEGF and matrix metalloproteinase-2 protein in the culture supernatant were each significantly higher than each of those for MKN-45. In the in vivo study, the volume of ascites and the mitotic index were significantly lower in the therapy group than in the nontherapy group. The survival curve of the therapy group was significantly higher than that of the non-therapy group. These results suggested that VEGF was correlated with peritoneal metastasis from gastric cancer. CONCLUSION: Findings suggested that bevacizumab for inhibiting VEGF could suppress peritoneal dissemination from gastric cancer. | Keishiro Aoyagi Kikuo Kouhuji Motoshi Miyagi Junya Kizaki Taro Isobe Kousuke Hashimoto Kazuo Shirouzu | 2013 | World Journal of Critical Care Medicine2013，2，4： | 12 |
| 3 | Inhibitory effects of carbon dioxide insufflation on pneumoperitoneum and bowel distension after percutaneous endoscopic gastrostomy显示文摘AIM:To evaluate the inhibitory effects of carbon dioxide (CO2) insufflation on pneumoperitoneum and bowel distension after percutaneous endoscopic gastrostomy (PEG).METHODS:A total of 73 consecutive patients who were undergoing PEG were enrolled in our study.After eliminating 13 patients who fitted our exclusion criteria,60 patients were randomly assigned to either CO2 (30 patients) or air insufflation (30 patients) groups.PEG was performed by pull-through technique after threepoint fixation of the gastric wall to the abdominal wall using a gastropexy device.Arterial blood gas analysis was performed immediately before and after the procedure.Abdominal X-ray was performed at 10 min and at 24 h after PEG to assess the extent of bowel distension.Abdominal computed tomography was performed at 24 h after the procedure to detect the presence of pneumoperitoneum.The outcomes of PEG for 7 d postprocedure were also investigated.RESULTS:Among 30 patients each for the air and the CO2 groups,PEG could not be conducted in 2 patients of the CO2 group,thus they were excluded.Analyses of the remaining 58 patients showed that the patients' backgrounds were not significantly different between the two groups.The elevation values of arterial partial pressure of CO2 in the air group and the CO2 group were 2.67 mmHg and 3.32 mmHg,respectively (P = 0.408).The evaluation of bowel distension on abdominal X ray revealed a significant decrease of small bowel distension in the CO2 group compared to the air group (P < 0.001) at 10 min and 24 h after PEG,whereas there was no significant difference in large bowel distension between the two groups.Pneumoperitoneum was observed only in the air group but not in the CO2 group (P = 0.003).There were no obvious differences in the laboratory data and clinical outcomes after PEG between the two groups.CONCLUSION:There was no adverse event associated with CO2 insufflation.CO2 insufflation is considered to be safer and more comfortable for PEG patients because of the lower incidence of pneumoperitoneum and less distension of the small bowel. | Shinji Nishiwaki Hiroshi Araki Motoshi Hayashi Jun Takada Masahide Iwashita Atsushi Tagami Hiroo Hatakeyama Takao Hayashi Teruo Maeda Koshiro Saito | 2012 | World Journal of Gastroenterology2012，18，27： | 7 |
| 4 | Systemic hemodynamics in advanced cirrhosis: Concerns during perioperative period of liver transplantation显示文摘Advanced liver cirrhosis is usually accompanied by portal hypertension. Long-term portal hypertension results in various vascular alterations. The systemic hemodynamic state in patients with cirrhosis is termed a hyperdynamic state. This peculiar hemodynamic state is characterized by an expanded blood volume, high cardiac output, and low total peripheral resistance. Vascular alterations do not disappear even long after liver transplantation(LT), and recipients with cirrhosis exhibit a persistent systemic hyperdynamic state even after LT. Stability of optimal systemic hemodynamics is indispensable for adequate portal venous flow(PVF) and successful LT, and reliable parameters for optimal systemic hemodynamics and adequate PVF are required. Even a subtle disorder in systemic hemodynamics is precisely indicated by the balance between cardiac output and blood volume. The indocyanine green(ICG) kinetics reflect the patient's functional hepatocytes and effective PVF, and PVF is a major determinant of the ICG elimination constant(kICG) in the well-preserved allograft. The kICG value is useful to set the optimal PVF during living-donor LT and to evaluate adequate PVF after LT. Perioperative management has a large influence on the postoperative course and outcome; therefore, key points and unexpected pitfalls for intensive management are herein summarized. Transplant physicians should fully understand the peculiar systemic hemodynamic behavior in LT recipients with cirrhosis and recognize the critical importance of PVF after LT. | Tomohide Hori Yasuhiro Ogura Yasuharu Onishi Hideya Kamei Nobuhiko Kurata Motoshi Kainuma Hideo Takahashi Shogo Suzuki Takashi Ichikawa Shoko Mizuno Tadashi Aoyama Yuki Ishida Takahiro Hirai Tomoko Hayashi Kazuko Hasegawa Hiromu Takeichi Atsunobu Ota Yasuhiro Kodera Hiroyuki Sugimoto Taku Iida Shintaro Yagi Kentaro Taniguchi Shinji Uemoto | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 5 | Characteristics and prognosis of gastric cancer in young patients显示文摘 | Taro Isobe Kousuke Hashimoto Junya Kizaki Motoshi Miyagi Keishiro Aoyagi Kikuo Koufuji Kazuo Shirouzu | 2013 | Oncology Reports2013，，1： | 2 |
| 6 | Bcl-x L Retrotranslocates Bax from the Mitochondria into the Cytosol显示文摘 | Frank Edlich Soojay Banerjee Motoshi Suzuki Megan M. Cleland Damien Arnoult Chunxin Wang Albert Neutzner Nico Tjandra Richard J. Youle | 2011 | Cell2011，，1： | 2 |
| 7 | FDG-PET is effective in the detection of granulocytic sarcoma in patients with myeloid malignancy显示文摘 | Koki Ueda Motoshi Ichikawa Miwako Takahashi Toshimitsu Momose Kuni Ohtomo Mineo Kurokawa | 2010 | Leukemia Research2010，，9： | 1 |
| 8 | Degradation of Tenascin-C and Activity of Matrix Metalloproteinase-2 Are Associated with Tumor Recurrence in Early Stage Non-small Cell Lung Cancer显示文摘 | Ming Cai Koji Onoda Motoshi Takao | 2002 | Clinical Cancer Research2002，8，4： | 1 |
| 9 | Molecular cloning of the second major allergen,Cry j II,from Japanese cedar pollen显示文摘 | Motoshi Namba Mayumi Kurose Kakuji Torigoe | 1994 | FEBS Letters1994，353，： | 1 |
| 10 | Intravesical instillation of Adriamycin in the presence or absence of verapamil for the treatment of superficial bladder cancer: preliminary report of a collaborative study显示文摘 | Yoshitada Ohi Hiroyuki Ohmori Tsutomu Shirahama Motoshi Kawahara Yosuke Matsumura Tomoyasu Tsushima Yasuo Ohashi | 1992 | Cancer Chemotherapy and Pharmacology1992，，1： | 1 |
| 11 | Cloning and characterization of four phosphate transporters in tobacco cDNAs显示文摘 | Motoshi K Kouji T Hirofumi A | 2002 | Plant qcience2002，163，： | 1 |
| 12 | Massive hemoptysis from a bronchial pulmonary arterial fistula after bronchial arterial infusion to treat a pulmonary metastasis显示文摘 | Suzuki T Motoshi MD Akira MD | 2001 | Journal of Bronchology2001，8，4： | 1 |
| 13 | Genetic and environmental variances of body size and morphological traits in communally reared clonal lines from gynogenetic diploid ayu,Plecoglossus altivelis显示文摘 | Nobuhiko T Motoshi Y Motohiro T | 1996 | Aquaculture1996，140，： | 1 |
| 14 | Ultra- high- resolution versus speckle noise-reduction in spectral-domain opti- cal coherence tomography 显示文摘 | Masanori Hangai Motoshi Yamamoto Atsushi Sakamoto | 2009 | Optics Express2009，17，5： | 1 |
| 15 | JAXA space plant research on the ISS with European ModularCultivation System显示文摘 | Motoshi Kamada Katsunori Omori Kazuhiko Nishitani | 2007 | Biological Sciences in Space2007，21，3： | 1 |
| 16 | Suppressive effect of bevacizumab on peritoneal dissemination from gastric cancer in a peritoneal metastasis model显示文摘 | Takuya Imaizumi Keishiro Aoyagi Motoshi Miyagi Kazuo Shirouzu | 2010 | Surgery Today2010，，9： | 1 |
| 17 | Evans syndrome with cytomegalovirus infection followed by emerging peripheral T-cell lymphoma显示文摘 | Go Yamamoto Masataka Hosoi Takuya Miyagawa Hanako Ohmatsu Motoshi Ichikawa Makoto Sugaya Mineo Kurokawa | 2012 | Annals of Hematology2012，，1： | 1 |
| 18 | Antibody-Conjugated Magnetoliposomes for Targeting Cancer Cells and Their Application in Hyperthermia显示文摘 | Shinkai Masashige Suzuki Motoshi Iijima Shinji | 1995 | Biotechnol Appl Biochem1995，21，2： | 1 |
| 19 | Reduction of retinaldehyde dehydrogenase 1 expression and production in estrogen-induced prolactinoma of rat显示文摘 | Ken Fujiwara Bulgan Davaadash Megumi Yatabe Motoshi Kikuchi Kotaro Horiguchi Kenji Kusumoto Tom Kouki Takashi Yashiro | 2008 | Medical Molecular Morphology2008，，3： | 1 |
| 20 | The Solution Structure of Human Mitochondria Fission Protein Fis1 Reveals a Novel TPR-like Helix Bundle显示文摘 | Motoshi Suzuki Seon-Yong Jeong Mariusz Karbowski Richard J. Youle Nico Tjandra | 2003 | Journal of Molecular Biology2003，，3： | 1 |
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