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| 1 | Viral and cellular determinants involved in hepadnaviral entry显示文摘Hepadnaviridae is a family of hepatotropic DNA viruses that is divided into the genera orthohepadnavirus of mammals and avihepadnavirus of birds.All members of this family can cause acute and chronic hepatic infec-tion,which in the case of human hepatitis B virus(HBV) constitutes a major global health problem.Although our knowledge about the molecular biology of these highly liver-specific viruses has profoundly increased in the last two decades,the mechanisms of attachment and productive entrance into the differentiated host hepa-tocytes are still enigmatic.The difficulties in studying hepadnaviral entry were primarily caused by the lack of easily accessible in vitro infection systems.Thus,for more than twenty years,differentiated primary hepato-cytes from the respective species were the only in vitro models for both orthohepadnaviruses(e.g.HBV) and avihepadnaviruses(e.g.duck hepatitis B virus [DHBV]).Two important discoveries have been made recently re-garding HBV:(1) primary hepatocytes from tree-shrews;i.e.,Tupaia belangeri,can be substituted for primary hu-man hepatocytes,and(2) a human hepatoma cell line(HepaRG) was established that gains susceptibility for HBV infection upon induction of differentiation in vitro.A number of potential HBV receptor candidates have been described in the past,but none of them have been confirmed to function as a receptor.For DHBV and prob-ably all other avian hepadnaviruses,carboxypeptidase D(CPD) has been shown to be indispensable for infection,although the exact role of this molecule is still under debate.While still restricted to the use of primary duck hepatocytes(PDH),investigations performed with DHBV provided important general concepts on the first steps of hepadnaviral infection.However,with emerging dataobtained from the new HBV infection systems,the hope that DHBV utilizes the same mechanism as HBV only partially held true.Nevertheless,both HBV and DHBV in vitro infection systems will help to:(1) functionally dis-sect the hepadnaviral entry pathways,(2) perform re-verse genetics(e.g.test the fitness of escape mutants),(3) titrate and map neutralizing antibodies,(4) improve current vaccines to combat acute and chronic infections of hepatitis B,and(5) develop entry inhibitors for future clinical applications. | Dieter Glebe Stephan Urban | 2007 | World Journal of Gastroenterology2007，13，1： | 35 |
| 2 | Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-specific Entry into Hepatocytes显示文摘 | Yi Ni Florian A. Lempp Stefan Mehrle Shirin Nkongolo Christina Kaufman Maria F?lth Jan Stindt Christian K?niger Michael Nassal Ralf Kubitz Holger Sültmann Stephan Urban | 2013 | Gastroenterology2013，，： | 5 |
| 3 | Entry of hepatitis B and C viruses — recent progress and future impact显示文摘 | Thomas F Baumert Luke Meredith Yi Ni Daniel J Felmlee Jane A McKeating Stephan Urban | 2013 | Current Opinion in Virology2013，，： | 3 |
| 4 | Strategies to Inhibit Entry of HBV and HDV Into Hepatocytes显示文摘 | Stephan Urban Ralf Bartenschlager Ralf Kubitz Fabien Zoulim | 2014 | Gastroenterology2014，，： | 3 |
| 5 | Abnormal High-Density Lipoprotein Induces Endothelial Dysfunction via Activation of Toll-Like Receptor-2显示文摘 | Thimoteus Speer Lucia Rohrer Przemyslaw Blyszczuk Rukshana Shroff Kira Kuschnerus Nicolle Kr?nkel Gabriela Kania Stephen Zewinger Alexander Akhmedov Yi Shi Tina Martin Damir Perisa Stephan Winnik Maja F. Müller Urban Sester Gabriel Wernicke Andreas Jung U | 2013 | Immunity2013，，： | 2 |
| 6 | Acute coronary syndromes in young patients: Presentation, treatment and outcome显示文摘 | Andreas W. Schoenenberger Dragana Radovanovic Jean-Christophe Stauffer Stephan Windecker Philip Urban Gregor Niedermaier Pierre-Frédéric Keller Felix Gutzwiller Paul Erne | 2009 | International Journal of Cardiology2009，，3： | 2 |
| 7 | Hepatitis B virus hepatotropism is mediated by specific receptor recognition in the liver and not restricted to susceptible hosts显示文摘 | Alexa Schieck Andreas Schulze Caroline G?hler Thomas Müller Uwe Haberkorn Alexander Alexandrov Stephan Urban Walter Mier | 2013 | Hepatology2013，，1： | 1 |
| 8 | The replication cycle of hepatitis B virus显示文摘 | Stephan Urban Andreas Schulze Maura Dandri Joerg Petersen | 2009 | Journal of Hepatology2009，，2： | 1 |
| 9 | Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism显示文摘 | Nicola Oehler Tassilo Volz Oliver D. Bhadra Janine Kah Lena Allweiss Katja Giersch Jeanette Bierwolf Kristoffer Riecken J?rg M. Pollok Ansgar W. Lohse Boris Fehse Joerg Petersen Stephan Urban Marc Lütgehetmann Joerg Heeren Maura Dandri | 2014 | Hepatology2014，，5： | 1 |
| 10 | Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor显示文摘 | Shirin Nkongolo Yi Ni Florian A. Lempp Christina Kaufman Thomas Lindner Katharina Esser-Nobis Volker Lohmann Walter Mier Stefan Mehrle Stephan Urban | 2013 | Journal of Hepatology2013，，： | 1 |
| 11 | The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with Hepatitis B Virus显示文摘 | Tassilo Volz Lena Allweiss Mounira Ben M′Barek Michael Warlich Ansgar W. Lohse J?rg M. Pollok Alexander Alexandrov Stephan Urban J?rg Petersen Marc Lütgehetmann Maura Dandri | 2012 | Journal of Hepatology2012，，： | 1 |
| 12 | Myristoylated PreS1‐domain of the hepatitis B virus L‐protein mediates specific binding to differentiated hepatocytes显示文摘 | Anja Meier Stefan Mehrle Thomas S. Weiss Walter Mier Stephan Urban | 2013 | Hepatology2013，，1： | 1 |
| 13 | 安全可靠地输送高温介质——新的排气技术提高了流程泵的可靠性显示文摘在很多流程工艺过程中都会用到导热油,正确的温度控制对保障最终产品的质量和平衡能源起着重要的作用。在现代化的流程工艺过程中,导热油输送循环过程扮演着重要的角色。Etanorm SYT系列流程泵的排气系统Ven Jet申请了专利保护,这一排气系统能够安全可靠地输送高温介质。 | Stephan Sylvain Schmitt Lutz Urban | 2012 | 流程工业2012，，5： | 0 |
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