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| 1 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 2 | Ultrasound-assessed non-culprit and culprit coronary vessels differ by age and gender显示文摘AIM: To investigate age-and gender-related differences in non-culprit versus culprit coronary vessels assessed with virtual histology intravascular ultrasound (VH-IVUS). METHODS: In 390 patients referred for coronary angiography to a single center (Luzerner Kantonsspital, Switzerland) between May 2007 and January 2011, 691 proximal vessel segments in left anterior descending, circumflex and/or right coronary arteries were imaged by VH-IVUS. Plaque burden and plaque composition(fibrous, fibro-fatty, necrotic core and dense calcium volumes) were analyzed in 3 age tertiles, according to gender and separated for vessels containing non-culprit or culprit lesions. To classify as vessel containing a culprit lesion, the patient had to present with an acute coronary syndrome, and the VH-IVUS had to be performed in a vessel segment containing the culprit lesion according to conventional coronary angiography. RESULTS: In non-culprit vessels the plaque burden increased significantly with aging (in men from 37% ± 12% in the lowest to 46% ± 10% in the highest age tertile, P < 0.001; in women from 30% ± 9% to 40% ± 11%, P < 0.001); men had higher plaque burden than women at any age (P < 0.001 for each of the 3 age tertiles). In culprit vessels of the lowest age tertile, plaque burden was significantly higher than that in non- culprit vessels (in men 48% ± 6%, P < 0.001 as compared to non-culprit vessels; in women 44% ± 18%, P = 0.004 as compared to non-culprit vessels). Plaque burden of culprit vessels did not significantly change during aging (plaque burden in men of the highest age tertile 51% ± 9%, P = 0.523 as compared to lowest age tertile; in women of the highest age tertile 49% ± 8%, P = 0.449 as compared to lowest age tertile). In men, plaque morphology of culprit vessels became increasingly rupture-prone during aging (increasing percentages of necrotic core and dense calcium), whereas plaque morphology in non-culprit vessels was less rupture-prone and remained constant during aging. In women, necrotic core in non-culprit vessels was very low at young age, but increased during aging resulting in a plaque morphology that was very similar to men. Plaque morphology in culprit vessels of young women and men was similar. CONCLUSION: This study provides evidence that age-and gender-related differences in plaque burden and plaque composition significantly depend on whether the vessel contained a non-culprit or culprit lesion. | Andreas W Schoenenberger Nadja Urbanek Stefan Toggweiler Andreas E Stuck Thérèse J Resink Paul Erne | 2013 | World Journal of Cardiology2013，5，3： | 7 |
| 3 | 最新高效率光伏逆变器拓扑结构及功率器件介绍显示文摘效率正成为电力电子装置设计中越来越重要的参数。在某些应用中,效率甚至成为行业发展的驱动力,典型的如太阳能发电行业。因为对于光伏发电行业,效率的提升可以直接带来经济效益。本文详细介绍了最新的能够提供高效率的光伏逆变器拓扑结构和功率器件,包括单相和三相逆变器,功率因数补偿对策,高效电流双向流动逆变器等。 | Michael Frisch Ern Temesi 韩军 陈道杰 | 2009 | 变频器世界2009，，3： | 6 |
| 4 | Acute coronary syndromes in young patients: Presentation, treatment and outcome显示文摘 | Andreas W. Schoenenberger Dragana Radovanovic Jean-Christophe Stauffer Stephan Windecker Philip Urban Gregor Niedermaier Pierre-Frédéric Keller Felix Gutzwiller Paul Erne | 2009 | International Journal of Cardiology2009，，3： | 2 |
| 5 | The Road to Bioabsorbable Stents: Reaching Clinical Reality?显示文摘 | Paul Erne Matthias Schier Therese J. Resink | 2006 | CardioVascular and Interventional Radiology2006，，1： | 2 |
| 6 | A POSTERIORI ENERGY-NORM ERROR ESTIMATES FOR ADVECTION-DIFFUSION EQUATIONS APPROXIMATED BY WEIGHTED INTERIOR PENALTY METHODS显示文摘我们建议错误与异构、各向异性的散开为加权的内部惩罚估计 advection-diffusion-reaction 方程的不连续的 Galerkin 近似并且分析后验精力标准。重量,在分析起一个关键作用,取决于散开张肌并且被用来在不连续的 Galerkin 方法提出一致性术语。错误上面的界限,所有常数在被指定,由三个术语组成:仅仅取决于元素的一个剩余评估者分离溶液剩余,在方法使用的重量明确地进入的一个散开的流动评估者,和是因为不连续的有限元素空格的使用的非零的一个非遵守的评估者的明智的变化。三个评估者能被近似错误局部地围住。注意在本地人在常数的问题参数上被给相关性的详细规格降低错误界限。为中等移流,关于散开异质的完整的坚韧性在不连续的 Galerkin 方法由于重量的特定的设计被完成,这被显示出,当时完全本地的散开 anisotropies 遗体和影响通过条件的方形的根的常数散开张肌数。为主导的移流,它被显示出,在由连续有限元素上的 Verf ür th 的以前的工作的精神,本地人降低错误界限,这能被写,常数包含一为本地网孔尺寸到的比率截止散开张肌的最低本地 eignevalue 的方形的根相互。 | Alexandre Ern AnnetteF.Stephansen | 2008 | Journal of Computational Mathematics2008，26，4： | 2 |
| 7 | The category of Z-continuous posets显示文摘 | Bandelt H J Erne M | 1983 | Journal of Pure and Applied Algebra1983，，2： | 1 |
| 8 | 显示文摘 | Auta M Ern L M Hameed B H | 2014 | Journal of Analytical and Applied Pyrolysis2014，107，： | 1 |
| 9 | Development and validation of a three-dimensional finite element model of the pelvic bone显示文摘 | Dalstra M Hukskes R van Erning L | 1995 | J Biomech Eng1995，117，3： | 1 |
| 10 | Effects of percutaneous coronary interventions in silent ischemia after myocardial infarction: the SWISSI II randomized controlled trial显示文摘 | Erne P Schoenenberger AW Burckhardt D | 2007 | JAMA2007，297，： | 1 |
| 11 | Z-continuous posets and their topological manifestation显示文摘 | Erne M | 1999 | Applied Categorical Structures1999，7，： | 1 |
| 12 | Effects of antiischaemic drug therapy in silent myocardial ischaemia type Ⅰ:the swiss interventional study on silent ischaemia type Ⅰ (SWISSI I):a randomized,controlled pilot study显示文摘 | Erne P Schoenenberger AW Zuber M | 2007 | Eur Heart J2007，28，： | 1 |
| 13 | Ozone therapy in lumbar seiatic pain显示文摘 | D'ERNE M SCARCHILLI A ARTALE A M | 1998 | Radiol Med Torino1998，95，1： | 1 |
| 14 | Correlation of platelet calcium antihypertensive therapy显示文摘 | Erne P Bolli P Burgisser E | 1984 | N Engl J Med1984，310，： | 1 |
| 15 | Decomposition of nitrous Oxideon AlFe-pilc catalyst显示文摘 | ErnE Kiss Tatjana J Vulic | 2005 | React Kinet Catal Lett2005，86，6： | 1 |
| 16 | The road to bioabsorbable stents:Reaching clinical reality?显示文摘 | Erne P Schier M Resink T J | 2006 | Cardiovascular Int Radiology2006，29，1： | 1 |
| 17 | Projected iterative algorithms with application to multicomponent transport显示文摘 | Ern A Giovangigli V | 1997 | Linear Algebra Appl1997，250，： | 1 |
| 18 | Likelihood ratio tests of correlated multivariate samples 显示文摘 | JOHAN LIM ERNING LI SHIN-JAE LEE | 2010 | Journal ofMultivariate Analysis2010，101，： | 1 |
| 19 | Safety and performance of the drug-eluting absorbable metal scaffold (DREAMS) in patients with de-novo coronary lesions:12 month results of the prospective,multicentre,first-in-man BIOSOLVE-I trial显示文摘 | Haude M Erbel R Erne P | 2013 | Lancet2013，381，9869： | 1 |
| 20 | Global distribution of atomic oxygen in themesopause region as derived from SCIAMACHY O(1S) green line measurements显示文摘 | Kaufmann M Zhu Y Ern M | 2014 | Geophysical Research Letters2014，41，1： | 1 |
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