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| 1 | Caspase-3 activation as a bifurcation point between plasticity and cell death显示文摘Death-mediating proteases such as caspases and caspase-3 in particular,have been implicated in neurodegenerative processes,aging and Alzheimer's disease.However,emerging evidence suggests that in addition to their classical role in cell death,caspases play a key role in modulating synaptic function.It is remarkable that active caspases-3,which can trigger widespread damage and degeneration,aggregates in structures as delicate as synapses and persists in neurons without causing acute cell death.Here,we evaluate this dichotomy,and discuss the hypothesis that caspase-3 may be a bifurcation point in cellular signaling,able to orient the neuronal response to stress down either pathological/apoptotic pathways or towards physiological cellular remodeling.We propose that temporal,spatial and other regulators of caspase activity are key determinants of the ultimate effect of caspase-3 activation in neurons.This concept has implications for differential roles of caspase-3 activation across the lifespan.Specifically,we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain. | Shikha Snigdha Erica D Smith G Aleph Prieto Carl W Cotman | 2012 | Neuroscience Bulletin2012，28，1： | 91 |
| 2 | Formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiographic study显示文摘Objective:To develop and characterize multiple-unit-type oral floating microsphere of famotidine to prolong gastric residence time and to target stomach ulcer.Methods:The floating microspheres were prepared by modified solvent evaporation method,Eudragil S-100 was used as polymer.Microspheres were characterized for the micromeritic properties,floating behavior,entrapment efficiency and scanning electron microscopy.The invitro release studies and floating behavior were studied in simulated gastric fluid at pH 1.2.Different drug release kinetics models were also applied for all the batches.Selected formulations were also subjected for X-ray radiographic study.Results:Floating microspheres were successfully prepared by modified solvent evaporation technique.Microspheres showed passable flow properties.The maximum yield of microspheres was up to(95.11±0.35)%.On the basis of optical microscopy particle size range was found to be ranging from(52.18±182.00) to(91.64±5.16) μm.Scanning electron microscopy showed their spherical size,perforated smooth surface and a cavity inside microspheres.Microspheres were capable to float up to 20 h in simulated gastric fluid.X-ray radiographic studies also proved its better retention in the stomach.Conclusions:On the basis of the results,such dosage forms may be a good candidate for stomach targeting and may be dispensed in hard gelatin capsules. | Rishikesh Gupta Sunil Kumar Prajapati Snigdha Pattnaik Peeyush Bhardwaj | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，9： | 2 |
| 3 | Mechanism of aflatoxin uptake in roots of intact groundnut ( Arachis hypogaea L.) seedlings显示文摘 | M. Snigdha P. Hariprasad G. Venkateswaran | 2013 | Environmental Science and Pollution Research2013，，12： | 1 |
| 4 | Facile synthe- sis of ultra-small monodisperse ceria nanocrystals at room tempera- ture and their catalytic activity under visible light 显示文摘 | YATENDRA S CHAUDHAR Y SNIGDHA P | 2010 | Journal of Materials Chemistry2010，20，： | 1 |
| 5 | Electrophoretic deposition of doped ceria in anti-gravity set-up显示文摘 | Snigdha Panigrahi Laxmidhar Besra Bimal P. Singh S.P. Sinha Sarama Bhattacharjee | 2010 | Advanced Powder Technology2010，，5： | 1 |
| 6 | A comprehensive review on bioactive peptides derived from milk and milkproducts of minor dairy species显示文摘Milk from different species has been exploited for the isolation of various functional ingredients for decades.Irrespective of the source,milk is considered as a complete food,as it provides essential nutrients required by the human body.Proteins and their fractions are valuable sources of bioactive peptides that might exert a health beneficial role in the human body such as immune-modulation,antioxidant activity,ACE-inhibitory activity,anti-neoplastic,anti-microbial,etc.In milk,bioactive peptides may either be present in their natural form or released from their parental proteins due to enzymatic action.The increasing interest in bioactive peptides among researchers has lately augmented the exploration of minor dairy species such as sheep,goat,camel,mithun,mare,and donkey.Alternative to cow,milk from minor dairy species have also been proven to be healthier from infancy to older age owing to their higher digestibility and other nutritive components.Therefore,realizing the significance of milk from such species and incentivized interest towards the derivatization of bioactive peptides,the present review highlights the significant research achievements on bioactive peptides from milk and milk products of minor dairy species. | Snigdha Guha Heena Sharma Gaurav Kr Deshwal Priyanka Singh Rao | 2021 | Food Production, Processing and Nutrition2021，3，1： | 1 |
| 7 | Phytochelatin Plays a Role in UV-B Tolerance in N2-fixing Cyanobacterium Anabaena Doliolum显示文摘 | POONAM B ASHISH K S SNIGDHA U l | 2005 | J Plant Physiol(S0176-1617)2005，162，11： | 1 |
| 8 | Ziprasidone and aripipra- zole attenuate olanzapine--induced hyperpbagia in rats显示文摘 | Snigdha S Tbumbi C Reynolds G P | 2008 | Journal of Psychopbarmacology2008，22，5： | 1 |
| 9 | Understanding the self-assembly of Fmoc-phenylalanine to hydrogel formation 显示文摘 | SINGH V SNIGDHA K SINGH C | 2015 | Soft Matter2015，11，26： | 1 |
| 10 | Loss of WISP-2/CCN5 signaling in human pancreatic cancer: A potential mechanism for epithelial-mesenchymal-transition显示文摘 | Gopal Dhar Smita Mehta Snigdha Banerjee Ashleigh Gardner Bryan M. McCarty Sharad C. Mathur Donald R. Campbell Suman Kambhampati Sushanta K. Banerjee | 2007 | Cancer Letters2007，，1： | 1 |
| 11 | Catalytic application of red mud, an alumin- ium industry waste : A review 显示文摘 | Snigdha S Vidya S B | 2008 | Applied Catalysis B : Environmen- tal2008，21，1： | 1 |
| 12 | Di- etary and behavioral interventions proteCt against age re- lated aCtivation of Caspase CasCades in the Canine brain 显示文摘 | Snigdha S BerChtold N Astarita G Saing T | 2011 | PLoS One2011，6，24： | 1 |
| 13 | Oxidation of As(III) to As(V) using ozone microbubbles显示文摘 | Snigdha Khuntia Subrata Kumar Majumder Pallab Ghosh | 2013 | Chemosphere2013，，： | 1 |
| 14 | “Inflammation and arterial stiffness in humans”显示文摘 | Snigdha Jain Rohan Khera Vicente F. Corrales–Medina Raymond R. Townsend Julio A. Chirinos | 2014 | Atherosclerosis2014，，： | 1 |
| 15 | Phytochelatin plays a role in UV-B tolerance in N2-fixing cyanobacterium Anabaena doliolum显示文摘 | Poonam B Ashish K S Snigdha U | 2005 | Journal of Plant Physiology2005，162，： | 1 |
| 16 | Natural course of complex sleep apnea—a retrospective study显示文摘 | Tomasz J. Kuzniar Snigdha Pusalavidyasagar Peter C. Gay Timothy I. Morgenthaler | 2008 | Sleep and Breathing2008，，2： | 1 |
| 17 | Analysis of fly ash heavy metal content and disposal in three thermal power plants in India显示文摘 | Snigdha Sushil Vidya S Batra | 2006 | Fuel2006，，85： | 1 |
| 18 | Serum proteome analysis of vivax malaria: An insight into the disease pathogenesis and host immune response显示文摘 | Sandipan Ray Karthik S. Kamath Rajneesh Srivastava Dinesh Raghu Kishore Gollapalli Rekha Jain Shipra V. Gupta Sayantan Ray Santosh Taur Snigdha Dhali Nithya Gogtay Urmila Thatte Rapole Srikanth Swati Patankar Sanjeeva Srivastava | 2011 | Journal of Proteomics2011，，10： | 1 |
| 19 | Design and Inplementation of a CORBA Commodity Grid Kit显示文摘 | Snigdha Verma Manish Parashar Jarek Gawor | 2001 | Concurrency and Computation:Practice and Experience2001，07，： | 1 |
| 20 | Caspase3activationasabifurcation pointbetweenplasticityandcelldeath显示文摘 | SnigdhaS Smith E D Prieto G A CotmanC W | 2012 | NeurosciBull2012，28，： | 1 |
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