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| 1 | Novel endogenous angiogenesis inhibitors and their therapeutic potential显示文摘Angiogenesis,从先存在的 vasculature 的新血容器的形成为胚胎的开发和织物动态平衡是必要的。它也在象癌症和 retinopathy 那样的疾病起关键作用。在 pro-angiogenic 和 anti-angiogenic 因素之间的精细的平衡保证正常生理的动态平衡。内长的 angiogenesis 禁止者是在身体被形成并且有能力限制 angiogenesis 的蛋白质或蛋白质碎片。许多内长的 angiogenesis 禁止者被发现了,并且表继续成长。内长的蛋白质 / 肽禁止者是相对不太有毒,更好容忍了并且有药抵抗的更低的风险,它作为药候选人使他们漂亮。在这评论,我们加亮在最后五年以内发现的十个新奇内长的蛋白质 angiogenesis 禁止者,包括 ISM1, FKBPL,薄片, ARHGAP18, MMRN2, SOCS3, TAp73, ZNF24, GPR56 和 JWA。尽管一些这些蛋白质很好为另外的生物功能被描绘了,我们在 angiogenesis 抑制集中于他们的新、特定的角色并且为治疗学的申请讨论他们的潜力。 | Nithya RAO Yu Fei LEE Ruowen GE | 2015 | Acta Pharmacologica Sinica2015，36，10： | 7 |
| 2 | Effects of selenomethionine on acute toxicities from concurrent chemoradiation for inoperable stage Ⅲ nonsmall cell lung cancer显示文摘AIM: To prospectively determine the safety and tolerability of oral L-selenomethionine(SLM) with concurrent chemoradiation(CCRT) for Stage Ⅲ non-small cell lung cancer(NSCLC) and estimate if the incidence and/or severity of adverse events could be reduced by its use.METHODS: Sixteen patients with stage Ⅲ NSCLC were accrued to this single arm, phase Ⅱ study. CCRT consisted of radiation given at 2 Gy per fraction for 30-33 fractions, 5 d per week with concurrent weekly Ⅳ paclitaxel 50 mg/m2 followed by carboplatin dosed at an area under the time-concentration curve of 2. SLM was dosed in a loading phase at 4800 μg twice daily for one week prior to CCRT followed by once daily dosing during treatment. RESULTS: No selenium-related toxicity was observed. Analysis revealed grade 3 or higher esophagitis in 3 of 16 patients(19%), pneumonitis in 0, leukopenia in 2(12.5%), and anemia in 1(6%); the latter two were significantly reduced when compared to the protocolstated expected rate of 35%(P = 0.045 for leukopenia, and P < 0.01 for anemia). Median overall survival was 14.9 mo and median failure-free survival was 9 mo(95%CI: 3.3-21.5).CONCLUSION: There may be some protective benefit of selenium in the setting of CCRT for inoperable NSCLC. The data suggests decreased rates of myelosuppression when compared to similarly-treated historical and contemporary controls. Further evaluation of selenium in this setting may be warranted. | Michael Mix Nithya Ramnath Jorge Gomez Charles de Groot Saju Rajan Shiva Dibaj Wei Tan Youcef Rustum Michael B Jameson Anurag K Singh | 2015 | World Journal of Clinical Oncology2015，6，5： | 4 |
| 3 | Isolation of heterotrophie bacteria from Patk Bay sediments showing heavy metal tolerance and antibiotic production 显示文摘 | NITHYA C PANDIAN S K | 2010 | Microbiol Res2010，165，7： | 1 |
| 4 | The effect of nerve growth factor on the early responses during the process of wound healing显示文摘 | Nithya M Suguna L Rose C | 2003 | Biochem Biophys Acta2003，1620，： | 1 |
| 5 | MCM2 is an independent predictor of survival in patients with non - small - cell lung eancer显示文摘 | Nithya Ramnath Francisco J Hernandez | 2001 | J Clin Oncol2001，19，： | 1 |
| 6 | Solitary porokeratosis of Mibelli at an unusual site显示文摘 | Raghunath Nithya Metikue Vijayashankar | 2012 | Our Dermatol Online2012，3，4： | 1 |
| 7 | The effect of nerve growth factor on the early responses during the process of wound healing显示文摘 | Nithya M Suguna L Rose C | 2003 | Biochimica et Biophysica Acta2003，1620，13： | 1 |
| 8 | Spermatotoxicity of a protein isolated from the root of Achyranthes aspera : a comparative study with gossypol显示文摘 | Mohanan Nair Mohana Kumari Anuja Ramachandran Nair Saraswathy Amma Nithya Chellam Rajamanickam Indira Madambath | 2010 | Contraception2010，，4： | 1 |
| 9 | Li CoxMn1-xPO4/C:A high performing nanocomposite cathode material for lithium rechargeable batteries显示文摘 | NITHYA C THIRUNAKARAN R SIVASHANMUGAM A | 2012 | Chem Asian J2012，7，： | 1 |
| 10 | Pattenrs of cervical metastasis from carcinoma of the oral tongue显示文摘 | Nithya CS Pandey M Naik BR | 2003 | World J Surg Oncol2003，1，1： | 1 |
| 11 | Increased Risk for Vitamin D Deficiency in Obese Children with Both Celiac Disease and Type 1 Diabetes显示文摘 | Nithya Setty-Shah Louise Maranda Benjamin Udoka Nwosu Rami Eliakim | 2014 | Gastroenterology Research and Practice2014，，： | 1 |
| 12 | Material flows in the life cycle of leather 显示文摘 | Joseph K Nithya N | 2009 | Journal of Cleaner Production2009，17，： | 1 |
| 13 | Sensor network data fault typos 显示文摘 | Ni Kevin Ramanathan Nithya | 2009 | ACM Transactions on Sensor Networks2009，5，3： | 1 |
| 14 | Molecular detection of Colletotrichumfalcatum causing red rot dis- ease of sugarcane ( Saccharum o~winarum) using a SCAR marker 显示文摘 | Nithya K Bukhari K A I M Valluvaparidasan V | 2012 | Annals of Applied Biology2012，160，2： | 1 |
| 15 | Spermicidal action of a protein isolated from ethanolic root extracts of Achyranthes aspera:an in vitro study显示文摘 | Anuja MM Nithya RS Swathy SS | 2011 | Phyto Medicine2011，18，： | 1 |
| 16 | Effect of vitrification on meiotic maturation and expression of genes in immature goat cumulus oocyte complexes显示文摘 | Brahmasani Sambasiva Rao Yelisetti Uma Mahesh Katari Venu Charan Komjeti Suman Nithya Sekhar Sisinthy Shivaji | 2012 | Cryobiology2012，，3： | 1 |
| 17 | Comparative study on bio-inspired approach for soil classification 显示文摘 | Sumangala K Nithya G | 2012 | International Journal of Computer Applications2012，38，4： | 1 |
| 18 | Solid state synthesis of Mg-Ni ferrite and characterization by XRD and XPS 显示文摘 | MITTAL V K SANTANU BERA NITHYA R SRINIVASAN M P VELMURUGAN S NARASIMHAN S V | 2004 | Journal of Nuclear Materials2004，335，3： | 1 |
| 19 | Development and application of active films for food packaging using antibacterial peptide of Bacillus licheniformis Mel 显示文摘 | Nithya V Murthy P S Halami P M | 2013 | Journal of Applied Microbiology2013，115，2： | 1 |
| 20 | Antiperoxidative and Antiinflammatory Effect of Sida Cordifolia Linn. on Quinolinic Acid Induced Neurotoxicity显示文摘 | S. S. Swathy Seema Panicker R. S. Nithya M. M. Anuja S. Rejitha M. Indira | 2010 | Neurochemical Research2010，，9： | 1 |
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