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| 1 | Epigenetics of hepatocellular carcinoma:Role of microRNA显示文摘Hepatocellular carcinoma(HCC)represents a major form of primary liver cancer in adults.MicroRNAs(miRs),small non-coding single-stranded RNAs of 19-24nucleotides in length,negatively regulate the expression of many target genes at the post-transcriptional and/or translational levels and play a critical role in the initiation and progression of HCC.In this review we have summarized the information of aberrantly expressed miRs in HCC,their mechanism of action and relationship to cancer.The recent advances in HCC research reveal that miRs regulate expression of various oncogenes and tumor suppressor genes,thereby contributing to the modulation of diverse biological processes including proliferation,apoptosis,epithelial to mesenchymal transition and metastasis.From a clinical viewpoint,polymorphisms within miR-binding sites are associated with the risk of HCC.Polymorphisms in miR related genes have been shown to correlate with survival or treatment outcome in patients.Furthermore,the review focuses on the potential role of miRs as novel biomarkers and their translational applications for diagnosis and therapy in HCC.With further insights into miR deregulation in HCC,it is expected that novel miR-based therapeutics will arise.Also,we orient the readers to other reviews that may provide better understanding of miR research in HCC. | Sharad Khare Qiong Zhang Jamal A Ibdah | 2013 | World Journal of Gastroenterology2013，19，33： | 12 |
| 2 | Pulmonary delivery of nanoparticle chemotherapy for the treatment of lung cancers: challenges and opportunities显示文摘 | Sharad MANGAL Wei GAO Tonglei LI Qi (Tony) ZHOU | 2017 | Acta Pharmacologica Sinica2017，38，6： | 10 |
| 3 | Efficient Synthesis of 3-Methyl-flavanones and Evaluation of Their Anti-bacterial Activity显示文摘一系列 2-phenyl-2,3-dihydrochromon-4-one 衍生物(黄烷酮衍生物) 被硅石胶化综合在 74%88% 产量的几 -methyl-2-hydroxy chalcones 的帮助异构化。这些黄烷酮被在 60 点在 dimethyl sulphoxide 使用碘进一步氧化到 3 甲基黄酮 ? 湡 ? 浩慰瑣猠湥楳楴楶祴獲轠吗?? | Nawghare Beena Funde Sharad Raheem Abdul Lokhande Pradeep | 2012 | Chinese Journal of Chemistry2012，30，8： | 6 |
| 4 | Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide显示文摘Objective:To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,a-tocopherol acetate,citric acid,salicylic acid,and estimate H_2O_2induced apoptosis in renal cell carcinoma cells.Methods:The intracellular antioxidant potency of antioxidants was investigated.H_2O-2-induced apoptosis in RCC-26 was assayed with the following parameters:cell viability(%apoptosis),nucleosomal damage and DNA fragmentation, bcl-2 levels and flow cytometery analysis(ROS production evaluation).Results:Ine anticancer properties of antioxidants such as ascorbic acid,a- tocopherol acetate,citric acid,salicylic acid with perdurable responses were investigated.It was observed that these antioxidants had protective effect(anti-apoptotic activity) against hydrogen peroxide(H_2O_2) in renal cell carcinoma(RCC-26) cell line.Conclusions:This study reveals and proves the anticancer properties.However,in cancer cell lines anti-apoptotic activity can indirectly reflect the cancer promoter activity through radicals scavenging,and significantly protect nucleus and bcl-2. | Garg Neeraj K Mangal Sharad Sahu Tejram Mehta Abhinav Vyas Suresh P Tyagi Rajeev K | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 4 |
| 5 | Design of a gastroretentive mucoadhesive dosage form of furosemide for controlled release显示文摘The aim of the present study was to develop and characterize a gastroretentive dosage form suitable for controlled drug release.It consists of a drug loaded polymeric film made up of a bilayer of immediate(IR)and controlled release(CR)layers folded into a hard gelatin capsule.Gast roretention results from unfolding and swelling of the film and its bioadhesion to the gastric.mucosa.Furosemide,a drug with a narrow absorption window,was selected as the model drug.Inclusion of hydroxypropyl β-cyclodextrin in both layers and Carbopol■ 971P NF in the CR layer of the bilayer film resulted in optimum drug release,bioadhesion and mechanical properties.The film with zig-zag folding in the capsule was shown to unfold and swell under acidic conditions and provide IR of drugover 1 hand CR for up to 12 h in acidic medium.X-ray diffraction,differential scanning calorimetry and scanning electron microscopy revealed uniform dispersion of furosemide in the polymeric matrices.The results indicate the dosage form is gastroretentive and can provide controlled release of drugs with narrow therapeutic wind ows. | Sharad S.Darandale Pradeep R.Vavia | 2012 | Acta Pharmaceutica Sinica B2012，2，5： | 4 |
| 6 | Response of blood pressure after percutaneous transluminal renal artery angioplasty and stenting显示文摘AIM: To evaluate the short and intermediate term out-come of percutaneous transluminal renal artery angioplasty (PTRA) and stenting particularly on blood pressure (BP) control and renal function and to evaluate predictors of poor BP response after successful PTRA and stenting. METHODS: We conducted a prospective analysis of all patients who underwent PTRA and stenting in our institute between August 2010 to September 2012. A total number of 86 patients were underwent PTRA and renal stenting. Selective angiography was done to confirm at least 70% angiographic stenosis. The predilatation done except few cases with critical stenosis, direct stenting was done in the rest of cases. All patients received aspirin 325 mg orally, and clopidogrel 300 mg orally within 24 h before the procedure. Heparin was used as the procedural anticoagulant agent. Optimal results with TIMI-Ⅲ flow obtained in all cases. Following stent placement, aspirin 150 mg orally once daily was continued for a minimum of 12 mo and clopidogrel 75 mg orally once daily for at least 4 wk. The clinical, radiological, electrocardiography, echocardiography and treatment data of all patients were recorded. The BP measurement, serum creatinine and glomerular filtration rate (GFR) were recorded before the procedure and 1 and 6 mo after PTRA. RESULTS: A total of 86 patients were included in the study. The mean age of study population was 55.87±11.85 years old and 67 (77.9%) of patients were male. There was a significant reduction in both systolic and diastolic BP at 1 mo after the procedure: 170.15±20.10 mmHg vs 146.60±17.32 mmHg and 98.38±10.55 mmHg vs 89.88±9.22 mmHg respectively (P=0.0000). The reduction in BP was constant throughout the follow-up period and was evident 6 mo after the procedure: 144.23±18.19 and 88.26±9.79 mmHg respectively (P=0.0000). However, no improvement in renal function was observed at any time during the follow-up period. After multivariate analysis, we found male sex, low GFR (<60 mL/min) and higher baseline mean BP as a poor predictors of successful outcome on BP response after PTRA and stenting. CONCLUSION: The PTRA and stenting can be considered as an effective therapeutic intervention for improving BP control with minimal effect on renal function. The male sex, higher baseline BP and low GFR are associated with poor BP response after successful PTRA and stenting. | Jayesh S Prajapati Sharad R Jain Hasit Joshi Shaurin Shah Kamal Sharma Sibasis Sahoo Kapil Virparia Ashok Thakkar | 2013 | World Journal of Cardiology2013，5，7： | 3 |
| 7 | Current and emerging therapeutic strategies in pancreatic cancer: Challenges and opportunities显示文摘Pancreatic carcinoma(PC)is one of the leading causes of cancer-related deaths worldwide.Despite early detection and advances in therapeutics,the prognosis remains dismal.The outcome and therapeutic approach are dependent on the stage of PC at the time of diagnosis.The standard of care is surgery,followed by adjuvant chemotherapy.The advent of newer drugs has changed the landscape of adjuvant therapy.Moreover,recent trials have highlighted the role of neoadjuvant therapy and chemoradiotherapy for resectable and borderline resectable PC.As we progress towards a better understanding of tumor biology,genetics,and microenvironment,novel therapeutic strategies and targeted agents are now on the horizon.We have described the current and emerging therapeutic strategies in PC. | Manish Manrai TVSVGK Tilak Saurabh Dawra Sharad Srivastava Anupam Singh | 2021 | World Journal of Gastroenterology2021，27，39： | 3 |
| 8 | Magnetic Resonance Spectroscopy显示文摘 | Sachin K Gujar Sharad Maheshwari Isabella Bj?rkman-Burtscher Pia C Sundgren | 2005 | Journal of Neuro-Ophthalmology2005，，3： | 2 |
| 9 | Effect of replenishment of vitamin D on survival in patients with decompensated liver cirrhosis:A prospective study显示文摘AIM To assess the vitamin D(VD) deficiency as a prognostic factor and effect of replenishment of VD on mortality in decompensated cirrhosis. METHODS Patients with decompensated liver cirrhosis were screened for serum VD levels. A total of 101 VD deficient patients(< 20 ng/mL) were randomly enrolled in two groups: Treatment group(n = 51) and control group(n = 50). Treatment group received VD treatment in the form of intramuscular cholecalciferol 300000 IU as loading dose and 800 IU/d oral as maintenance dose along with 1000 mg oral calcium supplementation. The VD level, clinical parameters and survival of both the groups were compared for 6-mo.RESULTS Prevalence of vitamin D deficiency(VDD) in decompensated CLD was 84.31%. The mean(SD) age of the patients in the treatment group(M:F: 40:11) and control group(M:F: 37:13) were 46.2(± 14.93) years and 43.28(± 12.53) years, respectively. Baseline mean(CI) VD(ng/mL) in control group and treatment group were 9.15(8.35-9.94) and 9.65(8.63-10.7), respectively. Mean(CI) serum VD level(ng/mL) at 6-mo in control group and treatment group were 9.02(6.88-11.17) and 29(23-35), respectively. Over the period of time the VD, calcium and phosphorus level was improved in treatment group compared to control group. There was nonsignificant trend seen in greater survival(69% vs 64%; P > 0.05) and longer survival(155 d vs 141 d; P > 0.05) in treatment group compared to control group. VD level had no significant association with mortality(P > 0.05). In multivariate analysis, treatment with VD supplement was found significantly(P < 0.05; adjusted hazard ratio: 0.48) associated with survival of the patients over 6-mo. CONCLUSION VD deficiency is very common in patients of decompensated CLD. Replenishment of VD may improve survival in patients with decompensated liver cirrhosis. | Ashish Kumar Jha Sharad Kumar Jha Amarendra Kumar Vishwa Mohan Dayal Sanjeev Kumar Jha | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，3： | 2 |
| 10 | A cost-effective and fast synthesis of nanoporous SiO 2 aerogel powders using water-glass via ambient pressure drying route显示文摘 | Sharad D. Bhagat Yong-Ha Kim Myung-Jun Moon Young-Soo Ahn Jeong-Gu Yeo | 2007 | Solid State Sciences2007，，7： | 2 |
| 11 | Adequacy of esophageal squamous mucosa specimens obtained during endoscopy: are standard biopsies sufficient for postablation surveillance in Barrett’s esophagus?显示文摘 | Neil Gupta Sharad C. Mathur John A. Dumot Vikas Singh Srinivas Gaddam Sachin B. Wani Ajay Bansal Amit Rastogi John R. Goldblum Prateek Sharma | 2012 | Gastrointestinal Endoscopy2012，，： | 2 |
| 12 | Laparoscopic versus open distal pancreatectomy: a single-institution case-control study显示文摘 | Sanket Sharad Mehta Ghalia Doumane Thibault Mura David Nocca Jean-Michel Fabre | 2012 | Surgical Endoscopy2012，，2： | 2 |
| 13 | 颈深部多间隙脓肿34例临床分析显示文摘目的回顾性分析颈深部多间隙脓肿的临床特征、诊断、治疗和预后。方法总结分析2013年1月~2019年8月我院收治的34例颈深部多间隙脓肿患者的临床资料。结果32例行手术切开引流,2例保守治疗,感染来源以牙源性感染和异物常见,常见致病菌为链球菌,咽痛和颈部肿胀是最常见的临床表现,其中咽旁间隙和颈前间隙最常受累,术后并发症以低蛋白血症和电解质紊乱常见。该组患者33例治愈,1例死于感染性休克,随访1~3个月无复发。结论颈深部多间隙脓肿诊断明确后,及时有效的切开引流和合理抗生素的选择是治疗的关键,重视术后并发症的预防及处理,有利于该疾病的早期治愈。 | 曹武 黄志纯 冯立人 冯旭 孙宝宾 杨鑫 Sharad Paudel | 2020 | 中国耳鼻咽喉头颈外科2020，27，5： | 2 |
| 14 | The utility of a novel narrow band imaging endoscopy system in patients with Barrett’s esophagus显示文摘 | Prateek Sharma Ajay Bansal Sharad Mathur Sachin Wani Rachel Cherian Douglas McGregor April Higbee Sandra Hall Allan Weston | 2006 | Gastrointestinal Endoscopy2006，，： | 2 |
| 15 | Highlights from the literature on risk assessment techniques adopted in the mining industry:A review of past contributions,recent developments and future scope显示文摘In this paper a comprehensive review is presented of risk assessment techniques adopted in the mining industry worldwide;those techniques applied in other hazardous industries and potential techniques which are robust,mature and holistic and can be implemented for the Indian mining industry in future to enhance workplace safety are also presented.Findings from the review are indicative of the fact that socio-technical complexity of industrial systems has increased.Recent developments in the area of risk management highlight the need for implementation of the latest robust techniques of risk assessment in the mining sector.In consideration of the present scenario,the development of a model for risk analysis having an interface between hazard identification and risk assessment,along with an interface between risk assessment and accident causation to predict if an accident will occur under given conditions,has become dire necessity.This will increase hazard awareness and enable mine management to select and prioritize problem areas and identify safety system weaknesses in both underground and surface mining.This will ultimately help decision makers,risk analysts and safety managers make a major contribution in the development of workplace safety with a near-to-zero accident rate. | Verma Shikha Chaudhari Sharad | 2016 | International Journal of Mining Science and Technology2016，26，4： | 2 |
| 16 | Battery Energy Storage to Strengthen the Wind Generator in Integrated Power System显示文摘The wind energy generation,utilization and its grid penetration in electrical grid are increasing world-wide.The wind generated power is always fluctuating due to its time varying nature and causing stability problem.This weak interconnection of wind generating source in the electrical network affects the power quality and reliability.The localized energy storages shall compensate the fluctuating power and support to strengthen the wind generator in the power system.In this paper,it is proposed to control the voltage source inverter (VSI) in current control mode with energy storage,that is,batteries across the dc bus.The generated wind power can be extracted under varying wind speed and stored in the batteries.This energy storage maintains the stiff voltage across the dc bus of the voltage source inverter.The proposed scheme enhances the stability and reliability of the power system and maintains unity power factor.It can also be operated in stand-alone mode in the power system.The power exchange across the wind generation and the load under dynamic situation is feasible while maintaining the power quality norms at the common point of coupling.It strengthens the weak grid in the power system.This control strategy is evaluated on the test system under dynamic condition by using simulation.The results are verified by comparing the performance of controllers. | Sharad W. Mohod Mohan V. Aware | 2011 | Journal of Electronic Science and Technology2011，9，1： | 2 |
| 17 | Chiral nanocomposite of sulfobutyl ether-b-cyclodextrin embedded in carbon nanofibers for enantioselective electrochemical discrimination of amlodipine, metoprolol and clenbuterol enantiomers显示文摘A highly sensitive and selective electrochemical chiral sensor was developed based on the competitive supramolecular interaction of carbon nanofibers(CNFs)embedded sulfobutyl ether-b-cyclodextrin(SBEb-CD)with optically active cationic drugs at glassy carbon electrode(GCE).The difference in intermolecular hydrogen bonding/stability constant/enantioselectivity coefficient and Gibbs free energy of anionic host SBE-b-CD with enantiomers of amlodipine(R-/S-AML),clenbuterol(R-/S-CBL)and metoprolol(R-/S-MET)as a guest paved the way for efficient discrimination.The proposed sensing platform(CNFs-SBE-b-CD/GCE)could recognize the aforementioned enantiomers based on the discernible difference of peak potential(S/R-AML(△Ep=135 mV),R/S-MET(△Ep=99 mV)and R/S-CBL(△Ep=111 mV).The binding mechanisms and thermodynamic study of the enantiospecific behavior have been investigated using the host-guest chemistry approach inside the nanocavity and results suggest that S-AML,RMET,and R-CBL show stronger stability constants than their antipodes.Formation of the diastereomeric complex was taken as a measure of enantioselectivity and experimental results indicated that anionic SBE-b-CD is a better chiral ligand than neutral cyclodextrins.The fabricated sensor could be a useful lowcost electrochemical tool for molecular recognition of a variety of cationic species not only of drugs but also from other sources. | Pramod K.Kalambate Sharad S.Upadhyay Yue Shen Wanida Laiwattanapaisal Yunhui Huang | 2021 | Journal of Materiomics2021，7，2： | 2 |
| 18 | Ciliated hepatic foregut cyst:an increasingly diagnosed condition显示文摘BACKGROUND:Ciliated foregut cysts of the liver are rare, with only 96 cases diagnosed since the first description in 1857.They are being increasingly diagnosed recently;the majority of the cases have been reported in the last 15 years. Although they bear a close resemblance to the simple cyst of the liver which has essentially a benign course,ciliated hepatic foregut cysts(CHFCs)can progress to malignancy with devastating consequences.It is imperative that this group of conditions be diagnosed and treated adequately. DATA SOURCES:This review includes discussion of the data from all the 96 reported cases from English and non-English literature.Analysis of the incidence rates, embryogenesis,growth,clinical features,risk of malignancy and the prognosis are highlighted systematically.The roles of various diagnostic modalities including ultrasound, CT,MRI,fine needle aspiration cytology(FNAC), immunohistochemistry and surgery are further discussed. RESULTS:The mean age of patients with CHFC was 48± 12 years.The male/female ratio was 1.1∶1.The majority of patients with CHFC(62%)were asymptomatic,and the common mode of presentation was right upper abdominal pain.The cysts occurred in the left lobe in 51 patients, with sole location in segmentⅣin 44,and in the right lobe in 26.The average size of the cysts was 3.6±2.12 cm. The majority of the cysts were unilocular,and only 7 cases were multilocular.Cyst contents were described as viscous or mucinous in 73 patients,whereas bilious fluid was noted in 3.Large cysts having squamous carcinoma were cited in 3 patients,and 2 had extensive squamous metaplasia without malignancy.Others had benign histopathology. CONCLUSIONS:Clinicians have become increasingly aware of CHFC.Imaging alone is not diagnostic per se, but when considered in the context of the global picture does provide important clues to the diagnosis.FNAC is diagnostic by the presence of the ciliated columnar aspirate but lacks sensitivity.Infantile presentation is usually accompanied by biliary communication and mandates a different surgical approach.The demonstration of malignant transformation in 3 cases and its fatal course emphasizes the need for surgical resection in all cases once the diagnosis is made. | Sharad Sharma Amanda G.Dean Ayumi Corn Vivek Kohli Harlan I Wright Anthony Sebastian Nicolas Jabbour | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，6： | 2 |
| 19 | Some aspects of the role of surfactants in the formation of nanoparticles显示文摘 | Sharad G Dixit Anand R Mahadeshwar Santosh K Haram | 1998 | Colloids and Surfaces A:Physicochemical and Engineering Aspects1998，133，7： | 1 |
| 20 | Examining Transport Futures with Scenario Analysis and MCA显示文摘 | Robin H Sharad S | | 0，，： | 1 |
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