|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Systemic treatment strategies for triple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC) is defined by the lack of immunohistochemical expression of the estrogen and progesterone receptors and human epidermal growth factor receptor 2(EGFR2). Most TNBC has a basal-like molecular phenotype by gene expression profiling and shares clinical and pathological features with hereditary BRCA1 related breast cancers. This review evaluates the activity of available chemotherapy and targeted agents in TNBC. A systematic review of PubM ed and conference databases was carried out to identify randomised clinical trials reporting outcomes in women with TNBC treated with chemotherapy and targeted agents. Our review identified TNBC studies of chemotherapy and targeted agents with different mechanisms of action, including induction of synthetic lethality and inhibition of angiogenesis, growth and survival pathways. TNBC is sensitive to taxanes and anthracyclins. Platinum agents are effective in TNBC patients with BRCA1 mutation, either alone or in combination with poly adenosine diphosphate polymerase 1 inhibitors. Combinations of ixabepilone and capecitabine have added to progression-free survival(PFS) without survival benefit in metastatic TNBC. Antiangiogenic agents, tyrosine kinase inhibitors and EGFR inhibitorsin combination with chemotherapy produced only modest gains in PFS and had little impact on survival. TNBC subgroups respond differentially to specific targeted agents. In future, the treatment needs to be tailored for a specific patient, depending on the molecular characteristics of their malignancy. TNBC being a chemosensitive entity, combination with targeted agents have not produced substantial improvements in outcomes. Appropriate patient selection with rationale combinations of targeted agents is needed for success. | Budhi Singh Yadav Suresh C Sharma Priyanka Chanana Swaty Jhamb | 2014 | World Journal of Clinical Oncology2014，5，2： | 18 |
| 2 | Biomarkers in triple negative breast cancer:A review显示文摘Breast cancer is an intrinsically heterogeneous disease. In the world about 1 million cases of breast cancer are diagnosed annually and more than 170000 are triplenegative. Characteristic feature of triple negative breast cancer(TNBC) is that it lacks expression of oestrogen,progesterone and human epidermal growth factor receptor-2/neu receptors. They comprise 15%-20% of all breast cancers. We did a systematic review of Pub Med and conference databases to identify studies published on biomarkers in TNBC. We included studies with biomarkers including: Epidermal growth factor receptor,vascular endothelial growth factor,c-Myc,C-kit and basal cytokeratins,Poly(ADP-ribose) polymerase-1,p53,tyrosinase kinases,m-TOR,heat and shock proteins and TOP-2A in TNBC. We also looked for studies published on synthetic lethality and inhibition of angiogenesis,growth,and survival pathways. TNBC is a complex disease subtype with many subclasses. Majority TNBC have a basal-like molecular phenotype by gene expression profiling. Their clinical and pathologic features overlap with hereditary BRCA1 related breast cancers. Management of these tumours is a challenge to the clinician because of its aggressive behaviour,poor outcome,and absence of targeted therapies. As the complexity of this disease is being simplified over time new targets are also being discovered for the treatment of this disease. There are many biomarkers in TNBC being used in clinical practice. Biomarkers may be useful as prognostic or predictive indicators as well as suggest possible targets for novel therapies. Many targeted agents are being studied for treatment of TNBC. | Budhi S Yadav Priyanka Chanana Swaty Jhamb | 2015 | World Journal of Clinical Oncology2015，6，6： | 13 |
| 3 | ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages显示文摘到巨噬细胞的不同类型的区别决定他们的不同功能。联系肿瘤的巨噬细胞(TAM ) 由于他们的 proangiogenic 和类似于那些的免疫者镇压的功能支持 tumorigenesis 或者激活(M2 ) 巨噬细胞。我们报导那反应的氧种类(ROS ) 生产为巨噬细胞区别和 superoxide 的那抑制是批评的(O 2−) 生产明确地堵住 M2 巨噬细胞的区别。我们发现当单核白血球被触发区分时, O 2− 为 biphasic 英皇家空军之阶级最低之兵激活被产生并且被需要,它为巨噬细胞区别是批评的。我们证明由 butylated hydroxyanisole (BHA ) 和另外的 ROS 禁止者的那 ROS 消除堵住巨噬细胞区别。然而,当房间被极化到时,巨噬细胞区别上的 ROS 消除的禁止的效果被克服古典主义地激活(M1 ) ,然而并非 M2,巨噬细胞。更重要地, ROS 禁止者 BHA 的连续管理高效地堵住了 TAM 的出现并且显著地在老鼠癌症模型压制了 tumorigenesis。由堵住 ROS 指向 TAM 能是为癌症治疗的一个潜在地有效的方法。 | Yan Zhang Swati Choksi Kun Chen Yelena Pobezinskaya Ilona Linnoila Zheng-Gang Liu | 2013 | Cell Research2013，23，7： | 12 |
| 4 | Necroptosis of tumor cells leads to tumor necrosis and promotes tumor metastasis显示文摘 | Delong Jiao Zhenyu Cai Swati Choksi Dan Ma Moran Choe Hyung-Joon Kwon Jin Young Balk Brian G. Rowan Chengyu Liu Zheng-gang Liu | 2018 | Cell Research2018，28，8： | 9 |
| 5 | 高效液相色谱-荧光检测法测定人血浆中的匹伐他汀(英文)显示文摘Pitavastatin belongs to the class of coenzyme A reductase inhibitors.Very few methods of assaying pitavastatin from human plasma are available in literature.An analytical method is presented for the determination of the drug from human plasma making use of the fluorescent property of the drug.The drug is extracted from plasma using ethyl acetate under neutral condition and then analyzed by reversed-phase high performance liquid chromatography(HPLC) with fluorescence detection(λEx 245 nm;λEm 420 nm).Analysis of pitavastatin was carried out on a C18 HPLC column using a gradient flow of mobile phase(0.01 mol/L monobasic potassium phosphate(pH 3.20)-acetonitrile,63:37,v/v).Fluorescein isothiocyanate was used as internal standard.The dynamic range of assay was 3 to 50 ng/mL.The intraday precision was less than 10% and accuracy ranged from 95.2% to 112.6%.The same for interday check was less than 12% and 92.8% to 105.1%,respectively.The drug was found to be stable under the assay conditions.The developed method is simple,precise,accurate,and stable.This indicates that it can be applied to routine analysis of this drug in human subjects where there are large numbers of samples without the need of specialized instruments like column switching. | OJHA Ashwini GUTTIKAR Swati VAYEDA Chintan PADH Harish | 2007 | 色谱2007，25，5： | 8 |
| 6 | Hepatitis B and C virus co-infections in human immunodeficiency virus positive North Indian patients显示文摘AIM: To determine the prevalence of hepatitis B and C virus infections in human immunodeficiency virus (HIV) -positive patients at a tertiary care hospital in New Delhi, India. METHODS: Serum samples from 451 HIV positive patients were analyzed for HBsAg and HCV antibodies during three years (Jan 2003-Dec 2005). The control group comprised of apparently healthy bone-marrow and renal donors. RESULTS: The study population comprised essentially of heterosexually transmitted HIV infection. The prevalence rate of HBsAg in this population was 5.3% as compared to 1.4% in apparently healthy donors (P < 0.001). Though prevalence of HCV co-infection (2.43%) was lower than HBV in this group of HIV positive patients, the prevalence was significantly higher (P < 0.05) than controls (0.7%). Triple infection of HIV, HBV and HCV was not detected in any patient. CONCLUSION: Our study shows a significantly high prevalence of hepatitis virus infections in HIV infected patients. Hepatitis viruses in HIV may lead to faster progression to liver cirrhosis and a higher risk of antiretroviral therapy induced hepatotoxicity. Therefore, it would be advisable to detect hepatitis virus co- infections in these patients at the earliest. | Swati Gupta Sarman Singh | 2006 | World Journal of Gastroenterology2006，12，42： | 7 |
| 7 | Dual solutions in boundary layer flow of a moving fluid over a moving permeable surface in presence of prescribed surface temperature and thermal radiation Dual solutions in boundary layer flow of a moving fluid over a moving permeable surface in presence of prescribed surface temperature and thermal radiation Dual solutions in boundary layer flow of a moving fluid over a moving permeable surface in presence of prescribed surface temperature and thermal radiationDual solutions in boundary layer flow of a moving fluid over a moving permeable surface in presence of prescribed surface temperature and thermal radiation显示文摘An analysis of the heat transfer for a boundary layer forced convective flow past a moving permeable flat surface parallel to a moving fluid is presented. Prescribed surface temperature at the boundary is considered, A thermal radiation term in the energy equation is considered. The similarity solutions for the problem are obtained and the reduced ordinary differential equations are solved numerically. To support the validity of the numerical results, a comparison is made with the available results for some particular cases of this study. Dual solutions exist when the surface and the fluid move in the opposite directions. | Swati Mukhopadhyay | 2014 | Chinese Physics B2014，23，1： | 7 |
| 8 | 一种电力电缆的随机电热退化模型(英文)显示文摘In this paper a methodology is proposed to model the stochastic electro-thermal degradation accumulation in cables.The cable life and the reliability are predicted by estimating the accumulated electro-thermal degradation during seasonal load cycles.The degradation is considered,in a novel approach,as stochastic in nature due to variations in the manufacturing process of insulation raw material and in operational and environmental conditions.The methodology is based on estimation of life by using combined electro-thermal life model,simulation of degradation accumulation process under electro-thermal stress in each season of the year based on Miner’s cumulative damage theory and reliability prediction from a probabilistic point of view.A case study is demonstrated on 10 k V XLPE cables which are directly buried in the UK and China.Results show that,the electro-thermal life of the cable is 56 and 69 years in China and the UK,respectively at 50%failure probability,or the life of the cable in the UK would be 13 years longer than in China,when other stresses such as mechanical and environmental are also considered and assumed to be the same. | Swati Sachan Rui Wen Yong Xiang Leiming Yao Chengke Zhou | 2015 | 高电压技术2015，41，4： | 6 |
| 9 | Histone modifications and alcohol-induced liver disease:Are altered nutrients the missing link?显示文摘Alcoholism is a major health problem in the United States and worldwide,and alcohol remains the single most significant cause of liver-related diseases and deaths.Alcohol is known to influence nutritional status at many levels including nutrient intake,absorption,utilization,and excretion,and can lead to many nutritional disturbances and deficiencies.Nutrients can dramatically affect gene expression and alcohol-induced nutrient imbalance may be a major contributor to pathogenic gene expression in alcohol-induced liver disease(ALD).There is growing interest regarding epigenetic changes,including histone modifications that regulate gene expression during disease pathogenesis.Notably,modifications of core histones in the nucleosome regulate chromatin structure and DNA methylation,and control gene transcription.This review highlights the role of nutrient disturbances brought about during alcohol metabolism and their impact on epigenetic histone modifications that may contribute to ALD.The review is focused on four critical metabolites,namely,acetate,S-adenosylmethionine,nicotinamide adenine dinucleotide and zinc that are particularly relevant to alcohol metabolism and ALD. | Akshata Moghe Swati Joshi-Barve Smita Ghare Leila Gobejishvili Irina Kirpich Craig J McClain Shirish Barve | 2011 | World Journal of Gastroenterology2011，17，20： | 6 |
| 10 | MicroRNA exhibit altered expression in the inflamed colonic mucosa of ulcerative colitis patients显示文摘AIM To investigate the miRNA expression in colonic mucosal biopsies from endoscopically inflamed and non inflamed regions of ulcerative colitis(UC) patients. METHODS Colonic mucosal pinch biopsies were analyzed from the inflamed and non inflamed regions of same UC patient. Total RNA was isolated and differential miRNA profiling was done using microarray platform. Quantitative Real Time PCR was performed in colonic biopsies from inflamed(n = 8) and non-inflamed(n = 8) regions of UC and controls(n = 8) to validate the differential expression of miRNA. Potential targets of dysregulated miRNA were identified by using in silico prediction tools and probable role of these miRNA in inflammatory pathways were predicted.RESULTS The miRNA profile of inflamed colonic mucosa differs significantly from the non-inflamed. Real time PCR analysis showed that some of the miRNA were differentially expressed in the inflamed mucosa as compared to non inflamed mucosa and controls(mi R-125 b, mi R-223, miR-138, and mi R-155), while(miR-200a) did not show any significant changes. In contrast to microarray, where mi R-378 d showed downregulation in the inflamed mucosa, q RT-PCR showed a significant upregulation in the inflamed mucosa as compared to the non inflamed. The in silico prediction analysis revealed that the genes targeted by these mi RNAs play role in the major signaling pathways like MAPK pathway, NF-κB signaling pathway, cell adhesion molecules which are all assciated with UC.CONCLUSION The present study reports disease specific alteration in the expression of mi R-125 b, mi R-155, mi R-223 and mi R-138 in UC patients and also predict their biological significance. | Swati Valmiki Vineet Ahuja Jaishree Paul | 2017 | World Journal of Gastroenterology2017，23，29： | 6 |
| 11 | Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration显示文摘Necroptosis 是词法上类似于坏死的规划、 caspase 独立的房间死亡。导致 TNF 的 necroptosis 被交往受体的蛋白质调停 kinases, RIP1 和 RIP3,和混合的系 kinase 像域(MLKL ) 。在是由 RIP3 的 phosphorylated 以后, MLKL 是到血浆膜的 translocated 并且调停 necroptosis。然而, necroptosis 的实行和它在发炎和另外的细胞的回答的角色留下大部分逃犯。在这研究,我们报导房间表面朊酶的那调停 MLKL 的激活 disintegrin 和 metalloprotease (ADAM ) 家庭支持 necroptosis,发炎和房间移植。当 MLKL 是 phosphorylated 和 translocated 到房间血浆膜时,亚当斯明确地在 necroptosis 的早阶段被激活。亚当斯的激活导致包括粘附分子,受体,生长因素和 cytokines 多样的房间表面蛋白质流的 ectodomain。重要地,流房间表面蛋白质破坏房间粘附并且加速 necroptosis,当劈开的蛋白质的可溶的碎片触发煽动性的回答时。我们也证明从 necroptotic 房间流 E-cadherin ectodomain 支持房间移植。因此,我们的学习提供导致 necroptosis 的发炎和新卓见的新奇机制进房间死亡的这种唯一的形式的生理、病理学的功能。 | Zhenyu Cai Anling Zhang Swati Choksi Weihua Li Tao Li Xue-Min Zhang Zheng-Gang Liu | 2016 | Cell Research2016，26，8： | 5 |
| 12 | Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells显示文摘蛋氨酸 adenosyltransferase II (地席 II ) 是在细胞的新陈代谢的关键酶并且从 L 蛋氨酸和 ATP 催化 S-adenosylmethionine (一样) 的形成。正常休息 T 淋巴细胞举办最小的地席 II 活动,而白血病的房间显著地显示出的激活的增殖的 T 淋巴细胞和转变 T 提高了地席 II 活动。这个工作被执行在白血病的 T 房间的幸存检验地席 II 活动和一样的生合成的角色。在一样的层次的地席 II 和结果的减少的抑制提高了 FasL mRNA 和蛋白质的表示,并且导致了圆盘(导致发信号的建筑群的死亡) 有 FADD (联系船边交货的死亡域) 和 procaspase-8 招募的形成,以及 caspase-8 激活的伴随物增加和在 c 扭动的减少铺平。开始船边交货的发信号由地席 II 抑制导致了被观察经由出价劈开连接到 mitochondrial 小径并且最终在这些房间导致增加的 caspase-3 激活和 DNA 破碎。而且,堵住地席 2A mRNA 表示,它编码地席 II 的催化子单元,用一条小介入的 RNA 途径提高了 FasL 表示和房间死亡,验证在 T 白血病的房间的幸存的地席 II 活动的必要性质。 | Tanvi S Jani Leila Gobejishvili Prachi T Hote Aditya S Barve Swati Joshi-Barve Giorgi Kharebava Jill Suttles Theresa Chen Craig J McClain Shirish Barve | 2009 | Cell Research2009，19，3： | 5 |
| 13 | Identification, occurrence, and validation of DRE and ABRE Cis-regulatory motifs in the promoter regions of genes of Arabidopsis thaliana显示文摘Plants posses a complex co-regulatory network Researchwhich helps them to elicit a response under diverse adverse conditions.We used an in silico approach to identify the genes with both DRE and ABRE motifs in their promoter regions in Arabidopsis thaliana.Our results showed that Arabidopsis contains a set of 2,052 genes with ABRE and DRE motifs in their promoter regions.Approximately 72%or more of the total predicted 2,052 genes had a gap distance of less than 400 bp between DRE and ABRE motifs.For positional orientation of the DRE and ABRE motifs,we found that the DR form(one in direct and the other one in reverse orientation)was more prevalent than other forms.These predicted 2,052 genes include 155 transcription factors.Using microarray data from The Arabidopsis Information Resource(TAIR)database,we present 44 transcription factors out of 155 which are upregulated by more than twofold in response to osmotic stress and ABA treatment.Fifty-one transcripts from the onepredicted above were validated using semiquantitative expression analysis to support the microarray data in TAIR.Taken together,we report a set of genes containing both DRE and ABRE motifs in their promoter regions in A.thaliana,which can be useful to understand the role of ABA under osmotic stress condition. | Sonal Mishra Aparna Shukla Swati Upadhyay Sanchita Pooja Sharma Seema Singh Ujjal J.Phukan Abha Meena Feroz Khan Vineeta Tripathi Rakesh Kumar Shukla Ashok Shrama | 2014 | Journal of Integrative Plant Biology2014，56，4： | 5 |
| 14 | Nanodiamonds with powerful ability for drug delivery and biomedical applications:Recent updates on in vivo study and patents显示文摘Nanodiamonds are novel nanosized carbon building blocks possessing varied fascinating mechanical,chemical,optical and biological properties,making them significant active moiety carriers for biomedical application.These are known as the most‘captivating’crystals attributed to their chemical inertness and unique properties posing them useful for variety of applications in biomedical era.Alongside,it becomes increasingly important to find,ascertain and circumvent the negative aspects associated with nanodiamonds.Surface modification or functionalization with biological molecules plays a significant role in managing the toxic behavior since nanodiamonds have tailorable surface chemistry.To take advantage of nanodiamond potential in drug delivery,focus has to be laid on its purity,surface chemistry and other considerations which may directly or indirectly affect drug adsorption on nanodiamond and drug release in biological environment.This review emphasizes on the basic properties,synthesis techniques,surface modification techniques,toxicity issues and biomedical applications of nanodiamonds.For the development of nanodiamonds as an effective dosage form,researchers are still engaged in the in-depth study of nanodiamonds and their effect on life interfaces. | Swati Chauhan Neha Jain Upendra Nagaich | 2020 | Journal of Pharmaceutical Analysis2020，10，1： | 5 |
| 15 | Treatment of wheat straw using tannase and white-rot fungus to improve feed utilization by ruminants显示文摘Background: Current research to enrich cattle feed has primarily focused on treatment using white rot fungi, while there are scarce reports using the enzyme tannase, which is discussed only in reviews or in the form of a hypothesis. In this context, the aim of the present study was to evaluate the effect of tannase on wheat straw(WS)and also the effect of lyophilized tannase at concentrations of 0.1%, 0.2%, and 0.3%(w/w) on WS followed by fermentation with Ganoderma sp. for 10 d and compared in relation to biochemical parameters, crude protein(CP)content, and nutritional value by calculating the C/N ratio in order to improve the nutritional value of cattle feed.Results: Penicillium chorlesii, a tannase-producing microorganism, produced 61.4 lU/mL of tannase in 54 h when 2%(w/v) tannic acid(TA) was initially used as a substrate in medium containing(% w/v) sucrose(1.0), NaN03(1.0), and MgS〇4(0.08 pH, 5.0) in a 300-L fermentor(working volume 220 L), and concomitantly fed with 1.0%(w/v) TA after24 h. The yield of partially purified and lyophilized tannase was 5.8 lU/mg. The tannin-free myco-straw at 0.1%(w/w) tannase showed 37.8%(w/w) lignin degradation with only a 20.4%(w/w) decrease in cellulose content and the in vitro feed digestibility was 32.2%. An increase in CP content(up to 1.28-fold) along with a lower C/N ratio of25.0%, as compared to myco-straw, was obtained.Conclusions: The use of tannin-free myco-straw has potential to improve the nutritional content of cattle feed.This biological treatment process was safe, eco-friendly, easy to perform, and was less expensive as compared to other treatment methods. | Shailendra Raghuwanshi Swati Misra Rajendra Kumar Saxena | 2014 | Journal of Animal Science and Biotechnology2014，5，2： | 5 |
| 16 | Pathogenesis and clinical spectrum of primary sclerosing cholangitis显示文摘Primary sclerosing cholangitis(PSC) is a disease of the biliary tract, which has been documented in the literature since 1867. This disease has a strong predilection for affecting men and can be seen in individuals as young as 2 years of age. PSC has a strong associated with inflammatory bowel disease, more commonly with ulcerative colitis, and is also part of the clinical spectrum of Ig G4-related diseases. Smallduct PSC, a variant of PSC, also has an association with inflammatory bowel disease. The exact pathogenesis of PSC is not well understood at present, however, is likely a combination of a genetic predisposition with alteration of the molecular structure of the gut. Abnormal serum liver chemistry and presence of certain autoimmune markers are usually the first indicators leading to a diagnosis of PCS, however, these may often be normal in early stages of this disease. The diagnosis is made by cholangiography, which is now considered the gold standard. PSC is a known pre-malignant condition. Such patients have an increased risk of developing cholangiocarcinoma, gallbladder neoplasia, and colon cancer. Many new treatment modalities have emerged in the recent past, including anti-tumor necrosis factor-α and anti-integrins; however, liver transplantation is the only known cure for PSC. Despite past and present research, PSC remains an enigmatic biliary disease with few viable treatment options. | Neelam G Gidwaney Swati Pawa Kiron M Das | 2017 | World Journal of Gastroenterology2017，23，14： | 4 |
| 17 | Slip Effects on an Unsteady Boundary Layer Stagnation-Point Flow and Heat Transfer towards a Stretching Sheet显示文摘An analysis is presented for an unsteady boundary layer stagnation-point flow of a Newtonian fluid and the heat transfer towards a stretching sheet taking non-conventional partial slip conditions at the sheet.The self-similar equations are obtained using similarity transformations and solved numerically by the shooting method.Effects of the parameters involved in the equations,especially velocity slip and thermal slip parameters on the velocity and temperature profiles,are analyzed extensively.It is revealed that due to the velocity and thermal slip parameters,the rate of heat transfer from the sheet and the wall skin friction change significantly. | Krishnendu Bhattacharyya Swati Mukhopadhyay G.C.Layek | 2011 | Chinese Physics Letters2011，28，9： | 4 |
| 18 | Heat Transfer Analysis of the Unsteady Flow of a Maxwell Fluid over a Stretching Surface in the Presence of a Heat Source/Sink显示文摘The unsteady two-dimensional flow of a MHD non-Newtonian Maxwell fluid over a stretching surface with a prescribed surface temperature in the presence of a heat source/sink is investigated.Similarity solutions for the governing equations are obtained.The transformed boundary layer equations are then solved numerically by using the shooting method.Fluid velocity initially decreases with the increasing unsteadiness parameter,and temperature decreases significantly due to unsteadiness.It is also found that the fluid velocity decreases with the increasing magnetic parameter.Increasing the Maxwell parameter values has the effect of suppressing the velocity field and increasing the temperature. | Swati Mukhopadhyay | 2012 | Chinese Physics Letters2012，29，5： | 4 |
| 19 | Morphological and molecular analyses define the genetic diversity of Asian bitter gourd (Momordica charantia L.)显示文摘 | Dalamu Behera T K Gaikwad A B Saxena Swati Bharadwaj C Munshi A D | 2012 | EN2012，，2： | 3 |
| 20 | Casson fluid flow and heat transfer over a nonlinearly stretching surface显示文摘A boundary layer analysis is presented for non-Newtonian fluid flow and heat transfer over a nonlinearly stretching surface. The Casson fluid model is used to characterize the non-Newtonian fluid behavior. By using suitable transformations, the governing partial differential equations corresponding to the momentum and energy equations are converted into non-linear ordinary differential equations. Numerical solutions of these equations are obtained with the shooting method. The effect of increasing Casson parameter is to suppress the velocity field. However the temperature is enhanced with the increasing Casson parameter. | Swati Mukhopadhyay | 2013 | Chinese Physics B2013，22，7： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员