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| 1 | Antimicrobial activity of Sapindus mukorossi and Rheum emodi extracts against H pylori: In vitro and in vivo studies显示文摘AIM: To evaluate the antibacterial activity of Sapindus mukorossi (S. mukorossi) and Rheum emodi (R. emodi). METHODS: Powders of S. mukorossi and R. emodi were extracted successively with petroleum ether, benzene, chloroform and ethanol and were concentrated in vacuum. The disk diffusion method was used for in vitro studies and in vivo studies were performed on male Wister rats. Thirty resistant clinical isolates of H pylori, as determined by their antibiotic sensitivity patterns by E-test, along with two Gram +ve (S. aureus, B. subtilis) and two Gram -ve (E. coli, P. vugaris) organisms were screened for their susceptibility patterns against these extracts. RESULTS: In our screening, all 30 resistant isolates and the other four organisms (two Gram +ve S. aureus, B. subtilis and two Gram -ve, E. coli, P. vugaris) were sensitive to the test compounds. It was found that ethanol and chloroform extracts of S. mukorossi and ethanol and benzene extracts of R. emodi inhibited H pylori at very low concentrations. In the in vitro study, the isolates showed a considerable zone of inhibition at very low concentrations (10 μg/mL) for both the extracts. In the in vivo study, the H pylori infection was cleared with minimal doses of extracts of S. mukorossi (2.5 mg/mL) and R. emodi (3.0 mg/mL) given orally for seven days. CONCLUSION: We can conclude from this study that the extracts of S. mukorossi and R. emodi inhibited the growth of pylori in vitro and, in in vivo studies, the H pylori infection cleared within seven days at very low concentrations. We also found that H pylori did not acquire resistance against these herbal extracts even after 10 consecutive passages. | Mohammed Ibrahim Aleem A Khan Santosh K Tiwari Mohammed Aejaz Habeeb MN Khaja CM Habibullah | 2006 | World Journal of Gastroenterology2006，12，44： | 46 |
| 2 | Challenges in diagnosis of pancreatic cancer显示文摘Pancreatic cancer is a growing source of cancer related death, yet has poor survival rates which have not improved in the last few decades. Its high mortality rate is attributed to pancreatic cancer biology, difficulty in early diagnosis and the lack of standardised international guidelines in assessing suspicious pancreatic masses. This review aims to provide an update in the current state of play in pancreatic cancer diagnosis and to evaluate the benefits and limitations of available diagnostic technology. The main modalities discussed are imaging with computed tomography, magnetic resonance imaging, endoscopic ultrasound and positron emission tomography and tissue acquisition with fine needle aspiration. We also review the improvements in the techniques used for tissue acquisition and the opportunity for personalised cancer medicine. Screening of high risk individuals, promising biomarkers and common mimickers of pancreatic cancer are also explored, as well as suggestions for future research directions to allow for earlier detection of pancreatic cancer. Timely and accurate diagnosis of pancreatic cancer can lead to improvements in the current poor outcome of this disease. | Lulu Zhang Santosh Sanagapalli Alina Stoita | 2018 | World Journal of Gastroenterology2018，24，19： | 39 |
| 3 | Underground void filling by cemented mill tailings显示文摘Underground mining always create voids.These voids can cause subsidence of surface.So it is always a demand to fill the void in such a manner that the effect of underground mining can be minimized.Void filling using mill tailings especially in metal mining is one of the best techniques.The tailings produced in milling process have traditionally been disposed in tailing ponds creating a waste disposal and environmental problems in terms of land degradation,air and water pollution,etc.This disposal practice is more acute in the metal milling industry where the fine grinding,required for value liberation,results in the production of very fine tailings in large percentage.This paper includes discussions on the effectiveness of different paste mixes with varying cement contents in paste backfilling operations.The results revealed that material composition and use of super plasticizer strongly influenced the strength of cemented backfill. | Choudhary Bhanwar Singh Kumar Santosh | 2013 | International Journal of Mining Science and Technology2013，23，6： | 18 |
| 4 | 基于超宽带无线定位的农业设施内移动平台路径跟踪研究显示文摘为实现农业设施内车辆自动导航,提出了一种基于超宽带(ultrawideband,UWB)无线定位的路径跟踪方法。运用4个基站组建UWB无线定位系统,采用加权最小二乘法(weighted least squares, WLS)法解超静定方程组,提高了移动标签的定位精度。重新定义前视距离,根据车体航向与前视直线的夹角界定车体偏差程度,并提出基于动态前视距离的改进型纯追踪模型。在MATLAB 2016a软件环境下的仿真说明该文算法优于采用固定视距的传统纯追踪算法,并进行实车试验。结果显示,在UWB定位系统的引导下,车体在不同初始状态下均能很好地收敛到期望直线,当速度为0.5 m/s时,在4种初始状态下进行直线跟踪,稳态偏差为5.4~8.4 cm,稳态偏差均值为6.3 cm。在矩形路径跟踪时,当横向偏差和航向偏差均为0的初始状态下,全程平均偏差为20.6 cm,跟踪偏差主要出现在90°转向处,最大偏差为85.5 cm,说明改进后的纯追踪算法的路径追踪质量均优于采用固定视距的传统纯追踪模型,能满足农业设施内移动平台自动导航的需求。该方法可为农业设施内车辆导航提供新思路。 | 姚立健 Santosh K Pitla 杨自栋 夏坡坡 赵辰彦 | 2019 | 农业工程学报2019，35，2： | 18 |
| 5 | Effect of tacrolimus in idiopathic membranous nephropathy: a meta-analysis显示文摘 | Santosh, Thapa Liu Hong Liu Bicheng | 2014 | Chinese Medical Journal2014，，14： | 17 |
| 6 | Association between cag-pathogenicity island in Helicobacter pylori isolates from peptic ulcer,gastric carcinoma,and non-ulcer dyspepsia subjects with histological changes显示文摘AIM: To investigate the presence of the cay-pathogenicity island and the associated histological damage caused by strains with complete cay-PAI and with partial deletions in correlation to the disease status.METHODS: We analyzed the complete cag-PAI of 174representative Helicobacter pylori (H pylori ) clinical isolates obtained from patients with duodenal ulcer,gastric ulcer, gastric cancer, and non-ulcer dyspepsia using eight different oligonucleotide primers viz cagA1,cagA2, cagAP1, cagAP2, cagE, cagT, LEC-1, LEC-2spanning five different loci of the whole cag-PAI by polymerase chain reaction (PCR).RESULTS: The complete screening of the genes comprising the cag-PAI showed that larger proportions of subjects with gastric ulcer (97.8%) inhabited strains with complete cag-PAI, followed by gastric cancer (85.7%),non-ulcer dyspepsia (7.1%), and duodenal ulcer (6.9%),significant differences were found in the percentagedistribution of the genes in all the clinical groups studied.It was found that strains with complete cag-PAI were able to cause severe histological damage than with the partially deleted ones.CONCLUSION: The cay-PAI is a strong virulent marker in the disease pathogenesis as it is shown that a large number of those infected with strain with complete cag-PAI had one or the other of the irreversible gastric pathologies and interestingly 18.5% of them developed gastric carcinoma. The presence of an intact cayPAI correlates with the development of more severe pathology, and such strains were found more frequently in patients with severe gastroduodenal disease. Partial deletions of the cag-PAI appear to be sufficient to render the organism less pathogenic. | Mahaboob Ali Aleem A Khan Santosh K Tiwari Niyaz Ahmed L Venkateswar Rao CM Habibullah | 2005 | World Journal of Gastroenterology2005，11，43： | 15 |
| 7 | Recent advances on the association of apoptosis in chronic non healing diabetic wound显示文摘Generally, wounds are of two categories, such as chronic and acute. Chronic wounds takes time to heal when compared to the acute wounds. Chronic wounds include vasculitis, non healing ulcer, pyoderma gangrenosum, and diseases that cause ischemia. Chronic wounds are rapidly increasing among the elderly population with dysfunctional valves in their lower extremity deep veins, ulcer, neuropathic foot and pressure ulcers. The process of the healing of wounds has several steps with the involvement of immune cells and several other cell types. There are many evidences supporting the hypothesis that apoptosis of immune cells is involved in the wound healing process by ending inflammatory condition. It is also involved in the resolution of various phases of tissue repair. During final steps of wound healing most of the endothelial cells, macrophagesand myofibroblasts undergo apoptosis or exit from the wound, leaving a mass that contains few cells and consists mostly of collagen and other extracellular matrix proteins to provide strength to the healing tissue. This review discusses the various phases of wound healing both in the chronic and acute wounds especially during diabetes mellitus and thus support the hypothesis that the oxidative stress, apoptosis, connexins and other molecules involved in the regulation of chronic wound healing in diabetes mellitus and gives proper understanding of the mechanisms controlling apoptosis and tissue repair during diabetes and may eventually develop therapeutic modalities to fasten the healing process in diabetic patients. | Awadhesh K Arya Richik Tripathi Santosh Kumar Kamlakar Tripathi | 2014 | World Journal of Diabetes2014，5，6： | 14 |
| 8 | Epidural anesthesia is effective for extracorporeal shock wave lithotripsy of pancreatic and biliary calculi显示文摘AIM: To evaluate the efficacy of thoracic epidural analgesia for extracorporeal shock wave lithotripsy (ESWL). METHODS: ESWL is an effective, non-invasive technique for the treatment of difficult pancreatic and large bile duct calculi. The procedure is often painful and requires large doses of analgesics. Many different anesthetic techniques have been used. Patients with either large bile duct calculi or pancreatic duct calculi which could not be extracted by routine endoscopic methods were selected. Thoracic epidural anesthesia (TEA) was routinely used in all the subjects unless contraindicated. Bupivacaine 0.25% with or without clonidine was used to block the segments D6 to D12. The dose was calculated depending on the age, height and weight of the patient. It was usually 1-2 mL per segment blocked.RESULTS: Ninety eight percent of the 1509 patients underwent ESWL under TEA. The subjects selected were within American Society of Anesthesiologists grade Ⅰ to Ⅲ. ESWL using EA permitted successful elimination of bile duct or pancreatic calculi with minimal morbidity. The procedure time was shorter in patients with TEA than in those who underwent ESWL under total intravenous anesthesia. CONCLUSION: Almost all patients undergoing ESWL with EA had effective blocks with a single catheter insertion and local anesthetic injection. | Santosh Darisetty Manu Tandan Duvvuru Nageshwar Reddy Rama Kotla Rajesh Gupta Mohan Ramchandani Sandeep Lakhtakia Guduru Venkat Rao Rupa Banerjee | 2010 | World Journal of Gastrointestinal Surgery2010，2，5： | 13 |
| 9 | Introduction to magnesium alloy processing technology and development of low-cost stir casting process for magnesium alloy and its composites显示文摘This paper presents the processing of magnesium alloys and its composite through different stir casting technologies.Design and devel-opment of stir casting technology that is suitable for processing of magnesium alloys has been done in this study.The low-cost stir casting processing of magnesium alloy and its composite with flux and without flux has been explained.The magnesium alloy and its composite have been fabricated by both the stir casting process.The micro structural characterization and mechanical properties of the developed composites has been evaluated.The optical emission spectroscopy of the developed alloy and factography of the developed alloy as well as composite was also examined. | Anil Kumar Santosh Kumar N.K.Mukhopadhyay | 2018 | Journal of Magnesium and Alloys2018，6，3： | 11 |
| 10 | More anxious than depressed:prevalence and correlates in a 15-nation study of anxiety disorders in people with type 2 diabetes mellitus显示文摘Background Anxiety disorder, one of the highly disabling, prevalent and common mental disorders, is known to be more prevalent in persons with type 2 diabetes mellitus (T2DM) than the general population, and the comorbid presence of anxiety disorders is known to have an impact on the diabetes outcome and the quality of life. However, the information on the type of anxiety disorder and its prevalence in persons with T2DM is limited. Aims To assess the prevalence and correlates of anxiety disorder in people with type 2 diabetes in different countries. Methods People aged 18-65 years with diabetes and treated in outpatient settings were recruited in 15 countries and underwent a psychiatric interview with the Mini-International Neuropsychiatric Interview. Demographic and medical record data were collected. Results A total of 3170 people with type 2 diabetes (56.2% women;with mean (SD) duration of diabetes 10.01 (7.0) years) participated. The overall prevalence of anxiety disorders in type 2 diabetic persons was 18%;however, 2.8% of the study population had more than one type of anxiety disorder. The most prevalent anxiety disorders were generalised anxiety disorder (8.1%) and panic disorder (5.1%). Female gender, presence of diabetic complications, longer duration of diabetes and poorer glycaemic control (HbA1c levels) were significantly associated with comorbid anxiety disorder. A higher prevalence of anxiety disorders was observed in Ukraine, Saudi Arabia and Argentina with a lower prevalence in Bangladesh and India. Conclusions Our international study shows that people with type 2 diabetes have a high prevalence of anxiety disorders, especially women, those with diabetic complications, those with a longer duration of diabetes and poorer glycaemic control. Early identification and appropriate timely care of psychiatric problems of people with type 2 diabetes is warranted. | Santosh K Chaturvedi Shayanth Manche Gowda Helal Uddin Ahmed Fahad D Alosaimi Nicola Andreone Alexey Bobrov Viola Bulgari Giuseppe Carra Gianluca Castelnuovo Giovanni de Girolamo Tomasz Gondek Nikola Jovanovic Thummala Kamala Andrzej Ki Nebojsa Lalic Dusica Lecic-Tosevski Fareed Minhas Victoria Mutiso David Ndetei Golam Rabbani Suntibenchakul Somruk Sathyanarayana Srikanta Rizwan Taj Umberto Valentini Olivera Vukovic Wolfgang Wolwer Larry Cimino Arie Nouwen Cathy Lloyd Norman Sartorius | 2019 | General Psychiatry2019，32，4： | 11 |
| 11 | Influences of trans-trans farnesol,a membrane-targeting sesquiterpenoid,on Streptococcus mutans physiology and survival within mixed-species oral biofilms显示文摘Trans-trans farnesol (tt-farnesol) is a bioactive sesquiterpene alcohol commonly found in propolis (a beehive product) and citrus fruits, which disrupts the ability of Streptococcus mutans (S. mutans) to form virulent biofilms. In this study, we investigated whether tt-farnesol affects cell-membrane function, acid production and/or acid tolerance by planktonic cells and biofilms of S. mutans UA159. Furthermore, the influence of the agent on S. mutans gene expression and ability to form biofilms in the presence of other oral bacteria (Streptococcus oralis (S. oralis) 35037 and Actinomyces naeslundii (A. naeslundii) 12104) was also examined. In general, tt-farnesol (1 mmol·L-1) significantly increased the membrane proton permeability and reduced glycolytic activity of S. mutans in the planktonic state and in biofilms (P<0.05). Moreover, topical applications of 1 mmol·L-1 tt-farnesol twice daily (1 min exposure/treatment) reduced biomass accumulation and prevented ecological shifts towards S. mutans dominance within mixed-species biofilms after introduction of 1% sucrose. S. oralis (a non-cariogenic organism) became the major species after treatments with tt-farnesol, whereas vehicle-treated biofilms contained mostly S. mutans (>90% of total bacterial population). However, the agent did not affect significantly the expression of S. mutans genes involved in acidogenicity, acid tolerance or polysaccharide synthesis in the treated biofilms. Our data indicate that tt-farnesol may affect the competitiveness of S. mutans in a mixed-species environment by primarily disrupting the membrane function and physiology of this bacterium. This naturally occurring terpenoid could be a potentially useful adjunctive agent to the current anti-biofilm/anti-caries chemotherapeutic strategies. | Jae-Gyu Jeon Santosh Pandit Jin Xiao Stacy Gregoire Megan L. Falsetta Marlise I. Klein Hyun Koo | 2011 | International Journal of Oral Science2011，3，2： | 10 |
| 12 | Genetic risks and familial associations of small bowel carcinoma显示文摘Adenocarcinoma of small intestines(SBA) is a relatively rare malignancy with poor outcomes due to delayed diagnosis.Fifty percent of patients have metastases on presentation and therefore early detection and treatment offers the best long term outcomes.Certain genetic polyposis syndromes and familial diseases are associatedwith increased risks for SBA.These include familial adenomatous polyposis(FAP),Lynch syndromes(LS),Juvenile polyposis syndrome,Peutz-Jeghers syndrome,Crohn's disease(CD) and celiac disease.Mutations in APC gene,Mismatch repair genes,STK11 gene,and SMAD4 gene have been implicated for the genetic diseases respectively.While there are no specific inherited genetic mutations for CD,genome-wide association studies have established over 140 loci associated with CD.CpG island mutations with defects in mismatch repair genes have been identified in celiac disease.Significant diagnostic advances have occurred in the past decade and intuitively,it would seem beneficial to use these advanced modalities for surveillance of these patients.At present it is debatable and no clear data exists to support this approach except for established guidelines to diagnose duodenal polyps in FAP,and LS.Here we discuss the genetic alterations,cancer risks,signaling mechanisms and briefly touch the surveillance modalities available for these genetic and clinical syndromes.English language articles from Pub Med/Medline and Embase was searched were collected using the phrases 'small-bowel adenocarcinoma,genetics,surveillance,familial adenomatous polyposis,lynch syndromes,Peutz-Jeghers syndrome,juvenile polyposis syndrome,CD and celiac disease'.Figures,tables and schematic diagram to illustrate pathways are included in the review. | Santosh Shenoy | 2016 | World Journal of Gastrointestinal Oncology2016，8，6： | 9 |
| 13 | Antioxidant and antimutagenic activities of bark extract of Terminalia arjuna显示文摘Objective:The alcoholic extract of stem bark of Terminalia arjuna(ALTA) was screened for antioxidant and antimutagenic(anticlastogenic) activity.Methods:Antioxidant property was determined by l,l,Diphynyl,2-Picryl hydrazyl(DPPH) assay,super oxide radical scavenging activity,lipid peroxidation assay and total polyphenolic content was determined by Folin-Ciocalteau’s reagent.Antimutagenic activity was evaluated using micronucleus test in mice. Results:The ALTA has shown potent antioxidant activity with EC50 of 2.491±0.160,50.110±0.150 & 71.000±0.250 in DPPH assay,superoxide radical scavenging activity and lipid peroxidation assay, which is comparable with ascorbic acid with EC50 of 2.471±0.140,40.500±0.390 and 63.000±0.360 respectively.In micronucleus test,ALTA(100 & 200 mg/kg,p.o.) showed significant reduction in percentage of micronucleus in both polychromatic erythrocytes(PCE) and normochromatie erythrocytes(NCE) and also shown significant reduction in P/N ratio.Conclusions:These results suggested that ALTA possess significant antioxidant and antimutagenic activity. | Gollapalle Lakshminarayana shastry Viswanatha Santosh Kumar Vaidya Ramesh C Nandakumar Krishnadas Srinath Rangappa | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 9 |
| 14 | Spinel + quartz-bearing ultrahigh-temperature granulites from Xumayao,Inner Mongolia Suture Zone,North China Craton:Petrology,phase equilibria and counterclockwise p-T path显示文摘在在北方中国 Craton 的内部蒙古缝术地区(IMSZ ) 以内的 Khondalite 带是为 Paleoproterozoic 的一个经典例子超离频温度(UHT ) 变态。这里,我们在 IMSZ 的南部的领域以内在 Xumayao 从一个新地区报导新忍受尖晶石的 metapelitic granulites。Petrological 研究并且尖晶石 + 的热力学的建模忍受石英的集合证明这些岩石以 UHT 条件经历了极端变态。尖晶石组织上发生在二背景:1 ) 高 XZn (Zn/(Mg +FeII + Zn )= 0.0710.232 ) 有在岩石矩阵的 perthitic K 长石,矽线石和石英的尖晶石;并且 2 ) 低 XZn (0.0450.070 ) 尖晶石作为在与石英和矽线石联合的石榴石 porphyroblasts 以内的包括。我们当模特儿的阶段 equilibria 在这些岩石的变形进化期间显示二个主要阶段: 1 )从 975 的在等压附近的冷却????畘慭慹?????????????朠慲畮楬整????????????????慲潴????????煥極楬牢慩?????????????胴?? | Huatian Zhang Jianghai Li Shoujie Liu Wenshan Li M. Santosh Honghao Wang | 2012 | Geoscience Frontiers2012，3，5： | 8 |
| 15 | Goblet cell carcinoids of the appendix:Tumor biology,mutations and management strategies显示文摘Malignant neoplasms of the appendix are rare and represent less than 1% of gastrointestinal cancers.Goblet cell carcinoids(GCC) tumors are a distinctive group of heterogeneous appendiceal neoplasm that exhibit unique clinical and pathologic features.This review focuses on the current diagnostic procedures,pathogenesis,possible signaling mechanisms and treatment options for GCC.Perspectives for future research are discussed.The tumor likely arises from pluripotent intestinal epithelial crypt base stem cells.Previous findings of Notch signaling as a tumor suppressor in Neuroendocrine tumors may have a similar role in this tumor too.Loss of Notch signaling may be the driver mutation with other successive downstream mutations likely favors them into progressing and behavior similar to poorly differentiated adenocarcinoma with minimal neuroendocrine differentiation.A multidisciplinary approach is suggested for optimal outcomes.Surgery remains the main treatment modality.Simple appendectomy may be sufficient in early stages while right hemicolectomy is recommended for advanced tumors.Cytoreductive surgery with heated intraperitoneal chemotherapy may improve survival in a select few with metastatic peritoneal disease.These tumors have an unpredictable behavior even in early stages and local recurrence and delayed metastases may be seen.Lifelong surveillance is warranted. | Santosh Shenoy | 2016 | World Journal of Gastrointestinal Surgery2016，8，10： | 7 |
| 16 | MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα显示文摘In human adipose tissue and obesity,miR-99a expression is negatively correlated with inflammation.Therefore,the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation.M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and M1 phenotypes.Phenotype-switching experiments established an association between upregulated miR-99a expression and the M2 phenotype.Overexpression of miR-99a prevented M1 phenotype activation and attenuated bactericidal activity.Likewise,knockdown of miR-99a abolished M2 phenotype activation.By means of in silico target prediction tools and a luciferase reporter assay,TNFαwas identified as a direct target of miR-99a.Knockdown of TNFαrecapitulated the effect of miR-99a overexpression in M1 BMDMs.In a db/db mice model,miR-99a expression was reduced in eWAT and F4/80+ATMs.Systemic overexpression of miR-99a in db/db mice attenuated adipocyte hypertrophy with increased CD301 and reduced CD86 immunostaining.Flow cytometry analysis also showed an increased M2 and a reduced M1 macrophage population.Mimics of miR-99a also improved the diabetic dyslipidemia and insulin signaling in eWAT and liver,with an attenuated expression of gluconeogenesis and cholesterol metabolism genes in the liver.Furthermore,adoptive transfer of miR-99a-overexpressing macrophages in the db/db mice recapitulated in vivo miR-99a mimic effects with increased M2 and reduced M1 macrophage populations and improved systemic glucose,insulin sensitivity,and insulin signaling in the eWAT and liver.The present study demonstrates that miR-99a mimics can regulate macrophage M1 phenotype activation by targeting TNFα.miR-99a therapeutics in diabetic mice reduces the adipose tissue inflammation and improves insulin sensitivity. | Anant Jaiswal Sukka Santosh Reddy Mohita Maurya Preeti Maurya Manoj Kumar Barthwal | 2019 | Cellular & Molecular Immunology2019，16，5： | 7 |
| 17 | Retinal structural-vascular-functional relationship using optical coherence tomography and optical coherence tomography -angiography in myopia显示文摘Background:To examine the retinal structure–vascular-function relationship using optical coherence tomography(OCT)and optical coherence tomography angiography(OCTA)in myopia.Methods:This was a prospective cross-sectional study comprising 86 eyes of 45 individuals with varying axial lengths and spherical equivalents and no posterior segment abnormalities.All eyes underwent optical coherence tomography with the Spectralis SD-OCT and OCTA with RTVue-XR Avanti;Optovue.Individual macular retinal layer thicknesses and flow areas and vessel densities were measured on OCT and OCTA,respectively.Linear correlations were made between the macular layer thicknesses,flow areas and vessel densities with axial length,spherical equivalent and visual acuity.Results:The participants’mean ages were 33.34±14.45 years,mean spherical equivalent refractions were−7.17±5.71 D and axial lengths were 25.95±2.41 mm.There were significant positive correlations of foveal angle(r=0.757,p=0.001),inner retinal(r=0.764,p=0.001)and outer plexiform layer(r=0.771,p=0.001)thickness on OCT and vessel densities in deep capillary plexus(r=0.313,p=0.003)on OCTA with axial length and negative correlations with spherical equivalents and visual acuity.Significant negative correlations of outer nuclear layer(r=−0.560,p=0.03)and photoreceptor outer segment layer thickness(r=−0.856,p<0.001)were noted on OCT with axial length and positive correlations with spherical equivalents and visual acuity.Conclusion:The lateral retinal stretching in myopia could possibly explain the correlation between retinal layer thickness,vascular density and visual acuity in these eyes.Further research is required to investigate this. | Ramesh Venkatesh Shivani Sinha Deepika Gangadharaiah Santosh G.K.Gadde Ashwin Mohan Rohit Shetty Naresh Kumar Yadav | 2019 | Eye and Vision2019，6，1： | 7 |
| 18 | 大西洋庸鲽(Hippoglossus hipoglossus L.)精液脂肪酸分析及激素GnRHa诱导对其组成的影响显示文摘采用气相色谱检测的方法,进行大西洋庸鲽精液脂肪酸组成分析及激素GnRHa诱导对其组成影响的研究。结果表明,大西洋庸鲽精液中含量最高的脂肪酸种类为22:6n-3(DHA,二十二碳六烯酸),占总脂肪酸比例25.67%±0.94%;其次为16:0(PA,棕榈酸)、20:5n-3(EPA,二十碳五烯酸);重要必需不饱和脂肪酸20:4n-6(AA,花生四烯酸)含量较低,为1.76%±0.01%。精液中高不饱和脂肪酸(PUFA)含量较高,为44.25%±0.30%;饱和脂肪酸(SAT)含量为27.72%±0.22%。重要脂肪酸比例DHA/EPA为2.33±0.26;EPA/AA为6.30±0.51;n-3/n-6为9.22±0.60。激素诱导未对精液中脂肪酸组成产生显著影响。重要必需脂肪酸DHA、EPA、AA,以及n-3、n-6等重要种类的脂肪酸总量在激素诱导组与非诱导对照组样品间无显著差异;在激素诱导后的三个取样时间的样品间也无显著差异(P<0.05)。 | 丁福红 Santosh P.Lall 李军 雷霁霖 马爱军 | 2010 | 海洋与湖沼2010，41，6： | 6 |
| 19 | A convenient one-pot three component synthesis of 3-aminoalkylated indoles catalyzed by 3-chlorophenylboronic acid显示文摘An efficient protocol was developed for the synthesis of 3-aminoalkylated indoles using 3- chlorophenylboronic acid as a catalyst under ambient temperature conditions.The three-component reaction of indoles,aromatic aldehydes and N-methyl aniline offered corresponding 3-aminoalkylated indoles in excellent yields.This protocol presents some remarkable features such as mild reaction conditions,simple workup procedure and excellent yields. | Santosh V.Goswami Prashant.B.Thorat Vijay N.Kadam Sachin A.Khiste Sudhakar R.Bhusare | 2013 | Chinese Chemical Letters2013，24，5： | 6 |
| 20 | Liver cirrhosis in hepatic vena cava syndrome(or membranous obstruction of inferior vena cava)显示文摘Hepatic vena cava syndrome(HVCS) also known as membranous obstruction of inferior vena cava reported mainly from Asia and Africa is an important cause of hepatic venous outflow obstruction(HVOO) that is complicated by high incidence of liver cirrhosis(LC) and moderate to high incidence of hepatocellular carcinoma(HCC). In the past the disease was considered congenital and was included under Budd-Chiari syndrome(BCS). HVCS is a chronic disease common in developing countries, the onset of which is related to poor hygienic living condition. The initial lesion in the disease is a bacterial infection induced localized thrombophlebitis in hepatic portion of inferior vena cava at the site where hepatic veins open which on resolution transforms into stenosis, membrane or thick obstruction,and is followed by development of cavo-caval collateral anastomosis. The disease is characterized by long asymptomatic period and recurrent acute exacerbations(AE) precipitated by clinical or subclinical bacterial infection. AE is managed with prolonged oral antibiotic. Development of LC and HCC in HVCS is related to the severity and frequency of AEs and not to the duration of the disease or the type or severity of the caval obstruction. HVOO that develops during severe acute stage or AE is a pre-cirrhotic condition. Primary BCS on the other hand is a rare disease related to prothrombotic disorders reported mainly among Caucasians that clinically manifest as acute, subacute disease or as fulminant hepatic failure; and is managed with life-long anticoagulation, portosystemic shunt/endovascular angioplasty and stent or liver transplantation. As epidemiology, etiology and natural history of HVCS are different from classical BCS, it is here, recognized as a separate disease entity, a third primary cause of HVOO after sinusoidal obstruction syndrome and BCS. Understanding of the natural history has made early diagnosis of HVCS possible. This paper describes epidemiology, natural history and diagnosis of HVCS and discusses the pathogenesis of LC in the disease and mentions distinctive clinical features of HVCS related LC. | Santosh Man Shrestha | 2015 | World Journal of Hepatology2015，7，6： | 6 |
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