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| 1 | 幽门螺杆菌胃溃疡的三联治疗与炎性因子水平观察显示文摘目的:观察分析幽门螺杆菌胃溃疡患者经三联疗法治疗对其炎性因子水平的影响。方法:选择幽门螺杆菌感染胃溃疡患者150例,按数字奇偶法将其分为观察组(n=75)与对照组(n=75),其中对照组患者接受奥美拉唑+克拉霉素+阿莫西林治疗,观察组患者接受雷贝拉唑+克拉霉素+阿莫西林治疗,连续治疗4周后,检测其血清炎性因子水平和胃肠激素指标变化,并评估其临床疗效。结果:治疗前,两组IL-6、IL-8水平比较,差异无统计学意义(P>0.05),治疗后,两组IL-6、IL-8水平较治疗前比较明显降低,观察组IL-6、IL-8水平明显低于对照组,差异有统计学意义(P<0.05);治疗前,两组MTL、GAS水平比较,差异无统计学意义(P>0.05),治疗后,两组MTL、GAS水平较治疗前比较明显降低,观察组MTL、GAS水平明显低于对照组,差异有统计学意义(P<0.05);治疗后,观察组治疗总有效率(93.33%)明显高于对照组(72.00%),差异有统计学意义(P<0.05)。结论:选择雷贝拉唑+克拉霉素+阿莫西林治疗Hp感染胃溃疡,可有效降低患者血清炎症因子水平和胃肠激素水平,提升临床治疗效果,临床推广应用价值较高。 | 葛鲜艳 | 2019 | 吉林医学2019，40，12： | 4 |
| 2 | Preparation and Characterization of Lung-targeting Cefquinome-loaded PLGA Microspheres显示文摘We developed poly lactic-co-glycolic acid(PLGA) microspheres loaded with cefquinome and tested their effectiveness in a mouse model. The microspheres were prepared by optimizing several key parameters such as PLGA molecular weight, drug/polymer ratio, internal water volume and ethyl acetate. Drug loading efficiency, stability, in vitro release and tissue distribution in mouse were evaluated. The average particle size of the microspheres was 27.84 μm. The drug loading efficiency was 64.57%. The in vitro release of cefquinome from microspheres after 4 h was about 40% compared with over 90% for the drug alone. The concentration of cefquinome in lung reached 25 μg/g 0.25 h after injection, and kept at 10 μg/g 4 h after injection. However, the concentration of cefquinome was very low in other organs even 0.25 h after injection. In conclusion, Cefquinome-loaded PLGA microspheres are compatible as an effective lung-targeting drug delivery system and have a good sustained release efficacy. | 张瑞丽 HAO Zhihui DING Zhaopeng 吕志华 | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，2： | 0 |
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