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| 1 | Down-Regulation of Neurocan Expression in Reactive Astrocytes Promotes Axonal Regeneration and Facilitates the Neurorestorative Effects of Bone Marrow Stromal Cells in the Ischemic Rat Brain显示文摘脑卒中后缺血组织边界形成胶质疤痕,抑制轴突再生。神经蛋白聚糖是一种轴突延长抑制分子,在卒中后胶质疤痕中表达上调。骨髓基质干细胞(BMSCs)可降低胶质疤痕壁的厚度,加速缺血周边区的轴突重塑。为了进一步明确BMSCs在轴突再生中的作用及机制,本文重点研究脑缺血组织中BMSCs对神经蛋白聚糖表达的作用。31只成年雄性Wistar大鼠大脑中动脉阻塞(MCAo)2 h,24 h后从中选择16只给予尾静脉注射3×106鼠BMSCs(BMSCs组),15只注射磷酸盐缓冲生理盐水(对照组)。缺血后8 d处死实验大鼠,免疫染色表明反应性星形胶质细胞是神经蛋白聚糖的原始来源,且BMSCs组缺血半暗带脑组织的神经聚糖表达明显低于对照组,生长相关蛋白43表达高于对照组,这在蛋白印迹分析中得到确认。为了进一步检测BMSCs在星形胶质细胞神经蛋白聚糖表达中的作用,用激光捕获显微切割法从缺血周边区收集单纯的反应性星形胶质细胞。BMSCs组的神经蛋白聚糖基因表达明显下调(n=4/组)。原代培养的星形胶质细胞也表现出相同改变,糖氧剥离的星形胶质细胞再给氧时与BMSCs共培养会抑制神经蛋白聚糖基因的表达上调(n=3/组)。本研究表明BMSCs通过下调梗死周边星形胶质细胞中神经蛋白聚糖的表达来促进轴突再生。 | LI HONG SHEN YI LI QI GAO SMITA SAVANT-BHONSALE AND MICHAEL CHOPP | 2008 | 神经损伤与功能重建2008，3，6： | 51 |
| 2 | Heteromeric and Homomeric Geranyl Diphosphate Synthases from Catharanthus roseus and Their Role in Monoterpene Indole Alkaloid Biosynthesis显示文摘Catharanthus roseus 是二很重要的 monoterpene 吲哚碱(MIA ) 的唯一的来源反癌症代理人:vinblastine 和长春新碱。MIA 拥有萜烯和分别地从 terpenoid 和 shikimate 小径导出的吲哚一半。Geranyl diphosphate (GPP ) ,入口点到萜烯一半的形成,由 GPP synthase (GPPS ) 是 isopentenyl diphosphate (IPP ) 和 dimethylallyl diphosphate (DMAPP ) 的冷凝作用的一个产品。这里,我们报导与顺序类似编码蛋白质到大子单元(CrGPPS.LSU ) 和 heteromeric GPPS,和 homomeric 的小子单元(CrGPPS.SSU ) 的三基因 GPPS。CrGPPS.LSU 是生产 GPP 和 geranyl geranyl diphosphate (GGPP ) 的 bifunctional 酶, CrGPPS.SSU 是不活跃的,而 CrGPPS 是形成 GPP 的 homomeric 酶。在 Escherichia coli 的两个子单元的合作表示与生产仅仅 GPP 的提高的活动导致了 heteromeric 酶。当 CrGPPS.LSU 和 CrGPPS 在更旧、更年轻的叶子显示出更高的表示时,分别地, CrGPPS.SSU 显示出一个增加的趋势并且逐渐地减少了。叶子的甲基 jasmonate (MeJA ) 处理显著地导致了仅仅 CrGPPS.SSU 的表示。而 CrGPPS 是 mitochondrial, GFP 本地化显示 CrGPPS.SSU 是 plastidial。在 C 的 AmGPPS.SSU 的短暂 overexpression。roseus 叶子导致了增加的 vindoline, vinblastine 和长春新碱的立即的 monomeric 先锋。尽管 C。roseus 有 heteromeric 和 homomeric GPPS 酶,我们的结果含有有为 MIA 生合成调整 GPP 流动的 CrGPPS.SSU 的仅仅 heteromeric GPPS 的参与。 | Avanish Rai Shachi S. Smita Anup Kumar Singh Karuna Shanker Dinesh A. Nagegowda | 2013 | Molecular Plant2013，6，5： | 20 |
| 3 | Retinopathy of prematurity: Past, present and future显示文摘Retinopathy of prematurity(ROP) is a vasoproliferative disorder of the retina occurring principally in new born preterm infants. It is an avoidable cause of childhood blindness. With the increase in the survival of preterm babies, ROP has become the leading cause of preventable childhood blindness throughout the world. A simple screening test done within a few weeks after birth by an ophthalmologist can avoid this preventable blindness. Although screening guidelines and protocols are strictly followed in the developed nations, it lacks in developing economies like India and China, which have the highest number of preterm deliveries in the world. The burden of this blindness in these countries is set to increase tremendously in the future, if corrective steps are not taken immediately. ROP first emerged in 1940 s and 1950 s, when it was called retrolental fibroplasia. Several epidemics of this disease were and are still occurring in different regions of the world and since then a lot of research has been done on this disease. However, till date very few comprehensive review articles covering all the aspects of ROP are published. This review highlights the past, present and future strategies in managing this disease. It would help the pediatricians to update their current knowledge on ROP. | Parag K Shah Vishma Prabhu Smita S Karandikar Ratnesh Ranjan Venkatapathy Narendran Narendran Kalpana | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 13 |
| 4 | 新型高分子助剂在自动洗碗机清洁剂的应用显示文摘研究了一种新型高分子助剂Noverite^(TM) AD810的钙离子螯合能力、玻璃杯浸泡老化实验及在含氯或含酶自动洗碗凝胶及自动洗碗粉中的应用性能。实验结果表明,Noverite^(TM) AD810有着良好的钙离子螯合能力,并且不会引起有花纹玻璃杯颜色变化。在所测试的多种自动洗碗机清洁剂产品中,含Noverite^(TM) AD810配方均显示出良好的抗成膜、抗成斑点及阻止碳酸钙沉积在器皿表面性能。 | 白剑芸 曲向华 BRIJMOHAN Smita HSU Gordon | 2017 | 日用化学品科学2017，40，7： | 9 |
| 5 | Synthesis and Characterization of Bio-based Epoxy Blends from Renewable Resource Based Epoxidized Soybean Oil as Reactive Diluent显示文摘A novel bioresin, epoxidized soybean oil was synthesized by in situ method and was characterized employing FTIR and NMR. The bioresin was blended with epoxy(DGEBA) at different ratios as reactive diluents for improved processibility and toughened nature. The composition with 20 wt% bioresin exhibited improved impact strength to the tune of 60% as compared to virgin epoxy. Fracture toughness parameters critical stress intensity factor(KIC) and critical strain energy release rate(GIC) were evaluated using single edge notch bending test and demonstrated superior enhancement in toughness. Dynamic mechanical, thermal, thermo mechanical and fracture morphological analyses have been studied for bio-based epoxy blends. Curing kinetics has been evaluated through DSC analysis to investigate the effect of bioresin on cross-linking reaction of neat epoxy with triethylenetetramine as curing agent. | Sushanta K Sahoo Smita Mohanty Sanjay K Nayak | 2015 | Chinese Journal of Polymer Science2015，33，1： | 8 |
| 6 | Clinical Validation of Global Coagulation Tests to Guide Blood Component Transfusions in Cirrhosis and ACLF显示文摘Background and Aims:Patients with cirrhosis and acuteon-chronic liver failure(ACLF)may have bleeding complications and need for invasive procedures.Point-of-care(POC)coagulation tests like thromboelastography(TEG)and Sonoclot may be better for guiding patient management than the standard coagulation tests(SCTs),like prothrombin time,platelet count and international normalized ratio.Methods:We prospectively compared and validated the POC tests and SCTs in 70 persons with ACLF and 72 persons with decompensated cirrhosis who had clinical bleeding and checked for episodes of re-bleeding and transfusion requirements.We assessed pre-procedure requirement of blood components when correction was done based on an SCT or POC strategy.Results:Episodes of bleeding were seen in 45%and 28%of ACLF and cirrhosis patient,respectively(p=0.036),with the major site of bleeding being gastrointestinal(31%and 16%,respectively).Platelet counts correlated with TEG-maximum amplitude in cirrhosis(p=0.045)and prothrombin time correlated positively with TEG-reaction(R)time(p=0.032),TEG-Clot kinetics(K)time(p=0.042),Son-activated clotting time(p=0.038)and negatively with clot rate(p=0.043)in ACLF,making these correctable target variables in POC transfusion algorithms.Of 223 procedures,transfusion of fresh frozen plasma and platelet concentrate was reduced by 25%(p=0.035)and 20.8%(p=0.045)by using a POC strategy in 76 patients.Correction of deranged Son-activated clotting time and TEG-reaction time was noted in 68%and 72%after 24 h of fresh frozen plasma transfusion in ACLF and 85%and 80%in cirrhosis,respectively.Conclusions:Our study clinically validates that POC tests can better detect coagulation defects and transfusion thresholds in ACLF and cirrhosis,whereas use of conventional tests appear to be less suitable in patients with clinical bleeding.Trial Registration:NCT04332484. | Madhumita Premkumar Rohit Mehtani Smita Divyaveer Kamal Kajal Anand VKulkarni Syed Ahmed Harmanpreet Kaur Harpreet Kaur Radhakrishna Dhiman Ajay Duseja Arka De | 2021 | Journal of Clinical and Translational Hepatology2021，9，2： | 7 |
| 7 | Determinants of environmental innovation in US manufacturing industries显示文摘 | Smita B Brunnermeier Mark A Cohen | 2003 | Journal of Environmental Economics and Management2003，，2： | 6 |
| 8 | Histone modifications and alcohol-induced liver disease:Are altered nutrients the missing link?显示文摘Alcoholism is a major health problem in the United States and worldwide,and alcohol remains the single most significant cause of liver-related diseases and deaths.Alcohol is known to influence nutritional status at many levels including nutrient intake,absorption,utilization,and excretion,and can lead to many nutritional disturbances and deficiencies.Nutrients can dramatically affect gene expression and alcohol-induced nutrient imbalance may be a major contributor to pathogenic gene expression in alcohol-induced liver disease(ALD).There is growing interest regarding epigenetic changes,including histone modifications that regulate gene expression during disease pathogenesis.Notably,modifications of core histones in the nucleosome regulate chromatin structure and DNA methylation,and control gene transcription.This review highlights the role of nutrient disturbances brought about during alcohol metabolism and their impact on epigenetic histone modifications that may contribute to ALD.The review is focused on four critical metabolites,namely,acetate,S-adenosylmethionine,nicotinamide adenine dinucleotide and zinc that are particularly relevant to alcohol metabolism and ALD. | Akshata Moghe Swati Joshi-Barve Smita Ghare Leila Gobejishvili Irina Kirpich Craig J McClain Shirish Barve | 2011 | World Journal of Gastroenterology2011，17，20： | 6 |
| 9 | Differential Sensitivity of Macrocarpa and Microcarpa Types of Chickpea (Cicer arietinum L.) to Water Stress: Association of Contrasting Stress Response with Oxidative Injury显示文摘Chickpea (Cicer arietinum L.) 是特别地敏感的在它的繁殖阶段浇应力并且在水应力的条件下面,将放弃花和豆荚,因此减少收益潜力。有 chickpea 的二种类型:(i) Macrocarpa (Kabuli ) 它有大,击打塑造头的、轻棕色的种子;并且(ii ) Microcarpa (Desi ) 它有小、尖、黑暗褐的种子。相对说, Kabuli 被报导了更敏感比 Desi 浇应力。与对比敏感流水联系的内在的机制在新陈代谢的水平强调井没被理解。我们假设了一个原因因为在 chickpea 的二种类型的形成对照的水压力敏感可以是在氧化损害的一个变化。在现在的学习,两种类型的植物是为 14 d 在繁殖舞台强调的水。由于压力, Kabuli 类型与为 Desi 类型观察的 64% 减小相比在控制上在种子产量展出了 80% 减小。在叶水潜力(w) 的减少与 Desi 类型相比在 Kabuli 是更快的。在水压力时期的结束, w 被归结为 ? 2.9 并且 ? 分别地,没有他们之间的任何重要差别,在 Desi 和 Kabuli 的 3.1 MPa 打字。在应力的最后一天, Kabuli 比 Desi 经历了 20% 更多的膜损害。叶绿素内容和光合的率与 Kabuli 相比在 Desi 是显著地更大的。malondialdehyde 和 H2O2 内容与 Desi 相比在在 Kabuli 的水压力的结束是显著地更高的,显示在前者的更大的氧化应力。抗氧化剂的层次例如维生素酸和谷胱甘肽,比 Kabuli 在 Desi 是显著地更高的。, Superoxide dismutase 和过氧化氢酶活动没在第 10 天, ascorbate peroxidase 的活动, dehydroascorbate reductase,和谷胱甘肽 reductase 在 chickpea 的二种类型之间显著地不同在 Desi 是更高的。这些调查结果显示在 Desi 类型的更大的应力公差可以被归功于到它维持更好的水地位的优异能力,它导致更少的氧化损坏。另外,实验室研究由使 chickpea 的两种类型遭到到聚乙烯的类似的层次进行了导致乙二醇的水应力并且到 10 .mol/L abscisic,酸显示了 Desi 类型的一个更大的能力比 Kabuli 类型处理氧化应力。 | Harsh Nayyar Smita Singh Satwinder Kaur Sanjeev Kumar Hari D. Upadhyaya | 2006 | Journal of Integrative Plant Biology2006，48，11： | 6 |
| 10 | Congenital pulmonary airway malformation: A report of two cases显示文摘Congenital pulmonary airway malformation(CPAM), previously known as congenital cystic adenomatoid malformation is a congenital disorder of the lung similar to bronchopulmonary sequestration. In CPAM, usually an entire lobe of lung is replaced by a non-working cystic piece of abnormal lung tissue. This abnormal tissue will never function as normal lung tissue. The underlying cause for CPAM is not known. It occurs in approximately 1 in every 30000 pregnancies. The association between CPAM and malignancy has been well documented. There is a small risk(0.7%) of malignant transformation within the cyst. So early diagnosis and surgical resection is important to prevent the grave complications. Herein, we are reporting two interesting cases of CPAM and one belonged to Type Ⅱ and other belonged to Type Ⅲ of Stocker's classification. | Saroj Bolde Smita Pudale Gopal Pandit Kirti Ruikar Sachin B Ingle | 2015 | World Journal of Clinical Cases2015，3，5： | 5 |
| 11 | Evaluation of antiinflammatory activity of Tephrosia purpurea in rats显示文摘Objective:To evaluate the antiinflammatory activity of orally administered ethanolic extract of Tephrosia purpurea in acute and subacute inflammation in rats.Methods:An ethanolic extract of Tephrosia purpurea was prepared.Carrageenan induced paw edema and cotton pellet granuloma were the models for acute and subacute inflammation respectively.Four groups of rats in each model were treated orally with 2%gum acacia,100 mg /kg of aspirin,500 mg/kg and 1 000 mg/kg of ethanolic extract of Tephrosia purpurea respectively.In carrageenan induced paw edema model, subplantar injection of 1%carrageenan was made into the hind paw of the rats sixty minutes after the administration of the respective drugs.The paw volume was measured immediately after injection of carrageenan,at 3 hours and at 6 hours.Then percentage inhibition of edema was calculated.In the cotton pellet granuloma model,animals were administered drugs for six days after placing cotton pellets in the axilla on each side.On the 7th day,dry weight of granuloma was calculated.Results:The rats treated with Tephrosia purpurea did not exhibit any significant decrease in paw volume and serum ceruloplasmin levels as compared to the control and aspirin treated groups in the acute inflammation model;while,there was a significant(P < 0.01) decrease in the weight of granuloma in Tephrosia purpurea and aspirin treated groups as compared to control in subacute inflammation.Conclusions:The ethanolic extract of orally administered Tephrosia purpurea shows significant antiinflammatory effect in subacute inflammation but not in acute inflammation in rats. | Shenoy Smita Shwetha K Prabhu K Maradi R Bairy KL Shanbhag T | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，3： | 5 |
| 12 | Antimicrobial metabolites from marine microorganisms显示文摘Marine ecological niches have recently been described as 'particularly promising' sources for search of new antimicrobials to combat antibiotic-resistant strains of pathogenic microorganisms. Marine organisms are excellent sources for many industrial products, but they are partly explored. Over 30 000 compounds have been isolated from marine sources. Bacteria, fungi, and cyanobacteria obtained from various marine sources secret several industrially useful bioactive compounds, possessing antibacterial, antifungal, and antimycobacterial activities. Sustainable cultivation methods for promising marine organisms and biotechnological processes for selected compounds can be developed, along with the establishment of biosensors for monitoring the target compounds. The semisynthetic modifications of marine-based bioactive compounds produce their new derivatives, structural analogs and mimetics that could serve as novel lead compounds against resistant pathogens. The present review focuses on promising antimicrobial compounds isolated from marine microbes from 1991-2013. | Prasanna Habbu Vijayanand Warad Rajesh Shastri Smita Madagundi Venkatrao H. kulkarni | 2016 | Chinese Journal of Natural Medicines2016，14，2： | 5 |
| 13 | Growth inhibition mediated by PSP94 or CRISP-3 is prostate cancer cell line specific显示文摘94 氨基酸(PSP94 ) 的能分泌的蛋白质被显示出与充满半胱氨酸的能分泌的蛋白质交往的前列腺 3 (CRISP-3 ) 在里面人的精液的血浆。有趣地, PSP94 表示被减少或在前列腺瘤的多数输了,而 CRISP-3 表示与正常前列腺织物相比是在前列腺癌症的 upregulated。为了获得单个角色的更好的理解,这些蛋白质在前列腺 tumourigenesis 和他们的相互作用的功能的关联有,我们宫外地在三根前列腺细胞线(PC3, WPE1-NB26 和 LNCaP ) 与 CRISP-3 一起表示了 PSP94 或 PSP94 并且执行了生长抑制试金。反向的抄写聚合酶链反应和西方的污点分析被用来为 PSP94 和 CRISP-3 表示屏蔽前列腺房间线。为人的 PSP94 和 CRISP-3 的哺乳动物的表示构造也被产生, recombinant 蛋白质的表示,本地化和分泌物是由西方的污点分析和 immunofluorescence 试金跟随的 transfection 的 assayed。PSP94 或 CRISP-3 的宫外的表示在房间生长上有的效果被 clonogenic 幸存试金追随者 transfection 学习。评估二蛋白质的合作表示的效果,表示了 PSP94 的 PC3 的稳定的克隆被产生。他们是随后有 CRISP-3 表示构造的 transfected 并且使遭到了到 clonogenic 幸存试金。我们的结果证明 PSP94 和 CRISP-3 能各在一根细胞线导致生长抑制特定的举止。尽管 CRISP-3-positive 房间线的生长被 PSP94 禁止,生长抑制由 CRISP-3 调停了没被 PSP94 的存在或缺席影响。这建议 CRISP-3 可以在前列腺 tumourigenesis 期间参予 PSP94 独立的活动。 | Bhakti R. Pathak Ananya A. Breed Vaishali H. Nakhawa Dhanashree D. Jagtap Smita D. Mahale | 2010 | Asian Journal of Andrology2010，12，5： | 3 |
| 14 | Correlation of pattern reversal visual evoked potential parameters with the pattern standard deviation in primary open angle glaucoma显示文摘AIM:To evaluate whether glaucomatous visual field defect particularly the pattern standard deviation(PSD)of Humphrey visual field could be associated with visual evoked potential(VEP)parameters of patients having primary open angle glaucoma(POAG).METHODS:Visual field by Humphrey perimetry and simultaneous recordings of pattern reversal visual evoked potential(PRVEP)were assessed in 100 patients with POAG.The stimulus configuration for VEP recordings consisted of the transient pattern reversal method in which a black and white checker board pattern was generated(full field)and displayed on VEP monitor(colour 14')by an electronic pattern regenerator inbuilt in an evoked potential recorder(RMS EMG EP MARK II).RESULTS:The results of our study indicate that there is a highly significant(P<0.001)negative correlation of P100 amplitude and a statistically significant(P<0.05)positive correlation of N70 latency,P100 latency and N155 latency with the PSD of Humphrey visual field in the subjects of POAG in various age groups as evaluated by Student's t-test.CONCLUSION:Prolongation of VEP latencies were mirrored by a corresponding increase of PSD values.Conversely,as PSD increases the magnitude of VEP excursions were found to be diminished. | Ruchi Kothari Pradeep Bokariya Ramji Singh Smita Singh Purvasha Narang | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 3 |
| 15 | Evaluation of Traditional Indian Antidiabetic Medicinal Plants for Human Pancreatic Amylase Inhibitory Effect In Vitro显示文摘 | Sudha Ponnusamy Remya Ravindran Smita Zinjarde Shobha Bhargava Ameeta Ravi Kumar | 2010 | Evidence-Based Complementary and Alternative Medicine2010，，： | 3 |
| 16 | Status of precision medicine approaches to traumatic brain injury显示文摘Traumatic brain injury(TBI)is a serious condition in which trauma to the head causes damage to the brain,leading to a disruption in brain function.This is a significant health issue worldwide,with around 69 million people suffering from TBI each year.Immediately following the trauma,damage occurs in the acute phase of injury that leads to the primary outcomes of the TBI.In the hours-to-days that follow,secondary damage can also occur,leading to chronic outcomes.TBIs can range in severity from mild to severe,and can be complicated by the fact that some individuals sustain multiple TBIs,a risk factor for worse long-term outcomes.Although our knowledge about the pathophysiology of TBI has increased in recent years,unfortunately this has not been translated into effective clinical therapies.The U.S.Food and Drug Administration has yet to approve any drugs for the treatment of TBI;current clinical treatment guidelines merely offer supportive care.Outcomes between individuals greatly vary,which makes the treatment for TBI so challenging.A blow of similar force can have only mild,primary outcomes in one individual and yet cause severe,chronic outcomes in another.One of the reasons that have been proposed for this differential response to TBI is the underlying genetic differences across the population.Due to this,many researchers have begun to investigate the possibility of using precision medicine techniques to address TBI treatment.In this review,we will discuss the research detailing the identification of genetic risk factors for worse outcomes after TBI,and the work investigating personalized treatments for these higher-risk individuals.We highlight the need for further research into the identification of higher-risk individuals and the development of personalized therapies for TBI. | Sahithi Reddi Smita Thakker-Varia Janet Alder Anna O.Giarratana | 2022 | Neural Regeneration Research2022，17，10： | 3 |
| 17 | Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation显示文摘导致消炎痛的胃的溃疡在试验性的老鼠模型由 ellagic 酸(EA ) 愈合的机制在我们的学习被描述。溃疡索引(UI ) 和 myeloperoxidase (军邮局) 胃纸巾的活动在消炎痛以后在第三天显示出最大的溃疡(18 mg/kg,单个剂量) 管理。UI 和军邮局活动的初步的观察建议 EA 拥有愈合溃疡的活动。另外的反溃疡参数象前列腺素 E2 的层次那样, cyclooxygenase (艇长) 1 和 2 酶,反煽动性的 cytokines [ interleukin ( IL ) -4 和-5], pro-angiogenic 因素例如脉管的 endothelial 生长因素, hepatocyte 生长因素( HGF ),并且 endothelial 生长因素( EGF )由消炎痛是下面调整的。为 3 天的处理转移了的 EA (7 mg/kg/day ) 导致消炎痛的支持 inflammatory 愈合的生物化学的参数站在一起。这些活动与 EA 的能力被相关改变愈合的 COX-2-dependent 小径。然而, EA 的愈合溃疡的活动被特定的 COX-2 禁止者, celecoxib,和 NS-398 的管理前损害。一起拿,这些结果建议 EA 处理加速溃疡由导致 IL-4 愈合, EGF/HGF 铺平并且提高 COX-2 表示。 | Ananya Chatterjee Sirshendu Chatterjee Smita Das Arpita Saha Subrata Chattopadhyay Sandip K.Bandyopadhyay | 2012 | Acta Biochimica et Biophysica Sinica2012，44，7： | 3 |
| 18 | Evaluation of antihyperglycemic and antioxidant activities of Saraca asoca (Roxb.) De Wild leaves in streptozotocin induced diabetic mice显示文摘 | Sunil Kumar Smita Narwal Dinesh Kumar Gurvirender Singh Sumit Narwal Renu Arya | 2012 | Asian Pacific Journal of Tropical Disease2012，，3： | 3 |
| 19 | Prevalence of excessive internet use and its correlation with associated psychopathology in 11th and 12th grade students显示文摘Background Globally, the number of internet users has crossed the three-billion mark, while in India users grew over 17% in the first 6 months of 2015 to 354 million. This study presented a background on internet use and the existence of excessive internet use. Aim To study the extent of internet use in 11th and 12th grade students and the psychopathology, if any, associated with excessive internet use. Methods 426 students who met the inclusion criteria were recruited from 11 th and 12th grade classes from Kendriya Vidyalaya, New Delhi, India, and were assessed by Young's Internet Addiction Test and the Strength and Difficulties Questionnaire. Results Among the 426 students, the mean internet addiction total score was 36.63 (20.78), which indicated mild level of internet addiction. 1.41%(six students) was diagnosed as excessive internet users, while 30.28% and 23.94% were classified as moderate and mild internet users, respectively. The prevalence of internet addiction between gender was 58.22% in males and 41.78% in females. While both positive (prosocial) and negative (hyperactivity, emotional, conduct and peer problem) impacts of internet use were reported by students, in the current study excessive use of internet had a negative impact on students' lives as compared with positive impact, which was statistically significant (p<0.0001). Conclusion Excessive internet use led to abnormal behaviours which cause negative consequences to users. Early diagnosis of risk factors related to excessive internet use, provides education about responsible use and supervision of students by family members. | Nitin Kumar Arvind Kumar Subodh Kumar Mahto Manish Kandpal Smita Neelkanth Deshpande Parul Tanwar | 2019 | General Psychiatry2019，32，2： | 3 |
| 20 | Self-assembled vertically aligned gold nanorod super-lattices for ultra-high sensitive detection of molecules显示文摘我们显示出超点阵能作为探针或底层服务为的那自我装配的垂直地排列的金 nanorod (VA-GNRs ) 超离频各种各样的分子的敏感察觉。d葡萄糖和2,4,6强烈炸药( TNT )由于他们的很低的拉曼剖面图被选择了为模型系统( 5.6 佩?????汣獡????汰獵瀭畬???㈠?猯'T￣慮潮畴敢??????????????????????吗???????????????????￡???霔?? | Amey Apte Prashant Bhaskar Raja Das Smita Chaturvedi PankajPoddar Sulabha Kulkarni | 2015 | Nano Research2015，8，3： | 3 |
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