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| 1 | Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers显示文摘AIM:To determine the expression of membrane-bound mucins and glycan side chain sialic acids in Helicobacter pylori(H.pylori)-associated,non-steroidal inflammatory drug(NSAID)-associated and idiopathic-gastric ulcers.METHODS:We studied a cohort of randomly selected patients with H.pylori(group 1,n=30),NSAID(group 2,n=18),combined H.pylori and NSAID associated gastric ulcers(group 3,n=24),and patients with idiopathic gastric ulcers(group 4,n=20).Immunohistochemistry for MUC1,MUC4,MUC17,and staining for Erythrina cristagalli agglutinin and Sambucus nigra agglutinin(SNA)lectins was performed on sections from the ulcer margins.RESULTS:Staining intensity of MUC17 was higher in H.pylori ulcers(group 1)than in idiopathic ulcers(group4),11.05±3.67 vs 6.93±4.00 for foveola cells,and10.29±4.67 vs 8.00±3.48 for gland cells,respectively(P<0.0001).In contrast,MUC1 expression was higher in group 4 compared group 1,9.89±4.17 vs 2.93±5.13 in foveola cells and 7.63±4.60 vs 2.57±4.50 for glands,respectively(P<0.0001).SNA lectin staining was increased in group 4,in parallel to elevated MUC1expression,indicating more abundantα2-6 sialylation in that group.CONCLUSION:Cytoplasmic MUC17 staining was sig-nificantly decreased in the cases with idiopathic ulcer.The opposite was observed for both MUC1 and SNA lectin.This observation may reflect important pathogenic mechanisms,since different mucins with altered sialylation patterns may differ in their protection efficiency against acid and pepsin. | Yaron Niv Doron Boltin Marisa Halpern Miriam Cohen Zohar Levi Alex Vilkin Sara Morgenstern Vahig Manugian Erica St Lawrence Pascal Gagneux Sukhwinder Kaur Poonam Sharma Surinder K Batra Samuel B Ho | 2014 | World Journal of Gastroenterology2014,20,40: | 5 |
| 2 | Bamboo shoot:a potential source of food security显示文摘 | SANTOSH S POONAM S LALIT M B | | 0,,01: | 1 |
| 3 | Tissue culture studies of tomato (Lycopersicon esculentum) 显示文摘 | Poonam B Nanjappa A Tissa S | 2004 | Plant Cell Tissue and Organ Culture2004,78,: | 1 |
| 4 | Ectopic Pregnancy--two years review from BPKIHS, Nepal显示文摘 | Poonam Uprety D Banerjee B | 2005 | Kathmandu Univ Med J(KUMJ)2005,3,4: | 1 |
| 5 | PAK signaling in oncogenesis显示文摘 | Poonam RM DQ Li Murray B | | 0,,28: | 1 |
| 6 | Punicalagins-A large polyphenol compo unds found in pomegranate:A therapeutic review显示文摘 | Satyanand T Ajeet S Poonam B | 2012 | J Plant Sci2012,5,2: | 1 |
| 7 | Phytochelatin Plays a Role in UV-B Tolerance in N2-fixing Cyanobacterium Anabaena Doliolum显示文摘 | POONAM B ASHISH K S SNIGDHA U l | 2005 | J Plant Physiol(S0176-1617)2005,162,11: | 1 |
| 8 | Robust features for noisy speech recognition using MFCC computation from magnitude spectrum of higher order autoeorrela- tion coefficients显示文摘 | Dev A Poonam B | 2010 | International Journal of Computer Applications2010,10,8: | 1 |
| 9 | A unique approach for watermarking non-numeric relational database显示文摘 | Rajneesh K B Purva G Poonam G | | 0,,07: | 1 |
| 10 | PAK signaling inoncogenesis显示文摘 | Poonam RM DQ Li Murray B | 2009 | Oncogene2009,28,28: | 1 |
| 11 | Biomarkers in risk assessment of asbestos exposure显示文摘 | Kunal B Elke D Poonam K | 2005 | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis2005,579,1: | 1 |
| 12 | Bamboo shoot processing: food quality and safety aspect 显示文摘 | Santosh S Lalit M B Poonam S | 2010 | Trends in Food Science and Technology2010,21,4: | 1 |
| 13 | Ownership effect in the Wild: Influence of Land Ownership on Agribusiness Goals and Decisions in the Argentine Pampas显示文摘 | Poonam A Federico B Guillermo P | 2015 | Journal of Behavioral and Experimental Economics2015,58,10: | 1 |
| 14 | Punicalagins-A large polyphenol compounds found in pomegranate:A therapeutic review显示文摘 | Satyanand T Aject S Poonam B | 2012 | Plant Sci2012,5,2: | 1 |
| 15 | Phytochelatin plays a role in UV-B tolerance in N2-fixing cyanobacterium Anabaena doliolum显示文摘 | Poonam B Ashish K S Snigdha U | 2005 | Journal of Plant Physiology2005,162,: | 1 |
| 16 | Impact of different abiotic stresses on growth, photosynthetic electron transport chain, nutrient uptake and enzyme activities of Cu-acclimated Anabaena doliolum显示文摘 | Thapar R Srivastava A K Poonam B P | 2008 | Journal of Plant Physiology2008,165,3: | 1 |
| 17 | Action of Capparis deciduas against alloxan-induced oxidative stress and diabetes in rat tissues显示文摘 | Shubashish S Deepak B | 1997 | Pharmacological Research1997,36,3: | 1 |
| 18 | Bamboo shoot processing: food quality and safety aspect显示文摘 | SANTOSH S LALIT M B POONAM S | 2010 | Trends in Food Science & Technology2010,21,4: | 1 |
| 19 | Ad Hoc Network routing protocols: an overiew显示文摘 | K Sarla B Poonam S Rajeshwar | 2010 | International Journal of Technology and Applied Science2010,,1: | 1 |
| 20 | Tissue culture studies of to- mato (Lycopersicon esculentum)显示文摘 | Poonam B Nanjappa A Senaratna T | 2004 | Plant Cell Tissue and Organ Culture2004,78,: | 1 |