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| 1 | Resveratrol inhibits matrix metalloproteinases to attenuate neuronal damage in cerebral ischemia:a molecular docking study exploring possible neuroprotection显示文摘The main pathophysiology of cerebral ischemia is the structural alteration in the neurovascular unit, coinciding with neurovascular matrix degradation. Resveratrol has been reported to be one of the most potent chemopreventive agents that can inhibit cellular processes associated with ischemic stroke. Matrix metalloproteinases(MMPs) has been considered as a potential drug target for the treatment of cerebral ischemia. To explore this, we tried to investigate the interaction of resveratrol with MMPs through molecular docking studies. At 30 minutes before and 2 hours after cerebral ischemia/reperfusion induced by occlusion of the middle cerebral artery, 40 mg/kg resveratrol was intraperitoneally administered. After resveratrol administration, neurological function and brain edema were significantly alleviated, cerebral infarct volume was significantly reduced, and nitrite and malondialdehyde levels in the cortical and striatal regions were significantly decreased. The molecular docking study of resveratrol and MMPs revealed that resveratrol occupied the active site of MMP-2 and MMP-9. The binding energy of the complexes was –37.848672 k J/mol and –36.6345 k J/mol for MMP-2 and MMP-9, respectively. In case of MMP-2, Leu 164, Ala 165 and Thr 227 were engaged in H-Bonding with resveratrol and in case of MMP-9, H-bonding was found with Glu 402, Ala 417 and Arg 424 residues. These findings collectively reveal that resveratrol exhibits neuroprotective effects on cerebral ischemia through inhibiting MMP-2 and MMP-9 activity. | Anand Kumar Pandey Pallab Bhattacharya Swet Chand Shukla Sudip Paul Ranjana Patnaik | 2015 | Neural Regeneration Research2015，10，4： | 12 |
| 2 | Genetic polymorphism in CD14 gene, a co-receptor of TLR4 associated with non-alcoholic fatty liver disease显示文摘AIM To evaluate the pathogenic role of toll-like receptor(TLR) gene polymorphisms in patients with nonalcoholic fatty liver disease(NAFLD).METHODS Two hundred and fifty subjects(NAFLD = 200, healthy volunteers = 50) underwent polymerase chain reaction and restriction fragment length polymorphism to assess one polymorphism in the toll-like receptor 2(TLR2) gene(A753G), two polymorphisms in the TLR4 gene(TLR4 Asp299 Gly and Thr399 Ile allele), and two polymorphisms in the cluster of differentiation 14(CD14)(C-159 T and C-550T) gene, a co-receptor of TLR4. Association of TLR gene polymorphisms with NAFLD and its severity was evaluated by genetic models of association.RESULTS On both multiplicative and recessive models of gene polymorphism association, there was significant association of CD14 C(-159) T polymorphism with NAFLD; patients with TT genotype had a 2.6 fold increased risk of developing NAFLD in comparison to CC genotype. There was no association of TLR2 Arg753 Gln, TLR4 Asp299 Gly, Thr399 Ile, and CD14 C(-550) T polymorphisms with NAFLD. None of the TLR gene polymorphisms had an association with histological severity of NAFLD.CONCLUSION Patients with CD14 C(-159) T gene polymorphism, a co-receptor of TLR4, have an increased risk of NAFLD development. | Shweta Kapil Ajay Duseja Bal Krishan Sharma Bhupesh Singla Anuradha Chakraborti Ashim Das Pallab Ray Radha K Dhiman Yogesh Chawla | 2016 | World Journal of Gastroenterology2016，22，42： | 7 |
| 3 | Piroxicam-mediated modulatory action of 5-hydroxytryptamine serves as a “brake” on neuronal excitability in ischemic stroke显示文摘Our previous studies indicated an increase in extracellular γ-aminobutyric acid(GABA) in rodent's ischemic brain after Piroxicam administration, leading to alleviation of glutamate mediated excitotoxicity through activation of type A GABA receptor(GABAA). This study was to investigate if GABAA activation by Piroxicam affects extracellular 5-hydroxytryptamine or not. High performance liquid chromatography revealed that there was a significant decrease in extracellular 5-hydroxytryptamine release in ischemic cerebral cortex and striatum in Piroxicam pre-treated rat brains. This suggests a probable role of Piroxicam in reducing extracellular 5-hydroxytryptamine release in ischemic cerebral cortex and striatum possibly due to the GABAA activation by Piroxicam. | Pallab Bhattacharya Anand Kumar Pandey Sudip Paul Ranjana Patnaik | 2015 | Neural Regeneration Research2015，10，9： | 4 |
| 4 | Anisotropy Properties of Tissues: A Basis for Fabrication of Biomimetic Anisotropic Scaffolds for Tissue Engineering显示文摘Tissue engineering has been a subject of extensive scientific exploration in the last two decades making gradual inroads into clinical studies as well.Along with regenerative cells and growth factors,biomaterial scaffolds are integral to the development of a tissue engi neered construct.It is now appreciated that scaffolds should mimic the target tissue properties intimately in order to provide a micro-environment milieu that allows the seeded cells to differentiate into the desired tissue.Even from a structural viewpoint,mismatch between scaffold and native matrix properties can cause cell necrosis through mechanisms such as stress shielding.One of the key prop erties of most body tissues is that they exhib社anisotropy.However,most fabrication methods generate isotropic scaffolds and require specific modifications to produce anisotropic scaffolds.In the last decade,the advent of additive manufacturing and bioprinting has provided facile tools to fabricate scaffolds with desired anisotropy.On the other hand,a biomimetic scaffold can be designed only when target tissue anisotropy is well known to the tissue engineer.This review presents an overview of the anisotropic properties of different tissues,which will be critical for developing biomimetic engineered constructs.The traditional anatomical records do not adequately present these properties from the perspective of designing tissue engineering scaffolds.Subsequently,present state-of-the art in devel opment of anisotropic scaffolds as well as tissue constructs using different conventional and emerging fabrication techniques is discussed.It is expected that the readers will obtain a comprehensive reference on the research area by examining these two aspects juxtaposed to each other and gain key trends for fabrication of anisotropic scaffolds,plausibly with improved regenerative outcomes. | Pallab Datta Veena Vyas Santanu Dhara Amit Roy Chowdhury Ananya Barui | 2019 | Journal of Bionic Engineering2019，16，5： | 4 |
| 5 | A possible therapeutic potential of quercetin through inhibition of μ-calpain in hypoxia induced neuronal injury:a molecular dynamics simulation study显示文摘The neuroprotective property of quercetin is well reported against hypoxia and ischemia in past studies.This property of quercetin lies in its antioxidant property with blood-brain barrier permeability and anti-inflammatory capabilities.μ-Calpain,a calcium ion activated intracellular cysteine protease causes serious cellular insult,leading to cell death in various pathological conditions including hypoxia and ischemic stroke.Hence,it may be considered as a potential drug target for the treatment of hypoxia induced neuronal injury.As the inhibitory property of μ-calpain is yet to be explored in details,hence,in the present study,we investigated the interaction of quercetin with μ-calpain through a molecular dynamics simulation study as a tool through clarifying the molecular mechanism of such inhibition and determining the probable sites and modes of quercetin interaction with the μ-calpain catalytic domain.In addition,we also investigated the structure-activity relationship of quercetin with μ-calpain.Affinity binding of quercetin with μ-calpain had a value of –28.73 k J/mol and a Ki value of 35.87 μM that may be a probable reason to lead to altered functioning of μ-calpain.Hence,quercetin was found to be an inhibitor of μ-calpain which might have a possible therapeutic role in hypoxic injury. | Anand Kumar Pandey Swet Chand Shukla Pallab Bhattacharya Ranjana Patnaik | 2016 | Neural Regeneration Research2016，11，8： | 3 |
| 6 | Smoking and the pathogenesis of gastroduodenal ulcer – recent mechanistic update显示文摘 | Pallab Maity Kaushik Biswas Somenath Roy Ranajit K. Banerjee Uday Bandyopadhyay | 2003 | Molecular and Cellular Biochemistry (-)2003，，1： | 2 |
| 7 | Free radical scavenging activity of Castanopsis indica in mediating hepatoprotective activity of carbon tetrachloride intoxicated rats显示文摘 | Narayan Dolai Indrajit Karmakar RB Suresh Kumar Biswakanth Kar Asis Bala Pallab Kanti Haldar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，，1： | 1 |
| 8 | Sensorless current mode control-an observer-based technique for DC-DC converters 显示文摘 | Pallab Midya | 2001 | IEEE Trans2001，16，4： | 1 |
| 9 | Causality relationship between electricity consumption and GDP in Bangladesh显示文摘 | Pallab Mozumder Achla Marathe | 2005 | Energy Policy2005，，1： | 1 |
| 10 | Recombinant OMP28 antigen-based indirect ELISA for serodiagnosis of bovine brucellosis显示文摘 | Pallab Chaudhuri Rajeev Prasad Vinth Kumar | 2010 | Molecular and Cellular Probes2010，24，3： | 1 |
| 11 | Heat exchanger network synthesis:the possibility of randomization显示文摘 | SAMARJIT C PALLAB G | 1999 | Computers and Chemical Engineering1999，72，： | 1 |
| 12 | Quantum dot lasers and integrated optoelectronics on silicon platform Invited Paper显示文摘Chip-scale integration of optoelectronic devices such as lasers,waveguides,and modulators on silicon is prevailing as a promising approach to realize future ultrahigh speed optical interconnects.We review recent progress of the direct epitaxy and fabrication of quantum dot(QD)lasers and integrated guided-wave devices on silicon.This approach involves the development of molecular beam epitaxial growth of self- organized QD lasers directly on silicon substrates and their monolithic integration with amorphous silicon waveguides and quantum well electroabsorption modulators.Additionally,we report a preliminary study of long-wavelength(>1.3μm)QD lasers grown on silicon and integrated crystalline silicon waveguides using membrane transfer technology. | Pallab Bhattacharya | 2008 | Chinese Optics Letters2008，6，10： | 1 |
| 13 | Multiplex PCR for rapid diagnosis of tuberculous meningitis显示文摘 | Kusum S Aman S Pallab R | 2011 | J Neurol2011，258，： | 1 |
| 14 | Multiplex PCR for rapid diagnosis of tuberculous meningitis显示文摘 | Kusum S Aman S Pallab R | 2011 | J Neurol2011，258，10： | 1 |
| 15 | Multiplex PCR for rapid diagnosis of tuberculous meningitis显示文摘 | Kusum S Aman S Pallab R | | 0，，10： | 1 |
| 16 | Mechanics of very fine-grained nanocrystalline materials with contributions from grain interior, GB zone, and grain-boundary sliding显示文摘 | Pallab Barai George J. Weng | 2009 | International Journal of Plasticity2009，，12： | 1 |
| 17 | Contribution of the blood glucose level in perinatal asphyxia显示文摘 | Pallab Basu Sabbasachi Som Nabendu Choudhuri Harendranath Das | 2009 | European Journal of Pediatrics2009，，7： | 1 |
| 18 | Recombinant OMP28 antigen-based indirect ELISA for serodiagnosis of bovine brucellosis显示文摘 | Pallab C Rajeev P Vinth K e? al | 2010 | Molecular and Cellular Prubes2010，24，： | 1 |
| 19 | Recombi- nant OMP28 Antigen - based indirect ELISA fur Serodiagnosis of Bovine Brucellosis显示文摘 | Pallab Chaudhuri Rajeev Prasad Vinth Kumar | 2010 | Molecular and Cellular Prubes2010，24，： | 1 |
| 20 | Graphene and MWCNT based bi-functional polymer nanocomposites with enhanced microwave absorption and supercapacitor property显示文摘 | Pallab Bhattacharya Saptarshi Dhibar Mrinal Kantl Kun- du | 2015 | Materials Research Bulletin2015，66，： | 1 |
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